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Volume 11 (1961)
- Issue 6 Pages 383-
- Issue 5 Pages 309-
- Issue 4 Pages 236-
- Issue 3 Pages 154-
- Issue 2 Pages 80-
- Issue 1 Pages 1-
Volume 11, Issue 2
Displaying 1-7 of 7 articles from this issue
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[in Japanese]1961 Volume 11 Issue 2 Pages 80-94
Published: 1961
Released on J-STAGE: November 11, 2009
JOURNAL FREE ACCESSDownload PDF (3144K) -
Manabu Momma1961 Volume 11 Issue 2 Pages 95-103
Published: 1961
Released on J-STAGE: November 11, 2009
JOURNAL FREE ACCESSThis report presents some conspicious pathological findings in the central nervous system of guinea pigs, which were caused by Habu-snake-Venom injection.
Characteristic histopathological changes in the nerve cells were :
a) Acute swelling, shrinkage and ischemic changes of the cortical pyramidal cells or Purkinje's cells of the cerebellum.
b) Vacuolar degeneration of the subcortical nerve cell's nuclei. In the Processes of vacuolization, sometimes the nerve cells have undergone some destructive effect.
Vacuolizing processes may be either or both of the followings : Habu-venom acts directly to the nuclei through the criculating blood, or edematous invation of the blood-plasm has a vacuolizing effect.View full abstractDownload PDF (3467K) -
Shoichi Takekoshi1961 Volume 11 Issue 2 Pages 104-118
Published: 1961
Released on J-STAGE: November 11, 2009
JOURNAL FREE ACCESSVitamin A was intramuscularly injected into ddN mice daily for 4 days from 11th day of pregnancy to investigate for teratogenic effect on the embryo. Also effects of vitamin A (10, 000 units, given in 4 days) on the adrenal of male mice were observed.
1) Malformations were observed in 71.21% of living embryos ft om 10, 000 unit group-tetradactylia of the hindlimb 39.3%, that of the forelimb 7.4%, syndactylia of the hindlimb 38.1%, that of the forelimb 7.4%, cleft palate 34.0%, crooked tail 2.1%, and encephalocele 1.03%.
2) Malformations were produced in 8.25% of living embryos of 5, 000 unit group-tetradactylia 2.06%, syndactylia 5.15%, and crooked tail 1.03%.
3) No malformations developed in 2, 000 unit group.
4) In 10, 000 and 5, 000 unit groups, hyperplasia of cartilage was noted in the nasal septum.
5) Male mice given 10, 000 units seemed to show adrenocortical hyperfunctlon. As the consequence, vitamin A is considered to have not only direct teratogenic action, but also indirect effect through over-produced adrenocortical hormone.View full abstractDownload PDF (6376K) -
1. EXAMINATION OF CHEMICAL ASSAY OF URINARY GONADOTROPIN IN NON-PREGNANT AND PREGNANT WOMENYasuji Oka1961 Volume 11 Issue 2 Pages 119-130
Published: 1961
Released on J-STAGE: November 11, 2009
JOURNAL FREE ACCESSCrooke' s chemical method for urinary gonadotropin assay utilizing chromatography was critically examined by reduplication.
1. From non-pregnant women, urinary gonadotropin was extracted by kaolin adsorption method, and change in its value in normal menstrual cycle was determined by an modification of Crooke' s method. The results were compared with those of bioassay, which was performed concurrently, and parallel relation was observed between them. It was consequenently concluded that the Crooke' s method can be applied clinically along with the hitherto used biological method.
2. Urinary gonadotropin from pregnant women were extracted by different methods hitherto used, determined by combination of modified and original Crooke' s method, and examined for change in the course of pregnancy. The results were compared with those by the bioassay, and it was found that GB* obtained by kaolin adsorption method and Crooke's original method was approximately in agreement with change in chorionic gonadotropin in pregnancy and with its biological effects which have been published up to the present.
*GA and GB, designations used by CrookeView full abstractDownload PDF (3295K) -
Yasuji Oka1961 Volume 11 Issue 2 Pages 131-141
Published: 1961
Released on J-STAGE: November 11, 2009
JOURNAL FREE ACCESSUrinary gonadotropin assay was performed by kaolin adsorption method and a modification of Crooke' s chemical method on women in adolescence, climacterium and lactation, and patients with ovarian dysfunction.
1. Rise in gonadotropin value seemed to occur before menarche in adolescence, before return of menstruation in lactation, and nearly with gradual cessation of menstrual function in climacterum.
2. Patients with abnormal menstrual cycle did not show normal GA and GB or GB/GA in many occasions.
3. Administrations of various hormones each elicited alteration in GA and GB.
4. Urinary gonadotropin assay is considered necessary for the diagnosis of ovarian dysfunction, for the indication of therapy for this disease, and for the evaluation of the effect of the therapy. And the chemical assay can be used clinically along with the bioassay.View full abstractDownload PDF (1737K) -
Yasuji Oka1961 Volume 11 Issue 2 Pages 141-147
Published: 1961
Released on J-STAGE: November 11, 2009
JOURNAL FREE ACCESSFrom the latter part of pregnancy through parturition and puerperium, urinary gonadotropin was assayed chiefly by the chemical method and partly in combination with the biological method.
1. GA as assayed by the original Crooke' s method showed little alteration, slightly declining towards parturition, while GB showed large change, rising to a peak several days before parturition, slightly declining immediately before it, again rising slightly at parturition, and remarkably declining in puerperium.
2. Nearly identical pattern was obtained by the bioassay as by the chemical assay.
3. Both the chemical and biological assay revealed change in urinary gonadotropin value in the latter of pregnancy several days before the, onset of labor. This seems to indicate that gonadotropin would endocrinologically participate in the induction of parturition.View full abstractDownload PDF (1015K) -
1961 Volume 11 Issue 2 Pages 148-153
Published: 1961
Released on J-STAGE: November 11, 2009
JOURNAL FREE ACCESSDownload PDF (1231K)
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