This study evaluated liver function using gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) to improve assessment of patients with liver tumors compared to Child-Pugh classification (CPC). Materials and methods: The liver function of 59 patients was assessed to determine the indication for heavy ion therapy. Clinical and laboratory assessments, including 99mTc-GSA liver scintigraphy and indocyanine green retention index (ICGR15), were performed for liver function assessment. EOB-MRI was performed on T1W1 images both before and after Gd-EOB-DTPA administration and hepatobiliary phase images were acquired 20-min post-injection. Liver parenchymal enhancement ratio (LER) was measured based on liver-to-spleen (L/Sp) ratios calculating the average liver intensity divided by spleen intensity. Results: The mean LER values on MRI were 138.2±12.8 (133.9-142.5), 115.7±11.6 (110.0-121.5), and 93.2±15.8 (73.6-112.9) in CPC-A, -B and -C, respectively. From the correlation between the LER on MRI and ICGR15 and parameters of 99mTc-GSA liver scintigraphy, LER on MRI was highly significantly correlated with ICGR15 (r=-0.67; p<0.0001). Discussion: This study demonstrated that LER values on EOB-MRI could classify liver function and had high correlation with CPC and ICGR15.
症例1は76歳女性で，主訴は逆流症状と食思不振．胃癌に合併した食道裂孔ヘルニアで，ESD困難であり，幽門側胃切除，食道裂孔縫縮術を行った．症例2は78歳女性，主訴は嘔気嘔吐．胃体部の縦隔内への脱出を認め，通過障害に対し手術を行った．逆流症状を認めていなかったため噴門形成を行わず，食道裂孔縫縮術を行った．症例3は68歳女性で，主訴は継続的な嘔吐で，通過障害を認めた．逆流性食道炎の既往があり，噴門形成とメッシュを用いた食道裂孔縫縮術を行った．いずれの症例も胃の軸捻転を伴い胸腔内にほぼ全胃が陥入しており，比較的稀なupside down stomachを呈した食道裂孔ヘルニアに対しての手術を経験したので若干の文献的考察を加えて報告する．