In order to reveal the histogenesis of leiomyoma which may arise from the muscle layar of the stomach, a histological study was carried out on 32 leiomyomas out of 30 cases obtained at autopsy in Tokyo Geriatric Hospital (1958-1969) and surgical specimens in Gunma University Hospital (1958-1977). There were 17 males and 13 females in this series. All sections were stained by Haematoxylin and Eosin and Mallory Azan. In addition Van Geison, silver stain and S-100 protein stain were also used if necessary.
In this series, minute leiomyomas under 5 mm in diameter were in 11 cases (34.3%). The relationthips between the location of minute leiomyomas and growth types were discussed. Results of this study were as follows :
1) Eighty per cent of leiomyomas of the stomach was located at upper third portion of the stomach as the exogastric type.
2) The smaller the size of gastric leiomyoma, the higher the incidence of exogastric type at fundus of the stomach.
3) Eighty two per cent of minute leiomyomas was assumed to be originated from the external muscle layer. 45 per cent of leiomyomas might grow outard and 36 per cent of them might be situated as the intramural type.

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Two hundred and thirty-six trigger fingers in 202 cases treated during the last eight and a half years in rural areas were examined.
1) There were only 5 cases with 8 trigger fingers recognized in children, far fewer than in urban areas as reported in various other surveys.
2) Out of 228 trigger fingers in 197 adult patients, 162 cases (82.2%) were females and many of them were in the age range 40-60 years.
As to the affected fingers, the following percental distribution from the thumb to the little finger was found : 58.7 (134 cases), 3 (7 cases), 23.2 (53 cases), 14 (32 cases), and less than 1 (2 cases) per cent. There were no significant differences between rural and urban areas as far as those data were concerned.
3) In treating trigger fingers in children, it is desirable to observe their developments for a certain period of time while applying a conservative treatment.
In treating adult patients, a surgical operation seems best for a quick and definite recovery.

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We have studied the modes of in vitro and in vivo sustained release of testosterone from vinyl polymer-testosterone composites prepared by radiation induced polymerization. We were successful in preparing the testicular prosthetic implants, which was made from vinyl polymer-testosterone composites. It was ascertained to release testosterone from the testicular prosthesis implanted subcutaneously in the back of the rabbit. It opend the way to the clinical usage of the testicular prosthesis which release testosterone for a long period.
It was also ascertained that in vivo and in vitro release of testosterone from biodegradable copolypeptide-testosterone composites were well controlled as well as vinyl polymer-testosterone composites.

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Rehabilitation of rheumatoid arthritis (RA) is troublesome for its variable and unsettled symptoms but physical therapy remains a keystone of treatment.
A case of RA, a 48-year-old woman with deformities of all extremities, compression fractures in thoracic and lumbar spine and spondylolisthesis was reported.
She could not stand nor walk for muscle weakness of lower extremities and deformities of bilateral knee joints, one of which was ankylotic and the other flailed. There was not effusion, pain nor heat consequent to the inflammatory synovitis. As her general condition was good, she wanted to stand and walk on her own legs. In apprehensions of relapse and the more destruction of knee and ankle joints, physical therapy program was set up and then range-of-motion exercises, muscle strengthening exercises and standing balance, ambulation training with weight bearing braces were started. Receiving these training with a strong will, she was able to obtain four-point alternate crutch gait with Lofstrand crutches and weight bearing braces seven months after. And still now, relapse and the more destruction of the joints are not occured fortunately.
Of course there are many factors which make this trial succeeded, the most important one is thought to be her own will.

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A 60-year old woman was admitted to our hospital because of acute myocardial infarction, giant negative U wave of 4 mm in depth were observed in V4 during the impending state of myocardial infarction.
Although negative U waves have been observed not infrequently in impending myocardial infarction, giant negftive U waves as seen in this case are rare.

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Bronchofiberscopic Nd-YAG laser irradiation therapy was performed for a case of pulmonary metastasis of synovial sarcoma which showed polypoid regrowth at the site of tracheal bifurcation, which caused severe dyspnea. Although possibility of bleeding by the laser irradiation had been anticipated, there was little bleeding during and after the treatment. The patient had been relieved from the symptom of large airway obstruction, but the effect was temporary in this case.
The indication of endoscopic laser surgery in the tracheobronchial tree was also discussed.

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A bipartite patellae is usually no clinical significans. However, we have seen two patients with tender painful patellae, bipartite at the superior lateral pole. Non operative Treatment failed to relieve these symptoms. But excision of the bone fragment resulted in a painless knee.

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A patient with primary pontine hemorrhage showed cheiro-oral syndrome with only mild cerebellar and pyramidal signs. Serial CT scans showed a resolution of the hematoma and correlated with clinical improvement.
A 54-year-old woman with a history of approximate ten years hypertension was hospitalized because of acute onset of mild unsteady gait and subjective paresthesia in the left face and left fingers two days before. General physical examination revealed a blood pressure of 150/112 mmHg and no arrhythmia. On neurological examination she was alert and good oriented without meningeal signs. The visual fields were intact to confrontation, and the pupils were normal in size bilaterally and briskly reactive. The eye movements were full and nystagmus was not observed. Facial weakness, hearing loss, dysarthria and dysphagia were not present. Motor examination revealed mild Barré's sign on the left hand. Deep tendon reflexes and muscle tone were normal, and Babinski's sign was not preset. Mild limb ataxia on the left sided extremities were present. Sensory examination revealed paresthesia on the left face, especially perioral and forehead areas, and the left fingers (cheiro-oral syndrome). Touch and pain senses were decreased on the same areas. CT scans (Figure 1) showed a high density area in the pons that was not enhanced after injection of contrast material. The increased density was mainly located in the right side, but extended to the opposite side as well as to the lower midbrain. There was no localized lesion in the cerebrum, thalamus and cerebellum.
A CT scan obtained after two weeks showed a resolution of the high density. Limb ataxia and Barré's sign disappeared nearly within one week, and she could walk well on tandem gait. The paresthesia on the left face and fingers decreased gradually.
The lesion of our case was illustrated in Figure 2 at the pontine level. The lesion might include some parts of pontocerebellar tract, corticospinal tract and right medial lemniscus. We consider the lesion of the some parts of right medial lemniscus is responsible for the contralateral cheiro-oral syndrome in this case.

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