THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN

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The Fas-associated death domain containing protein, FADD, is an adaptor for relaying apoptotic signals. However, recent studies have shown that FADD also plays an important role in the growth and regulation of the cell cycle, and FADD gene amplifications were observed in oral squamous cell carcinoma (OSCC). The purpose of this study was to elucidate the role of FADD in oral leukoplakia, known as potentially malignant disorder.

Methods : The gene amplifications of FADD from the fresh-frozen tissues and the formalin-fixed paraffin-embedded tissues of 51 patients who underwent biopsy or surgical resection of oral leukoplakia were detected : singleplex and multiplex assays were employed.

Results : The gene amplifications of FADD were detected in the samples of 3 patients who were diagnosed pathologically with severe epithelial dysplasia or early invasive carcinoma.

Conclusion : Because the gene amplifications of FADD were observed in early invasive carcinoma rather than precancerous lesions, the FADD gene amplification was not useful for the predictive marker of cancerization and is possibly related to the malignancy of OSCC including metastatic potential.

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