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Volume 9, Issue 2
Displaying 1-6 of 6 articles from this issue
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SUSUMU HARASHIMA, TOSHIO TOYAMA, TSUTOMU SAKURAI1960 Volume 9 Issue 2 Pages 81-90
Published: 1960
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSThe level of serum total and esterified cholesterol was estimated and the ratio of esterified to total cholesterol was calculated in the total of 134 CS2 workers and 48 controls in four representative viscose rayon plants in a rural district of Japan. The four plants were grouped into two categories according to CS2 concentration in the air of working places: the A group consisted of two plants where CS2 concentration was ranging from 5 to 19 ppm and the number of subjects was 64, and the B group comprised two plants where CS2 concentration was from 15 to 65 ppm and 70 subjects were selected randomly.
In the A group the average values of total cholesterol, esterified cholesterol and ratio of esterified to total cholesterol in the serum were 157.5 mg percent, 95.0 mg percent and 60.4 percent, respectively. There was no statistical sig-nificant difference between these average values in the CS2 exposed workers and the controls, whose total cholesterol, esterified cholesterol and ester ratio were measured as 154.0 mg percent, 96.1 mg percent and 62.2 percent re-spectively.
In the B group the average values of total cholesterol, esterified cholesterol and ester ratio were 212.6 mg percent, 111.4 mg percent and 52.8 percent respectively. The significant differences were ascertained statistically in total cholesterol, esterified cholesterol and ratio of esterified to total cholesterol of the CS2 workers from the controls. The serum total and esterified cholesterol appeared to be higher and the ester ratio was lower in the subjects of the B group which was exposed to a relatively high concentration of CS2 than in the A group which was exposed to a lower concentration. Among 70 subjects of the B group, 12 persons had a slight headache, 5 fatigue during their shift, 6 irritability, 8 impaired appetite, 10 sleeplessness and 5 pains in legs.
The blood change of the same type was assured by an experiment of rabbits which were exposed to 150 to 180 ppm of CS, for 200 days.
We would like to conclude that the change of the serum cholesterol level can be taken for one of the early signs of chronic CS2 poisoning.View full abstractDownload PDF (486K) -
YOICHI YAMAGUCHI, MASAHARU TSUCHIYA, TADAYOSHI AKIBA, KICHIYA KOBAYASH ...1960 Volume 9 Issue 2 Pages 91-102
Published: 1960
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1. Various lesions were produced in the pancreas, stomach, lungs and adrenals by giving nervous irritation directly to the cervical autonomic nerves, coeliac autonomic ganglia or the splanchnic nerve.
2. Production of these lesions were prevented or ameliorated by administration of Chlorpromazine or Cortisone in adequate doses or by hypophysectomy, whereas administration of these agents in larger doses, or of ACTH aggravated these lesions.
3. These experimental results were interpreted as indicating that irritation given to the organism induces various lesions in various organs through a direct pathway of peripheral autonomic nerves, as well as through that of peripheral autonomic nerve-diencephalon-pituitary-adrenal axis. In other words, both the autonomic nervous system and pituitary adrenal axis are participating cooperatively with each other, in the pathogenesis of Reilly's phenomena as well as in that of Selye's general adaptation syndrome. Finally, the authors wish to stress that these two unspecific phenomena must be summarized and organized theoretically in a category of “agressology.”View full abstractDownload PDF (6804K) -
KIYOFUMI HIRATA, KUNIZO KATAOKA, YOICHI YAMAGUCHI1960 Volume 9 Issue 2 Pages 103-111
Published: 1960
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSAn 18-year-old girl, who presented manifestations of dwarfism and typical Cushing's syndrome as well as some features of virilization, was presented. Height-and weight-age of the patient were 10 and 121/2 years, respectively. In spite of an increased androgen as was indicated by presence of an enlarged clitoris and increased output of 17-KS, retardation of osseous development and epiphyseal fusion was disclosed in x-rays of bones. These findings are attrib-utable to excessive secretion of glucocorticoids overwhelming the effect of androgen. At the same time, however, the increase in serum alkaline phos-phatase level suggests the presence of an accelerated osteoblastic activity.
The removal of the left adrenal, which was almost normal in appearance resulted in marked improvement of clinical and. laboratory findings such as lowered blood pressure, restoration of regular menstruation, disappearance of glucosuria, normal circulating eosinophil, disappearance of hypernatremia and return of urinary corticosteroids to normal.View full abstractDownload PDF (788K) -
MAREAKI NAKAMURA1960 Volume 9 Issue 2 Pages 113-130
Published: 1960
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1. The effect of serotonin on the evoked responses in the cerebral cortex of mintal anaesthetized cat, was examined through an electrophysiological method.
2. Serotonin was topically applied on the cortical surface in the first part of the experiments, whereas the said agent was given by intravascular injection in the second part. The concentration of the applied agent ranged from 1 to 1000γ per cc.
3. In the variety of the evoked potentials such as somato-sensory response, , direct cortical response and callosal response, topically administered serotonin (particularly in 10γ per cc solution) resulted the depression of negative phases unanimously.
4. No significant potential change was observed in somato-sensory response following infusion of 1-1000γ serotonin and 5 HTP (with or without pretreatment. with iproniazid).
5. Long-lasting type of potential change with no particulr change within, the first 30 min., showed gradual increase of evoked activity over 2 hrs., after intra-carotid injection of 100γ -serotonin.
6. These prolonged facilitations were modified more by the pretreatment with reserpine than with chlorpromazine.
7. Topical application of 10γ -LSD produced the reduction of surface negative component in somato-sensory response.
8. From the above observations, the author would like to draw the con-clusion that;
a) the effect of directly applied serotonin is the result of the inhibition of post-synaptic transmission of cortical neurons.
b) the prolonged facilitation following intra-arterial infusion of serotonin is presumably attributable to the secondary effects of serotonin.
c) serotonin and 5 HTP, precursor of serotonin, cannot pass through the blood-brain-barrier under these conditions.
d) no antagonistic action between serotonin and LSD was observed as far as this set of experiments is concerned.View full abstractDownload PDF (12163K) -
YASUNOBU SUZUKI, EIMEI YAMAGUCHI, MINORU IIDA, ISAO MIYABE, MASAHARU T ...1960 Volume 9 Issue 2 Pages 131-142
Published: 1960
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSSuzuki et ses collaborateurs écrient le détail de quatre cas de l'hémorrhagie rénale idiopatique qui étaient guéris par la tonsillectomie ou 1'hibernothérapie introduise par la chlorpromazine avec la prométhazine.
Cliniquernent, on n'a permis jamais jusqu'ici la cause de l'hémorrhagie rénale idiopatique. Cependant 1'expérience de J. Reilly est très interessant. Les auteurs sont d'accords avec les travaux experimentaux de Reilly qui ont permis que l'irritation des nerfs sensitifs était incriminé pour influencer sur les désordres vasomoteurs dans les reins.
Encouragés par les opinions de Reilly, les auteurs croient que le traitement de bloquage de l'irritation des nerfs sensitifs de la région pharynigienne, c'est à dire la tonsillectomie ou l'hibernothérapie, soit efficace.
We are very grateful to the instruction and assistance of Prof. T. Ni. shihata, Department of Oto-Rhino-Laryngology and at the same time, thank Prof. H. Tamura, Department of Urology.
This article is released on Feb. 24, 1957 at 344 Session of Oto-Rhino-Laryngology in Kanto District.View full abstractDownload PDF (607K) -
ESPECIALLY IN DIABETES MELLITUSHERLEY FUJIY1960 Volume 9 Issue 2 Pages 143-157
Published: 1960
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1. Serum mucoprotein levels were increased with age, both in diabetics and in controlled group. In diabetics, the level revealed somewhat higher than the controlled group.
2. No significant relation was found between serum mucoprotein levels and duration of diabetes.
3. Diabetics who had renal dysfunction, myocardial damages or essential hypertension as diabetic complications had higher levels of serum mucoprotein than diabetics without these complications.
4. In retinal arteriolosclerosis according to Scheie's classification, there was no definite difference between diabetics and non-diabetics when they had same degree of retinal arteriolosclerosis, but there was a tendency to increase serum mucoprotein levels when retinal arteriolosclerosis increased.
5. No significant correlation between fasting blood sugar level and serum mucoprotein level was observed.
6. In diabetic patients, higher levels of serum mucoprotein were found in high cholesterol group (more than 250 mg/dI) than the other group.
7. In diabetic patients whose β and α ratio of serum lipoprotein were higher than 2.4 revealed high serum mucoprotein levels than others.
8. No correlation was obtained between serum mucoprotein levels and amount of total keton bodies in whole blood.
9. Diabetic patients who had diabetic retinopathies showed higher levels of the serum mucoprotein than diabetic patients without it.
10. Diabetic patients who had calcification of abdominal aorta by X-ray exami-nation had higher levels of serum mucoprotein than diabetic patients without it.
11. There was no significant correlation between serum mucoprotein levels and results of petechiometer.
12. Acute infectious cases showed high levels of serum mucoprotein, while there was no significant difference of serum mucoprotein levels between chronic infectious patients and controlled group.
13. Very high levels of serum mucoprotein were found in cases which had leucocytosis.
14. In pulmonary tuberculosis cases, parallel relation was observed between serum mucoprotein levels and severity of the disease.
15. In serum mucoprotein fractions, diabetic group had decreased albumin and a, globulin fractions, but increased α2 and β globulin fractions.View full abstractDownload PDF (746K)
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