巻号一覧
17 巻 (1970)
- 4 号 p. 153-
- 3 号 p. 105-
- 2 号 p. 55-
- 1 号 p. 1-
17 巻, 4 号
選択された号の論文の6件中1～6を表示しています
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HIROSHI KAWASAKI, KATSUJIRO IMASATO, TAKESHI KODAMA, EIJI KIMOTO, SHOJ ...1970 年 17 巻 4 号 p. 153-160
発行日: 1970/12/20
公開日: 2009/08/11
ジャーナル フリーPrevious immunof luorescent studies (1) revealed that the gastric mucosaspecif is epithelial glycoprotein distributed in mucoid cells and secreted mucus in the normal gastric mucosa as well as even in the diffusely and invasively proliferated gastric cancer cells in the mucosal, submucosal and muscular layer.Krukenberg tumor, which metastasizes frequently not only to the ovary but also to other various organs, is generally characterized by mucin-producing epithelial cells having a signet ring form. Its primary tumor is recognized to be most often in the gastrointestinal tract (2-5).The present investigation dealt with the immunofluorescent staining of such cancer cells which metastasized to different organs apart from the primary gastric lesion.抄録全体を表示PDF形式でダウンロード (8679K) -
I PERIPHERAL ACTIONKOICHIRO TAKASAKI, TETSUKO YAMABE, HIROFUMI DEGUCHI, YOZO OHNO, TERUHI ...1970 年 17 巻 4 号 p. 161-179
発行日: 1970/12/20
公開日: 2009/08/11
ジャーナル フリーVarious experiments were conducted on dl-piperonyl-methylaminopropane (dl-PMAP).1) The intravenous injection of dl-PMAP in dogs caused a rise of blood pressure and a persistent rise was achieved through reserpine administration. However, such a rise was weaker than in methamphetamine. Such pressor effect was inhibited or abolished by cocaine or tolazoline. The repeated administration of dl-PMAP caused tachyphylaxis but a larger dose than methamphetamine was required. Moreover, a cross tachyphylaxis was seen between methamphetamine and dl-PMAP. In an experiment on blood pressure and ECG changes, bradycardia was definitely observed but disappeared after vagotomy or atropine administration, being mediated reflex by the vagus nerve. However, no special change was found in ECG types.2) Through intravenous administration of dl-PMAP in dogs, respiratory excitation was exhibited, probably through the carotid sinus reflex and a central excitation effect.3) dI-PMAP exerts an facilitating effect on the isolated heart of frogs and rabbits, and rabbit heart in vivo. An inhibitory effect was seen upon the use of large doses.4) A vasoconstrictive action was observed on the blood vessels of the ear of rabbits, the whole body of frogs and the paw of dogs.5) In the isolated and intact intestine of rabbits, a slight inhibition of motility was noted. These experimental results indicated a weaker effect of dl-PMAP than that of methamphetamine. Repeated administration caused a decreasing of the effect. The action of dl-PMAP is quantitatively different from that of metham hetamine in many respects but similar in outline.The mechanism of action is apparently based on the release of norepinephrine from the peripheral adrenergic nerve, the drug being useful as a mild sympathomimetic amine.抄録全体を表示PDF形式でダウンロード (15715K) -
II TOXICITY AND CENTRAL ACTIONKOICHIRO TAKASAKI, TETSUKO YAMABE, KAZUKO FURUSAWA, KIYOMI FUJII, SUMI ...1970 年 17 巻 4 号 p. 181-198
発行日: 1970/12/20
公開日: 2009/08/11
ジャーナル フリーThe toxicity and central action of dl-piperonyl-methylaminopropane (dl-PMAP) were investigated in mice and rabbits.1) After 24 hr the LD50 of the dl-PMAP which was injected in mice subcutaneously was 56.2μg/g. It was clearly greater than that of methamphetamine (25.5μg/g).2) With dl-PMAP 1- 2μg/g injected in mice subcutaneously, symptoms of sedation were noted. The stimulant actions were, however, elicited after the administration of 5μg/g and over.3) Decrease of norepinephrine content in mouse brain occurred 5 min after the administration of dl-PMAP, and a transient recovery of norepinephrine content was observed after 10 min of the drug. However, it then decreased again gradually to less than the control level 3 hr later.4) The sleeping time with hexobarbital, thiopental and pentobarbital was reduced by the administration of dl-PMAP 10μg/g. Furthermore, with the administration of dl-PMAP the sleeping time produced by the combined administration of reserpine and hexobarbital was reduced markedly, while that produced by the chlorpromazine and hexobarbital was hardly shortened. In the experiments with reserpine and hexobarbital, dl-PMAP caused the lowering of norepinephrine content in mouse brain. But in. that with chlorpromazine and hexobarbital it produced almost no change in norepinephrine content.5) The high voltage and large waves appeared, and small waves diminished in the encephalogram immediately after the administration of 1 mg/kg of dl-PMAP in rabbit ear vein.From these experimental results, the toxicity and central excitation caused by dl-PMAP were found to be weaker than that of methamphetamine. In addition the mechanism of action on the central nervous system excitement caused by the drugs was discussed freely.dl-PMAP might be useful as a mild “wake amine” or as a phenylalkylamine giving priority to peripheral action over central action.抄録全体を表示PDF形式でダウンロード (5523K) -
MASAHISA SHINGU, YOSHIHIRO TANAKA, SHIGEYUKI NOMIYAMA, YOH NAKAGAWA1970 年 17 巻 4 号 p. 199-203
発行日: 1970/12/20
公開日: 2009/08/11
ジャーナル フリーMany papers report the inhibitory effect of N1, N1- anhydrobis-(β-hydroxyethyl) biguanide hydrochloride (ABOB) on influenza virus multiplication and its prophylactic and therapeutic evaluation in clinical trials.Inhibitory activity of ABOB on new type of influenza A virus (Aichi/2/68 strain), was tested in this study. This type of virus came into epidemic in Hong Kong in summer 1968. The antigenic properties of this virus were a little different from type A2 virus which is a previous epidemic strain.抄録全体を表示PDF形式でダウンロード (446K) -
MASAHISA SHINGU, KUNITADA TSUTSUMI, TAKESHI OZAWA, MASAOMI GOSHI, YOH ...1970 年 17 巻 4 号 p. 205-210
発行日: 1970/12/20
公開日: 2009/08/11
ジャーナル フリーThe first distinctive epidemic of hand, foot and mouth disease was reported in 1957 in Toronto, Canada and Coxsackie virus group A type 16 was implicated.Robinson, Doane and Rhodes described an illness evidently due to an A 16 Coxsackie virus in which the febrile course was marked by oral blisters and a maculopapular rash of the hands and the feet that characteristically became vesicular and to which the name “hand, foot and mouth” disease is frequently applied.Type A16 is most common, but A5 and A10 have been reported occasionally.The following is a report of 14 cases of hand, foot and mouth disease studied in the summer of 1968.Coxsackie virus A16 was isolated from four patients, with suckling mice and established green monkey kidney cell culture and serum neutralizing antibody titers to this virus were demonstrated in seven tested cases.抄録全体を表示PDF形式でダウンロード (555K) -
SHIGEMI ANRAKU, CHISHIN MIURA, HIRONORI MORI, TOSHIAKI FUKUTOMI1970 年 17 巻 4 号 p. 211-224
発行日: 1970/12/20
公開日: 2009/08/11
ジャーナル フリーPDF形式でダウンロード (9421K)
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