On the assumption that gelation in sero xelo-gel figure would be influenced by pH at the time of the reaction, acid and alkali were added to serum to observe their effect on the figure, and the following results were obtained.
1) Sero-xelo-gel figure of serum from normal healthy persons turned positive the more perfectly the further its pH was elevated above the neutral point by adding alkali, until at last it became type IX.
2) Serum which was turned positive by adding alkali again became negative when acid was added to it, thus demonstrating reversibility of the reaction.
3) When acid was added to tumor-positive serum, transition of the figure toward negativity was observed. However, perfect type IX tumor serum did not give such transition in some cases
4) Statistically, no correlation was observed between the reaction type and pH of serum from normal healthy subjects and pregnant women, but the correlation was positive in a medium degree for tumor serum.

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The author succeeded to form artificially sero-xelo-gel figure by using protein (cattle albumin), calcium and magnesium and by changing pH of mixture of them. Further the author investigated relation of the figure with Cohn's F (II-IIIw), F (III-0), F (VI-1) and F (v) of human serum. The results showed that F (II-IIIw) was strongest in the figureforming power, followed by F (v), and F (III-0) and F (IV-1) were weakest. It was consequently assumed that sero-xelo-gel figure would not be simple but multiple nature, consisting of aggregation these various factors

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In this paper, the histopathological study of the liver, the spleen and lymph nodes of both groups reinfected with 10^-7mg of virulent strain of S. enteritidis 3 weeks after infection with 10^-5mg attenuated strain, or thrice infected with 10^-5mg or 10^-2mg virulent strain 3 weeks after reinfection again, was discribed to elucidate the mechanism of reimmunization with living bacteria.
The group of reinfected mice was divided into two groups that is to say, A group : survival mice achieved high grade immunity, B group : death in the cause of septicamia with allergic reaction. On the other hand, all mice thrice-infected with 10^-5mg virulent strain was survival and obtained highest grade immunity, and mice with 10^-2mg, almost died within 6 days in the cause of allergic reaction.
Histopathologically, survival mice of both group exhibited tubercles which were break down owing to Arthus's phenomenon within 24 hours after re- and thriceinfection, and afterwards, showed slight proliferation with PAS reaction positive substances of reticuloendothelial cells on each investigated tissues, and multification of plasma cell with large amount of Rassel's bodies in the lymphatic medullary cord.
Sacrificed mice of each group showed remarkable infiltration of inflammatory cells and reticuloendotheliosis on each reseached tissues, multiple necrosis of liver cells and reticuloendothelial tissue in the spleen, bacterial colonies, fibrinous thrombus and histiocytosis in blood vessel cavity, and so forth.
It is considered that those complicated morbid changes of each survival group were related to reaction of mechanism reimmunized with living bacteria, and that most resemble to those of human salmonellosis.

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Functional relation beteen gonad and thyroid was investigated clinically and experimentally, and the following points were elucidated :
(1) BMR, PBI and I¹³¹uptake were simultaneously assayed mainly on amenorrheal patients out of 200 cases with menstrual disorders, and thyroid dysfunction was observed in about 10% of them. In the majority, the above mentioned values were low, but unlike the hitherto published reports, they were neither predominantly low nor predominantly high.
(2) In single test, abnormal value was given by 30% in average.
(3) Abnormal values were given more in the 2nd grade amenorrhea than in the other menstrual disorders.
(4) With prolongation of amenorrhea, the assayed values tended to fall. In some of them, therefore, hypothyroidsm seemed to be the result of amenorrhea rather than its cause.
(5) Investigation revealed correlation of menstrual disorders to PBI and I¹³¹uptake.
(6) As for the relation between various urinary hormone values and thyroidal function, PBI corresponded with estrogen, and BMR and PBI tended to lower with decline in gonadotrophin value.
(7) Menstrual disorder was seen approximately in 90% of thyropathic patients. But it was, in many, transient, and there was scarcely any relation between grades of thyroidal and ovarian function. In hyperthyroidism, urinary estrogen, gonadotrophin and 17KS were high.
(8) Some cases of menstrual disorder resulted from metabolic insufficiency
(9) Thyroid therapy was efficient on patients with menstrual disorder in whom thyroid function assay found abnormality, But it was harmful when used only empirically.
(10) In immature rats with hypothyroidism, action of PMS was remarkably increased. This was not observed after hypophysectomy
(11) The same was not observed in the action of HCG.
(12) When thyroidal function was enhanced in immature rats, PMS action mostly diminished, This was not the case with hypophysectomized rats.
(13) Action of estrogen on the uterus was altered by the administration of thyroxine.

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1. By means of eletrical stimulation of the amygdala, the anterior limb of the anterior commissure and the mesencephalic reticular formation, the centrifugal influences of these areas upon the potential wave evoked by the electrical stimulation of the olfactory epithelium (A-wave) were studied in the rabbit.
2. When a single electric shock was applied onto the medial part of the amygdala, monophas ic or diphasic negative wave appeared in the bulb. It did not show an effect upon the A-wave which may suggest a true inhibition. When a single shock was applied onto the lateral part of the amygdala, a diphasic potential which is a small electro-negative wave followed by a large positive wave of about 70 to 80 msec appeared in the olfactory bulb. The A-wave decreased its amplitude for 600 to 800 msec after the appearance of the above potential. From the shape of the potential, the magnitude and length of the influence of the potential upon the A-wave and the histological finding of the bulb, It was concluded that there is an inhibitory tract to the olfactory bulb from the lateral part of the amygdala.
3. Single or repetitive stimulation of the mesencepalic reticular formation did not show any effect upon the A-wave. However, when the lateral part of the amygdala was repetitively stimulated together with the above stimulation, the inhibitory effect which was produced only by the former stimulation was strikingly elongated. Consequently, it was supposed that the centrifugal control of the olfactory bulb depends upon the excitatory state of the cerebrum.
4. The electrical stimulation of the anteri or limb of the anterior commissure did not show any inhibitory effect upon the A-wave. The same negative result was obtained even when the stimulation of the mesencephalic reticular formation was simultaneously applied.
5. Single shocks were applied onto various points in the intermediate part of the cerebrum between the olfactory bulb and the amygdala, and the fibers from and to the olfactory bulb were sought. The potential waves evoked in the bulb by this way were compared with those evoked by the stimulation of the amygdala. From the similarity of the potential shapes, the sites of recording and the histological finding, it was concluded that the Inhibitory tract from the amygdala to the olfactory bulb runs just above and in parallel with the lateral olfactory tract and reaches the granule cell of the olfactory bulb.

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