[in Japanese]

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The relationships between sodium and potassium balances, plasma renin activity and systolic blood pressure were studied in rabbits during the development of renal hypertension and its reversal.
Animals were divided into two groups. Group A consisted of 15 rabbits in which the left renal artery was clipped and the right kidney was left intact. Group B consisted of 15 rabbits in which the left renal artery was clipped 4 weeks after removal of the right kidney. Each animal of both groups was unclipped 2 weeks after the clipping. Animals were studied in metabolic cages for daily sodium and potassium balances, which were estimated on the basis of dietary intake and urinary and faecal excretion. Each animal was given 100g/day of the standard pellets (CR1, Japan Clea Ltd.) and distilled water at libitum. Plasma renin activity was measured before, 14 days after the clipping and 14 days after the unclipping.
The main points of the results obtained are as follows :
1) Blood pressure increased rapidly in both groups after the clipping, and it decreased after the unclipping, but still remained above the normal 2 weeks after the unclipping. There was a striking similarity in the course of blood pressure between the two groups.
2) After the clipping, cumulative sodium balance became slightly negative in the 1st week and tended to recover in the next week in group A. On the contrary, it became markedly positive in the 1st week and tended to decline in the next week in group B. There were no significant correlations between the cumulative sodium balance and the blood pressure elevation in both groups. After the unclipping, cumulative sodium balance became negative in group B and the negative sodium balance was correlated with the fall in blood pressure.
3) There was no significant difference in potassium balance during the periods of both development of hypertension and its reversal between the two groups.
4) After the clipping, plasma renin activity showed no significant changes in group A, while it significantly decreased in group B. After the unclipping, no significant changes were seen. There were no positive correlations between plasma renin activity and blood pressure in both groups.
5) After the clipping, the faecal sodium excretion and the faecal sodium/potassium (Na/K) ratio decreased in group A and after the unclipping, they recovered.
These results suggest that the sodium and potassium metabolism and the renin-angiotensin system do not play a primary role in the pathogenesis of experimental renal hypertension

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The effect of verapamil on sinoatrial and atrioventricural conduction were studied on 11 dogs under the urethane-chloralose anesthesia.
The sinoatrial conduction time determinded by using the premature atrial stimulation method and represened as antegrade plus retrograde conduction time was significantly prolonged following the intravenous administration of 0.05mg/kg of verapamil. However, the sinoatrial conduction time was almost unchanged when larger doses of verapamil were administrated. On the other hand, the sinus cycle length and A-H time were prolonged as to the verapamil dose was increased, while H-V time was unchanged. The systolic and diastolic pressures were depressed as to the verapamil dose was increased.
The present rather curious observation that the sinoatrial conduction time was not affected by larger dose of verapamil was suspected to be resulted from the prolongation of sinus cycle length and/ or the increased reflex sympathetic tone.

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A 29 year old female admitted with the neurological disorders consistent with acute myelitis was diagnosed as 45, XO/47, XXX mosaicism associated with atrial septal defect of secundum type and mild pulmonary valvular stenosis. Although the association of congenital heart disease with the chromosome aberration in the present patient might be coincidental, this case was reported because only few similar associations have been described before.

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An autopsy case of Creutzfeldt-Jakob disease, Heidenhain type, was reported. The patient was a 66 year old housewife who had developed deterioration of memory and visual disturbance. Later she showed marked perseveration of speech, visual object agnosia, visual spatial agnosia, finger agnosia and agraphia. She was also slow in movement. Occasional myoclonic jerk was noted in the right arm. CT scan was normal. The EEG showed diffused slowing of background activity and periodic synchronous discharge. She finally fell into akinetic mutism and died of acute bronchopneumonia. The total clinical course was 4 months.
The brain weighed 1, 010 gm. Microscopically, throughout the cerebral cortex was diffused status spongiosus and astroglial proliferation involving indiscriminate diffusion in the deep layers of the cerebral cortex. It was most severe in the occipital lobe. The neurons were diminished and frequently shrunken and hyperchromatic. Large amounts of sudanophilic lipids were deposited in glial cells and intercellular tissue. In the cerebral white matter, there existed pallor of myelin and fibrillary gliosis extending from the overlying gray matter.
In the caudate nucleus, putamen and thalamus, there was also a fine diffused spongy matter associated with astroglial prolifelation. Mild changes were seen in the globus pallidus. In the molecular layer of the cerebellum, sudanophilic lipids were deposited. There were no changes in the motor neuron system.
Electron microscopy revealed cavity of status spongiosus formed by a cluster of destended cell processes in the cerebral cortex.
In other organs, liver dysfunction, chronic hepatitis, and cirrhosis of the liver existed.
Clinical and pathological characteristics of Heidenhain-type of Creutzfeldt-Jakob disease were discussed.

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Data on 1742 cases, treated with radiotherapy in recent eight years from June 1972 to Dec. 1979, were analized. Among them, the number of cases Head and Neck Cancer were 568, Lung and Mediatinum 370, Female Pelvis 319, and these composed 72%.
The number of old age patients more than 70 year old were 454 and they were 26% of whole irradiated patients.

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