Body fluid distribution in DOCA-salt hypertension rats was measured by means of isotope dilution method in prehypertensive, early and chronic stages of hypertension. Plasma volume (PV), extracellular fluid volume (EFV) and total body water (TBW) were determined using 131-I-RISA, 35-S-Na₂SO₄ and tritiated water, respectively. Mean arterial pressure (MAP) was measured directly through a carotid artery. Plasma renin activity (PRA) was also determined.
Three experiments were performed under unanesthetized rats. Experiment 1 : Body fluid volumes in DOCA-salt treated rats on 3 day after DOCA-salt treatment were normotensive in spite of increased PV. The DOCA-salt rats on 7 day were still normotensive, whereas EFV and calculated interstitial fluid volume (IFV) were prominently increased without an increase in PV. The DOCA-salt rats on 14 day revealed elevated arterial pressure, but there were no significant differences in any of body fluid compartments as compared to control groups which were given only salt. The values of PRA in the DOCA-salt groups both on 3 day and 7 day were prominently suppressed and PRA in DOCA-salt group on 14 day was lower than those in the control group.
Experiment 2 : DOCA-treated rats were divided into three groups which were given three graded salt intake ; high, normal, and low salt intakes. Control groups of rats were given the same three graded salt intakes as in the DOCA-treated rats. MAP and body fluid volume determination were performed on 28 day. The groups of DOCA with high salt and with normal salt were hypertensive, and no statistical difference was observed in MAP between them. Only the DOCA with high salt group had increased body fluid volumes, which were distributed proportionally among the PV, EFV, and calculated intracellular fluid volume (ICFV). The DOCA with normal salt and low salt group had no excess in body fluid volumes. The values of PRA in both DOCA with high and normal salt group were extremely suppressed, while those in DOCA with low salt group were not. Experiment 3 : Another group of DOCA with high salt was made, in which sodium was restricted for 2 weeks from 29 day after DOCA and salt treatment. The MAP in this group fell to control levels without significant changes in PV, while IFV was reduced to nomal levels.
These results indicate that 1) in DOCA-salt treated rats, MAP elevation was preceded by increase in PV, following the normalization of PV in place of increase in IFV. There was no measurable increment of body fluid volumes in DOCA-salt treated rats at the early stage of hypertension ; however, the fluid volume changes in extracellular fluid compartments may be related to the initial pressure rise in DOCA-salt hypertension. 2) The excess in body fluid volume in chronic stage of DOCA induced hypertension is not necessary for DOCA to maintain hypertension, because there was expansion of body fluid volumes in DOCA with high salt group while no increase in body fluid volume in DOCA with normal salt group, and there was no significant difference in elevated MAP between them. 3) PRA suppression under DOCA administration as observed in experiment 1 and 2, is not induced simply by the expansion of body fluid volumes.

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The statistical study for dysuria in the aged male was performed with the support of Gunma-Ken Aged Club Association. The analized results were as follows.
(1) Mass data was 33, 723 cases which was approximate 30% of the male above 60ys in Gunma-Ken.
(2) Average age was Approximate 73ys, frequency of night voiding 1.7%, severe voiding disturbance 1.4% of all cases and complete urinary retention in the past history 7.2%. These symptomes were observed gradually from the beginning of 60's and elevated with the increasing age.
(3) The genesis was mainly benign prostatic hypertrophy and partially neurogenic bladder which was accompanied secondly with cerebro-vascular disease.

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From January 1970 to June 1982, among 4, 294 patients with malignant neoplasms, herpes zoster (HZ) occurred in 87 (2.0%) after irradiation. The incidence of HZ infection was rather high in patients with malignant lymphoma (8.3%), epipharyngeal cancer (8.2%), ovarial tumor (4.8%) and testicular tumor (4.2%). Most of these patients received extensive radiation therapy along the spinal cord and/or nerve root.
The location of HZ infection was devided as follows : HZ infectious lesion located in the area of (I-A) innervated segment of the irradiated nerve root (74%), (I-B) irradiated dermatome (3%) and (II) not associated with radiation field (23%).
In 55 (86%) of 64 patients of I-A, HZ infection occurred within one year, particularly in six months (41 cases (64%)) after the complesion of radiation therapy. This incubation period between completing irradiation and the manifestation of HZ infection was likely to be compatible with the period between radiation therapy and earlier radiation injury. Among 20 patients in Group II, 12 patients (60%) developed HZ infection over a year after irradiation.
The cumulative 5-year survival of these patients except for the patients with malignant lymphoma was 42% and HZ infection was considered to have no prognostic significance.
In 19 cases treated with 3-Germylopropionic acid sesquioxide (Biositon-8), all were free of severe neuralgia and 11 patients were cured within 2 weeks. Ongoing clinical trial investigating the use of Biositon-8 appears promising against HZ infection.

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Extravasation of contrast media in cerebral angiography was recognized in 16 cases of hypertensive intracerebral hemorrhage. Hematoma evolution by repeated CT scans was demonstrated 3 out of 4 cases at acute stage of hemorrhage. These signs of hematoma enlargement were seen within 4 hours after the onset of apoplectic stroke. Large hematoma at the initial CT scan, and extravasation in cerebral angiography were the signs of very grave prognosis. Urgent surgical intervention may offer a chance of recovery even a large hematoma which was small or medium sized at the initial CT scan and showed leakage of contrast media in cerebral angiography.
Differential diagnosis of hypertensive intracerebral hemorrhage from traumatic intracerebral hematoma was easy in typical cases. However, both hemorrhages were sometimes difficult in complicated cases such as hypertensive hemorrhage was modified by traumatic intracranial hemorrhage, and traumatic hematoma was located in wellknown site of hypertensive intracerebral hemorrhage.

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Coronary arteriography were performed on 106 children with Mucocutaneous lymph node syndrome from July 1982 to July 1983. Coronary arterial lesions were seen in 46 (43.4%) of the 106 cases. This is 14.1% of outpatients with Mucocutaneous lymph node syndrome. Incidence of coronary arterial lesion were higher in male and more younger infants.
The coronary arteriography is very useful for diagnosis of coronary arterial lesion on Mucocutaneous lymph node syndrome.

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This hospital used renogram as the first renal function test, especially in preoperative examination.
From 1978 to 1980, total renograms of 2760 times with 1810 cases were examined. Of 548 cases in department of surgery except for urology undergoing operation, 240 cases indicating abnormal renogram patterns were investigated about the significance of renogram as preoperative renal function test.
Following results were obtained.
1) Only 4 cases which have almost no functions were stopped undergoing surgical procedure by renogram. 2) 476 cases which indicated normal, unilateral damaged and slightly damaged renogram patterns did not needed concerns in pre-and postoperative renal function. All of 39 cases showing moderately damaged renogram patterns were managed well on the basis of preoperative renogram pattern, resulting in radical operation without exacerbation of renal function. 3) Severely damaged patterns of 4/25 and non-functioning patterns of 2/8 brought to death by accompanying postoperative renal failure. 4) In spite of nearly low and flat patterns, 6 of 8 cases had temporasy mecovery without giving up their operations.
The above may prove the usefulness of renogram as preoperative renal function test. Besides, it was beneficial that exclusion of IVP and PSP-test in patients more than 90% had been possible.

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The purpose of this study is to determine whether the lipoperoxidation is playing a significant causative role in adramycin cardiomyopathy.
Cardiac alterations with characteristic histologic changes such as vacuolizations of myocardial cells, myolysis and the interstitial fibrosis developped in rabbits when 2. 5 mg/kg of adriamycin was intravenously administered once a week for 8 weeks. Blood and cardiac malondialdehyde was significantly increased in these animals. Although daily administrations of 50 mg/kg of alpha tocopherol, a free radical scavenger, obviously suppressed the increase of blood and cardiac malondialdehyde, the development of cardiac lesions could not be prevented by this drug.
The present observations may suggest that the lipoperoxidation is a result and not a cause of adriamycin cardiomyopathy.

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