巻号一覧
63 巻 (1996)
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63 巻, 2 号
選択された号の論文の15件中1～15を表示しています
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増原 英一1996 年 63 巻 2 号 p. 281-286
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーPDF形式でダウンロード (7765K) -
海野 雅浩1996 年 63 巻 2 号 p. 287-295
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーPDF形式でダウンロード (2639K) -
菊川 郁雄1996 年 63 巻 2 号 p. 296-312
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーIt has been reported that periodontal ligament cells (PDLC) show osteoblastic phenotypes in culture. In most previous studies, PDLC have been obtained from the tooth root surface, however, a new method in which PDLC are obtained from the coagulum after tooth extraction has been proposed recently. To compare PDLC from tooth surface with these from coagulum, PDLC from both sources were cultured and examined. PDLC from both sources responded to PTH or PGE2 increasing cAMP and showed high alkaline phosphatase (ALP) activity. Some PDLC cultures produced mineralized tissues and these mineralizing cultures showed high ALP activity with high gene expression level of type I collagen, bone sialoprotein, and osteopontin in comparison with non-mineralizing cultures. PDLC from both sources expressed various osteob-lastic or cementoblastic phenotypes and seemed to contain heterogenous mesenchymal cell population with various differentiation potentials. However, the frequency of cellular trans-migration, rate of mineralized tissue formation, increased level of cAMP that responded to PTH or PGE2, and osteopontin expression pattern were different between PDLC from both sources. These differences indicate that PDLC cultures from coagulum contain more immature cells than PDLC from tooth surface.抄録全体を表示PDF形式でダウンロード (11153K) -
稲田 穣1996 年 63 巻 2 号 p. 313-333
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーModulation of evoked potentials following electrical tooth stimulation (Dental EPs) and visual analogue scale (VAS) were studied in 11 healthy adult volunteers to investigate the possibility of controlling reaction of pain sensation by using pre-auditory stimulus.
They were recorded by these two paradigms.
1) Only electrical tooth stimulation delivered in random interval.
2) A preceding tone beep, to enable subjects to anticipate the coming tooth stimulus.
Preceding time, inter stimulation intervals (1ST) were 0.5, 1.0, 3.0, 5.0, and 7.Osec.
The results were as follows
1) The Dental EPs were recorded in every volunteer, and the N2-P2 amplitude was the largest at vertex areas (Cz) .
2) The P2 latency and N2-P2 amplitude were modulated by the preceding tone beep, reduced in ISI = 0.5 and 1.0sec, and increased in ISI = 5.0 and 7.0sec., and a linear correlation was found between their variations.
3) There were no significant differences in the VAS score between each paradigm.
These findings suggested that
1) The late component of Dental EPs reflects not only the physiological process of the pain sensation but also psychological process of expectation and anxiety.
2) Pre-auditory stimulus and time lag between pre-auditory stimulus and electrical tooth stimulation influence the psychological process and modulate the Dental EP result.抄録全体を表示PDF形式でダウンロード (2206K) -
増田 一郎1996 年 63 巻 2 号 p. 334-353
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーIn order to develop in vitro models which are similar to native tissues, human oral mucosal models were reconstructed from gingival cells in three-dimensional culturs and the characteristics of the models were examined. Keratinocytes and fibroblasts from human normal gingival tissues were cultured in Keratinocyte Growth Medium (KGM) and in Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum (FBS) respectively. The models were reconstructed by seeding keratinocytes on contracted collagen gels containing f ibroblasts (CCG), which corresponded to the lamina propria, and co-culturing in Reconstruction Medium composed of one part of DMEM supplemented with 10% FBS and three parts of 1.5mM CaCl2- added-KGM at the gas-liquid interface for 10 days. Stratified epithelial layers were formed on CCG, and terminal differentiation of the keratinocytes were recognized in the epithelial layers. Cell nuclei were still observed in the keratinized layers such as parakeratinized gingival tissues. Involucrin expression in the epithelial layers showed normal distribution by immunohistochemical detection. Transmission electron microscopic observation demonstrated that, in the epithelial layers, the formation of intercellular desmosomes and intermediate filaments in cytoplasms increased from the basal layer to the keratinized layers. These results suggest that oral mucosal models are well-differentiated and histologically similar to native tissues.抄録全体を表示PDF形式でダウンロード (19171K) -
宮本 一世1996 年 63 巻 2 号 p. 354-374
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーTwo hundred fifty-five solitary and 42 multiple cases of fibro-osseous lesions of the jaws, and 74 cases of sclerosing osteomyelitis were studied clinico-pathologically, in order to discuss the entity of peculiar cemental lesion with sequester-like appearance, which occurs mainly in the mandibular molar area of over middle-aged females.
Four allied lesions, including the sequester-like cemental lesion, were revealed. They were provisionally designated sequestrated cemental masses, cemental masses, focal cemento-osseous dysplasia, and periapical cemental masses respectively, because no entities that were consistent with them could be found in the classifications of World Health Organization (WHO) . The above-mentioned peculiar cemental lesion was equivalent to sequestrated cemental masses, which consist of sclerotic cementum and/or osteocementum with inflammation. Cemental masses and periapical cemental masses were related to sequestrated cemental masses. Focal cemento-osseous dysplasia was considered to be a counterpart of lesion which had been recently reported by Summerlin et al.
In consideration of similarity and continuity of the histological and clinical findings, the four allied lesions were thought to be arranged in a continuous spectrum of fibro-cemento-osseous dysplasia of the jaws, along with periapical cemental dysplasia and florid cemento-osseous dysplasia that are mentioned in the WHO classification.抄録全体を表示PDF形式でダウンロード (20638K) -
寳田 雅規1996 年 63 巻 2 号 p. 375-386
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーThe transforming growth factor-β (TGF-β) is a multifunctional homodimeric protein with an apparent molecular weight of 25 KDa. TGF-βtransduces signals by forming heteromeric complexes of their type-I (TβR-I) and type-II (TβR-II) serin/threonine kinase receptors. TGF-βbinds first to TβR-II receptor, and then the ligand in this complex is recognized by TβR-I, resulting in formation of a heteromeric receptor complex composed of TβR-I and TβR-II. Once received, TβR-I becomes phosphorylated in the GS domain by the associated constitutively active TβR-II and transmits the downstream signal. It has been reported that formation of the heteromeric complex is indispensable at least in epithelial cells for growth inhibition and extracellular matrix production induced by TGF-β.
In this study, the functional role of TβR-II for the TGF-β-induced signals in osteoblastic cells was investigated by using a dominant negative type of TβR-II mutant receptors (TβRIIDNR) . ROS 17/2.8 and MG 63 cells were found to express TβR-I, TβR-II, and TβR-III, and their cell growth was inhibited by TGF-β, whereas alkaline phosphatase activity was stimulated. Cells that were stably transfected with the TβRIIDNR plasmid showed decreased response to TGF-β during growth and alkaline phosphatase activity.
These results indicate that the intracellular serine/threonine kinase domain of TβR-II is essential for signal transduction of the TGF-β-induced alkaline phosphatase activity as well as growth inhibition.抄録全体を表示PDF形式でダウンロード (3787K) -
―低Ca食飼育老齢ラットの骨組織の骨形態計測法による解析―田中 健一1996 年 63 巻 2 号 p. 387-407
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーAge-related functional changes of bone is not well understood. The effect of aging on bone response to a low calcium feeding was studied using senescent rats. Male Wistar rats aged 23 to 28 months were fed either a low calcium diet (0.05% Ca, 0.35% P) or a normal calcium diet (0.5% Ca, 0.35% P) by using a pair feeding technique. They were sacrificed at intervals of 6, 9, and 20 days. Bone mineral density of the femur showed no changes in both cancellous and cortical bone in the low calcium group compared with the normal calcium group. The increment of osteoclast number was observed on day 6 in the cancellous bone of the tibia, but no significant changes were found during other periods. Mineralizing surface (MS/BS) and mineral appositional rate (MAR) were increased during the experimental period. On the other hand, cortical bone showed a transient increase of MS/BS on day 6, but other parameters revealed no changes during the experimental period. The magnitude of response was more evident in the cancellous bone than in the cortical bone. These results indicated that although responsiveness of remodeling activity to low calcium feeding is decreased in senescent rats, they are obvious in both the cancellous and cortical bone.抄録全体を表示PDF形式でダウンロード (9787K) -
藤崎 臣弘1996 年 63 巻 2 号 p. 408-421
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーCondylar movement of patients with mandibular prognathism who received sagittal splitting ramus osteotomy (SSRO) was investigated using computer aided diagnostic axiography (CADIAX) .
Linear and angular parameters were used to evaluate the maximum opening and closing paths of the condyle projected on the sagittal plane. The motion paths of six subjects with mandibular prognathism (MP group) were examined immediately before surgery and during the retention period. The results were compared with the recording from six normal subjects (control group) .
The results were as follows :
(1) The average change in the maximum translating distance of the condyle in the retention period was 99.4±14.5% of the presurgical value on right side and 97.8±20.8% on the left side. The difference was not significant.
(2) The shape of the opening translating curve of the MP group was flatter than that of the control group, however, no significant differences were found between the pre-and postsurgical curves of the MP group.
(3) The coordination between the maximum opening and closing paths of the control group was fairly stable and smooth. However, although some improvement was observed, the paths of the MP group were unstable even after surgical treatment and large individual variations were observed.抄録全体を表示PDF形式でダウンロード (1692K) -
黒田 敬之, 本橋 信義, 榎本 勤1996 年 63 巻 2 号 p. 422-427
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーPDF形式でダウンロード (1965K) -
大山 紀美栄1996 年 63 巻 2 号 p. 428
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーPDF形式でダウンロード (139K) -
上野 俊明, 大山 喬史1996 年 63 巻 2 号 p. 429
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーPDF形式でダウンロード (179K) -
―臨床応用に向けて―小牧 基浩, 石川 烈1996 年 63 巻 2 号 p. 430
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーPDF形式でダウンロード (135K) -
福田 秀昭, 宮入 裕夫1996 年 63 巻 2 号 p. 431
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーPDF形式でダウンロード (116K) -
春日井 昇平, 大谷 啓一1996 年 63 巻 2 号 p. 432
発行日: 1996/06/30
公開日: 2010/10/08
ジャーナル フリーPDF形式でダウンロード (1747K)
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