Adrenocortical function of patients with menstrual disorders were investigated chiefly by assaying urinary 17-OHCS.
1. Six women with normal menstruation were assayed for urinary 17-OHCS, and two peaks were observed during a menstrual cycle. The level in the luteal phase was significantly higher than in the follicular phase.
2. Urinary 17-OHCS was assayed with 159 patients of menstrual disorders (9 with primary amenorrhea, 111 secondary amenorrhea, 33 with anovulatory cycle, and 6 with uterine amenorrhea).The value was high in many with anovulation and secondary amenorrhea. Especially in those with secondary amenorrrhea of less than 6 month duration, adrenocorical hyperfunction is assumed to play an important role as a causative factor,
3, Tests for hypophyseal reserve (Su 4885 test) and for adrenocortical reserve (ACTH test) were performed with 16 patients with menstrual disorders. The result revealed that in no cast amenorrhea seemed to result from reduction in adrenocortical reserve, and that many exhibited hypothalamohypophyseal dysfunction. This, however, can not be considered as the cause of menstrual disorders, since there were also cases which showed the normal reserve,
4. Many patients with functional uterine bleeding gave high urinary 17-OHCS level. None of these patients showed adrenocortical hypofunction.
5. Three cases of Cushing syndrome had secondary amenorrhea of grade 2. Their estrogen activity was low, but their urinary gonadotrophin level was normal or high.
6. Analysis of data from 28 cases with environmental menstrual disorders disclosed that in many, urinary 17-OHCS or 17-KS level was high, and gonadotrophin level was normal or low. This indicates that on the level of the hypophysis, hypercorticotrophism and hypogonadotrophism, especially of LH occurs concurrently. This is supposed to be an endocrinological feature of environmental menstrual disorders. This was confirmed also in animal experiments.

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Mononuclear phagocytes derived from liver, subcutaneous tissue and peritoneal cavity of mouse hyperimmunized with live vaccine of Salmomella enteritidis inhibited intracellular multiplication of the same organisms and resisted to cell degeneration, while mononuclear phagocytes of mouse immunized with killed vaccine or normal mouse did not. Such a resistance of phagocytes was refered to as cellular immunity. Employing immune transfer and immune adherence, cellular antibody was detectable in mononuclear phagocytes of mice hyperimmunized with live vaccine of S. enteritidis. This cellular antibody was specifically reactive against live vaccine and was not absorbed with killed one.
It was discussed in this paper on the origin of the cellular antibody and on antibody producing cell series.

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An autopsy case of typical traumatic rupture of the aorta is reported. The rupture was caused by deceleration injury, resulting from an automobile accident. A transverse linear tear was situated in the thoracic aorta just below the inserted portion of ligamentum arteriosum (Botalli). The tear transected the aorta almost completely, except for a small area 0.5cm in length. Both grossly and histologically, there was no evidence of previous disease of the aorta such as mesaortitis syphilitica, atherosclerosis, medionecrosis idiopathica cystica, etc.

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An autopsy case of primary mesothelioma of the pericardium was reported. The case was male Japanese, 53 years old.
He was admitted to this hospital with chief complaints of tightnese sensation in the chest, he had a large heart shadow and numerous, tumor cells were found in the hemorrhagic pericardial fluid.
However, tumor formation was not discovered anywhere by clinical examination.
At autopsy, left lung was displaced laterally and posteriorly by greatly enlarged pericardial sac. The pericardial cavities contained hemorrhagic fluid and all pericardial surfaces were studded with gray and brown nodules, and so the parietal pericardium was thickened. There were no metastases in other organs.
Microscopic examination and multiple sections revealed tumor tissue invasing visceral and parietal pericardium.
The tumor was composed of two main cell types, epithelial and spindle. Cells were arranged in a fibrous tissue with a small amount of interspersed hyaline matrix. In most areas the tumor was papillary or formed clefts while elsewhere sheets of spindle cells were prominent.

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