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Volume 41 (1991)
- Issue 6 Pages 799-
- Issue 5 Pages 723-
- Issue 4 Pages 525-
- Issue 3 Pages 365-
- Issue 2 Pages 245-
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Volume 41, Issue 6
Displaying 1-11 of 11 articles from this issue
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[in Japanese]1991 Volume 41 Issue 6 Pages 799-805
Published: November 01, 1991
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSDownload PDF (1226K) -
TSUNEO YAMAZAKI1991 Volume 41 Issue 6 Pages 807-819
Published: November 01, 1991
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSIn order to clarify the ultrastructural characterization of diffuse plaques (DP) in the frontal cortex and cerebellar molecular layer, four Alzheimer-type dementia brains were examined using 1) β/A4 immunoelectron microscopy, 2) pairs of routine electron microscopic sections and adjacent semithin sections, which were immunolabeled for β/A4 protein and 3) methenamine silver electron microscopy. In the frontal cortex, DP consisted of small bundles of amyloid fibrils, non-fibrillar β/A4 reactive substances and occasionally small degenerating neurites. The β/A4 reactive substances existed between cell processes and/or on part of cell membranes. The number of degenerating neurites was proportional to the amount of amyloid fibrils and the size of DP. Compared to frontal DP, cerebellar DP had fewer amyloid fibrils and more degenerating neurites. These results suggest that β/A4 protein initially appears between cell processes and/ or on parts of cell membranes as non-fibrillar forms and subsequently turns into fibrillar forms (amyloid fibrils).View full abstractDownload PDF (10507K) -
SHIGEKI INABA1991 Volume 41 Issue 6 Pages 821-831
Published: November 01, 1991
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSLatent carcinoma and nodular hyperplasia of the prostate were studied histopathologically in men born and bred in Japan.
We examined the incidence, age distribution, localization and histopathology of latent carcinoma and nodular hyperplasia in the prostate by means of the step-section technique in 51 subjects (males, over 40 years of age) who underwent autopsy at the Gunma University School of Medicine from June, 1986 through November, 1987.
Latent carcinoma of the prostate was detected in 10 subjects (19.6%). When different age groups were compared, the greatest incidence was found in older patients, reaching 50% in the over 80 years age group.
The site of latent carcinoma was exclusively in the external regions. There was no difference in the frequency when compared anteroposteriorly, right to left, and superioinferiorly.
Anteroposteriorly located latent carcinoma was found to occur frequently around the verumontanum.
Histopathological examinations revealed a higher incidence of well-differentiated adenocarcinoma and smaller sized carcinomas.
Nodular hyperplasia was exclusively found in the internal regions, especially between the bladder neck and the verumontanum in the anterior regions.
We propose from these regional findings that nodular hyperplasia of the prostate might not be a risk factor for latent carcinoma of the prostate.View full abstractDownload PDF (5197K) -
TOKUYUKI KITAHARA, JUN'ICHI TAMURA, MORIO SAWAMURA, MITSURU KOBAYASHI, ...1991 Volume 41 Issue 6 Pages 833-836
Published: November 01, 1991
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA 74-year-old female was admitted to the Gunma University Hospital for the re-evaluation of anemia and thrombocytopenia in May, 1990. She was already diagnosed as having refractory anemia with ringed sideroblasts 10 months before and had received repeated blood transfusions. Hematologic examinations confirmed her diagnosis but the administration of vitamin B6, anabolic steroid, and vitamin D3 failed to improve her situation. During this period of admission, she was considered to have chronic thyroiditis by positive antithyroid and antimicrosome tests, and decreased serum level of free T3. Positive antiglobulin tests and increased platelet-associated IgG level were considered to be related to multiple blood transfusions. Natural killer activity, and CD16, CD56 and CD57 positive cells were decreased. In addition, the CD4/CD8 ratio was markedly increased and anti-centromere antibody was detected. These findings suggest that there may have been immunologic abnormalities in this case of myelodysplastic syndrome.View full abstractDownload PDF (418K) -
TAKASHI TANAKA, HIROKO YAMAZAKI, YOICHI NAKAZATO1991 Volume 41 Issue 6 Pages 837-843
Published: November 01, 1991
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSFourteen cases with intracranial vascular tumors including 5 hemangioblastomas, 7 hemangiopericytic meningiomas, and 2 hemangioblastic meningiomas were investigated by immunohistochemistry using antibodies against alpha-smooth muscle actin, alpha tubulin, collagen type 4, desmin, epithelial membrane antigen (EMA), fibronectin, cytokeratin AE1/AE3, myosin and vimentin. A positive immunoreactivity for EMA was observed in the tumor cells of hemangioblastic meningiomas. Since other vascular tumors did not react with EMA antibody, EMA immunostaining seemed to be useful for differencing hemangioblastic meningioma from other types of vascular neoplasms. Alpha-smooth muscle actin proved to be an excellent marker of vascular pericytes. Tumor cells of hemangiopericytic meningiomas, however, did not immunostain with alpha-smooth muscle actin antibody. This does not support the theory of a pericytic origin for hemangiopericytic meningioma. Neither an endothelial marker nor a pericytic marker was detected in stromal cells of the hemangioblastomas. The histogenesis of the stromal cells remains to be ascertained.View full abstractDownload PDF (3529K) -
KEIJI ISHIZAKI, KENICHI ARAI, TATSUSI FUJITA1991 Volume 41 Issue 6 Pages 845-851
Published: November 01, 1991
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSTumor necrosis factor (TNF) has been implicated as a mediator of endotoxemia. Mean lethal dose was estimated to be 1.47 mg of recombinant human TNF per kilogram of body weight. The endotoxin content of this TNF was less than 0.2 ng per milligram of protein. A 2 mg dose of TNF caused metabolic acidosis and hemoconcentration. Release of lysosomal enzyme and hyperkalemia was observed. The cyclooxygenase inhibitor indomethacin and platelet activating factor antagonist CV-3998 given before TNF treatment prevented death at five hours. These agents prevented metabolic acidosis, hemoconcentration, release of lysosomal enzyme and hyperkalemia. Since similar physiological changes have been reported after endotoxin injection, our data support the suggestion that TNF production is a critical factor in the development of septic shock. These findings indicate that increased production of prostaglandins and platelet activating factor is important in TNF shock.View full abstractDownload PDF (836K) -
OSAMU HOSOMI, AKIRA TAKEYA1991 Volume 41 Issue 6 Pages 853-859
Published: November 01, 1991
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSUDP-GlcNAc : Galβ1-4Glc (NAc) β1-3N-acetylglucosaminyltransferase from human plasma was found to contain a minor component which did not bind to the CM-Sepharose column as well as did the major component [Hosomi et al. (1989) Jpn. J. Med. Sci. Biol., 42, 77]. This unbound fraction included two enzyme components (GNA-TIII and GNA-TIV) which could be separated from each other by a DEAE-Sepharose column. These enzymes require Mn2+ ions for activity, and their maximal activities could be observed between pH 7.5 and 8.5. Apparent Km values for N-acetyllactosamine and lactose were 8.8-9.2 and 12.3mM, respectively. Glycosidase and methylation analyses of the reaction products of these enzymes (GNA-TIII and GNA-TIV) demonstrated that both products had the structure GlcNAc β1-3Gal β1-4Glc. These two GlcNAc-transferases have a similar molecular weight of about 130, 000.View full abstractDownload PDF (844K) -
MASAHIRO AIZAKI, TATSUMASA ANDO, HITOSI ISHIKAWA, SYUICHIRO ASAUMI, YU ...1991 Volume 41 Issue 6 Pages 861-865
Published: November 01, 1991
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSIn surgery for sigmoid colon and rectal disease patients, we often choose anastomosis over proctostomy. We use anastomosis even for elderly patients and those with possibly serious general conditions. Anal canal decompression with nasal airways was the method previously employed. However, this technique often promoted drain contamination after internal cavity obliteration and deciduation. We encountered several patients with this symptom and faced difficulties in treating them.
Thus we began utilizing the anal canal decompression method with bendable joint tubes in anesthetic machines. In 1989, a total of 14 cases were treated, and we met with good results.
This method utilized waste, and was regarded to be effective, especially in cases of preoperative ileus. Furthermore, as sufficient decompression effect was gained in cases with slight suture failure, this method was considered effective for treating postoperative suture failure.View full abstractDownload PDF (1194K) -
NAOKI TOMIZAWA, JUN TANAKA, YUKIO KOIBUCHI, HITOSI ISHIKAWA, SHUUICHIR ...1991 Volume 41 Issue 6 Pages 867-878
Published: November 01, 1991
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSAdult type mesenteric cysts are rare. We experienced 2 mature cases. One was a 50-year-old male with a cyst of unknown origin in the mesocolon of the ascending colon. The other was a 40-year-female with a cyst of lymphogenic origin in the mesenterium of jejunum. Based on investigation of 21 cases including our 2 cases, most cases present between is 20 and 40 years of age. Five patients were above 60 years, the oldest case being an 81-years-old female.
The contents of the cyst were chyme in 12, serous fluid in 5, no record in 4, monocystic in 9 and polycystic in 5. The pathology of the cystic wall was classified as 1) epithelial cell with smooth muscle layer (9) 2) only epithelial cell (1) 3) only smooth muscle (1) 4) connective tissue (4), and 5) no pathological report (5).
In most cases, the cyst had originated from lymphogenic tissue. The pathology, of the cystic wall is important for determining its genesis. However, in some cases it cannot be determined because of sloughing of the epithelial cells.
In such cases, biochemical analysis is necessary to determine the genesis.
If it achieved, detailed re-examination with US and CT is useful for determining etiology in same patients such as our female case.View full abstractDownload PDF (5433K) -
YOSHIMI TAMURA, YASUO NAKAZAWA, MASAMI MURAKAMI, YOSHIHIRO ONO, SEIJI ...1991 Volume 41 Issue 6 Pages 879-884
Published: November 01, 1991
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA 67-year-old man was hospitalized urgently complaining of chills, fever and pain in the left abdomen, accompanied by hyperglycemia on July 30, 1990. He was diagnosed as having emphysematous pyelonephritis because a CT scan revealed gas formation in the left kidney. He was put under observation in an attempt to save the kidney, but his fever did not subside, so we performed a simple left nephrectomy on August 6. He made satisfactory progress after the operation, and was discharged in 32 days. The sample extraction showed that parts of the abscess wall were so thin that it could easily have perforated.
Because emphysematous pyelonephritis is an inflammatory disease that can be intractable, as it was in this case, it is important to perform a nephrectomy in time, before the abscess wall ruptures.View full abstractDownload PDF (1849K) -
TOSHIJI SHITARA, YASUNORI OKADA, NORIKO SAIKAWA, MANABU SOTOMATSU, SHI ...1991 Volume 41 Issue 6 Pages 885-891
Published: November 01, 1991
Released on J-STAGE: October 21, 2009
JOURNAL FREE ACCESSA case of allogeneic bone marrow transplantation (BMT) in a child with acute myeloblastic leukemia (AML) is reported. The patient was initially diagnosed as having AML (FAB M2) in 1988, at the age of 13. He obtained a complete remission after chemotherapy. However he suffered a relapse in the bone marrow and also in the central nervous system. He was then treated with allogeneic BMT from his HLA identical sister. Etoposide (60mg/kg) and cytosine arabinoside (3g/m2 for 8 doses) were used for conditioning, together with total body irradiation (12Gy) over 4 fractionated doses. Engraftment was successful, and confirmed on day 25 after transplantation. He is now being followed with no additional chemotherapy.View full abstractDownload PDF (1747K)
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