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Volume 5, Issue 2
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HIROSHI SASAMOTO, SHUNTETSU YOH1956 Volume 5 Issue 2 Pages 69-82
Published: 1956
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSIn 5 cases of mitral disorders and 8 cases of miscellaneous diseases (13 cases in all), gas characteristics and acid-base balance of so-called PC (pulmonary capillary) blood were observed in comparison with those of mixed arterial, mixed venous and capacity blood, and the following results were obtained:
1) Compared with mixed arterial and mixed venous blood, O2 content, O2 saturation and O2 partial pressure showed the highest values in PC blood, while CO2 content, plasma HCO3-, H2CO3 and CO2 partial pressure were the lowest in PC blood.
2) The reason why the CO2 content of PC blood is remarkably low and close to that of capacity blood is not because PC blood has passed through alveoli twice but because shunting blood which has never passed alveoli streams into PC blood only in a small amount. As CO2 partial pressure of PC blood is considered to be very close to that of alveolar air CO2 partial pressure of PC blood instead of that of mixed arterial blood which has been hitherto used should be employed as CO2 partial pressure of alveolar air for various kinds of calculations,
3) What makes O2 partial pressure of PC blood higher than that of mixed arterial and mixed venous blood is the fact that the former contains large amount of blood which has passed through alveoli more frequently.
4) Mean blood pressure and O2 partial pressure of PC blood show a fairly good correlation (r=-0.68, 0.02>p>0.01).
5) While plasma HCO3 of PC blood is lower than that of mixed arterial and mixed venous blood, anionized hemoglobin and anionized plasma protein are higher in PC blood than in mixed arterial and venous blood. Therefore, total buffer base of PC blood has no remarkable difference from the other samples. However, since CO2 partial pressure of PC blood is the lowest, pH in PC blood tends to alkaline.View full abstractDownload PDF (713K) -
ITTAKU MIKATA, KEITARO NARITA, MITSUMICHI MURAKAMI1956 Volume 5 Issue 2 Pages 83-122
Published: 1956
Released on J-STAGE: March 27, 2009
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TAKEO UEDA, SHIGESHI TOYOSHIMA1956 Volume 5 Issue 2 Pages 123-143
Published: 1956
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSThe fundamental experiments can be summarized as follows. PANS acts directly on Japanese B encephalitis virus, both unpurified and purified, and exerts a strong inactivating effect. A significant therapeutic effect is observed by a single intravenous injection of PANS 72 hours after intracerebral, intranasal or intraperitoneal inoculation of the virus. Examination of the time of effect from the standpoint of virus proliferation shows that PANS is effective even after virus has multiplied in the brain. A therapeutic effect can therefore be anticipated in Japanese B encephalitis patients.
Examination of the acute toxicity, effect on respiration, blood pressure, electrocardiogram, excised heart, intestine in vivo and excised intestine shows that PANS possesses no detrimental action on the internal organs and gives rise to no marked side effect. The drop in PANS blood concentration is rapid and in view of the fact that a maximum concentration is seen in the brain in 6 hours, it would be necessary to give PANS at frequent intervals when it is to be used clinically. It is suggested from the rapid excretion in the urine that there is little danger of accumulation.
On the basis of these findings, PANS was tried clinically for the treatment of Japanese B encephalitis in the summer of 1955.View full abstractDownload PDF (1010K)
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