The experience of recent treatment for head and neck carcinoma of 1, 280 cases during from 1972 to 1987 in Gunma Cancer Center was reviewed.
The radiation therapy for early lesions of squamous cell carcinomas had available treatment results in this recent decades. However more favourable effect could not be obtained in this treatment program, compared with other treatment method.
The surgical progress in head and neck carcinoma contributed in valuable reconstructive surgery. The extended major surgery for advanced cases of head and neck carcinoma, especially to oral, mesopharyngeal or hypopharyngeal carcinoma was indicated using with new reconstructive surgical technics. These reconstructive surgery had more advantage of the preserved patient's physical function and improvement of its survival rate. The chemotherapy for head and neck carcinoma was also progressed. The intra-arterial regional chemotherapy using 5-FU was contributed to successful multidisciplinary treatment for the carcinoma of the maxillary antrum. Otherwise, systemic administration using regimen of Cisplatin, Peplomycin or Methotrexate was also contributed for induction chemotherapy of the advanced head and neck carcinoma.

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A community hypertension control program was conducted and followed up for 15 years in Ueno village, Gunma Prefecture.
1) The mean systolic blood pressure of residents over 40 years old decreased significantly and the prevalence of ECG positives and ophthalmofunduscopic changes also decreased compared with the earliest examination data.
2) The annual incidence of stroke aged 40-69 years declined from 7.3 per 1, 000 population in 1970-72 to 1.9 in 1979-81.
3) Hypertension was shown to be the major risk factor for stroke judged by the relative risk of 12 years follow up study.
4) Of the aged 70 years or older, 85.6% had high activity of daily living at home (well-aging).
5) The cost of medical care for all kinds of diseases in Ueno village was smaller than that of the neighboring districts, especially in the impatient cost of cerebro-and cardio-vascular diseases of the aged 70 years or older.
A long term follow-up program for the prevention of cerebro-and cardio-vascular diseases was found to play an important role for promotion of community health for the aged.

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Little is known about the relation between thyroid dysfunction and the autonomic nervous system, particularly the parasympathetic nervous system. Variations in the R-R interval on the electrocardiogram (ECG) have been considered a reliable indicator of the parasympathetic nervous system abnormalities. We have attempted to apply this technique to patients with thyroid dysfunction.
Studies were conducted in 60 healthy subjects, 60 patients with Graves' disease and 34 patients with Hashimoto's thyroiditis. Variations in R-R intervals were expressed as a coefficients of variance of 100 heart rates while resting (CVq) and deep respiration (CVd), respectively.
A negative correlation between CVq and age was observed in control subjects. A similar phenomenon was also observed between CVd and age. CVq was significantly lower in untreated patients with Graves' disease than in treated, euthyroid patients with Graves' disease, and control subjects. Similar results were also observed with respect to CVd. CVq, on the other hand, was markedly decreased by administration of adrenaline and atropine in healthy subjects. Decreased CVq in untreated patients with Graves' disease was restored by antithyroid drug therapy and also by administration of propranolol and metoprolol, but not bunazosin. Patients with severe hypothyroidism (low T₄, low T₃ and elevated TSH) due to Hashimoto's thyroiditis had significantly lower CVq and CVd values than control subjects. Decreased CVq and CVd were restored by L-T₄ therapy. Similar results were also found in the hypothyroid state during antithyroid drug therapy for patients with Graves' disease.
The present investigation suggests that there is increased sympathetic activity associated with adrenergic β- (especially β₁-) effects in patients with hyperthyroidism. Furthermore, a decrease in serum T₃, in addition to a decrease in serum T₄, may be required for functional abnormalities of the parasympathetic nervous system to develop in patients with hypothyroidism.

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カナマイシン3'位の-OH基をリン酸化するアミノ配糖体不活化酵素は, その基質特異性から三群に分類されている.すなわちAPH (3') -1型酵素はカナマイシン, リビドマイシンをリン酸化するがブチロシンをリン酸化しない.APH (3') -II型酵素はカナマイシン, ブチロシンをリン酸化するがリビドマイシンをリン酸化できない.カナマイシン, ブチロシン及びリビドマイシンをリン酸化出来る酵素はAPH (3') -IIIと分類されている.ところで, 緑膿菌の染色体上にはAPH (3') -IIを支配する遺伝子 (aphA) のの存在が報告されている.同一酵素を支配するトランスポゾン (Transposon, Tn), Tn5は腸内細菌科のプラスミドに存在することが報告されている.従って自然界にAPH (3') -IIを産生する種々の菌種及びプラスミドを検索し, これらの遺伝子の性状を調べることは, aphA 遺伝子の普遍性を論ずる上で興味あることといえる.そこで緑膿菌染色体よりaphA 直遺伝子をクローニングし, 合わせてTn5を含む腸内細菌科由来aph遺伝子もクローニングし, aph 遺伝子の類似性について検討した.

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There is no doubt that transurethral resection is the treatment of choice in patients with superficial transitional cell carcinoma of the bladder. Although tumors will recur in more than 50% of the patients, the progression of the neoplastic disease in 25% of them is more important. The results in this report were the same as that by authors. However the relative survival rates in grade 1 and 2 were more than 1.0. It means that superficial bladder tumor is not crucial to the survival rate. However about 25% in all death causes of patients analyzed in this report was occupied by the bladder cancer. The question arises whether there exists any reliable and clinically applicable indicator for tumor progression.

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Twenty-eight patients were postoperatively irradiated for lung cancer between 1971 and 1984. Four patients underwent curative or relatively curative resections, nine relatively non-curative resections, six absolutely non-curative resections, and seven exploratory thoracotomies.
The cumulative five-year survival rate was 31%. Long-term survival, i.e., over five years was obtained in eight patients, of whom had underwent were three relatively curative resections, three relatively non-curative resections, one absolutely non-curative resection and one exploratory thoracotomy.
Radiotherapy has sufficiently locally effective for lung cancers in which the surgical treatment could not be performed effectively. Postoperative radiotherapy is considered one of the most significant combined therapies in the local control of lung cancer.

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We report a spontaneously occurring chromophobe adenoma of the pituitary gland in a rat (male Wistar rat, 16 months of age). The adenoma cells were arranged in diffuse or sinusoidal patterns. Secretory granules were noted in the adenoma cells. They were spherical, electron dense, measured 100-300 nm in diameter, and had an electron dense core, and were separated from the prominent limiting membrane by a narrow electron-lucent halo.

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The avidin-biotin-peroxidase complex (ABC) technique has become most widely used in the visualization of immunohistochemical reactions. Using this procedure, the authors attempted to detect transfusion-induced PBIgG in the serum of patients with blood diseases. In this study, it was found to be useful to fix platelets by gluthalaldehyde and suspend them in a carbonate-bicarbonate buffer (pH9.6) at a concentration of 100, 000/μl, then have them absorbed in a U-type immunoplate. The results obtained by this method were compared with those by the quantitative method for PBIgG by immunoperoxidase procedure. The results showed that the data were highly correlated, with a correlation coefficient of 0.775. Thus the authors have developed an assay for PBIgG that is simple, rapid and suitable for routine use in the clinical laboratory.

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A case of male breast cancer with cystic formation is reported. A 84-year-old man complaining of left breast tumor visited to Numata National Hospital on December 23, 1982. Physical examination showed an elastic firm, relatively defined, measured 3.5 × 3.0cm tumor with nipple retraction. Mammogram revealed a relatively defined tumor shadow without calcification and spicula formation. Excisional biopsy was performed.
Gross finding showed various and multiple features, i.e., intracystic papillomatous, cystic and solid lesion. Histologically, invasive papillotubular carcinoma with cystic formation was proven. Cystic formation was thought to be a secondary product due to obstruction of the duct such as ductal spreading of carcinoma. And also the appearance of gynecomastia was seen in the surrounding noncancerous mammary gland ; proliferation of dilated duct with edematous stroma.
Diagnosed left breast cancer (T_2a, N_{1 a}, M₀ Stage II), standard radical mastectomy was performed. This patient has been disease-free since six years after operation.

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We had an opportunity to examine two patients with Kawasaki disease complicated by multiple peripheral arterial aneurysms. They occurred in an 11-month-old boy and a 2-year-5-month-old boy. Angiograms showed multiple arterial aneurysms in the coronary artery, axillar artery and iliac artery.

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Retroperitoneal cystic lymphangiomas are uncommon tumors. When symptomatic, these tumors usually present as a palpable mass in the abdomen. Rarely, compression of adjacent structures may produce bowel obstruction.
A 49-year-old woman complained of general fatigue and a large mass filling the entire abdomen that was found by a physician. The mass was soft, smooth, and nontender. Computed tomography (CT) demonstrated a huge retroperitoneal mass in the abdomen. The left kidney was elevated and displaced anteriorly by the mass. The mass was homogeneous and had the density of water. A diagnosis of retroperitoneal cystic tumor was considered. At laparotomy, a large cystic mass was removed from the retroperitoneal space. The final pathologic diagnosis was cystic lymphangioma.

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Primary pulmonary hypertension (PPH) is an uncommon fatal disease. Although this is usually a nonfamilial disease, there are some cases of familial occurrence. We reported two families of PPH ; elder brother and younger sister in one family and elder sister and younger brother in the other. The former siblings died and postmortem examinations revealed plexiform lesion in the younger sister and obliteration of small pulmonary artery by medial hypertrophy in the elder brother.

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During the years 1970-1987, 427 patients with Hodgkins and Non-Hodgkins lymphomas underwent radio-therapy at the Department of Radiology, Gunma University School of Medicine. Among them, there were three patients with lung cancer. The occurrence of double primary malignant tumors was synchronous in 2 patients and metachronous in one patient.
All patients were received radiotherapy and the full dose could be given to the both tumors.
Tumors regressed as a result of initial therapy, but the patients died 10, 19 and 24 months, respectively after initial treatment. These patients showed no reoccurence of their malignant lymphoma up to the time of their deaths, so they are believed to have died of lung cancer, and their survival time was as same as patients who have lung cancer only.
It is of interest that double primary malignant tumors may be associated with immunological responsiveness of the host, however, we were unable to demonstrate any weaknesses in the immunological responsiveness of these three patients.

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悪性腫瘍はしばしば脊椎骨, 骨盤骨, 肋骨などに転移を起こすが, 原発巣としては肺, 乳腺, 前立腺の癌腫が多く, これら三者で骨転移の60～80%を占めると言われている.骨転移巣は形態的に骨形成性 (osteoplastic), 骨融解性 (osteolytic), 両者の混合に分けられ, 骨形成性転移は前立腺癌を除いては稀であり, 骨融解性が一般的である.私達は経過中のレ線上で骨融解性の椎体骨転移を示し, 剖検時には骨形成性の転移所見を呈した肺癌の一症例を経験したので, その病理解剖所見を報告し, 骨転移巣のレ線所見と剖検所見の不一致の矛盾について病理学的検討を加える.

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