Three hundred and eighty-five strains of Pseudomonas aeruginosa were isolated from patients in Gunma University Hospital from 1984 to 1987. Susceptibilities to eight kinds of antibiotics (PIPC, CFS, CAZ, IPM, AZT, GM, AMK, NFLX) were investigated and following results were obtained.
1) Ninety of 385 strains (23%) were resistant to some kind of antibiotic.
2) The isolation frequency of resistant strains increased year by year for most antibiotics, especially NFLX and PIPC. Strains with multiple resistance increased in 1986 and 1987.
3) Minimum inhibitory concentration curves indicated that, CFS, CAZ, IPM, AZT, and AMK were still effective for Psuedomonas infections.
4) The isolation frequency of resistant strains to each drug varied from source to source. For example, GM-resistant strains were isolated more frequently from urine (33%) than from the airway (3%).
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