On the phasic contraction of the uterus of the nonpregnant rabbit already reported many authors. But as for the contraction of the vagina, little is known.
It is reasonably assumed, when ve consider the anatomical relation of the uterus and vagina and their mechanism, that some similar movement must occur to the vagina as to the uterus. Therefore the author intended to inquire into the contraction, if any, and to compare it with that of uterus.
A balloon of proper size made of thin elastic rubber was put deep into the vagina from the introitus vaginae or the canal on the abdominal wall specially prepared for the purpose. If the balloon is expanded previously with adequate pressure, the change of its volume due to contraction of the vagina is recorded by means of the optical lever on the bromide paper.
The contraction curve shows in most cases relatively regular phasic contraction, having one or one and half cycle per minute. But in some cases after 7-15 days experiments (one or two hours a day), groups of several contractions appeared, and between the e were observed only small or no contraction. These groups occurred roughly once in 5-10 minutes. This state of contraction is similar to that of uterus, which is observed on the rabbit administered with follicular hormone.
From those results, it is concluded that the vagina of a non-pregnant rabbit has phasic contraction, which varies according to conditions.

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Manaka had been recording contractions of rabbit's uterus by making a canal on the abdominal wall. While she kept away from the experiment for several weeks the entrance of the uterus had been closed. So she opened the abdominal wall and observed the uterus, and found that the uterus was greatly enlarged like a pregnant one, assunablly due to the increase of inner pressure by stay of secreation. This induced us to the present experiment.
To enlarge the non-pregnant uterus, the abdominal wall was opened and the vagina was cut off at a distance about 1.5cm from the portio uteri, and uterus canals were formed on the abdominal wall. Several laminaria halls (diameter : ca. 0.5cm) were put into the uterus on one side, then the canal was closed temporarily. Several days after, more balls (5-6) were put into the uterus, and it was removed from the rabbit on the 14-15th day of the first treatment. The uterus was greatly enlarged like a pregnant one, but the other uterus, in which no laminaria ball was put in, showed almost the same dimension as before.
The histrogical examination of the tissues of the enlarged uterus showed that the muscle fibers were in somewhat stretched state, a little grown and passively extended, while in the pregnant uterus the muscle fibers were in actively extended and grown state. Except these few points, there were in actively extended and grown state. Except these few points, there was no fundamental difference beteween the tissues of uteri pregnant and artificially distended.
From these results, it is assumed that the growth of the items in the prgnancy occurs merely due to the growth of the foetus, regardless of the hoi mortal conditions.

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We have studied on the morning alkaline tide in the urine collected at the intervals or one hour. The pH, potassium and chloride were analyzed in the same urine specimens and the relatioaship between them were discussed. The results were as follows.
1. The morning alkaline tide took place even when the subject stayed awake all night. This seems to indicate that the morning alkaline tide is not necessarily caused by waking up, namely the rhythmic activity of the respiration center has its own rhythm independent of sleep or waking up.
2. The morning alkaline tide was observed generally associated with th e increased rate of excretion of urine, potassium and chloride, we confirmed the statement of Kobayashi who recently demonstrated that the excretion of urinary potassium varies inversely as the acid output.
3. The time of beginning of the morning alkaline tide and the increase of potassium exretiou did not always coincide. This seems to suggest the increased rate of potassium excretion i; caused partly by the acceleration of renal glonerular filtration.
4. when the subject took breakfast At after the morning alkaline tide had occurred the reaction of urine changed to the acide after about (acid tide) even in a hyperacidic individual, and thereafter turned to the alkaline side. If he did so prior to the occurreace of the morning alkaline tide the pH of urine did not decrease appreciably, and sooner or later begins to increase (alkaline tide). But even in the latter case titrable acid output per unit of time showed often slight increse in the urine specimen collected in about 30 minutes after the breakfast.

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We have studied on the rate of excretion of colloids in the morning urine of normal male subjects by the method of Donagio's reaction modified by one of the authors, Yamazoye. The results obtained were as follows.
1. The rate of excretion of urine colloids increased in the morning, coner or latter, when the subject-waked up and stayed quietly in bed. We prorse to call this phenomenon “morning colloid tide”.
2. Becaus this takes place in the morning w hen the subject keeps awake all night it seems probable that the “morning colloid tide” has no direct relationship with the waking up itself.
3. The “morning colloid tide” occurs generally associated with the temporary increase of creatinine excetion, but not necessarily with the morning alkaline tide and diuresis.
4. It is suggested that the “morning colloid tide”, at least in part, is due to the increase of renal function.

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Previously we observed the influences of the positive and negative colloidal substances upon the hemolysis, and remarked an interesting fact that the negative colloid ion inhibits the hemolysis and the equivalent positive colloid ion reactivates it. We made further research into the mechanism of this reaction and clarified that the inhibitory action of the negative colloid ion affects neither the hemolysis nor red blood cells but inactivates the complement reaction.
In the present experiment the complement wa fractioateb by treatments such as introduction of CO₂, heating at 56°C for 30 minutes, adding of yeast and NH₄OH, and absorption by sensitized red cells. And we investigated which of the complement's 4 components is affected by the anticomplement reaction of potassium salt of polyvinyl alcohol sulphate as negative colloid ion, making it clear that the salt inhibits the combinations of the mid-piece and end-piece with the sensitized red cells hut that it has no effect upon the 3rd and 4th components.

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Since June, 1950 we have extracted and examined parotid and madibular glands from 15 cases of rabic clogs which occurred in Gurnma-ken, with the following results :
(1) On parotid glands no remarkable degeneration or inflammatory changes were observed. There was generally noted atrophy.
(2) On mandibular glands were observed interstitial inflammation with strong degeneration of eipthelium.
(3) Interestitial inflammation developed diffusely or in scattered focuses and consisted in cell infiltration chiefly of lymphocytes, plasma cells and of some histiocytes. This reaction form is same as was observed on inflammatory focuses in the tissue of other organs of rabic dogs.
(4) As for degenerative focuses were noted pictures of various stages ranging from vacuole and karyorrhexis to destruction of cellbodies.
(5) The relation between the degeneration and interstitial inflammation of the mandibular glands cannot be said the sequence of the latter to the former as was reported by Orth, Gruber et al. We would rather regard it the interstitial inflammation accompanied by degeneration.
(6) Negri's bodies could not be demonstrated.
(7) We could not explain the cause of the remarkable difference in pathologic changes between the parotid and mandibular glands.

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We prepared highly bile-resistant strains of pneumococci type I, II, III, and a highly penicillin-resistant strain of pneumococcus type III, and investigated changes of their characters comparing them with the parent strains.
(1) The bile resistant strains resemble to Dawson's R in their colonial roughness, granular growth in fluid media, and instablity insaline, but they are different from Dawson's R in their bile resistance and irreversibillity to S.
(2) The bile-resistant strains are capable of fermenting mannitol.
(3) The penicillin-resistant strain of pneumococcus type III loses the power to ferment saccharose
(4) The bile-resistant strains are five to ten times as resistant to penicillin as their parent strains, and the penicillin resistant strain is three times as resistant to bile as its parent strain.

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In construction of Gumma Ohashi (Gumma Grand Bridge) 5 caissons were used which reached the depth of 20 meters. And by the completion of one pier 20 cases of caisson diseases ocurred. 75.5% of the patients fell illl within 30 minutes after their leaving the caisson. Chief symptom was bends. Many were affected on the left knees because of Japanese custom to put strength into the left legs when they use seoops. Pressure under which the cares occurred was 19, 0#-29. 5#. The work was performed in three shifts a day, and most of the cases (60.6%) occurred in the 3rd shift (Oh a. m. -8h a. m.), and 65. 6% of the patients were extra hands. The patients were all recovered by recompression in hospital lock.
To see the influences of high pressure upon human bodies we made blood examination with 9 nrinanalysis with 22 of those who engaged in the work. Andfurther with hospital loek we made experimentally develop caisson diseasse on guinea pigs. The results of blood examination were : decrease of erythrocytes, leucocytes and hemoglobin after 8 hours under the pressure of 10#-20. 5#. The result on guinea pig : decline of specific gravity of blood and serum (by copper slfate method) and hydremia were revealed.
In the urine of all cases under the pressure of 32# were clearly observed beer-like bubbles. After 8 hour pressure of 14# albuminuria developed 20. 6% There are supposed due to bubbles generated in renal capillaries. With those who worked-8 hours under high pressure the Donnaggio reaction (by Yamazoe method) showed a little rise, but it is not reliable because only a few ca-es were available.

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To a patient of dysentery with soor was administered aureomycin internally and in troch. The dosage : 500 mg. per 6 hours totalling 4 g and 2 troches per 2 hours totalling 72 troches, both administered simultaneously. The result : After 28 hours disappeared most of the white patches, and after 48 hours no spur was noted. The effct was more evident than by any other therapies hitherto applied to this disease. The authenticity of the soor in this case was demonstrated bacteriologically. We have had no report of effectiveness of aureomycin upon the soor in Japan.

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Since June 1949, we have ued a new method of artificial abortion (Shimizu's method) for 73 cases of pregnancy. The method and results are summarized as follows.
Method : 50 to 250cc of physiological saline is injected into between the uterine wall and membrane with Nelaton catheter. At the 4-5th month of pregnancy chininum hydrocloricum and pituitrin are administered 4-5 hours prior to this operation so that the uterus may be sensitized.
Results :
(1) This method is simple and especially successful in the second half of pregnancy. We succeeded in 83.5 per cent of all 73 cases.
(2) In cases of toxemia and nephropathia, use of glucose and magnecium sulfate is recommended instead of physiological saline.
(3) Even when this method is without success in the first half of pregnancy, dilation of cervix and curettage are performed very easily.
(4) There is no damage to fetus and mother.

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We experience a sport-like sound image corresponding to a line-or a plane-shaped sound sources. Searching for the relationship of this phenomenon to the direction perception, the author established the following.
When a point-shaped sound source is in a circular motion at various speeds in a frontal plane at a frontal distance of 1 meter, the sound image changes discontinuously in 6 stages with the increase of speed : (I) a circle at the lowest speed range, (II) an ellipse with reduced vertical axes, (III) an ellipse with redused vertical and horizontal axes, (IV) two glittering points right and left, (V) linear motion between two points, (IV) a fixed point. With variation in the direction or the distance of the sound source or the kind of the motion, various characteristic features are observed.
The mono-and bin-aural sound images are quite similar on the side, but unlike in other directions. The qualitative different sound images are heared monoanraly according to whether the sound source takes place in front, on the side, at the back or on the upside, and binauraly according to whether it takes place in front, at the back or on the upside. The feature of the binaural sound image seemes to be that the monoaural ones are modified chiefly by the function of the association and commisure paths in the cortex of the brain. When a sound source is in a circular motion in the horizontal plane around the head, there is a stage that the direction of the motion of the sound image becomes reverse. Perhaps itchiefly depends on the relation between the angular velocity and the speed of sound. There is the time required to perceive the direction. About the various characteristic features of the sound images a concept of the subjective coordinates is a subject for consideration.

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