北関東医学
Online ISSN : 1883-6135
Print ISSN : 0023-1908
ISSN-L : 0023-1908
18 巻, 5 号
選択された号の論文の5件中1~5を表示しています
  • 清水 正二郎
    1968 年 18 巻 5 号 p. 443-452
    発行日: 1968年
    公開日: 2009/10/15
    ジャーナル フリー
    1. Calcium uptake by rabbit skeletal muscle microsomes was stimulated by the addition of Na+ or K+ alone or both, but the synergistic action of Na+ and K+ was not remarkable.
    2. The stimulation of calcium uptake was the highest at the concentration of 20 mM of Na+ or 40mM of K+.
    3. The pH optimum of calcium uptake was 6.8. The pH optimum of ATPase activity was about 78 in the case of Mg2+ alone or Mg2++Na+, and about 7.4 in the case of Mg2++ Na++K+
    4. ATPase activity was also stimulated by the addition of Na+ or K+, but the synergistic action of Na+ and K+ was not observed. Ouabain did not affect the stimulated ATPase activity.
    5. ATPase activity was stimulated by a low concentration of Ca2+ in the presence of Na+ and K+ alone or both regardless of the presence of oxalate. In the presence of Mg2+ alone the ATPase activity was stimulated slightly by the addition of Ca2+, but in the presence of oxalate the ATPase activity with Mg2+ alone was not stimulated by the presence of Ca2+.
    6. The addition of salyrgan depressed the ATPase activity to a certain level. The ATPase which links to Ca2+ uptake was considered to be Na+-K+ stimulated, Ca2+ stimulated ouabain insensitive and salyrgan sensitive enzyme.
  • 佐藤 昭一
    1968 年 18 巻 5 号 p. 453-486
    発行日: 1968年
    公開日: 2009/10/15
    ジャーナル フリー
    1. Histopathological investigation were performed on the cerebellum of 54 autopsy cases in order to elucidate the pattern of degenerative lesion and its destribution in the cerebellum and 35 control cases of vavious age without any gross lesion in the central nervous system.
    2. In cases with atrophy of the afferent cerebellar systems, the change in the cerebellum appeared as degeneration of the cerebellar white matter. In 3 cases of olivo-ponto-cerebellar atrophy, the pallor in myelinstaing was observed in the white matter of cerebellar hemisphers. In the vermis cerebelli, the change was confined to the medullary lamina of the monticulus. The degeneration was therefore pronounced in phylogenetieally newer part of the cerebellum. In some cases with degeneration of the spinocerebellar tracts in the medulla and spinal cord on the other hand, the degenerative lesion could be traced even in the medullary lamina of the anterior lobe of the cerebellar vermis.
    3. There were 9 cases which showed extensive foci in the unilateral cerebral hemisphere and degenerations in the ipsilatereal corticospinal and corticopontile tracts on the level of the brainstem. Five of these 9 cases showed atrophic or degenerative lesion in the cerebellar hemisphere, contralateral of the cerebral hemisphere with foci, There was, however, no regularity in the distribution of foci in the cerebellum and histological features of the lesion were not identical in their nature, No sufficient findings were, therefore, obtained to support the presence of the so-called crossed cerebro-cerebellar atrophy, resulting from combination of the two degenerations through a definite fiber system.
    4. In cases of patients who had clinically manifested epileptic fits, was observed characteristic lesion loss of Purkinie cells associated with glial shrub formation in the molecular layer of the cerebellum, These cases were also characterized by particular distribution of foci, being remarkable in deeper folia and in the depth of sulci.
    5. Fusiform swelling of the Pnrkinje cells axon, which is known by the name of “torpedo”, was observed in a case of cerebello-olivary atrophy and in aged cases with abundant senile plaque and marked Alzheimer'stype of neurofibrillary change of nerve cells in the cerebral cortex, but more frequently it was observed in those cases which showed, such degeneration of the myelinated fibers in the cerebellar white matter as olivo-ponto-cerebellar atrophy, Implication of this lesion as an alteration of Purkinje cells, which is transneurally induced in association with white matter lesion, is worth to notice.
    6. In 7 of the 54 investigated cases, the so-called acute selective necrosis of the cerebellar granular layer was observed, This lesion is characterized by reduced stainability of nerve cells of the granular layer, and is found extensively and irregularlly distributed in the deeper folia. It is little significant as a process, since it lacks glial cell reaction.
    7. As the lesions of the cerebellar parenchyma associated with aging, there were decrease in number of Purkinje cells, increase of dark stained and atrophied Purkinje cells, proliferation of Bergmanns glial cells, formation of torpedo of Purkinje cell axon, dendritic expansion of Purkinje cells and waste pigment accumulation in nerve cells of the dentate nucleus, Purkinje cell lesion tended to be pronounced in the superior vermis and in the summits of convolution of the superior cerebellar hemisphere. Purkinje cells which occurred heterotopically in the molecular layer had no relation with aging, Almost all the cases showed focal lobular sclerosis or dysplasia in the nodulus, uvula and pyramis of the vermis cerebelli, and in the biventral lobule of the cerebellar hemisphere.
  • 第4報日脳アンプリファイヤーとしてのブタの意義
    中村 忠義, 砂盃 圭子, 松本 陸子, 松山 達夫, 大谷 明
    1968 年 18 巻 5 号 p. 487-493
    発行日: 1968年
    公開日: 2009/10/15
    ジャーナル フリー
    The frequency and time of occurrence of natural swine infection by Japanese encephalitis virus was demonstrated during 1965-67 by study of HI antibody and isolation of virus from blood samples collected in Gunma prefecture. Infection by JE virus occurred during July and August as evidenced by both viremia and HI antibody development in pigs.
    In 1965, viremia in swine was first detected in late of July and continued about 3 weeks, and JE virus was recovered from 10 to 50% of pigs by intracerebrally inoculation into suckling mice, No virs was isolated after 100% of pigs became infected in late August, Similar results were obtained in 1966 and 1967.
    Majority of human JE cases wes occurred within 2-3 weeks of demonstration of viremia in pigs. Mosquitoe infection obsrved by virus isolation was limited to the early August-late September.
    Incidence of infected pigs in summer was definitely indicated by deyelopment of 2-mercaptoethanol sensitive antibodies.
  • 第 5 報 蚊と日本脳炎
    松山 達夫, 中村 忠義, 大谷 明, 緒方 隆幸
    1968 年 18 巻 5 号 p. 494-500
    発行日: 1968年
    公開日: 2009/10/15
    ジャーナル フリー
    Mosquito factors concerning the human epidemics of Japanese encephalitis (JE) were strongly suggested from the data of the field trials during 1959 to 1965. In these research programs, mosquitoes were collected at study sites every year from May to October and tested for JE virus, and specimens from the patients clinically diagnosed as encephalitis and other related illness were examined throughout the year for etiological agent.
    The results are as followsi
    1) 12 species of mosquitoes were collected in study sites. However, JE virus was isolated from only C. tritaeniorhynchus and C. pipiens, and from none of other spebies. Abuot 99% of isolates were obtained from C. tritaeniorhynchus and it was the most commonly infected mosquito in this area.
    2) By serologic and virologic examinations, no JE patient was found except in the summer season when the mosquito infections were observed.
    3) Mosquito infection in this area was regularly limitted to the period from July to September, and the first human cases occurred about 2 weeks after the first isolate was obtained from mosquitoes.
    4) In the years of major outbreaks, infected mosquitoes were found earlier than in normal years and high isolation efficiency (ratio of infected to total C. tritaeniorhynchus populations) was also observed.
  • 誘発行動における抗アンフェタミン作用について
    奥谷 雅生, 小沼 杏坪
    1968 年 18 巻 5 号 p. 501-505
    発行日: 1968年
    公開日: 2009/10/15
    ジャーナル フリー
    The “cloister method” was used for evaluating the acute and chronic effects of Isoprophenamine onmice behavior.
    Results may be summarizeb as follows.
    1. In acute administration tests, the effectof Isoprophenamine (10 mg/kg) on mice behavior was similar to that of saline controls.
    After administration of a relatively high dose of Iscprophenamine (20 mg/kg), reduction of motor activity was observed.
    2. In chronic administration tests, 10 mg/kg of Isoprophenamine was given daily in the diet over a 4-week period. No obvious behavioral changes were observed in those animals compared with control animals who received no Isoprophenamine.
    3. In the above-stated chronic administration tests, Methamphetamine-induced hypermotility and a high rate of R% (a ratio of cyclic walk) which was describedin detail in a previous paper was markedly dimiuished.
feedback
Top