北関東医学
Online ISSN : 1883-6135
Print ISSN : 0023-1908
ISSN-L : 0023-1908
40 巻, 2 号
選択された号の論文の14件中1~14を表示しています
  • 玉城 修
    1990 年 40 巻 2 号 p. 139-149
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    The histology, immunohistochemistry and ultrastructure of three types of intracytoplasmic degenerative structures (Rosenthal fibers, rounded granular corpuscles and hyaline inclusions) were studied in 10 gliomas containing these structures.
    The elongated hyaline bodies known as Rosenthal fibers were found in three pilocytic astrocytomas. Immunoperoxidase stain for GFAP were generally negative and the bodies were often encompassed peripherally by GFAP-positive rims of the cytoplasm. Electron microscopic examination revealed that these bodies were osmiophilic amorphous masses of irregular shape, closely associated with cytoplasmic filaments of intermediate size. In two other gliomas (pleomorphic astrocytoma and mixed oligo-astrocytoma) cells packed with tiny eosinophilic granules were found within the tumor tissue. By electron microscopy the granules were found to have a structure corresponding to that of Rosenthal fibers. It is considered that degradation of glial filaments may be in some way related to the formation of Rosenthal fibers.
    Rounded granular corpuscles appeared as round or oval bodies with finely granulated internal structures. The corpuscles were observed in 3 pilocytic astrocytomas and 5 pleomorphic astrocytomas. Immunohistochemically, the corpuscles were generally positive for S-100 protein and their peripheral rims were immunoreactive for GFAP. By electron microscopy the bodies were found to be distended cytoplasms of neoplastic astrocytes packed with numerous membrane-bound dense bodies, vacuoles and membranous profiles. Intracytoplasmic filaments were found pushed towards the periphery of the cytoplasm. Intracytoplasmic hyaline inclusions were found in 5 pleomorphic astrocytomas. These were of a globular or oblong shape and their size varied greatly. By electron microscopy the inclusions appeared as rounded electrondense bodies of varying size within the cytoplasm of neoplastic cells, some of which were membrane-bound. Larger inclusions of oblong shape displayed a complicated internal structure. Because of the fine structural features both the granular corpuscles and hyaline inclusions were considered to be of lysosomal origin.
  • 大島 幸雄
    1990 年 40 巻 2 号 p. 151-159
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    Natural killer (NK) cell activities were measured in 16 IDDM children with insulin-dependent diabetes mellitus (IDDM) to assess the involvement of immune dysfunction in this chronic metabolic disorder.
    No significant difference was found between average NK cell activities in 16 IDDM children and 20 healthy children, however, in IDDM children, NK cell activities were significantly lower in the group with a longer disease duration (L group) than in that with a shorter duration (S group). There were no correlation between NK cell activity and either sex, age, age of onset, or control of the disease, defined by blood glucose level and HbAlc. The responsiveness of NK cells to the exogenous addition of recombinant IL 2 was also determined, and NK cell activity was shown to increase in IDDM children in the S group but not in the L group. NK cell activity was independent of the expression of surface phenotype of NK cells, defined by CD 16 or Leu 7. These results suggest that functional disability but not decreased number of NK cells is responsible for the decreased NK cell activity in the L group IDDM children, and imply the presence of a secondary mechanism in suppression of the immune function in long-term treated IDDM children.
  • 工藤 隆弘, 大西 一徳
    1990 年 40 巻 2 号 p. 161-168
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    The activation of peripheral T cells in patients with systemic scleroderma was examined by two-color flow cytometry. Twenty-eight patients with untreated scleroderma, satisfying the ARA criteria for scleroderma, were studied. As controls, 23 age-and sex-matched healthy persons were also studied. Mononuclear cells separated from heparinized peripheral blood by Ficoll-Paque gradient method, were stained with a panel of anti-human mouse monoclonal antibodies. In order to analyze activated T cells by two-color flow cytometry, cells were double-stained with FITC-CD3 -CD4, or -CD8 and PE-HLA-DR antibodies. Although the lymphocyte subpopulation (CD3+, CD4+, CD8+, CD19+ and CD 16+) was not changed, CD3+ HLA-DR+ cells (activated T cells) were increased in scleroderma patients as compared with healthy controls. An increase in CD3+ HLA-DR+ cells was observed in patients with scleroderma associated with dermatomyositis/polymyositis, CREST syndrome or diffuse scleroderma, whereas patients with acrosclerosis exhibited no significant increase in activated T cells. In addition, an increase in CD3+ HLA-DR+ cells was associated with a high frequency of bibasilar pulmonary fibrosis and positive anti-ENA antibody in patients. In contrast, the incidence of proximal scleroderma was significantly decreased in patients with high T cell activation levels. These results suggest that activated T cells may participate in the patho-mechanism of lung fibrosis, which might differ from that of skin sclerosis.
  • 高柳 昇
    1990 年 40 巻 2 号 p. 169-178
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    In order to investigate the diagnostic value of transbronchial lung biopsy (TBLB) and the subsequent responsiveness to therapy, cases of collagen vascular disease with pulmonary involvement in which TBLB was performed between September 1977 and March 1989 were reviewed. The total number of cases was 38 including those of rheumatoid arthritis (17 cases), polymyositis (6 cases), dermatomyositis (1 case), progressive systemic sclerosis (6 cases), systemic lupus erythematosus (2 cases) and Sjögren's syndrome (6 cases).
    TBLB was performed 45 times in these 38 cases, revealing positive findings in 34 cases (89. 5%), and in 39 of 45 procedures (86.7%). In 25 of 34 positive cases, prednisolone therapy was given, and 19 of 25 cases were effective. All cases of rheumatoid arthritis and Sjögren's syndrome with alveolitis revealed by TBLB were effective to prednisolone therapy. On the other hand, cases of polymyositis and progressive systemic sclerosis in which TBLB revealed alveolitis or bronchoalveolar lavage (BAL) showed elevation of the proportion of lymphocytes or polymorphonuclear cells were responsive to prednisolone therapy. Open lung biopsy was performed in only one case. The pathologic diagnosis in this case was pulmonary multiple nodular amyloidosis. Namely TBLB findings provide useful information in making the diagnosis of pulmonary involvement in cases of collagen vascular diseases and in evaluating the indication for steroid treatment.
  • 藤永 隆
    1990 年 40 巻 2 号 p. 179-189
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    Radioallergosorbent test for measurement of anti-Mycoplasma pneumoniae (Mp) IgG, IgE and IgG antibody in the sera of primary atypical pneumonia (PAP) patients and controls was performed. The antigen, MW 21, 000 protein most reactive for RAST, was purified from Mp (MAC strain). In conclusion : 1) Specific IgG antibody titers were correlated with specific IgD antibody titers. 2) Specific IgE antibody titers were correlated with cold agglutinin titers. 3) Specific IgE antibody titers were inversely proportional to CF titers. 4) Specific IgG antibody titers exceeded the mean +1 SD during epidemics of Mycoplasma pneumonia.
    Specific IgE antibodies might be produced in association with the process of cold agglutinin production, one of the autoantibodies. Even if PAP does not develop, specific IgG antibody responses will be provoked by Mp infection without any clinical manifestations.
  • 小林 敏宏, 曽根 克彦, 小林 富男, 小須田 貴史, 田端 裕之, 田代 雅彦, 小野 真康, 鈴木 隆
    1990 年 40 巻 2 号 p. 191-196
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    The congenital heart diseases associated with Down's syndrome children attending the department of pediatrics at Gunma Children's Medical Center were studied. Of 66 Down's syndrome children consulting us for cardiac examination, 58 were associated with congenital heart disease. We diagnosed congenital heart disease associated with Down's syndrome as early as possible in infancy, understood the severity of the disease, and decided to undertake long-term management. In long-term management, checking of pulmonary hypertension is important due to it's effect on the long-term prognosis of these children. We studied changes in pulmonary vascular resistance during torazoline, dopamine or isoproterenol infusion. Consequently, we consider that this may be a useful indicator in the management of pulmonary hypertension. In association with Down's syndrome, end cardial cushion defect is most common in America and Europe, but in Japan it is being replaced by ventricular septal defect. In our hospital, a similar trend was observed.
  • 宮本 幸男, 石川 仁, 蒔田 富士雄, 山田 保, 柿沼 臣一, 小川 哲夫, 勅使河原 修
    1990 年 40 巻 2 号 p. 197-201
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    Twenty seven cases of multiple early gastric cancer involving resection during from April 1965 to January 1989 were studied according to clinicopathologic features. The incidence of multiple early gastric cancer was 5.5% of a total 488 cases of early gastric cancer. The mean age of patients was 60.9 years, and there was a greater incidence of males. Both the primary and secondary lesions tended to show the same macroscopic type, and were located in the M area. Histologically, the differentiated type was of high incidence in both lesions. The depressed and flat types of less than 5mm in diameter tended to overlooked preoperatively. Examination of the whole stomach should be carefully practiced in elderly males with the differentiated type of gastric cancer.
  • 大和田 進, 宮本 幸男, 竹下 正昭, 神尾 政志, 佐藤 泰平, 川井 忠和, 泉雄 勝
    1990 年 40 巻 2 号 p. 203-210
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    We studied clinicopathologic aspects of cholangiocellular carcinoma in nine patients, among then hepatic resection was performed in eight cases, and two cases were associated with hepatolithiasis. In all cases, the first diagnostic modality was ultrasonography.
    The results were as follows;
    1. CA19-9 (carbohydrate antigen 19-9) had a high positive incidence (83.3%) and a high score.
    2. Ultrasonography and plain CT showed a hypoechoic and low density mass in all cases. The macroscopic massive type showed a hypoechoic heterogenous with an irregular margin and heterogenous enhancement on contrast CT. The macroscopic nodular type showed a homogeneous echoic mass with halo and marginal enhancement. In hepatic angiography, encasement and abruption were common in the massive type, and portal and hepatic vein involvement was prevalent. However, in the nodular type, tumor neovascularization was common. Cholangiography (ERCP, PTC) showed stenosis, dilatation, irregularity and obstruction at the first branch of the bile duct in the massive type, and peripherally from the second branch in the nodular type.
    3. The massive type showed infiltrative growth, and was bigger than the nodular type which showed expansive growth. Histologically, all cases showed tubular adenocarcinoma. Vascular and lymphatic vessel invasion was noted and intra-and perineural invasion was common, especially in the massive type infiltrating to the hepatic hilum.
    The prognosis was not so good in cases of such macroscopic and histological evidence. Therefore, early diagnosis is crucial and multimodality therapy may be important.
  • G-CSFの使用経験
    設楽 利二, 大木 康史, 外松 学, 末武 教行, 大島 幸雄, 由上 伸一郎
    1990 年 40 巻 2 号 p. 211-215
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    The effect of recombinant human granulocytic colony stimulating factor (G-CSF) on chemotherapy-induced neutropenia was evaluated in a patient with neuroblastoma. G-CSF was administered once daily as a subcutaneous injection at a dose level of 2 μg/kg/day for 10 days. Prompt recovery of granulocytes as well as total white blood cell count was obtained in comparison with previous chemotherapy not using G-CSF. G-CSF appears to be an appropriate means for increasing the number of granulocytes.
  • 今井 強一, 関原 哲夫, 真下 正道, 山中 英寿, 北浦 宏一, 登丸 行雄, 小屋 淳, 矢島 久徳, 黒沢 功, 熊坂 文成
    1990 年 40 巻 2 号 p. 217-222
    発行日: 1990/03/01
    公開日: 2010/02/09
    ジャーナル フリー
    The effect of Ofloxacin (OFLX) administrated orally at a dose of 600mg for 7 to 14 days in 57 patients with gonococcal and/or non gonococcal urethritis were investigated. The effect of OFLX on symptom, white blood cell count in urine or urethral discharge, volume of urethral discharge and bacteria was evaluated. Overall clinical efficacy was approximately 80%. We also analyzed the difficulty and problems encountered in drug evaluation studies on STD, comparing some reports published in Japan.
  • 篠崎 明美, 羽鳥 幹子, 岡本 正司, 鈴木 忠, 村田 和彦
    1990 年 40 巻 2 号 p. 223-226
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    A 38-year-old man had transient left posterior hemiblock and ST-segment elevation in leads II, III, and aVF during chest pain. Following sublingual administration of nitroglycerin, the chest pain subsided and the right axis deviation and ST elevation returned to normal. Coronary arteriogram revealed no significant occlusion of major coronary arteries, but collaterals were seen extending from the posterior descending artery up through the interventricular septum. This suggested that the septal branch of the left anterior descending artery had severe stenosis. This report is of a case of variant angina, documents right axis deviation as a feature of coronary spasm, and supports the concept of ischemic left posterior hemiblock.
  • 小須田 貴史, 曽根 克彦, 小林 敏宏, 小林 富男, 田代 雅彦, 田端 裕之, 小野 真康, 鈴木 隆
    1990 年 40 巻 2 号 p. 227-233
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    Between July 1982 and November 1989, 338 patients with MCLS were using with coronary angiography. Of these patients, 6 were associated with calcification of coronary arteries. In 4 of the 6 patients with calcification, maximum diameter of the coronary artery was over 12 mm. The remaining 2 showed a maximum diameter of the coronary artery over 8 mm. All 6 patients had severe signs of acute inflammatory phase. Myocardial infarction occured in 4 of the 6 patients after the acute stage of illness. Thus, the calcification of coronary arteries should be considered as an important sign for following up MCLS.
  • 武井 克巳, 伊藤 賢, 友政 剛
    1990 年 40 巻 2 号 p. 235-238
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
    Five HBV carriers in whom HBeAg disappeared without any special therapy are reported. Four of these seroconverted to anti-HBe later on. Serum GPT levels in these five cases were abnormally elevated for a variable period (34.8± 11.6 months ; mean±SD), but returned to normal levels coinciding with the disappearance of HBeAg. In three cases liver biopsy was performed. The histology showed persistent hepatitis in one case and chronic active hepatitis in two. In summary, clinical features before the disappearance of HBeAg were not distinguishable from those of chronic hepatitis.
    It is suggested that in pediatric HBeAg-positive HBV carriers with overt liver dysfunction, HBeAg is prone to disappear without any special therapy and, therefore, therapy with corticosteroid may not be indicated.
  • 1990 年 40 巻 2 号 p. 239-247
    発行日: 1990/03/01
    公開日: 2009/10/15
    ジャーナル フリー
feedback
Top