The KITAKANTO Medical Journal
Online ISSN : 1883-6135
Print ISSN : 0023-1908
ISSN-L : 0023-1908
Volume 24, Issue 1
Displaying 1-7 of 7 articles from this issue
  • KOICHIRO KISHI
    1974 Volume 24 Issue 1 Pages 1-10
    Published: January 01, 1974
    Released on J-STAGE: February 09, 2010
    JOURNAL FREE ACCESS
    It is clarified that there are common antigenicities between somatic antigens of Escherichia coli 2B-V, O6 and O86 and human blood group antigens H, A, and B respectively. On the other hand, the presence of any E. coli somatic antigen and blood group-active antigen was not detected in E. coli K-12 sublines.
    An Hfr his+ strain from E. coli K-12 was crossed with smooth E. coli his- recipient 2B-V, O6, and O86. Most of the his+ recombinants which received the E. coli K-12 his+ genes were phenotypically rough. This finding suggests that defective E. coli K-12 rfb genes had replaced the functional rfb+ genes of the smooth recipients. Also these recombinants were lost the somatic antigen and blood group-active antigen of respective recipient. In the reversed cross of a his+ strain of E. coli donor 2B-V, O6, and O86 with an E. coli K-12 his- recipient, most recombinants which received the his+ (rfb) genes were smooth and expressed a somatic antigen and blood group-active antigen of the respective donor strain, indicating that the parental E. coli K-12 has the capacity to attach E. coli 2B-V-, O6- or O86- specific repeating units. It is concluded that in E. coli the genes for somatic antigen and blood group-active antigen biosynthesis in strains of 2B-V, O6, and O86 are near his locus.
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  • PART II. ON THE OLFACTORY DISCRIMINATIVE ABILITIES OF THE ANTERIOR LIMB OF THE ANTERIOR COMMISSURE, THE LATERAL OLFACTORY TRACT AND THE OLFACTORY BULB
    HISAO UMEZAWA
    1974 Volume 24 Issue 1 Pages 11-20
    Published: January 01, 1974
    Released on J-STAGE: October 15, 2009
    JOURNAL FREE ACCESS
    Cycloheximide (Naramycin named by the Tanabe Phamaceutical Company) is known to have a strong rat repellent action. Rats were trained to discriminate between water containing one odour, and water containing the other odour and cycloheximide. The relative abilities of olfactory discrimination were studied in the following types of rats; the normal rats and the rats with the anterior limbs of the anterior commissure (AC) sectioned, the lateral olfactory tracts (LOT) sectioned, the AC plus the LOT sectioned and the olfactory bulbs (OB) removed bilaterally.
    1. The above rats' reactions were tested between the normal tap water and the water containing two drops of 0.02% cycloheximide. The rates of successful discrimination were all about 60%, and no difference was found among the above groups. Consequently, it was concluded that the odour of cycloheximide itself does not interfere with the results of the following discrimination experiments.
    2. When the concentrations of anise and camphor were diluted in four steps, the rates of success decreased gradually in each of the above groups of rats (Table 2). But a difference was found in the discriminative ability between the rats with the OB removed, and the other groups of rats even in the lowest concentrations of odours used.
    3. The discrimination tests were performed on rats between dl-camphor (10-3%) and each of the eight odours used (Table 3, 4 and 5). The discriminative ability decreased in this order, from the normal, to the AC sectioned, the LOT sectioned, the AC plus LOT sectioned and finally the OB removed rats.
    4. The discriminative abilities of rats with the OB removed were examined between the stimulants and non-stimulants of the trigeminal nerve. Thus, considerable contribution of the trigeminal nerve was proved to the discrimination of some odours (Table 6).
    5. A clear difference of discriminative ability was found between the AC plus LOT sectioned and the OB removed rats. The origin of this difference was considered.
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  • NOBUHIRO OOKI
    1974 Volume 24 Issue 1 Pages 21-42
    Published: January 01, 1974
    Released on J-STAGE: October 15, 2009
    JOURNAL FREE ACCESS
    Crude Habu snake venom was injected in the femoral muscle of mice and the ultrastructures of the microvessels in the lesions were examined by electoron microscopy. Most of the vessels encountered between the damaged muscle cells were capillaries, partially containing postcapillary venules. The results were as follows.
    1. There were various injuries of the endothelial cells, such as formation of villous projections and intravascular blebs from cells, degeneration of cellular organelles, especially decrease and disappearance of pinocytotic vesicles, swelling, darkning and thinning of cells, formation of endothelial gaps and celullar necrosis.
    2. The fluffy changes, discontinuities and deficiency of the basement membrane were observed.
    3. The hemorrhage by Habu snake venom were occured by discontinuities of both the endothelium and the underlining basement membrane.
    4. It is considered that the increasing hemorrhage may be caused not only by the destruction of capillary wall, but also by the disturbance of coagulant activities.
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  • (5) HIRSCHSPRUNG'S DISEASE IN THE NEWBORN
    SHIRO MATSUYAMA, KIKUO NAGASHIMA, NORIO SUZUKI, KENJI MOGAMI, MASAMI M ...
    1974 Volume 24 Issue 1 Pages 43-46
    Published: January 01, 1974
    Released on J-STAGE: October 15, 2009
    JOURNAL FREE ACCESS
    A case of neonatal Hirschsprung's disease in a 25-day-old female infant was presented. She had passed her first meconium stool about 48 hours after the normal delivery. Since then, the bowels had moved only every two or three days. She became distended on 21st day of life and began to vomit on 23rd day of life. The abdominal scout film revealed distended loops of small as well as large bowel with air-fluid levels and situs inversus totalis (Fig. 1).
    A gstrografin enema examination demonstrated a normal calibered rectum and dilated sigmoid and descending colon. There was a distinct caliber difference at the recto-sigmoid junction and spastic irregular bizarre contour changes were seen in the rectum (Fig. 2).
    Enemas failed to decompress and the emergency transverse colostomy was made. Her postoperative course was uneventful.
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  • SHIGERU TAKAHASHI, SUSUMU YOKOI, HIDEHIKO ICHIKAWA
    1974 Volume 24 Issue 1 Pages 47-56
    Published: January 01, 1974
    Released on J-STAGE: October 15, 2009
    JOURNAL FREE ACCESS
    Clinical and neuropathological studies of a sporadic case of sudanophilic leucodystrophy are reported here.
    The patient, 48 years old housewife, developed dementia and spastic paraplegia at the age of 45. Her mental and neurological status became worse and finally she fell into decerebrated rigidity or akinetic mutism. General weakness was superimposed and she died after a total clinical course of 3 years and 9 months.
    Brain weighed 910 gm and was very atrophic in general appearence. Neuropathologically the diffuse demyelination was observed symmetrically, bilaterally in the cerebral white matter, mostly intense in the frontal lobe. Cerebellum, brain stem and spinal cord were only slightly demyelinated, except for the secondary degeneration of the pyramidal tracts. But pons was partly demyelinated in ascending tracts.
    In the demyelinated foci, there was no perivascular inflammatory cell infiltratio but numerous lipid droplets which were stained reddish with Sudan III, were found. The transportation of the myelin breakdown products was retarded. The myelin breakdown products consisted of neutral fat, cholesterol ester and prelipid. The prelipid did not show a metachromasia with acetic acid cresyl-violet (Hirsch-Peiffer) staining and acriflavin reaction was also negative.
    Some of the granular cells and glial cells contained lipopigments which showed a yellow color and a positive iron reaction and most of them were found in the frontal lobe.
    Gliosis was relatively slight in the deep part of the cerebral white matter because of loss of glial cell. In some areas i.e. cortico-medullary junction where there was slight loss of myelin sheaths, a striking proliferation of glial fibers occurred.
    In the middle layer of the cerebral cortex, there were indistinctly limited demyelinated foci accompanied by the spongious state, where loss and shrinkage of nerve cells were found. There was myelin-axonal dissociation in the demyelinated foci and surviving axons were swollen.
    Neuropathologically and histochemically, this case was diagnosed as Sudanophilic leucodystrophy of simple form of Hallervorden, van Bogaert-Nyssen type.
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  • EIICHI OGAWA, SHIRO SUZUKI, HIROSHI TSUZUKI, MUTSUKO KAWAJIRI, HIROKAZ ...
    1974 Volume 24 Issue 1 Pages 57-64
    Published: January 01, 1974
    Released on J-STAGE: October 15, 2009
    JOURNAL FREE ACCESS
    203Hg-phenylmercury acetate (203Hg-PMA) was given to mice, and its retention, excretion and distribution were investigated. Furthermore various drugs were examined for 203Hg-expelling effect.
    1. Retention : the retention after the s.c., i.p. and p.o. administration were daily explored. The biological half-life was short, about 1-2 days in all cases.
    2. Excretion : The daily excretion was usually high in feces and low in urine.
    3. Distribution : The radioactivity after i.p. administration was highest in the kidney already at 1 hour, and attained the peak at 4 hours. At 1 hour, next in order were the pancreas, blood, liver, spleen, brain successively. At 24 hours, the liver exceeded pancreas.
    The subcellular distribution of 203Hg-PMA in the liver and kidney 24 hours after i.p. administration was greater in the supernatant fraction in both organs than the other fractions.
    4. Effects of administration of various drugs : In 3 day experiments on the whole-body retention of 203Hg-PMA was decreased by BAL only. L-CySH·Gly., EDTA, ZnSO4 were often found to increase 203Hg retention. BAL decreased 203Hg activity among the kidney, liver, pancreas, spleen, blood, but it significantly increase only the cerebral concentration of 203Hg. 2-Mercaptopropionyl glycine decreased 203Hg concentration in the pancrease and spleen in the experiment after i.p. administration of 203Hg-PMA, and in the kidney in experiment after oral administration of203Hg-PMA.
    5. Effect of starvation : The fecal excretion of 203Hg was decreased and the retention of it was increased by the starvation, and they were recovered by feeding.
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  • VII. BEHAVIOR OF JAPANESE ENCEPHALITIS VIRUS IN THE NON-EPIDEMIC YEARS
    TADAYOSHI NAKAMURA, SUSUMU SHIGEHARA, KOICHI TANAKA, FUMIYO TAKAHASHI, ...
    1974 Volume 24 Issue 1 Pages 65-70
    Published: January 01, 1974
    Released on J-STAGE: October 15, 2009
    JOURNAL FREE ACCESS
    In an attempt to explore the reason of sudden decrease in number of cases of Japanese Encephalitis observed in Gunma Prefecture as well as in all Japan since 1968, ecological fild study has been carried out. Following findings have been disclosed through the study;
    1) During the period from 1959 to 1967 when the epidemics of Japanese Encephalitis were observed at the interval of every three years in Gunma Prefecture, size of epidemics tended to be possitively associated with the number of mosquitoes carrying the agent virus in the year.
    2) The fact that no patient has been confirmed in the Prefecture since 1968 may be attributed largely to remarkable decrease of mosquitoes in number which resulted in decrease in quantity of the agent virus in the vectors followed by delay in time for the virus affecting the vectors.
    3) In contrast with the years of epidemics before 1967 when the infection rate of the pig population, as measured by HI titers in serum against Japanese Encephalitis virus, had reached 100% by the August, in the non epidemic years after 1968, the infection rate did not rise to 100% until the end of observation period of the end of October.
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