巻号一覧
37 巻, 6 号
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新井 孝之1987 年 37 巻 6 号 p. 481-492
発行日: 1987/11/01
公開日: 2010/02/09
ジャーナル フリーThe immunological functions of Kupffer cells isolated from rat livers were investigated. The culture supernatant from LPS-treated Kupffer cells caused significant increase in DNA synthesis in PHA-stimulated thymocytes ; therefore it contained interleukin 1.
In vitro polyclonal antibody production in human peripheral blood mononuclear cells was also enhanced significantly, when they were stimulated with both PWM and culture supernatant from LPS-treated Kupffer cells, in comparison with production in lymphocytes stimulated with PWM alone. This response was thought to be due at least partially to interleukin 1. DNA synthesis in PHA-, PWM-, or Con A-stimulated peripheral blood mononuclear cells, however, was inhibited by adding culture supernatant from Kupffer cells, and this suppressive effect on lymphocyte transformation proved to be due, at least in part, to prostaglandins produced by the Kupffer cells, because the effect was partially inhibited by treating Kupffer cells with indomethacin.
Moreover, Kupffer cells stimulated with LPS or culture supernatant from these cells decreased protein synthesis by isolated rat hepatocytes ; therefore the activated Kupffer cells were thought to be hepatocytotoxic.
These results suggest that activated Kupffer cells interact with lymphocytes and hepatocytes, and modulate inflammation in the liver.抄録全体を表示PDF形式でダウンロード (2047K) -
池田 均1987 年 37 巻 6 号 p. 493-503
発行日: 1987/11/01
公開日: 2009/10/15
ジャーナル フリーThe antitumor effect and cytotoxicity of combined use of cis-diamminedichloroplatinum (II) (CDDP) and verapamil, a calcium influx blocker, were examined in vivo and in vitro. The effect of CDDP on nude mouse-grown human neuroblastoma, NB-1-GU, was related to the dose administered. Regression of the tumor was observed when CDDP was administered at 4.2mg/kg/ injection. Retardation of tumor growth was observed in the group to which CDDP was administered at 2.1mg/kg/injection. When verapamil was administered with CDDP, regression of the tumor was observed in the group treated with CDDP at 2.1mg/kg/injection, and retardation of tumor growth was observed in the group treated with CDDP at 1.4mg/kg/injection. Cytotoxicity was measured by cell survival using a colony formation assay in a human neuroblastoma cell line, GOTO. The surviving fraction was significantly decreased, from 0.28 ± 0.04 to 0.18 ± 0.05, when the cells were exposed to 10μM CDDP with 10μM verapamil. These results indicate that verapamil enhances the antitumor effect and cytotoxicity of CDDP in human neuroblastoma.抄録全体を表示PDF形式でダウンロード (2674K) -
小川 徹男1987 年 37 巻 6 号 p. 505-521
発行日: 1987/11/01
公開日: 2009/10/15
ジャーナル フリーUrinary polyamine levels were analysed in 92 female patients with breast cancer. Ninety two patients with breast cancer consisted of 64 primary (TNM stage I, II and III) and 28 advanced (TNM stage IV and recurrent) carcinomas. Four polyamines (putrescine, cadaverine. spermidine and spermine) and 1-methylhistamine were found in all the urine samples analysed. Among these compounds, putrescine and spermidine were best correlated with disease status.
Putrescine was found to be elevated in 36% of primary breast cancer and in 57% of advanced disease cases, and spermidine in 36% and in 82% of those cases, respectively. In serial determination of urinary polyamine levels of patients with advanced disease, changes in polyamine levels tended to reflect the clinical course of the diseases, especially with the rise in polyamine values in progressive disease.
These results indicate that urinary polyamine determination can be used clinically for monitoring the disease aggressiveness of breast cancer. In the course of a present study on urinary polyamines, two metabolites of polyamines, hypusine and isoputreanine, were identified. The urinary excretion of both hypusine and isoputreanine increased in patients with breast cancer. These compounds such as polyamine metabolites may be applicable to the use of diagnosis and management of cancer patients, and also of cancer research.抄録全体を表示PDF形式でダウンロード (2415K) -
白倉 賢二1987 年 37 巻 6 号 p. 523-538
発行日: 1987/11/01
公開日: 2009/10/15
ジャーナル フリーThe quadriceps muscle force in knees with injured cruciate ligament was evaluated under isokinetic contraction. The evaluation of the biomechanical change in this entity is of great advantage in determining methods of treatment and rehabilitation.
The subjects of the experiments were 30 patients with anterior cruciate ligament (ACL) injuries, 19 with posterior cruciate ligament (PCL) injuries, 24 with other disorders of the knees and 30 controls.
The muscle force of concentric contraction was tested from 90 to 0 degrees, and eccentric contraction was from 0 to 90 degrees. The conclusions were as follows :
1) Both concentric and eccentric muscle force of ACL injured knees showed a significant difference from uninjured sides at less than 54 degrees of extension. But the maximum force and work totals for both concentric and eccentric contraction were the same as those for uninjured sides and controls.
2) Both concentric and eccentric muscle force of PCL injured knees showed a significant difference from uninjured sides at more than 36 degrees of flexion. The maximum force and work totals for concentric and eccentric contraction showed a significant difference from uninjured sides and controls.
3) The ratio of eccentric maximum force to concentric maximum force of ACL injured knees did not show a significant difference from that of controls.抄録全体を表示PDF形式でダウンロード (4499K) -
服部 瑛, 田口 修之, 大友 晋, 鏑木 豊1987 年 37 巻 6 号 p. 539-547
発行日: 1987/11/01
公開日: 2010/02/09
ジャーナル フリーWe investigated common skin lesions in 55 patients undergoing hemodialysis. There were various lesions such as dry skin (90.9%), pruritus (74.5%), pigmentation (89.1%), nail deformity (74. 5%), alopecia (63.6%), folliculitis (25.5%), and the development of verruca (29.1%) and purpura (25. 5%).
Electric measurement revealed a marked decrease in skin surface hydration and transepidermal water loss (TWL) in hemodialysis patients compared with healthy volunteers.
Furthermore, structural abnormalities of the skin surface occured in the patients with dry skin. These skin abnormalities were frequently observed in hemodialysis patients, and further studies are necessary to relieve hemodialysis patients of the skin troubles.抄録全体を表示PDF形式でダウンロード (2656K) -
中村 茂, 阪上 昌三郎, 木村 盛彦, 福田 敬宏, 一色 重雄, 清水 幸夫, 小井田 時廣1987 年 37 巻 6 号 p. 549-557
発行日: 1987/11/01
公開日: 2009/10/15
ジャーナル フリーFifty-six cases of gallbladder carcinoma treated in our center during the past 14 years (1972-' 86) were investigated clinicopathologically according to General Rules for Surgical and Pathological Studies on Cancer of Biliary Tract, published by the Japanese Society of Biliary Surgery, and the results of surgical treatment for 42 cases were examined, and the following results were obtained.
1) The primary surgical cases were 42 and the resected cases were 18 (42.9%) of the 42. The curative resection cases were 7 (38.9%) of the 18.
2) According to the macroscopical Stages, patients of Stages I, II, III and IV were 2, 3, 2 and 11, respectively. Thirteen (72.2%) of 18 cases were markedly advanced Stages III-IV.
3) With respect to macroscopical appearance, the infiltrative type was the most frequent, in 31 (63.3%) of 49.
4) Most patients in Stage I had tumors of the papillary type with cancer-infiltration to muscle layer. These showed better prognoses, but in Stages II, III and IV, most tumors were infiltrative or nodular types with positive serosal, vascular or perineural invasion. These had poorer prognoses.
5) The 2-year survival rate of 7 cases with curative resection was 51.4%. In 11 cases with non-curative resection, no one survived more than 2 years after the operation.
These results show that extended cholecystectomy with wedge-resection of the liver bed and radical lymphnode-dissection (R2) are indicated in Stage I, and more radical procedures or combined multidisciplinary therapy should be applied in the advanced Stages of this disease.抄録全体を表示PDF形式でダウンロード (1314K) -
桜井 敏雄, 中里 享美, 白倉 卓夫1987 年 37 巻 6 号 p. 559-562
発行日: 1987/11/01
公開日: 2009/10/15
ジャーナル フリーChanges in plasma viscosity in 31 cases of rheumatoid arthritis (RA), diagnosed as clinically “classical” RA, were investigated. The subjects consisted of six males and 25 females, ranging from54 to 85 years old. Plasma viscosity was measured at 37°C at a shear rate of 94.5 sec-1, by using a viscosimeter (Low Shear 30, Contraves Inc.)
The results obtained were as follows.
1) Plasma viscosity was 1.41±0.13 (M ± SDM) cP for the RA group and 1.28±0.04 cP for the healthy group. There was a significant difference between the two groups (p < 0.001).
2) Changes in plasma viscosity were studied in RA patients, compared with the RA-related parameters as erythrocyte sedimentation rate (ESR), fibrinogen (Fbg), concentration of globulin (Gl) and RAHA titer. There was a significant correlation between plasma viscosity and ESR, Fbg or Gl, but not RAHA titer.
3) Changes in plasma viscosity before and after effective therapy were studied in five patients that were followed by clinical and laboratory improvement. Plasma viscosity, ESR and Fbg were decreased in all cases after the therapy. However, Cl was increased in only two out of five cases. Neither tendency was observed for RAHA titer nor Hb concentration.
From these results it is concluded that plasma viscosity can be useful for estimating the activity of RA.抄録全体を表示PDF形式でダウンロード (569K) -
鈴木 丹次, 中野 眼一, 坂本 孝作, 工藤 通明, 野口 俊昭, 長町 幸雄1987 年 37 巻 6 号 p. 563-570
発行日: 1987/11/01
公開日: 2010/02/09
ジャーナル フリーACI, Buffalo 及びWistao 系ラットに1, 2-nimethyl-hydrazine (DMH) を週20mg/kg計9回投与し, 投与終了後6週目に屠殺した.Wistar系ラットの大腸腫瘍発生頻度 (32/50) は, ACI系 (10/44) 及び Buffalo 系 (8/50) に比し有意に高かった (P<0.005).
ACI 系ラットは, 生食水投与対照群及びDMH投与群のいずれでも, 他の2系より高い末梢血リンパ球数を示した.
対照群では, natural killer cell 活性に系統差を認めなかったが, DMH 投与群では Wistar 系ラットのみが高い活性を示した.大腸腫瘍発生頻度の高いWistao 系ラットでは, 血清ISS値は, 対照群, DMH 投与群ともに高かった.
以上の結果から, 本研究で用いた免疫学的パラメーターは, 実験大腸腫瘍の発生頻度と並行せず, DMH 発癌に対する感受性の系統差の説明には更に他の要因を考慮するべきと考えられた.抄録全体を表示PDF形式でダウンロード (1322K) -
本態性血小板血症久保田 一雄, 田村 遵一, 倉林 均, 白倉 卓夫1987 年 37 巻 6 号 p. 571-574
発行日: 1987/11/01
公開日: 2009/10/15
ジャーナル フリーPDF形式でダウンロード (699K) -
II. 酸・塩基平衡, 血液ガス : 最近の論点後藤 文夫1987 年 37 巻 6 号 p. 575-579
発行日: 1987/11/01
公開日: 2009/10/15
ジャーナル フリーPDF形式でダウンロード (872K)
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