The effects of anti-Habu-serum injection on the local and systemic pathological changes produced by Habu venom injection were histopathologically examined, using male guinea pigs as experimental aniamals.
Injection 1 ml serum for 1 mg venom, or 5 to 10 ml serum for 5 mg venom, both local and systemic pathological changes were repressed, if the serum injection was administered without delay. Even when the changes were produced, they were slight in degree.
When the amount of the serum used was insufficient-1 or 2 ml for 5 mg venom-the serum was not very effective; it could repress neither local nor systemic pathological changes. However, by comparison with the untreated control cases, life of the animals was prolonged by the use of serum.
Generally speaking, the characteristic systemic pathological changes produced by Habu venom consist in circulatory deficiency, which is due to the toxicity of the venom working either directly of indirectly. Immediate administration of the serum is recommended; but when the symptoms are serious, some allopathic treatment for shock must not be neglected in addition to the serum therapy.

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In order to investigate effects of electrolytes on cancer, Ehrlich's cancer cells were suspended in electrolyte solution of Magnesium, Natrium, Kalimn and Calcium, andaftervariou shours of incubation, each suspension was intraprioneally injected into mice or subcutaneously inocula-ted in the their abdomen to observe the growth of the cells. Also histological sam ples were prepared from each suspension for cytological observation.
Kalcium was found to act rather acceleratively on the growth of Ehrlich's cancer cells, but no effects of Magnesium and Natrium were observed. In contrast to these, Calcium was recognized to exert inhibitory action both on proliferation and metastasis of Ehrlich's cancer cells.
Also histological observation revealed scarcely any conspicuous effect of Magnesium, Natrium and Kalium on the cells, whereas pyknosis and destruction or almost all depletion of cytoplasma was shown after incubation with Calcium.
Also investigation was performed on the mechanism of specific inhibitory action of Calcium upon Ehrlich's cancer, and further on relationship between Calcium and cancer from epidemiological standpoint, to elucidate important effect Calcium on cancer.

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Recently numerrus reports have appeared on the surgical corection of mandibular prognathism, and various operative procedures for this deformity presented both in home and abroad. I used a modification the procedure, initiated by Kostecka and Lindermann, who resorted to osteotomy above the mandibular foramen on a horizontal plane In order to obtain broader contact surface and to enhance bony union, we recommended that the osteotomy line ehon be oblique in the asccnding ramus a and that the osteotomy line should be oblique in the ascending ramus and that the operation should be performed by the subcutaneous closed method with a Gigli saw and a special type K rgel needle. The postoperative treatment is essentially the same as in mandibular fractures.
The method described in this article permits all the teeth to be placed into occlusion, and the patient is given a good, functional jaw as well as improved physiognomy.
Moreover, the technique is simple, operative time short (30 to 40 minutes), and facial scars are absent, which are considered enough to recommend this method.

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In order to elucidate the mechanism concerning the development of arterial thrombosis, various blood coagulation factors and plasma 17-OHCS levels were determined in 18 cases of hypertension, 10 cases ob cerebromalacia, 13 cases of angina pectoris, 13 cases of myocardial infarction and 20 normal subjects simultaneously. Furthermore, effects of single or daily administration of prednisolone on the blood coagulation were observed in 17 cases with various diseases. The results obtained were as follows :
1. Shortening of prothrobinm time, increase in prothrombin concentration or factor 7 activity were observed in half of 10 patients in 69 hours after single oral dose of 25 mg of prednisolone. The daily administration of prednisolone was followed by similar changes in 6 out of 7 cases.
In this case, an increase in factor 5 activity was obtained in 6 cases, although no remarakable change was found after single dose.
2. Plasma 17-OHCS levels were significantly increased in patients with hypertension, angina pectoris, cerebromalacia or myocardial infarction. The levels tended to be higher in the latter two diseases, especially in fresh cases.
3. Significant increase in factor 7 activity was observed in all these patients, while significant increase in factor 5 activity was seen only in patients with myocardial infarction. In patients with cerebromalacia or myocardial infarction, one stage prothrombin time was significantly shortened. No significant increase in prothrombin concentration was found in all these patients. Changes in these blood clotting factors were more remarkable in patients with arterial thrombosis. From the clinical observation, these changes seemed to be related to the development of arterial thrombosis.
4. There was highly significant inverse relationship between 17-OHCS levels in plasma and one stags prothrombin time. Similarly, significant relationship was observed between 17-OHCS levels and factor 5 or 7 activity. There was no correlation between 17-OHCS levels and prothrombin concentration.
From the results above described, it is concluded that adrenocotrical hyperfunction may be responsible for an increase in blood coagulability and the development of thrombosis.

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