The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 7
Displaying 1-15 of 15 articles from this issue
  • DAIZO USHIBA, SABURO HIGUCHI, TOSHIHIKO OHASHI
    1958 Volume 7 Pages 1-15
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    A basic polypeptide was extracted from calf thymus which exerted the inhibition on the oxygen consumption and the growth in a semisynthetic medium of Salmonella enteritidis.
    A close correlation between the sensitivity of the organisms to the growth-inhibitory action of the polypeptide and their virulence for mice was found. The decrease in virulence during aged broth culture of a highly virulent strain of S. enteritidis was more closely correlated with the change in sensitivity to the polypeptide than with S-R mutation processes. However, no increase of virulence was accompanied when sensitive strains acquired in vitro a high resistance to the polypeptide.
    In the culture medium in which the growth-inhibitory action of the polypeptide is measured, the concentration of NaCl added was found to be critical in order to predict the difference in virulence of organisms tested.
    We are greatly indebted to the late Dr. B. Kitasato for his valuable help in the present study.
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  • HIROSHI SAKAGUCHI, YASUNOSUKE SUZUKI
    1958 Volume 7 Pages 17-37
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    An electron microscopic study of the renal tubule cells of rabbit by part was performed.
    1. Because of the apparent structural differences between the ceels of proximal convolution and the comparatively straight medullary portion, we added the straight medullary portion to Maximow-Bloom's classification of the nephron.
    2. In all parts of the nephron except the papillary duct, basal intus-susceptions were observed either in a well differentiated or an undifferentiated form.
    3. Two types of capillaries were seen in the medulla of the kidney. After the authors had corrected their first proof, the authors were given a chance to read Rhodin's work (International Review of Cytology, VII: 485-534, 1958). The authors believe that Rhodin's work is very excellent.
    The authors wish to express their gratitude to Prof. Tadayoshi Kobayashi and Dr. Yonosuke Watanabe for suggesting this investigation as well as for constant guidance in the course of work.
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  • YASUNOBU SUZUKI, HISAO FUKAZAWA, MINORU IIDA
    1958 Volume 7 Pages 39-60
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    (1) Experimental shock was produced in guinea pigs by instituting injection of croton oil into submucous tissue of the palate.
    (2) In order to produce shock in these animals 0.1 cc of croton oil proved to be sufficient and 35% of the number thus treated resulted in death due to shock; whereas the number of deaths due to administration of similar agent and dosage into abdominal subcutaneous tissue proved to be none whatsoever.
    (3) From these facts, it is conjectured that the region of the palate might be more vulnerable to causation of shock than areas elsewhere; that the resulting shock of the present experiment might be due to undue stimulation of the autonomic nervous system.
    (4) Pathologically the most remarkable changes were in the circulatory system and further degenerative changes were added to these changes.
    (5) Succeeded in preventing the state of shock caused from croton oil injection by using Chlorpromazine as the medicament before and after the croton oil injection. (made all the eighteen (18) animals possible to survive)
    (6) In order to examine the medicating effect of Chlorpromazine to the state of shock, made the test executing the administration of Chlorpromazine simultaneously with that of croton oil, but it proved to be ineffective.
    (7) Made clear the Chlorpromazine's restraining action to the state of shock by the histological examination on the visceral organs (lung, liver, kidney, adrenal gland).
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  • RETINITIS PIGMENTOSA
    MICHIO SAKANOUE
    1958 Volume 7 Pages 61-74
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The author carried out several experiments upon the biochemistry in pigmentary degeneration of the retina (P.D.R.) and the present paper is concerned with the experiments on the liver function, lipid metabolism, and lipoprotein-mucoprotein metabolism.
    The results were summarized as follows.
    1. The various colloidal reactions in P.D.R. resembled those of liver disease, but the grades of positivities were comparatively lower than those of liver disease. In the experiments on the liver function of P.D.R., it was assumed that latent liver functional disorders could be found in this disease.
    2. Both the concentration of total cholesterol and phospholipid in the serum remains statistically in normal average, and the fraction of esterified cholesterol were not decreased. Cholesterol-Phospholipid ratio(C/P) were lower than those of normal person. Then, the author noted that liver functional disorders in P.D.R. may not be evident but latent, and phospholipid may be comparatively increased in the serum to cholesterol. It is assumed that abnormal amount of lipid may be stored particularly in the cells of the central nervous system.
    3. Both alpha- and beta-lipoprotein were in normal concentration, and ratio of beta- to alpha-lipoprotein were also normal.
    4. It is thought that, the tapetoretinal degeneration including P.D.R. are due to faulty metabolism of fat with the resulting deposition of lipid in the cells of the central nervous system. P.D.R. is the late juvenile form of the tapetoretinal degeneration without dementia, then the author proved that this disease was one of the groups of degenerative diseases, and obviously associated with the abnormal lipid storage, and might be a disease of miscel-laneous disorders of lipid metabolism with tapetoretinal degeneration, and upon a wide construction it might be a kind of latent lipoidosis in thesaurimosis.
    Finally the author expresses his sincere thanks to Prof. M. Uyemura, Assistant Prof. Y. Kuwabara, Instructor K. Katow and Instructor K. Kawashima for continuous guidance and encouragement. And the author hereby convey to Dr. Saitow, Dr. Ozawa, and Dr. Numao my hearty thanks for the encouragement and the cooperation they gave me on this study.
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  • YASUNOBU SUZUKI, KUNIHIKO NAGASE
    1958 Volume 7 Pages 75-91
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • SUSUMU HARASHIMA, KENZABURO TSUCHIYA, HARUO KONDO, MASAO MOTOUCHI, TAK ...
    1958 Volume 7 Pages 93-105
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Experiments on the effectiveness of Ca EDTA upon lead poisoning were undertaken, on dogs and lead workers.
    1. In the animal experiments the following conclusion were reached.
    a. The parenteral administration of Ca EDTA changed the distribution of lead in arterial blood, and plasma lead was increased. This is thought to come from the red corpuscles in which the greatest portion of lead in the blood was found when lead absorption occurs, and also from the extravascular tissues.
    b. Decrease of A/G ratio was not prevented by the administration of the drug, although the symptoms, including anemia, were kept normal. This indicates that the decrease of A/G ratio appears in the earlier stage of lead poisoning, with the exception of coproporphyrinuria, as has beenn stated previously.
    2. Clinical and prophylactic use of the drug yielded the following results.
    a. Intravenous therapy did not increase the lead concentration in the blood but the urinary lead showed its highest level in the urine after three hours administration.
    b. Higher urinary lead excretion by oral administration was obscrved in only a few patients in contrast with the results seen by intravenous injection. This indicates that the absorption from the intenstine is very low, following the oral administration.
    c. Oral administration (which was extended over a period of more than six months) for the purpose of preventing chronic, potential lead poisoning, was successful in decreasing both the blood lead and urine lead quantity, in preventing appearance of the symptoms, and in improving anemia.
    d. Further study is necessary to determine a proper, daily, oral dosage.
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  • KIYOFUMI HIRATA, SEIICHI ASANO
    1958 Volume 7 Pages 107-118
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    A new method of bioassay for antidiuretic substance was reported. Assay was carried out with help of an apparatus for indicating automatically the time of natural urine voiding of several rats and the test material was injected intravenously into non-anesthetized rat.
    Antidiuretic response was expressed as the antidiuretic effect on a constant water diuresis, which could be expected for forty minutes.
    Antidiuretic activity of the plasma in the normal subjects was quite slight in the early morning, while significantly increased in the midday and tended to decrease in the evening.
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  • EXPERIMENTAL STUDY ON THE SO-CALLED INITIAL SHOCK AND APNEA
    NOBUKATSU SHIMADA, ROKURO TAKAYAMA, FUMIHIKO NAGAI, YOSHIZO NAKAMURA, ...
    1958 Volume 7 Pages 119-127
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • ITTAKU MIKATA
    1958 Volume 7 Pages 129-144
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • MASATAKA KATSU, IPPEI FUJIMORI, KOREYASU KURAHARA
    1958 Volume 7 Pages 145-155
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    First, we mentioned that intermittent or transient bacteremia appears quite frequently. And from the study of various cases of bacteremia, we found the importance of blood culture when the patient had fever after the surgical operations, minor operations or any kind of diseases. Then the latest findings and opinions concerning the prevention and treatment of such bacteremias were discussed.
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  • ON THE POSSIBILITY OF FURTHER IMPROVEMENT OF JAPANESE PHYSICAL STANDARDS
    KENTA OHMORI
    1958 Volume 7 Pages 157-167
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • TADAYOSHI KOBAYASHI, YOSHIYUKI IGARI, NAGAO WAKABAYASHI
    1958 Volume 7 Pages 169-177
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1. The mesenchymal tissue prospective to form the parietal bone of rabbit was transplanted into the anterior eye chamber of adult rabbits. Though bone formation was found in the transplanted mesenchym resected from a 16 day-old foetus and the older, it was not proved in the transplanted mesenchym originated from a 15 day-old foetus and the less. From this experiment, it is evident that the cranial mesenchym of rabbit foetus under 17 days old is not “determined” to osteogenesis.
    2. The mesenchym of rabbit foetus under 16 days old, in which osteogenesis was “undetermined” yet, exhibited osteogenetic activity only when the brain tissue co-existed with it in the anterior eye chamber. Then it is concluded that the parietal bone is “induced” by the brain tissue.
    3. It was proved that the brain tissue had an activity of bone induction in neonatal rabbits as well as in foeti, but the activity decreased rapidly one month after birth.
    4. The simultaneous completion of blood-brain barrier with disappearance of bone induction activity in the brain and its possible role were discussed.
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  • PRESENTATION OF THE CLINICO-PHYSIOLOGICAL ASPECTS OF THE SENILE PULMONARY EMPHYSEMA
    TETSURO YOKOYAMA, HIROSHI SASAMOTO
    1958 Volume 7 Pages 179-196
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1. The definition of expiratory incompetency of obstructive and of non-obstructive type is introduced using the vital capacity, the timed vital capacity, and the index of air trapping.
    2. Physiological aspects of the obstructive ventilatory involvement is dis-cussed with special referrence to the index of air trapping.
    3. The senile pulmonary emphysema is defined from the clinico-physiological standpoint.
    4. The ventilatory and alveolar functions of the senile pulmonary emphy-sema are discussed in comparison with those of the chronic pulmonary emphysema.
    5. Clinical importance of the senile pulmonary emphysema is emphasized with regard to the ventilatory functions in the aged.
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  • KIYOSHI SUZUK, FUMIO YAMASHITA, KEIICHIRO AKAI, NOBUO SEKI
    1958 Volume 7 Pages 197-206
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Voici les particularités de 1'amnésie observée chez un schizophrène qui avait subi la cure de Sakel.
    1. Cette amnésie débuta par une légère inquiétude.
    2. Elle rétrograduit jusqu'aux deux ans précédant le début de sa maladie. Pendant ce temps, le malade était sain et faisait ses études à l'université.
    3. L'objet de cette amnésie était total sans l'ile de mémoire et celle d'oubli.
    4. Cette amnésie manquait d'antérogradation.
    5. Le malade s'orientait toujours correctement et n'accompagnait pas la fabulation aprés la cure.
    6. La tache de remplir cette amnésie continuait sérieusement.
    La structure de cette amnésie est différente de celle du syndrome de Korsakow, mais elle ressemble à celle de la contusion cérébrale.
    Nous pensons done que cette amnésie fut provoquée par la cure de Sakel.+ + +
    Les auteurs sont infiniment reconnaissants à Monsieur le Prof. T. Miura de sa direction bienveillante et de son encouragement chaleureux.
    Nous exprimons aussi nos sincères remerciements à Dr. Y. Tsujiyama et à Dr. K. Iwasa.
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  • HIROSHI NAKAHAMA, SHIZUKO NATORI, MIKIO SAITO
    1958 Volume 7 Pages 207-224
    Published: 1958
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    A compound response was evoked in somatic area II by electrical stimula-tion to contralateral somatic II of the cerebral cortex of cat: surface positive deflection (P) prior to negative deflection (D) followed by a prolonged positive deflection (A). A spike sequence can also be recorded before and on the rising limb of component P.
    Studies were made of excitability characteristics determined with the use of paired identical stimuli at various intervals and recurrence rates. The effects. of local cortical application of potassium cyanide and strychnine sulfate were evaluated. Intracortical recording was made with approximately 10μ pipette electrodes. Interaction studies were also made by means of various combinations, of paired stimuli at different intervals.
    It is suggested from these experiments that component P represents the product of postsynaptic activity, being largely produced by the same cortical elements as the postsynaptic positive components of the primary response evoked. by contralateral and ipsilateral somatic afferent nerve stimulation. It is also suggested that component D is of similar origin as the dendritic response evoked by topical stimulation. Component A is considered to represent the activity of neurones different from those which occasion component P.
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