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Volume 13, Issue 1
Displaying 1-5 of 5 articles from this issue
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TADAO SAITO1966 Volume 13 Issue 1 Pages 1-10
Published: August 01, 1966
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSAn antigenic substance originated from the helminthic parasite appearing in the urine of infected host has been reported by Welt (1941), from his studies on Trichinella spiralis. Welt observed, during his experiment on monkeys artificially infected with Trichinella spiralis, that antigen was excreted into the urine of the monkeys several weeks after antibody had been produced in their sera . Subsequently, Okabe and Tanaka (1961) and Okabe and Ono (1961) discovered that an antigenic substance was transferred to the urine of a human patient infected with Schistosoma japonicum, and asserted that this fact had an important significance in the clinical diagnosis of schistosomiasis japonica. Furthermore, Okabe and his associates detected antigenic substances in the urine of human patients infected with liver and lung flukes, and reported the results of application of these substances to the clinical diagnosis of the respective diseases.It is difficult to collect adult worms of Wuchereria bancrofti for material in the preparation of antigen. Currently, an antigenic substance is extracted from adult worms of Dirofilaria immitis, instead of Wuchereria bancrofti, and used for the immunological diagnosis of the human filariasis.Should any antigenic substance originating from Wuchereria bancrofti appear in the urine of a human patient and be isolated from the urine, it will be a useful material for the immunological diagnosis of Wuchereria infection. Thus, a study on the urine of dogs infected with Dirofilaria immitis, was undertaken. It was confirmed that an antigenic substance, presumably derived from this filaria, had been excreted into the urine of the dogs. Furthermore, this substance was isolated, purified, and examined for biological and immunological properties. The results of the study are reported in the present paper.View full abstractDownload PDF (2344K) -
KEISUKE YASHIMA, SHIGE KONDO, YOSHINORI JOH1966 Volume 13 Issue 1 Pages 11-14
Published: August 01, 1966
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe structure of bacteriochlorophyll has been nearly determined by Fischer et al. and Golden et al. as shown by formula I. The main route of synthesizing this compound lies in the synthesis of bacteriooxochloroporphyrine e6 which is produced by dehydrogenating bacterio-chlorine e6 (II) or both A and B ring at 3, 4 and 7, 8 positions. Because since in the study of Fischer et al. 7 and 8 positions of porphyrine were hydrogenated, the similar way of hydrogenation at 3 and 4 position may be expected, and then the formation of the attached keto ring of C and the binding of phytol and Mg were successfully performed.View full abstractDownload PDF (295K) -
KYUICHI TANIKAWA, MIKIO TANAKA1966 Volume 13 Issue 1 Pages 15-21
Published: August 01, 1966
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe introduction of new drugs for clinical practice in recent years, has causedan increasing number of drug-induced hepatic injuries, which are currently receiving much attention because of their iatrogenic nature . As one of the approaches to the study of pathogenesis, electron microscopic studies have been undertaken. This report is concerned with an electron microscopic observation of the liver of a thioridazine-induced hepatitis patient with special reference to the bile canalicular alterations.View full abstractDownload PDF (11131K) -
KOICHIRO TAKASAKI1966 Volume 13 Issue 1 Pages 22-43
Published: August 01, 1966
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIn recent years, reserpine has been used extensively for the analyses of the action of adrenergic drugs. It is well known that reserpine interferes with the binding of catecholamines and depletes them from the storage sites of various organs. However, it has been clearly demonstrated that the reserpine administered intravenously in the anesthetized intact dogs does not produce changes in pressure or it produces a pronounced hypotension.In the present experiments, a prolonged and marked increase of blood pressure elicited by reserpine following the administrations of ephedrine or metamphetamine but not tyramine were recognized.These systemic arterial pressure changes by reserpine were analysed system-atically including the influences of blocking agents and attempts were made to elucidate the mechanism of reserpine and other adrenergic drugs.View full abstractDownload PDF (12307K) -
MICHIHIRO KOGA, HIDETO MASAKI, KIROKU OISHI, HIROAKI ITO, NORIYUKI NIS ...1966 Volume 13 Issue 1 Pages 44-48
Published: August 01, 1966
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe long-term results of surgical treatment of congenital cardiac diseases whichwas carried out in our Department have been summarily reported especially with regard to an improvement of physical conditions after the operation.View full abstractDownload PDF (1875K)
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