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Volume 8, Issue 3
Displaying 1-6 of 6 articles from this issue
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TOYOZO AIZAWA, Y. GOTO, Y. TAZAKI, H. MAKINO, H. NAKAZATO, T. AOKI, H. ...1959 Volume 8 Issue 3 Pages 117-128
Published: 1959
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSDownload PDF (637K) -
II. GLOMERULUSYASUNOSUKE SUZUKI1959 Volume 8 Issue 3 Pages 129-155
Published: 1959
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1) The author has observed by electron microscope the glomerular differentiation of rats.
2) Glomerular capillary is formed by the glomerular anlage cells which appear beneath the inner layer of the metanephrogenic vesicle.
3) Glomerular anlage cells proliferate immediately below the inner layer and form intercellular space and later on blood' cavities. From a very early stage these intercellular spaces or blood cavities have communication with sinusoids which exist in the renal cortex.
4) Basement membrane appears between the inner layer and glomerular anlage cells. The anlage cells further proliferate and successively produce new blood cavities in continuation with the first blood cavity immediately under the basement membrane.
5) As glomerulus develops the glomerular pattern grows more complicated but the arrangement of the components that compose the cavity walls remain unchanged from the early stages of immature gromerulus to maturity.
6) The differentiation of the glomerular structural components i.e., epithelial cells, basement membrane, endothelial cells and mesangium has been treated on.
The author would like to express his grateful appreciation to Prof. T. Kobayashi. The author also is indebted to Dr. H. Sakaguchi for his help and advice.View full abstractDownload PDF (39833K) -
EXPERIMENTAL WORK ON BLOOD FLOW OF BRAIN STEMROKURO TAKAYAMA, ICHIO KUDOH, MASAMITSU KATOH, KIHACHIRO MASUDA, KAZUO ...1959 Volume 8 Issue 3 Pages 157-167
Published: 1959
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSDownload PDF (1008K) -
GEORGE SEKINE1959 Volume 8 Issue 3 Pages 169-186
Published: 1959
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSMale rabbits and dogs, divided into 19 groups (Table 1, 2) were fed during one to three months to determine the effect of the disturbed lipid metabolism, hypertension and of the injury in intima, on the development of experimental coronary lesions:
1) Fatty deposition in the intima of coronary arteries were dbserved only in the animals with the hypercholesteremia, but no significant relationship could be established between the elevation of the total plasma cholesterol, lipoprotein index, lipid phosphorus ratio, and the incidence of coronary lesions.
2) There was no doubt about the fact that this experimentally produced hypertension remarkably increased the incidence of the lesions, but there was no significant correlation between the presence of hypertension and the development of lesions.
3) In all 19 groups, histopathological findings of coronary lesions were intimal thickening, the more acid mucopolysaccharide was found in the less fibrosed wall and the less in the more fibrosed wall, and the primary change of coronary lesion was progressive fibrotic degradation of the acid mucopolysaccharide.
4) In conclusion, various forms of intimal injuries may play the primary roll in the development of vascular lesions, while the factors such as the disturbance of lipid metabolism and the elevation of arterial pressure enhance it secondarily.View full abstractDownload PDF (6223K) -
I. MORPHOLOGICAL OBSERVATIONYUTAKA SATO1959 Volume 8 Issue 3 Pages 187-198
Published: 1959
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1) Japanese timothies were cultivated in absorbent cotton containing streptomycin and this disturbed the chlorophyll formation in the plant and the degree of disturbance varied proportionally with the concentration of streptomycin so that white leaves were produced, when the concentration of streptomycin reached a certain degree.
2) Petioles of the whitened leaves were undergrown, and roots were also remarkably shortened.
3) When streptomycin concentration was below 1mg/cc the germination rate of timothy showed no .significant decline.
4) When streptomycin was autoclaved at 120°C under 15 lbs pressure for 30 minutes and deprived of its antibacterial activity, it has lost -the power to disturb chlorophyll formation.
5) Microscopical examination of white leaves induced by streptomycin revealed that mesophyll cells in the leaves turned to foamy cells and looked transparent as if cytoplasm had been lost.
6) It is considered that streptomycin disturbs chlorophyll formation from the plastid-primordia which are contained in the cytoplasm of the mesophyll cells, and that it also prevents the changing process of chlorophyll into chloroplast.
7) The chlorophyll formation was found to be stopped after the contact with streptomycin, while it did not work against already produced chloroplasts.
8) Leaf blade grown to a certain grade under the influence of streptomycin remained unchanged with the same appearance in their injury after they were released from the influence and transplanted to water medium, and chlorophyll was not produced in them afterwards.
9) The activity same as that of streptomycin was also noticed in kanamycin and viomycin.
10) Penicillin, sodium para-amino salicylate, isonicotinic acid hydrazide and pyrazinamide did not exert any remarkable effect upon the chlorophyll formation, within the tested concentration.
11) The shrinkage of roots of timothy is not specific to the action of the antibiotics yielded from streptomyces group.
The author is indebted to Dr. Hideo Moriyama, the director of this institute, for his many valuable advices and encouragements.View full abstractDownload PDF (5263K) -
TAKEO UEDA, SHIGESHI TOYOSHIMA, KIYOSHI TAKAHASHI, MASAKO MURAOKA1959 Volume 8 Issue 3 Pages 199-209
Published: 1959
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS(1) The compounds of the hydrochlorides of p-alkylephedrine, and the hydrochlorides and methansulfonates of p-alkylnorephedrine were screened as to their chemotherapeutic effect. Among these compounds, Pseudo D. L.-p-methylnorephedrine methansulfonate named Methodrine was selected as the most effective.
(2) Methodrine is effective in in vivo test, but not in in vitro test. This finding is of interest in consideration of mode of action of Methodrine.
(3) Methodrine showed a comparatively low toxicity and pharmacological property suitable for clinical use.
(4) Methodrine is more promising than PANS-610, in balance of effectiveness, toxicity and side action.
(5) The therapeutic action of Methodrine may offer a key for the clarifing the mechanism of the multiplication of Jap-B virus, which is still in the dark.View full abstractDownload PDF (565K)
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