Thyroid/serum iodide ratio (T/S ratio), introduced by Vander Laan & Greer (1955), was examined from various view points as to its availability in appraisal of thyroidal function.
T/S ratio was maintained at a certain level after one time injection of 4-methyl-2 thiouracil and of 1-methyl-2 mercaptoimidazole. And time and dose necessary for this effect were sought. Administration of the latter for 2 consecutive weeks elevated T/S ratio, producing goiter.
Hypophysectomy in rats lowerde T/S ratio and thyroid weight. Feeding with seaweed rich in iodine resulted in far greater fall in these values, accompanied by a histological picture of hypothyroidism.
At 4 weeks after 1/4, 1/2and 3/4 thyroidectomy, T/S ratio in the remnant part increased to 2.02.5 times, and compensation hypertropy was in proportion with the size of the removed portion, increasing by 130% at 3/4 thyroidectomy. When excised unilateral lobe was transplanted below head skin, into the original site, or into the spleen, the result was unfavorable with its weight extremely reduced, T/S ratio in the remnant lobe increased samely as in the case of nontransplantation, and compensation hypertrophy far slighter.
Parahydroxyprophenon, which is said to have inhibitory effect on the hypophysis, was found utterly ineffective against increase in T/S ratio and compensation hypertrophy of the remnant part after 1/2 thyroidectomy. Methyozyl and Mercazole accelerated these, while Thyradin was strongly inhibitory.
After injection of 1000 i.u. of estradiol benzoate for 14 days, T/S ratio was elevated, while thyroid weight remained unchanged, histologically manifesting a picture of near hypothyroidism. Administration of estradiol benzoate for 2 consecutive weeks did not inhibit elevation of T/S ratio and swelling of thyroid, produced by consecutive administration of methyodile, but conversely accelerated them. Nor could it inhibit the same changes, produced by unilateral thyroidectomy.
Administration of 0.2ml of thyradine for 3 consecutive weeks decreased both thyroid weight and T/S ratio. After suspension of the administration, they gradually rose, surpassing the initial level in the end, and thus manifesting the rebound phenomenon. Concurrently measured weights of the hypophysis, ovary and uterus showed no remarkable change, but frequent estruses or lasting estrus was observed during Thyradine administration.
T/S ratio was evidently high in pregnancy, especially in the later pregnancy, and also in parturition.
Utilizing the Krieg's stereotaxic instrument, damage was electricly given to the anterior, medial and posterior area of the hypothalamus, and T/S ratio was found lowered by anterior and posterior damage, body weight decreased most heavily by posterior one, and estrus interrupted by anterior, medial and posterior one in the ascending order. Weights of the ovary and uterus were also remarkably reduced by posterior damage. In general persistence of corpus luteum was observed in the ovary.

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1. The author devised an original and simple method, using Anthron reaction, to determine urinarinary Mucoprotein the adequacy of this method was proved through clinical application.
2. By this method, 24 hour urinary excretion of Mucoprotein was compared between pregnant and non-pregnant women, and this value was found significantly higher in the former. It can subsequently be used as an auxiliary chemical method for the diagnosis of pregnancy.
3. Urinary excretion of Mucoprotein was increased in puerperium over that in pregnancy and non-pregnancy. This is considered to be due to a different mechanism.
4. In malignant tumor such as ca. colli, urinary excretion of Mucoprotein was significantly higher than in normal pregnancy. In uteral myoma, the value was varying from case to case, though higher in general than in normal myoma.
5. Increase in urinary excretion of Mucoprotein was also observed in inflammatory diseases and disorders in urinary passage.
6. Urinary excretion of Mucoprotein in men should be investigated from a different viewpoint from that for women.
7. In malignant tumor, parallel relation was observed betwen C.R.P. test and urinary excretion of Mucoprotein but no such relation in pregnancy. Therefore nothing conclusive can be said in this respect.
8. Determination of urinary aceton precipitation in Esbach tube can not be used for diagnosis of pregnancy.

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1) 群馬県下数地区の住民, 成人男女それぞれ970名, 487名, 計1457名の糖尿病集団調査を行ない18名の本患者をみいだした.
2) 自他覚的症状はあまり著明なものがなく典型的な臨床症状を示したものは1名に過ぎずこの点, 本病の集団検診の必要性を痛感する.
3) 本病と家族歴の有無, 血圧, 体型, 職業等との関連について若干の考察を加えとくに肥満との関係は注目すべきことをみた.
4) 本調査の経費は11,685円で人件費, 精検費等を除き本病患者1名発見に730円ついやしたことになる.

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