Clinical transplantation requires nonspecific immunosuppressive agents to prevent graft rejection. The use of such agents decrease morbidity and mortality from its associated side effects. Therefore, clinical application of the donor-specific tolerance is needed. We have proposed two transplantation tolerance systems. One is drug-induced tolerance and the other is monoclonal antibody-induced tolerance system. In this article, we reviewed our own donor-specific transplantation tolerance systems and argue its possibility of clinical application.
Background & Aims : Zinc (Zn) deficiency cause a variety of disorders including dermatological, neurological and immunologic abnormalities. Methods : To investigate the relation between serum levels of Zn ion and suppression of protective immunity, we measured the levels of Zn of 10 elderly patients with repeated infections (group 1), and compared with those of other 10 elderly without infections (group 2). Results and conclusions : The levels of serum Zn in group 1 were higher than those in group 2 (58.0±5.2μg/dl vs. 72.3±4.1μg/dl, P=0.0375 ; n=10, 10, respectively). Our result suggested that Zn deficiency might be a risk factor of infections in elderly.