北関東医学
Online ISSN : 1881-1191
Print ISSN : 1343-2826
ISSN-L : 1343-2826
57 巻, 4 号
選択された号の論文の13件中1~13を表示しています
原著
  • Akihide Negishi, Kenji Mogi, Toru Yamaguchi
    2007 年 57 巻 4 号 p. 307-310
    発行日: 2007/11/01
    公開日: 2007/12/12
    ジャーナル フリー
    Background & Aims : Some oral mucosal diseases display clear predispositions toward certain sites of occurrence. Oral lichen planus is one such disease, and is thought to have some relationships with cell-mediated immunity leading to a tendency to develop on the buccal mucosa. The aim of this study was to investigate the distribution of Langerhans cells in various sites of oral mucosa. Methods : Immunohistochemical examination using an anti-S100 antibody was performed for 47 samples of healthy oral mucosa and skin. Results : S100-positive cells were more frequent in lining mucosa than in masticatory mucosa. Significantly more S100-positive cells were found in buccal mucosa than in other sites. Conclusions : Langerhans cells are positive for S100 and are thought to represent antigen-presenting cells. These cells were most frequent in buccal mucosa, a result that is in accordance with the predisposition of oral lichen planus.
症例報告
  • 野田 大地, 佐藤 尚文, 高井 良樹, 尾形 敏郎, 五十嵐 清美, 井上 昭彦, 本間 学, 前原 康延
    2007 年 57 巻 4 号 p. 311-316
    発行日: 2007/11/01
    公開日: 2007/12/12
    ジャーナル フリー
     症例は57歳の男性. 不整脈, 高血圧にて通院治療中に上腹部, 背部の重圧感, 上腹部痛, 貧血の進行を認めた. CTで左後腹膜に6.4×6.4×4.3cmの周囲臓器に浸潤する辺縁の不明瞭な腫瘤を認めた. 上部消化管内視鏡で胃体上部後壁に発赤, 粘膜肥厚, 壁の変形, 白苔の付着を認めた. 後腹膜原発の間葉系悪性腫瘍を疑い手術を施行. 後腹膜腫瘍切除, 左腎, 左副腎, 噴門側胃, 膵体尾部, 脾, 横行結腸, 空腸合併切除を行った. 術後の10日目に病理組織学的検索で放線菌症の診断を得, 退院日である術後21日目までPIPCとAMKを使用した. 術後2年を経過した現在再発徴候は認めない. 確定診断は困難であることが多いが腹部腫瘤の鑑別疾患のひとつとして留意する必要がある.
  • Shuichi Hagiwara, Takashi Ogino, Yuga Takahashi, Akira Isaka, Taro Nam ...
    2007 年 57 巻 4 号 p. 317-320
    発行日: 2007/11/01
    公開日: 2007/12/12
    ジャーナル フリー
    Tegafur/uracil (UFT) is an oral anticancer drug composed of tegafur which is a derivative of fluorouracil (5-FU) and uracil in a molar ratio of 1 : 4. UFT is effective as adjuvant chemotherapy for breast cancer2, colorectal cancer3, non-small cell lung carcinoma4, head and neck cancer5 and other tumors. We report a 41-year-old man who orally ingested a large dose of UFT (tegafur : 40000 mg/uracil 9960mg) in an effort to commit suicide, and suffered from sub-acute toxicosis (main symptoms were bone-marrow suppression, and hair loss) of UFT. His life was saved by empiric antibiotic chemical treatment (meropenem, isapamicin, and micafungin), and granulocyte colony-stimulating factor (G-CSF). In the case of toxicosis of UFT, strong antibacterial empiric chemotherapy and G-CSF are necessary for rescue. If G-CSF is not work, biopsy of bone marrow woud be necessary, and the case of no stem cells, bone marrow transfusion should be thought.
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