All issues
Successor
Volume 37 (1987)
- Issue 6 Pages 481-
- Issue 5 Pages 423-
- Issue 4 Pages 347-
- Issue 3 Pages 269-
- Issue 2 Pages 139-
- Issue 1 Pages 1-
Volume 37, Issue 6
Displaying 1-10 of 10 articles from this issue
- |<
- <
- 1
- >
- >|
-
TAKAYUKI ARAI1987 Volume 37 Issue 6 Pages 481-492
Published: November 01, 1987
Released on J-STAGE: February 09, 2010
JOURNAL FREE ACCESSThe immunological functions of Kupffer cells isolated from rat livers were investigated. The culture supernatant from LPS-treated Kupffer cells caused significant increase in DNA synthesis in PHA-stimulated thymocytes ; therefore it contained interleukin 1.
In vitro polyclonal antibody production in human peripheral blood mononuclear cells was also enhanced significantly, when they were stimulated with both PWM and culture supernatant from LPS-treated Kupffer cells, in comparison with production in lymphocytes stimulated with PWM alone. This response was thought to be due at least partially to interleukin 1. DNA synthesis in PHA-, PWM-, or Con A-stimulated peripheral blood mononuclear cells, however, was inhibited by adding culture supernatant from Kupffer cells, and this suppressive effect on lymphocyte transformation proved to be due, at least in part, to prostaglandins produced by the Kupffer cells, because the effect was partially inhibited by treating Kupffer cells with indomethacin.
Moreover, Kupffer cells stimulated with LPS or culture supernatant from these cells decreased protein synthesis by isolated rat hepatocytes ; therefore the activated Kupffer cells were thought to be hepatocytotoxic.
These results suggest that activated Kupffer cells interact with lymphocytes and hepatocytes, and modulate inflammation in the liver.View full abstractDownload PDF (2047K) -
HITOSHI IKEDA1987 Volume 37 Issue 6 Pages 493-503
Published: November 01, 1987
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSThe antitumor effect and cytotoxicity of combined use of cis-diamminedichloroplatinum (II) (CDDP) and verapamil, a calcium influx blocker, were examined in vivo and in vitro. The effect of CDDP on nude mouse-grown human neuroblastoma, NB-1-GU, was related to the dose administered. Regression of the tumor was observed when CDDP was administered at 4.2mg/kg/ injection. Retardation of tumor growth was observed in the group to which CDDP was administered at 2.1mg/kg/injection. When verapamil was administered with CDDP, regression of the tumor was observed in the group treated with CDDP at 2.1mg/kg/injection, and retardation of tumor growth was observed in the group treated with CDDP at 1.4mg/kg/injection. Cytotoxicity was measured by cell survival using a colony formation assay in a human neuroblastoma cell line, GOTO. The surviving fraction was significantly decreased, from 0.28 ± 0.04 to 0.18 ± 0.05, when the cells were exposed to 10μM CDDP with 10μM verapamil. These results indicate that verapamil enhances the antitumor effect and cytotoxicity of CDDP in human neuroblastoma.View full abstractDownload PDF (2674K) -
TETSUO OGAWA1987 Volume 37 Issue 6 Pages 505-521
Published: November 01, 1987
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSUrinary polyamine levels were analysed in 92 female patients with breast cancer. Ninety two patients with breast cancer consisted of 64 primary (TNM stage I, II and III) and 28 advanced (TNM stage IV and recurrent) carcinomas. Four polyamines (putrescine, cadaverine. spermidine and spermine) and 1-methylhistamine were found in all the urine samples analysed. Among these compounds, putrescine and spermidine were best correlated with disease status.
Putrescine was found to be elevated in 36% of primary breast cancer and in 57% of advanced disease cases, and spermidine in 36% and in 82% of those cases, respectively. In serial determination of urinary polyamine levels of patients with advanced disease, changes in polyamine levels tended to reflect the clinical course of the diseases, especially with the rise in polyamine values in progressive disease.
These results indicate that urinary polyamine determination can be used clinically for monitoring the disease aggressiveness of breast cancer. In the course of a present study on urinary polyamines, two metabolites of polyamines, hypusine and isoputreanine, were identified. The urinary excretion of both hypusine and isoputreanine increased in patients with breast cancer. These compounds such as polyamine metabolites may be applicable to the use of diagnosis and management of cancer patients, and also of cancer research.View full abstractDownload PDF (2415K) -
KENJI SHIRAKURA1987 Volume 37 Issue 6 Pages 523-538
Published: November 01, 1987
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSThe quadriceps muscle force in knees with injured cruciate ligament was evaluated under isokinetic contraction. The evaluation of the biomechanical change in this entity is of great advantage in determining methods of treatment and rehabilitation.
The subjects of the experiments were 30 patients with anterior cruciate ligament (ACL) injuries, 19 with posterior cruciate ligament (PCL) injuries, 24 with other disorders of the knees and 30 controls.
The muscle force of concentric contraction was tested from 90 to 0 degrees, and eccentric contraction was from 0 to 90 degrees. The conclusions were as follows :
1) Both concentric and eccentric muscle force of ACL injured knees showed a significant difference from uninjured sides at less than 54 degrees of extension. But the maximum force and work totals for both concentric and eccentric contraction were the same as those for uninjured sides and controls.
2) Both concentric and eccentric muscle force of PCL injured knees showed a significant difference from uninjured sides at more than 36 degrees of flexion. The maximum force and work totals for concentric and eccentric contraction showed a significant difference from uninjured sides and controls.
3) The ratio of eccentric maximum force to concentric maximum force of ACL injured knees did not show a significant difference from that of controls.View full abstractDownload PDF (4499K) -
AKIRA HATTORI, NOBUYUKI TAGUCHI, SUSUMU OHTOMO, YUTAKA KABURAGI1987 Volume 37 Issue 6 Pages 539-547
Published: November 01, 1987
Released on J-STAGE: February 09, 2010
JOURNAL FREE ACCESSWe investigated common skin lesions in 55 patients undergoing hemodialysis. There were various lesions such as dry skin (90.9%), pruritus (74.5%), pigmentation (89.1%), nail deformity (74. 5%), alopecia (63.6%), folliculitis (25.5%), and the development of verruca (29.1%) and purpura (25. 5%).
Electric measurement revealed a marked decrease in skin surface hydration and transepidermal water loss (TWL) in hemodialysis patients compared with healthy volunteers.
Furthermore, structural abnormalities of the skin surface occured in the patients with dry skin. These skin abnormalities were frequently observed in hemodialysis patients, and further studies are necessary to relieve hemodialysis patients of the skin troubles.View full abstractDownload PDF (2656K) -
SHIGERU NAKAMURA, SYOZABURO SAKAUE, MORIHIKO KIMURA, TAKAHIRO FUKUDA, ...1987 Volume 37 Issue 6 Pages 549-557
Published: November 01, 1987
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSFifty-six cases of gallbladder carcinoma treated in our center during the past 14 years (1972-' 86) were investigated clinicopathologically according to General Rules for Surgical and Pathological Studies on Cancer of Biliary Tract, published by the Japanese Society of Biliary Surgery, and the results of surgical treatment for 42 cases were examined, and the following results were obtained.
1) The primary surgical cases were 42 and the resected cases were 18 (42.9%) of the 42. The curative resection cases were 7 (38.9%) of the 18.
2) According to the macroscopical Stages, patients of Stages I, II, III and IV were 2, 3, 2 and 11, respectively. Thirteen (72.2%) of 18 cases were markedly advanced Stages III-IV.
3) With respect to macroscopical appearance, the infiltrative type was the most frequent, in 31 (63.3%) of 49.
4) Most patients in Stage I had tumors of the papillary type with cancer-infiltration to muscle layer. These showed better prognoses, but in Stages II, III and IV, most tumors were infiltrative or nodular types with positive serosal, vascular or perineural invasion. These had poorer prognoses.
5) The 2-year survival rate of 7 cases with curative resection was 51.4%. In 11 cases with non-curative resection, no one survived more than 2 years after the operation.
These results show that extended cholecystectomy with wedge-resection of the liver bed and radical lymphnode-dissection (R2) are indicated in Stage I, and more radical procedures or combined multidisciplinary therapy should be applied in the advanced Stages of this disease.View full abstractDownload PDF (1314K) -
TOSHIO SAKURAI, KYOMI NAKAZATO, TAKUO SHIRAKURA1987 Volume 37 Issue 6 Pages 559-562
Published: November 01, 1987
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSChanges in plasma viscosity in 31 cases of rheumatoid arthritis (RA), diagnosed as clinically “classical” RA, were investigated. The subjects consisted of six males and 25 females, ranging from54 to 85 years old. Plasma viscosity was measured at 37°C at a shear rate of 94.5 sec-1, by using a viscosimeter (Low Shear 30, Contraves Inc.)
The results obtained were as follows.
1) Plasma viscosity was 1.41±0.13 (M ± SDM) cP for the RA group and 1.28±0.04 cP for the healthy group. There was a significant difference between the two groups (p < 0.001).
2) Changes in plasma viscosity were studied in RA patients, compared with the RA-related parameters as erythrocyte sedimentation rate (ESR), fibrinogen (Fbg), concentration of globulin (Gl) and RAHA titer. There was a significant correlation between plasma viscosity and ESR, Fbg or Gl, but not RAHA titer.
3) Changes in plasma viscosity before and after effective therapy were studied in five patients that were followed by clinical and laboratory improvement. Plasma viscosity, ESR and Fbg were decreased in all cases after the therapy. However, Cl was increased in only two out of five cases. Neither tendency was observed for RAHA titer nor Hb concentration.
From these results it is concluded that plasma viscosity can be useful for estimating the activity of RA.View full abstractDownload PDF (569K) -
TANJI SUZUKI, GEN-ICHI NAKANO, KOSAKU SAKAMATO, MICHIAKI KUDO, TOSHIAK ...1987 Volume 37 Issue 6 Pages 563-570
Published: November 01, 1987
Released on J-STAGE: February 09, 2010
JOURNAL FREE ACCESSRats of three strains, ACI, Buffalo and Wistar, were treated with 1, 2-dimethylhydrazine (DMH) 20 mg/kg/week, serially for nine weeks and sacrificed at the 6th week after the last injection. In control rats, saline was administered ad libitum. In Wistar rats, the incidence of colon tumors (32/ 50) was significantly higher than that in ACI rats (10/44) and Buffalo rats (8/50) (P <0.005).
Both the saline-treated and DMH-treated groups of ACI rats showed a higher peripheral lymphocyte count than those in Buffalo and Wistar rats. There was no strain difference in natural killer cell activity among the saline-treated groups. On the other hand, Wistar rats showed significantly higher natural killer cell activity among the three rat strains after DMH administration. The serum immunosuppressive substance level was high in the tumor-free and colonic tumor-bearing groups of Wistar rats. Thus immunological parameters selected in this study seemed to be insufficient to explain the strain difference in susceptibility to DMH.View full abstractDownload PDF (1322K) -
KAZUO KUBOTA, JUN'ICHI TAMURA, HITOSHI KURABAYASHI, TAKUO SHIRAKURA1987 Volume 37 Issue 6 Pages 571-574
Published: November 01, 1987
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSDownload PDF (699K) -
[in Japanese]1987 Volume 37 Issue 6 Pages 575-579
Published: November 01, 1987
Released on J-STAGE: October 15, 2009
JOURNAL FREE ACCESSDownload PDF (872K)
- |<
- <
- 1
- >
- >|