巻号一覧
36 巻, 1 号
選択された号の論文の11件中1～11を表示しています
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椎原 康史1986 年 36 巻 1 号 p. 1-17
発行日: 1986/02/20
公開日: 2009/10/15
ジャーナル フリーPDF形式でダウンロード (2990K) -
一連の認知課題による検討と批判的考察丹野 義彦, 町山 幸輝1986 年 36 巻 1 号 p. 19-38
発行日: 1986/02/20
公開日: 2009/10/15
ジャーナル フリー分裂病の認知障害の原因として注目されている左半球機能低下説および半球間連絡機能障害説について, 各種の感覚モダリティの認知課題を用いて検討した.その結果, 身体感覚性の課題に関しては, いずれの仮説をも支持する結果は得られなかった.また分割視野課題に関しては, 結果は実験条件によって著しく異なり, 両仮説と一致する結果と矛盾する結果とが相半ばした.さらに分割視野実験の結果は, 両仮説よりも半球機能均質説によってむしろよりよく説明されることが明らかとなった.これらの仮説を支持する先行研究者の結果に関しても, 実験条件や被験者側の要因統制が不十分であって確実な実験的根拠ではないこと, 結果を解釈する際の基準が不十分であったことなどが指摘された.以上の点からわれわれは半球機能低下説および半球問連絡機能障害説について主張するのはいまのところ慎重であるべきであると考える.今後は, 刺激提示の視角条件などの実験条件設定や利き目などの被験者側の要因について, より慎重な方法論的検討が必要であると同時に, 半球機能均質説に同等の注意を払うべきであると考える.抄録全体を表示PDF形式でダウンロード (3796K) -
野地 隆1986 年 36 巻 1 号 p. 39-48
発行日: 1986/02/20
公開日: 2009/10/15
ジャーナル フリーPlasma membrane preparations were isolated from mononuclear leukocytes obtained from 18 children with IDDM (insulin-dependent diabetes mellitus), 9 healthy children, and 8 normal adults.Their β-adrenergic receptor (β-receptor) was studied using 125I-iodohydroxybenzylpindolol (125I-IHYP) as a radioligand. The β-receptor densiy in the mononuclear leukocytes of the IDDM patients was found to be decreased (Bmax = 27.6 ± 2.0 fmol 125I-IHYP/mg protein : mean ± SE) compared with those of normal children (40.4 ± 3.5) and normal adults (36.9 ± 2.1), while no significant difference was seen in the density between normal children and adults. There were no significant differences in the binding affinities among those groups. When the IDDM patients were divided into groups on the basis of their blood glycosylated hemoglobin (HbAl) levels, group B patients (HbAl≥10%, n=9) had smaller receptor densities in the leukocytes than group A patients (HbAl<10%, n=9). In IDDM patients, a negative correlation was found between the receptor density and blood levels of glucose or HbAl, while no correlation was observed between the receptor density and plasma catecholamines, free insulin or glucagon.
As group B patients had high blood levels of both HbAl and glucose, the decrease in the recepter density might be a homeostatic response for restoring the poorly-controlled hyperglycemic state to normoglycemia.抄録全体を表示PDF形式でダウンロード (1464K) -
大西 一徳1986 年 36 巻 1 号 p. 49-57
発行日: 1986/02/20
公開日: 2009/10/15
ジャーナル フリーIn a previous study, murine skin sclerosis was induced with low-sulfated heparan sulfate (LSHS) which was isolated from the urine of patients with systemic scleroderma. In addition, patients with severe systemic scleroderma showed high values of urinary LSHS-related protein. The present investigation demonstrated cell-surface LSHS-related protein by flow cytometry, using anti-LSHS-related protein rabbit antiserum (1 : 32).
As a result, the cell-surface LSHS-related protein showed reproducible fluorescence intensity distinct from controls treated with unimmunized rabbit serum. In addition, bleomycin, which is able to induce skin sclerosis in man and animals, enhanced the fluorescence intensity of the cell-surface LSHS-related protein. This result suggests that bleomycin-induced skin sclerosis may be mediated by LSHS. In contrast, heparan sulfate from bovine kidney decreased that of LSHS-related protein. Sera from patients with systemic scleroderma as well as from normal controls failed to influence significantly the cell-surface LSHS-related protein.抄録全体を表示PDF形式でダウンロード (1543K) -
南 新三郎1986 年 36 巻 1 号 p. 59-70
発行日: 1986/02/20
公開日: 2009/10/15
ジャーナル フリーThe induction of β-lactamase and β-lactam resistance in Enterobacter cloacae were studied using clinical isolates and mutants with altered activity or inducibility of β-lactamase.
The majority of clinical strains tested were able to produce β-lactamase inducibly and the amount of increase of enzyme production was 20-to 350-fold in the presence of an inducer (ampicillin). The production of β-lactamase began to increase within 10 minutes after addition of the inducer and the increase continued linearly for at least 1 hour in exponentially growing cells. The amount of induced enzyme paralleled the drug concentration used.
The inducer activities of different β-lactams were different from each other and did not directly relate to the stability against the induced β-lactamase or to the M I C of the β-lactams.Even β-lactamase-susceptible drugs like piperacillin showed low MICs on the inducible strain when these drugs showed no inducer- activity for β-lactamase production. The results obtained revealed that the antibacterial activity of a β-lactam in E. cloacae is a sum of the following 4 activities : 1) permeability into the cell, 2) inhibitory activity against the target proteins (penicillin-binding proteins), 3) resistance to β-lactamase, and 4) inducibility of β-lactamase.抄録全体を表示PDF形式でダウンロード (2070K) -
矢部 正治, 中野 眼一, 坂本 孝作, 児嶋 高寛, 飯島 俊秀, 星 広人, 正田 弘一, 竹之下 誠一, 木村 浩, 石崎 政利, 平 ...1986 年 36 巻 1 号 p. 71-77
発行日: 1986/02/20
公開日: 2009/10/15
ジャーナル フリーMorbidity and mortality are not negligible when emergency surgical procedure is performed on patients with U.C. who are suffering a severe attack. Many attempts have been made to cure such patients. Among them, intraarterial administration of Prednisolone through selective catheterization of the mesenteric vessels has produced favorable responses.
In the present paper, the value of such treatment is evaluated through three cases which we have experienced. One of these cases showed a dramatic improvement after two administrations. The first patient was relieved of abdominal pain immediately after the first treatment, and no bloody stool was observed longer than 24 hours after the first injection. The second patient was discharged without surgical procedure one month after an effective single shot. The third patient was diagnosed as toxic megacolon, and colon gas was decreased by the first injection. However, two subsequent injections were ineffective, and ileostomy was required.
In conclusion, the intraarterial injection of steroid for severe attack of U.C. is considered to be valuable in that the clinical signs and symptoms are dramatically improved and that even in the case of moribund condition, a scheduled operation can be expected after several trial injections.抄録全体を表示PDF形式でダウンロード (2804K) -
唐戸 哲哉1986 年 36 巻 1 号 p. 79-85
発行日: 1986/02/20
公開日: 2009/10/15
ジャーナル フリーThe correlation between hemoglobin concentration and hematocrit value was studied, as follows. 1) By x2-test and NED-test, hemoglobin concentrations of random samples were determined, and hemoglobin concentrations showed a normal distribution with the former test, but not with the latter. 2) Average values of hemoglobin concentrations in men and women were compared by T-test, and Cr-test. 3) The arithmetric means of hemoglobin concentrations for each ten-year age group and F values were tested. 4) Confidence intervals for averages of population values were estimated. 5) Confidence limits of variance of nearly normal distribution were estimated. 6) Linear regression, correlation, confidence interval of regression coefficient and significance for hemoglobin concentration and hematocrit value were tested. 7) Coefficients of correlation between sample and population were compared as to their significance. 8) Spearman's rank correlation was examined.抄録全体を表示PDF形式でダウンロード (921K) -
曽根 克彦, 鈴木 隆, 田端 裕之, 小野 真康, 田代 雅彦, 竹内 東光1986 年 36 巻 1 号 p. 87-92
発行日: 1986/02/20
公開日: 2009/10/15
ジャーナル フリーCardiac catheterization is the most reliable examination in the accurate diagnosis of pediatric heart disease. In our center 550 cases of heart disease in whom the age ranged from newborm infant to 15 years old, the mean age being 3 year 8 months, were examined between July 1982 and August 1985.
The procedures for catheterization were right heart in 374 and left heart in 360 cases. Balloon atrio-septostomy (BAS) was done in 18 cases, most of which involved complete transposition of the great artery. Selective coronary arteriography performed on 167 cases with mucocutaneous lymph node syndrome revealed various abnormalities including aneurysm, dilatation, obstruction and stenosis of coronary arteries.
The kinds of pediatric heart disease appear to have been changing recently, because of declining rheumatic heart disease and increasing mucocutaneous lymph node syndrome.抄録全体を表示PDF形式でダウンロード (895K) -
渡辺 秀臣, 千木良 正機, 有田 覚, 篠崎 哲也1986 年 36 巻 1 号 p. 93-99
発行日: 1986/02/20
公開日: 2009/10/15
ジャーナル フリーLewis肺腫瘍細胞およびGunma clone-4細胞をおのおの同系マウスの皮下および尾静脈より投与し肺転移を転移率, 肺表面転移結節数, 肺重量および肺体重比をもって評価した.また各群で肺表面転移結節数と肺重量との相関, および肺表面転移結節数と肺体重比との相関を調べた.各群の転移率は25%から100%の間の値を示し, 肺表面転移結節数に著明な差が現われたものでも転移率では僅差かもしくは同じ値を示すものがみられ, 転移率の定量性が肺表面転移結節数のものに比べて低いことが示された.肺表面転移結節数と肺重量との間の各群の相関係数は0.712から0.996の間にあり, 腫瘍細胞にも接種方法にもかかわらず両者に有意の相関々係を示した.肺表面転移結節数と肺体重比との間の各群の相関係数は0.587から0.998の間にあり有意に相関することを示した.以上より肺重量および肺体重比は肺転移の評価にさいし肺表面転移結節数と同程度の定量性をもつことが示された.抄録全体を表示PDF形式でダウンロード (1286K) -
安斉 徹男, 川辺 昌道, 六本木 隆1986 年 36 巻 1 号 p. 101-105
発行日: 1986/02/20
公開日: 2009/10/15
ジャーナル フリーA case of ruptured abdominal aortic aneurysm treated by interruption of the abdominal aorta is reportod.
A 58-year-old man complained of severe abdominal and back pain and pulsatile abdominal tumor. His lower extremities had been amputated bilaterally at the age of 29 years, because of thromboangitis obliterans. Preoperative enhanced CT confirmed reptured abdominal aortic aneurysm.
On surgery, a large aneurysm located between the renal arteries and aortic bifurcation, penetrating into the retroperitoneal cavity. In addition, bilateral external iliac and left internal iliac arteries were occluded. Therefore, the abdominal aorta was transected and closed just below the renal arteries, and the right internal iliac artery was ligated. In spite of the acute interruption of the blood flow to lower extremities, the patient recovered completely after the operation.
This type of operation for adbominal aortic aneurysm is very rare only available to patients with severe arteriosclerosis obliterans and/or thromboangitis obliterans in their lower extremities.抄録全体を表示PDF形式でダウンロード (1462K) -
(3) Polyclonal immunoblastosis (小島) の1剖検例杉原 志朗, 斎藤 裕幸, 島野 俊一, 本間 学1986 年 36 巻 1 号 p. 107-110
発行日: 1986/02/20
公開日: 2009/10/15
ジャーナル フリーPDF形式でダウンロード (2784K)
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