The KITAKANTO Medical Journal
Online ISSN : 1883-6135
Print ISSN : 0023-1908
ISSN-L : 0023-1908
Volume 41, Issue 1
Displaying 1-22 of 22 articles from this issue
  • MAKOTO SHIGETA
    1991 Volume 41 Issue 1 Pages 1-9
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    We studied bronchial responsiveness in 325 asthmatic patients (200 boys and 125 girls, 0 to 18 years old, mean age, 8.7 years) and 133 disease control subjects (67 boys and 66 girls, 0 to 19 years old, mean age, 7.8 years). The bronchial responsiveness was measured by the methacholine inhalation challenge test. Those over six years old took the methacholine challenge using the Astograph method while those aged five or less used, the tcPO2-method. The tcPO2-method, which uses a transcutaneous oxygen pressure monitoring system, is useful for measuring bronchial responsiveness, especially in younger children.
    Dmin (bronchial sensitivity) was statistically lower in the asthmatic groups than in age-matched disease control groups. St (bronchial reactivity) was not statistically different between the asthmatic and disease control groups. Dmin was statistically lower in children aged 6 to 7 (8.07±1.61unit) than that in children aged 14 to 15 (28.58±5.96unit). The results showed a significant correlation between age and bronchial responsiveness in asthmatic and disease control groups. But there was no significant correlation between age and bronchial reactivity in either group.
    We found that age has a significant effect on bronchial hyper-responsiveness, especially in young children. When we evaluate the bronchial hyper-responsiveness in young children, we must consider the influence of age.
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  • AKIRA IWASHITA
    1991 Volume 41 Issue 1 Pages 11-20
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Hypothalamic hormone is suggested to have an effect on extrapituitary sites. Little information is available about the effects of hypothalamic-releasing hormones on the human autonomic nervous system. Variations in R-R intervals on electrocardiogram (ECG), a parameter of parasympathetic nervous system function, have been used clinically as an indicator of autonomic nervous system dysfunction in various diseases. An attempt was made to determine serial variations in R-R intervals on ECG.
    Studies were conducted with 23 healthy controls and 52 patients with Graves' disease. Variations in R-R intervals were expressed as the coefficient of variation of 100 resting heart rates (CV%=SD/Mean x 100, CVq).
    Injection of TRH (500μg, iv) to healthy controls produced a significant elevation of CVq (4.37±0.53% before vs. 5.46±0.40% after TRH, p <0.01) within 15 min. A similar result was obtained in patients with Graves' disease. Pretreatment with atropine (0.5mg, div) or pirenzepine hydrochloride (250mg, po) abolished the stimulatory effect of TRH on CVq. Pretreatment with Clofedanol (75mg, po), which is reported to have an inhibitory effect on the meddula oblongata, and hexamethonium bromide (300mg, po), a ganglionic blocker, resulted in a significant reduction in CVq during TRH test. There was no change in plasma catecholamine concentrations following TRH administrations. Intravenous injection of CRF (50μg) produced a significant decrease in CVq. Pretreatment with propranolol (30mg, po) blocked the effect of CRF. On the other hand, iv administration of GRF (50μg) or LHRH (100μg) had no effect on CVq, while normal responses of serum GH, LH and FSH were observed.
    In conclusion, TRH stimulates CVq in normal subjects and patients with Graves disease. It is suggested that TRH potentiates the parasympathetic nervous system, regardless of circulating thyroid hormone levels. In contrast, CRF has a suppressive effect on vagal activity in human subjects, probably associated with adrenergic β-effect. Both GRF and LHRH seemed to have little effect on the autonomic nervous system at clinical doses. The present study is the first demonstration that some hypothalamic-releasing hormones affect the autonomic nervous system, as indicated by the variations in R-R intervals on ECG.
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  • ISAMU AIZAWA
    1991 Volume 41 Issue 1 Pages 21-31
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Twenty-four hour contractile changes in the lower esophageal sphincter (LES) were studied by means of chronic implantation of force transducers on the LES, gastric body and gastric antrum in eight conscious mongrel dogs. In each dog, a gastric cannula was placed for decompression of the stomach.
    With ingestion of food, the basal tonicity in the LES increased and the increased tonicity lasted for 5 hr. During the ingestion of food, intermittent and rapid falls in tonicity from the increasing tonicity of the basal line, were seen, suggesting passage of food through the LES. In the gastric body, on the other hand, receptive relaxation was clearly demonstrated. During a 5-hr postprandial period, no remarkable contractile changes were observed in the LES. During the interdigestive state which started at 10 to 14 hr after feeding, the LES showed grouped tonic contractions in accordance with the interdigestive migrating contractions (IMC) in the stomach. Each tonic contraction occurred at 1.4±0.1 min of interval. The grouped contractions in the LES or lasted for 27.4 ± 0.7 min and recurred at 76.5 ± 2.7 min intervals of quiescence.
    The decompression of the stomach for 5 hr in the interdigestive state caused by opening of the gastric cannula did not influence the occurrence of the interdigestive contractions either in the LES or stomach ; this suggests that the interdigestive contractions in the LES were not induced in response to the increase in the intragastric pressure.
    Intravenous infusion of motilin (0.3-0.9μg/kg-hr) started at 10 min after the termination of the spontaneous interdigestive contractions induced a group of contractions similar to the spontaneous interdigestive contractions in the LES and stomach. The spontaneous and motilin-induced contractions were similar in their duration, contractile force and frequency, and were similarly inhibited by feeding and intravenous infusion of pentagastrin (0.6μg/kg-hr).
    The results of this study indicate that diurnal motor changes in the LES are closely correlated with those in the stomach in both the digestive and interdigestive states. Motility changes in the LES, particularly in the interdigestive state, have not been studied before, and in consideration of frequent episodes of heartburn in reflux esophagitis in fasted state, for instance, the importance of pathophysiology of the LES motility in the interdigestive state is emphasized.
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  • FUMIO SAKURAI
    1991 Volume 41 Issue 1 Pages 33-50
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    The effect of intravenous infusion of NCO-700, a new synthetic inhibitor of thiol protease, on infarct size and regional myocardial blood flow was studied in 36 anesthetized open-chest dogs. Dogs underwent either 1 hr or 3 hr of left anterior descending artery occlusion followed by reperfusion. Animals in the treated groups received a single bolus intravenous injection of NCO-700 (20mg/kg) before reperfusion followed by a 2-hour infusion of the same dose. Regional myocardial blood flow was determined serially by the hydrogen clearance method. At 12 hr after starting reperfusion, the zone at risk was defined by dye injection and the Zone of necrosis was subsequently determined by triphenyltetrazolium chloride staining of left ventricular slices. There were no major hemodynamic differences between control and treated groups. In the 1-hour occlusion groups, infarct size (as a percentage of the zone at risk) was markedly reduced in NCO-700 treated animals (n=10) compared with control animals (n=10) (9±3% vs 39±7%, p<0.01) (mean ± SEM). Regional myocardial blood flow in the ischemic region was significantly increased in treated animals at 1 hr after reperfusion (94±12% of baseline vs 59±5%, p<;0.01). Light and electron microscopy of the ischemic zone demonstrated a decrease in hemorrhage and relative preservation of the endothelial structure of the microvasculature in treated animals. In the 3-hour occlusion groups, there were no significant differences between control and treated animals in infarct size or regional myocardial blood flow. These observations suggested that intravenous administration of NCO-700 at reperfusion reduced infarct size and increased regional blood flow in the ischemic region after reperfusion.
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  • OSAMU HAGIWARA
    1991 Volume 41 Issue 1 Pages 51-64
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Sericultural asthma is an occupational disease caused by inhalation of the body components of silkworm ; cocoon chrysalis, moth scales, dried ripe larva urine and sericin. It has already been reported that the main allergic components of sericultural asthma are found in cocoon chrysalis.
    I performed partial purification and characterization of cocoon chrysalis antigens. The results were as follows :
    1) Two main antigenic fractions, FIV-1 and FIV-2, were obtained from cocoon chrysalis by gel filtration and ion exchange chromatography.
    2) FIV-1 was 5.32-fold higher in allergenicity than crude extract.
    3) The molecular weight of FIV-1 was 80, 000 while that of FIV-2 was 48, 000.
    4) FIV-1 was composed of sixteen amino acids, but contained no tryptophan or half-cystine. The ratio between basic and acidic amino acids was 1 : 1.9. FIV-2 was similar in amino acid composition to FIV-1 and contained no half-cystine. The ratio was 1 : 2.1.
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  • NOBORU ORIUCHI
    1991 Volume 41 Issue 1 Pages 65-80
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Clinical usefulness of 201T1 SPECT for evaluation of brain tumors was studied in comparison with 123I-IMP SPECT and 18F-FDG PET.
    201T1 SPECT and 123IMP SPECT were performed in 73 patients with brain neoplasm (group 1) and 15 patients with non-tumor cerebral diseases (group 2). Among them, 31 patients in group 1 and 5 patients in group 2 received 18F-FDG PET. SPECT was done with a ring type machine (HEADTOME SET011) and PET with a neuro PET (PCT H1).
    Forty-eight of 73 (65.8%) patients in group 1 showed increased accumulation of 201T1 in tumor site, whereas only 9 (12.3%) patients showed increased radioactivity of 123I-IMP in the lesion. Eighteen of 31 (58.1%) patients with neoplasm demonstrated increased regional cerebral metabolic rate of glucose (rCMRgl) in the lesion. Only two out of 15 (13.3%) patients with non-tumor lesion demonstrated increased accumulation of 201T1. None of them showed accumulation of 123I-IMP or increased rCMRgl. Patients with malignant neoplasm demonstrated higher uptake of 201T1 in the lesion than those with benign neoplasm or non-tumor lesions. Post-therapeutic patients with glioblastoma or metastatic tumors showed lower 201T1 uptake than before therapy. Superimposed images of both 201T1 and 123I-IMP resemble rCMRgl functional images, suggesting increased 201T1 radioactivity in viable tumor tissue with decreased radioactivity in surrounding areas.
    201T1 SPECT is useful for diagnosis of brain tumors and evaluation of effectiveness of therapy or evidence of residual tumor tissue. It may differentiate malignant tumors from benign tumors or non-tumor intracranial diseases including radiation injury and detect tumor recurrence earlier.
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  • ESPECIALLY IN PRIMARY BILIARY CIRRHOSIS
    SHUNICHI SAEKI
    1991 Volume 41 Issue 1 Pages 81-90
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    An immunofluorescence study using unfixed cryostat sections of rat pituitary glands was carried out on sera from 83 patients with various liver diseases [5 acute viral hepatitis, 28 chronic hepatitis, 18 liver cirrhosis, 5 hepatocellular carcinoma, 4 alcoholic hepatic fibrosis, 2 fatty liver, 1 drug-induced liver injury, 5 autoimmune hepatitis, 15 primary biliary cirrhosis (PBC)] and 10 healthy subjects.. After absorption of sera with rat liver tissues, anterior pituitary cell antibodies (PCA) were found in none of the healthy subjects, 6 of 15 patients with PBC (40.0%), 1 of 5 patients with autoimmune hepatitis (20.0%), 1 of 5 patients with hepatocellular carcinoma and 3 of 18 patients with liver cirrhosis (16.7%).
    The prevalence of PCA was highest in patients with PBC compared with other liver diseases, but PCA were detected only in the sera of patients with chronic non-suppurative destructive cholangitis (5 of 6 patients, 83.3%) or granuloma (5 of 8 patients, 62.5%) in biopsied liver tissues, not in the sera of patients without these lesions. PCA were considered to have a close association with the initiation of PBC.
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  • KOICHI SUGAHARA
    1991 Volume 41 Issue 1 Pages 91-99
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    In this study, DOCA-salt hypertensive (DSH) rats were used as the experimental model of hypertension in pregnancy, and changes in blood pressure, pressor response to norepinephrine (NE), and fetal development were investigated.
    The results were as follows :
    1) In DSH pregnant rats, the systolic blood pressure significantly decreased in late gestation, and this decrease was remarkable.
    2) In middle and late gestation, the pressor response to NE significantly decreased in DSH pregnant rats compared with DSH nonpregnant rats.
    3) The mean weight of the fetuses of DSH pregnant rats was significantly less than that of normotensive pregnant rats.
    In conclusion, these results suggest that refractoriness to pressor agents might play an important role in blood pressure in DSH pregnant rats and that the DSH pregnant rat is a useful model for investigating intrauterine growth retardation (IUGR).
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  • KEISUKE MACHIDA
    1991 Volume 41 Issue 1 Pages 101-124
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    The effects of EHDP on dentine calcification figures in rabbits were examined by the lead acetate time marking method. The following results were obtained.
    1) It was confirmed by hematoxylin staining of the decalcified sections, X-ray analysis and microradiograms of the undecalcified sections and image analysis that EHDP causes hypocalcification in dentine calcification figures. The minimum dose of subcutaneous injection of 3 5 mg/kg (0.751.25 mgP/kg) produced the hypocalcifications and the degree of hypocalcification was strengthened in proportion to the dose.
    2) Subcutaneous injection of EHDP 60 mg/kg (14.9 mgP/kg) each day for seven consecutive days caused EHDP rickety rats. Hypocalcification dentine is formed within the administration period, and not only the growth rate of teeth but also the development of bone are decreased.
    3) One-hour injection into the arteria maxillaris or the arteria thyroidea caused hypocalcification dentine on the arterial infusion side at only 5 mg/kg, and strong formation on the same side and opposite side at 10 mg/kg and 30mg/kg. However, there were no specific changes in the thyroid tissues.
    4) A 30 mg/kg subcutaneous injection did not affect serum Ca, Ca2+, P or PTH concentrations. It is conjectured that the concentration of EHDP in the blood is related to the dentine calcification figures.
    5) From these results, the disturbance in dentine calcification that results from infusion at above doses can be conjectured to be related to the local action produced by the dentine formative function of EHDP.
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  • FROM A HOSPITAL-BASED CASE-CONTROL STUDY
    KYOKO INO
    1991 Volume 41 Issue 1 Pages 125-134
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    A hospital-based case-control study was conducted in the north Kanto area in Japan, to clarify the relationship between dietary habits after the marriage and the incidence of colon and rectal cancers.
    Sixty-six colon cancer patients, 64 rectal cancer patients, and the controls matched for sex, age and occupation were interviewed by an interviewer. Foods and dietary habits were queried. Odds ratio (OR) and stepwise logistic regression were used to compare the dietary patterns of the case and control groups.
    The colon cancer group ate more bread during childhood (OR=3.43) than the controls, and ate less mochi (rice cake) (OR=0.33), and drank less green tea (OR=0.09) than the controls. On the other hand, the rectal cancer group ate more bread (OR 2.18) and less noodles (OR= 0.30) during childhood, and more natto (fermented soybeans) (OR 3.17) and mandarin oranges (OR =2.71) than the controls after the marriage.
    Stepwise logistic regression clarified the dietary patterns of the case and control groups. The incidence of colon cancer seemed related more with Western eating habits, while that of rectal cancer had remarkable relation neither with traditional Japanese nor Western diet. It may be concluded that the risk factors of the incidence of these two cancers were different in Japan.
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  • KAZUHIRO ASANO
    1991 Volume 41 Issue 1 Pages 135-151
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    A total of 133 rabbits were used for an experiment on autotransplantation of the incisor into the bone marrow of the tibia. The experiments were divided into four groups according to the grafts : Group A : basal end of the incisor with germinative regions ; Group B ; germinative region only ; Group C ; basal end of incisor only, excluding dental pulp and germinative regions ; Group D ; dental pulp only. Growth of the grafted teeth was serially observed by X-ray, and histopathological investigations were performed under electron microscope, together with histochemical analysis by immunohistochemistry.
    The transplanted teeth tissues in Groups A and B grew until the end of the 12-month observation period. In Group A, transplanted teeth grew like normal teeth in the bone marrow. In Groups A and B, specific histological features like fibro-osseous and odontoma-like conformations were observed. Fibro-osseous conformations were similar to human fibro-osseouss lesion containing cementoid and osseous tissues. Odontoma-like conformations were similar to human odontoma as well, with the appearance of irregular dentine and enamel epithelium.
    These histological findings were confirmed by electron microscope and immunohistochemistry. Anti-BrdU antibody revealed activated proliferating cells in the progenitive region and fibro-osseous conformations. In Groups C and D, transplanted tissues disappeared during the observation period. The experiment revealed that autotransplantation of rabbit incisors in the tibia was a useful animal model for elucidating the histogenesis of human fibro-osseous lesions of the mandible and odontoma.
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  • A STUDY OF INFANT CASES AND THE RELATION TO COLD AGGLUTININS
    TAKASHI FUJINAGA
    1991 Volume 41 Issue 1 Pages 153-157
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Radioallergosorbent test (RAST) was performed for the measurement of anti-Mycoplasma pneumoniae (Mp) IgG, IgD, IgE and complement fixing (CF) antibodies and cold agglutinin (CA) in the sera of 25 patients with primary atypical pneumonia (PAP) and controls. Of infants three years old or younger, 11% were positive for CF antibody, whereas positive rates for IgD, IgG and IgE antibody to Mp were 100%, 44% and 12.5%, respectively. The positive rates for IgD and IgG antibody to Mp were higher than that of CF antibody. Levels of IgE antibody in patients with high CA titers were significantly higher than those in patients with low CA titers.
    In conclusion, measurement of IgD and IgG antibody to Mp was useful in the serological diagnosis of infant Mp pneumonias. IgE antibody to Mp with cold agglutinin test would also support diagnosis in the cases with low CF titers.
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  • KUNIO ICHIKAWA, KENICHIRO ORIMO
    1991 Volume 41 Issue 1 Pages 159-170
    Published: January 01, 1991
    Released on J-STAGE: April 23, 2010
    JOURNAL FREE ACCESS
    Remnant-like particles (RLP) are the lipoproteins that do not bind to an immunoaffinity gel mixture made of anti-apo A-I and anti-apo B-100 monoclonal antibodies. It was previously shown that RLP could provide a useful index for potentially atherogenic chylomicron and very low density lipoprotein-like remnants.
    Liver is the most important organ for lipid metabolism. Thus we studied changes in cholesterol and triglyceride values of RLP [RLP (Ch) and RLP (TG)] in 364 patients with various liver diseases.
    There were no significant differences in RLP (Ch), RLP (TG), RLP (Ch) /RLP (TG) [ratio of RLP (Ch) to RLP (TG)] in patients with chronic hepatitis or compensated liver cirrhosis when compared with the control group. However, RLP (TG) and RLP (TG) /T-TG [ratio of RLP (TG) to total triglyceride of serum] were significantly lower, RLP (Ch) /RLP (TG) was higher in patients with decompensated liver cirrhosis or hepatocellular carcinoma than in controls (P<0.01).
    Good correlations between ICG 15min., serum choline esterase, serum albmin and RLP (TG), RLP (TG) RLP (TG) / RLP (TG) were obtained. These results suggest that RLP (TG), RLP (TG) /T-TG and RLP (Ch) /RLP (TG) are useful indexes of severe liver dysfunction and poor lipid metabolism.
    Patients with fatty liver and alcoholic liver injury with fatty change of liver also showed significantly higher RLP (Ch) and RLP (TG) values.
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  • REPORT OF A CASE AND REVIEW OF THE LITERATURE
    TERUMASA KURIHARA, TSUNEHIRO ISHIDA, TOORU YOKOTA, NORITAKA SUGAMATA, ...
    1991 Volume 41 Issue 1 Pages 171-180
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    A case of intracystic carcinoma of the breast is reported with a review of the Japanese literature. An 87-year-old woman was admitted to our department complaining of a lump in the left breast. Physical examination revealed an elastic firm, well-defined lump measuring 6.4 × 5.7 cm, in the outer quadrant near the nipple. Following a tentative diagnosis of intracystic carcinoma, partial resection of the mammary gland containing the tumor was done. Histological examination confirmed the diagnosis ofnoninvasive papillary carcinoma without intramural invasion.
    Ultrasonographic examination has been considered to be useful for detection of intracystic papillary tumor, and the best diagnostic procedure for intracystic tumor of the breast is thought to be aspiration cytology of the intracystic tumor under ultrasonographically guided needle aspiration.
    A total-of 80 cases of intracystic carcinoma of the breast including our case were reviewed and discussed. The frequency of lymph node metastasis was 17.6% of total cases, less than that of usual carcinoma of the breast. Histologically, papillotubular carcinoma and papillary carcinoma accounted for 67.1% of the cases. Frequency of invasion to the cyst wall was high, with32.1% of cases showing stromal invasion beyond the cyst wall.
    Surgical operation is the first choice of treatment for intracystic carcinoma of the breast, and we consider modified or standard radical mastectomy most suitable for intracystic carcinoma.
    In this case, tumor cells showed slight cellular atypism, but nuclear DNA analysis revealed an aneuploidy pattern and low values for the S-phase fraction and proliferative index. Nuclear DNA analysis is useful for the diagnosis of malignancy as well as histological examination.
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  • NAOHUMI SATO, TORU YOKOTA, MICHIO MAEMURA, FERUMASA KURIHARA, TOSIAKI ...
    1991 Volume 41 Issue 1 Pages 181-185
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Three patients with advanced biliary tract cancer (two patients with upper or middle common bile duct canon and, one intrahepatic cholangiocell cancer) were treated by surgical resection. Histologically, cancer cell rest was found in the bile duct stump or common hepatic duct wall. Postoperative intra-luminal irradiation was added using a remote after loading system (RALS). All three patients have remained alive for about two years without evidence of relapse. This method is extremely effective for post operative cancer rest is the hepatic bile duct stump, periductal lymphatic invasion and perineural invasion, especially if the radiation field is defined by cholangiography and percutaneous transhepatic cholangioscope (PTCS).
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  • AKIRA HASEGAWA, MASAKO HATORI, MASAO AMANO, TAKESATORU FUKUDA, OSAMU U ...
    1991 Volume 41 Issue 1 Pages 187-192
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    During recovery from exercise, there is an exponential decrease in the oxygen uptake (Vo2), which is composed of one fast and one slow component. We evaluated the effect of heart rate (HR) and cardiac function on the fast component. Vo2 was measured during treadmill exercise and in the recovery period in 8 patients with implanted rate-responsive pacemaker, 7 patients with mild chronic heart failure and 8 healthy men. Two sequential exercise tests were performed at random in 8 patients with the pacemaker programmed to either the fixed rate (VVI, 60bpm) or rate-responsive (VVI-R, peak HR 104bpm) mode. In the VVI-R mode, the rate of decrease in Vo2 is faster than in the VVI mode. In patients with VVI-R pacing and those with heart failure, the rates of decrease in Vo2 were similar, but were significantly prolonged compared with the healthy men. HR decreased more slowly in patients with heart failure than in healthy men. Thus, heart rate and cardiac function are important determinants of the rate of decrease in Vo2> after exercise.
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  • TAKUJI TOYAMA, YOUNOSUKE KITAHARA, NORIHIRO KATOU, SHIGERU UMEYAMA, SH ...
    1991 Volume 41 Issue 1 Pages 193-198
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    We performed percutaneous transluminal coronary angioplasty (PTCA) on 111 lesions in 100 patients from July 1988 through July 1989. We studied the primary success rate, complications, restenosis rate, improved myocardial function during treadmill testing and improvement in left ventricular ejection fraction (LVEF). The overall primary success rate was 82.9% (87.5% for LAD, 63.2% for LCX, 87.5% for RCA). Acute myocardial infarction occurred in one patient, who suffered cerebrovascular bleeding and died. The incidence of restenosis was 36.2% (25/69 lesions). Exercise capacity during treadmill testing was improved from 6.9±3.0mets to 9.0 ± 2.5mets after successful PTCA. LVEF was improved from 61.1 ± 12.4% to 65.5 ± 10.7% in patients without restenosis. The results of PTCA in 100 primary cases were favorable in comparison with those of other studies.
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  • MASAAKI TAKESHITA, TOORU WATANABE, TAMOTSU YAMADA, ISAO KOBAYASHI, SEI ...
    1991 Volume 41 Issue 1 Pages 199-207
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    We investigated cellular immunity and the sate of metastasis to lymph nodes according to the depth of invasion in gastric carcinoma.
    Skin tests (PHA, Su-PS, PPD), blastoformation (PHA, PWM) and T cell subsets (OKT 3, 4, 8, 4/8, Leu 11, 7) in peripheral blood and regional lymph nodes were evaluated.
    In patients with carcinoma invading from the mucosa to the submucosa, skin tests, the number of T cell subsets, and blastformation were not depressed in peripheral blood and lymph nodes.
    However cellular immunity was decreased and the rate of metastasis to lymph nodes was increased according to the invasion of carcinoma.
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  • MICHIO MAEMURA, TSUNEHIRO ISHIDA, TAKAO YOKOE, MASAFUMI KUROSUMI, YUUI ...
    1991 Volume 41 Issue 1 Pages 209-218
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Forty cases of primary aldosteronism were encountered at the Second Department of Surgery in Gunma University. In the present study, we evaluated the methods to localize the sites of tumors, operative procedures and the effects of removal of tumors on clinical manifestations. The localization of tumors were mainly established by adrenal computed tomographic scan (CT), venography, venous sampling and iodo-cholesterol scan. The accuracy rates of these methods were as followings, CT (89%), venography (70%), venous sampling (63%), and iodocholesterol scan (63%), respectively. In these combined methods, we could obtain 100% accuracy in the decision of localization. Adrenal explorations through a posterolateral approach were performed in 35 patients. To compare with transperitoneal approach, the amount of blood loss were smaller and the duration of operation were shorter. From these result, posterolateral approach may be most available procedure in adrenal exploration for aldosterone-producing adenoma. The levels of plasma renin activity, aldosterone and electrolytes were normalized in all patients after removal of tumors, while normal blood pressure was not obtained in some patients. Thus, the results of operative management for primary aldosteronism was mostly satisfactory and long-term follow-up and control of blood pressure might be necessary.
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  • AYAKO TAKAHASHI, SACHIE YOMODA, TETUO MACHIDA, YUKIHITO FUKUMURA, ISAO ...
    1991 Volume 41 Issue 1 Pages 219-226
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    A 13-years survey on drug-resistant S. aureus isolated in the microbiological section of the Clinical Laboratory Center of Gunma University Hospital from 1977 to 1989 is summarized. The frequency of methicillin-resistant S.aureus (MRSA) was less than 10% until 1987, but it began to increase greatly after 1988. More than 50% of S.aureus isolated in 1989 were MRSA. MRSA were common in inpatients, particularly those in the surgical departments. Another feature of MRSA isolated in recent yearn is their tendency to be resistant to multiple drugs : 18% of MRSA isolated in 1989 were resistant to 5 drugs.
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  • TOSHIYA KUROGOME, KOJI MATSUDA, YASUSHI MAEKAWA, TAKAKAZU GOZAWA, NOBO ...
    1991 Volume 41 Issue 1 Pages 227-233
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    Disease in the oral cavity of infants is different from that in adults because the oral tissues of infants are growing and developing and variables such as food and drink, as well as teeth, are different.
    We have recently seen the following two cases.
    Case 1 : a 4-month-old female with a ranula located in the right sublingual region.
    Case 2 : a 16-month-old female with juvenile xanthogranuloma in the right lower lip of the oral mucosa, clinically suspected to be a mucous cyst. The lesions were resected under general anesthesia and we made the diagnoses histopathologically.
    Cases like these two are rare in infants. Embryological predisposition is suggested in the pathogenesis of these diseases.
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  • TAKUJI TOYAMA, YASUO YAMAZAKI, YOSHIAKI KANEKO, SHUUICHI HASEGAWA, MIN ...
    1991 Volume 41 Issue 1 Pages 235-244
    Published: January 01, 1991
    Released on J-STAGE: October 21, 2009
    JOURNAL FREE ACCESS
    We experienced two cases of myocarditis diagnosed by endomyocardial biopsy, a 58-year-old man admitted because of palpitation, shortness of breath, cough and shock, and a 41-year-old woman with fever, cough and anterior chest pain. They had symptoms simulating common cold and cardiac symptoms, and were complicated with congestive heart failure. Moreover, abnormal ECG findings, cardiac enlargement on chest x-ray, reduced left ventricular function on UCG, elevated serum enzymes and inflammatory changes were observed in both patients. The diagnosis of myocarditis was established by endomyocardial biopsy.
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