The KITAKANTO Medical Journal
Online ISSN : 1883-6135
Print ISSN : 0023-1908
ISSN-L : 0023-1908
Volume 17, Issue 2
Displaying 1-4 of 4 articles from this issue
  • TOSHIKAZU SEKIGUCHI
    1967 Volume 17 Issue 2 Pages 85-99
    Published: March 01, 1967
    Released on J-STAGE: October 15, 2009
    JOURNAL FREE ACCESS
    Shichijo's reaction, a biological test for diagnosis of gastric diseases, is known to give fairly high percentage of positivity in gastric cancer. The author performed gastric biopsy with 415 cases using a fiber-gastroscope, and compared histological findings in gastric mucosa with Shichijo's reaction. Surgical specimens were also examined in some cases. In thes subjects tested were included 33 cases of early gastric cancer. The findings obtained were as follows :
    1) In the advanced gastric cancer, the positive group of Shichijo's reaction (inclusive of theintermediate type) accounted for 18 of the total 24 cases (75%), that was significantly higher than in benign gastric diseases : 23.3% in gastric ulcer, 16.5% in gastric polyp, and 15.4% in gastritis. These results were approximately equal to the previous reports.
    In the early gastric cancer, the positivity rate was 8 of 33 (24.2%), and many (21 of 33, i.e. 63.6%) gave type III and IV, the total cases of type III to IX of shichijo's reaction accounting for 29 of 33 cases (87.9%). In applying Shichijo's reaction as a screening test for gastric cancer in social wide examinations, it should therefore be better to include all the cases of type III to IX for detailed examination.
    3) Early gastric cancer, giving the intermediate and the positive type of Shichijo's reaction, frequently occurred in those of the protruding and the concaving type by the endoscopic classification (5 of 6 cases, i. e. 83.8%), whereas the negative type was frequently observed in those of the superficial flat type (22 of 25 cases, i. e. 88.8%).
    4) Pathohistological classification and developed sites of gastric cancer did not give any relation with types of Shichijo's reaction, but the depth of the cancer cell infiltration was related with the positivity; especially in cases with the muscular layer invaded the positivity rate was much high.
    5) Shichijo's reaction was not used as a supplementary method in differentiation of early gastric cancer from benign gastric diseases resembling it, since no differnce was od-served between them in any type of Shichijo's reaction.
    6) Relation- between stages of benign ulcer (which were assumed from histological findings of gastric biopsy specimens) and Shichijo's reaction was observed. It was found that the positivity was relatively higher in the almost healed and the scar stage ulcer.
    7) Some morphological classifications of polyp-like lesions and various gastritis had to definite relation with Shichijo's reaction, excepting the superficial nature of the former; in polyp-like lesions with rough surface, the positivity rate was higher than in those with smooth surface.
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  • SATONORI KURASHIGE, YUICHI KIMURA, TAKEZO SAGWA
    1967 Volume 17 Issue 2 Pages 100-105
    Published: March 01, 1967
    Released on J-STAGE: October 15, 2009
    JOURNAL FREE ACCESS
    Mononuclear phagocytes of mice hyperimmunized with live vaccine of Salmonella enteritidis inhibited intracellular multiplication of a virulent strain of the same organism and resisted cell degeneration caused by phagocytosis of bacteria, in the absence of antibody in cell culture medium. This was referred to as cellular immunity. According to the immune transfer and immune adherence hemagglutination technique, the cellular antibody was detectible in abdominal mononuclear phagocytes of immunized mice. The cellular antidody inhi bited the growth of a virulent strain of S. enteritidis with the aid of comlement and lysozyme, either on the nutrient agar plate or in the nonimmunized mononuclear phagocytes of normal mice. This antibody was not detectible in the serum of mice hyperimmunized with live vaccine or in themononuclar phagocytes immunized with killed vaccine of S. enteritidis. This antibody was extracted from abdominal mononuclear phagocytes of mice hyperimmunized with live vaccine and proved to bemacroglobulin by ultracentrifugal analysis
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  • AKIRA SAKAKIBARA
    1967 Volume 17 Issue 2 Pages 106-121
    Published: March 01, 1967
    Released on J-STAGE: October 15, 2009
    JOURNAL FREE ACCESS
    The apparent fall in haemoglobin concentration during pregnancy has been considered presumably the outcome of the hydraemia of pregnancy. But, on the most urgent problems is that pregnant women may be exposed to iron defficiency for synthesis of the haemoglobin molecule to fill the increase in blood volume or foetal demands. In this point of view, I have tried to analyse the haemodynamics of pregnancy. In early stage of pregnancy, haemoglobin level starts to fall, as compared with that of none-pregnant stage, and remains substantially decreased in late stage of pregnancy. The fall in haemoglobin commonly found in early stage is largely due to the plasma dilution without iron defficiency, and the total circulating haemoglobin increases gradually in amount. The haemoglobin concentrations of pregnant women who keep the normo-chromic state during pregnancy show above the corresponding average levels to late pregnancy, and recover slowly in puerperium. On the other hand, the haemoglobin levels of the cases followed by the drops in serum iron and hypo-chromic state show the apparent fall in late stage of pregnancy, and do not recover until 4 weeks of puerperium. In the cases of administration of iron to pregnant women from 5 months of pregnancy to terms of pregnancy, their haemoglobin concentrations are always kept significantly high levels above that of none-administered cases.
    There is no significant difference between the each of the haemoglobin concentrations of infants, delivered of pregnant women who are divided into three groups, normo-chromic state, hypo-chromic state, and iron-administered state.
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  • TERUAKI KAMIYAMA
    1967 Volume 17 Issue 2 Pages 122-162
    Published: March 01, 1967
    Released on J-STAGE: October 15, 2009
    JOURNAL FREE ACCESS
    Tracer studies with radioactive iron were carried out in 14 healthy subjects and 178 patients with various types of anemia. Both the plasma iron disappearance (PID) and the percentage red cell utilization (%RCU) had been estimated and the plasma iron turnover rate (PIT) and red cell iron rurnover rate (RCIT) were calculated. In addition to the ferrokinetic study, reticulcyte cour ts of the peripheral blood and erythroblast counts in the bone marrow weredetermined in the most of subjects. From these results, erythropoietic activity in patients with various types of anemia was evaluated.
    The results obtained were as follows :
    1) Confidence limits of means of the various values obtained from ferrokinetic study (P=0. 05) in healthy subjects were as follows;PID T/2 : 90±14 minutes, PIT : 0, 80± 0, 13 mg/kg/day, %RCU : 96±4% (9days), and RCIT : 0.76±0.13mg/kg/day.
    2) In patients with hemolytic anemia, markd acceleration in PID and increase in both PIT and RCIT were observed. Similar changes were found in patients with polycythemia vera. Percentage red cell utilization was elevated rapidly in either of these diseases. Thereafter, early drop of the utilization curve was observed in patients with hemolytic anemia.
    3) In panients with idiopathic aplastic anemia, PID was within normal limits or moderately retarded and PIT was in normal limits, while %RCU was low and RCIT was evidently decreased.lt was noted that patients, in which red cell utilization was more than 50%, had better prognosis as compared with patients with %RCU was less than 50%. There were several cases in which increase in erythropoiesis was not proved by ferrokinetic study, although anemia was evidently improved by various forms of treatment other than blood transfusion. From the results of survival study using Cr51-method, it was suggested in some of these cases that an elevation of Hb levels resulted from either stop of hemorrhage or prolongation of the short-end survival time of erythrocytes.
    4) Ferrokinetic pattern of patients with acute leukemia was similar to that of patients with aplastic anemia. Acceleration of PID, elevation of %RCU and increase in both PIT and RCIT were observed in patients in remission. In erythremic patients, PID was markedly accelerated, although %RCU was extremely low and RCIT was evidently decreased, In patients with chronic granulocytic luekemia, PID was normal or moderately accelerated, while PIT was within normal and both %RCU and RCIT were slightly decreased.
    5) In patients with multiple myeloma, PID was retarded %RCU was decreased. These changes were more remarkable in advanced case. Percentage of red cell utilization was decreased markedly, although PIT was within normal limits or slightly decreased.
    6) In patients with pernicious anemia, PID was markedly accelerated and PIT was in very high level as serum iron concentration was increased, although %RCU was as low as around 30% and RCIT was within normal limits. These results indicated an increase in the ineffective erythropoiesis in pernicious anemia.
    7) In patients with iron-deficiency anemia radioiron cleared from plasma at very rapid rate. In these cases, there was a significant relationship between PID and UIBC of serum. The fraction of iron removed per day per kg of body weight was within normal limits or slightly decreased, since the total plasma iron was low in all cases. Utilization by red cells was rapid and complete.
    8) In 2 cases of myelofibrosis, PID was markedly accelerated and PIT was evidently increased. In a case being able to maintain the Hb level around 12 g/dl, 90% of the injected iron was utilized by red cells by 9 th day following Fe59-globulinate injection. In another case in blastic phase, %RCU was very low and RCIT was less than normal. In the former case, in vivo measurement revealed an existence of extramedullaly hematopoiesis in the spleen.
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