The Kurume Medical Journal
Online ISSN : 1881-2090
Print ISSN : 0023-5679
ISSN-L : 0023-5679
18 巻, 1 号
選択された号の論文の6件中1~6を表示しています
  • Special Speech in the 63 rd Annual Meeting of the Formosan Medical Association 1970, November 22
    MUNENORI ENJOJI, M. D.
    1971 年 18 巻 1 号 p. 1-9
    発行日: 1971/03/20
    公開日: 2009/08/11
    ジャーナル フリー
  • TERUMI FUJII
    1971 年 18 巻 1 号 p. 11-18
    発行日: 1971/03/20
    公開日: 2009/08/11
    ジャーナル フリー
    The effect of four types of maternal diet during gestation and lactation on the growth rate of progeny was investigated. These diets included Commercial Laboratory Chow (PC) and formulated diets with lactalbumin (LA), lactalbumin and 0.05 % methionine (LM), or Alpha protein and 0.35 % methionine (αM). Although similar birth weights were observed among all of these groups, progeny of mother fed ad lib αM-diet evidenced retarded growth after birth compared with the other three groups, among which no significant differences in growth of progeny were noted. However, there were marked differences in food intake in the mothers particularly during the lactation period. Food intake was largest in PC-group and smallest in αM-group, and same between LA and LM. This result reflected the poor growth of progeny and their larger value of food intake per 100g body weight were similar amomg progeny of other three groups. Some aspects in relation to differences in food intake in mothers among these groups are discussed.
  • TERUMI FUJII
    1971 年 18 巻 1 号 p. 19-23
    発行日: 1971/03/20
    公開日: 2009/08/11
    ジャーナル フリー
    In earlier study from this laboratory, when fed Commercial Laboratory Chow, less feed efficiency in the progeny of underfed mothers during gestation and lactation was reported accompanying with the high nitrogen level in both the urine and the feces. Using the formulated diet with egg albumin, we have undertaken to measure feed efficiency and the pair feeding between normal and restricted progeny. Although we failed to find any significant difference in feed efficiency between the two groups, the pair feeding revealed the retarded growth in restricted progeny during a pair feeding experiment period, suggesting the presence of some abnormality involved in metabolism, particularly protein metabolism, in restricted progeny even when fed diet containing egg albumin.
  • SEIICHIRO YAMASAKI, TADASHI ARIMA
    1971 年 18 巻 1 号 p. 25-37
    発行日: 1971/03/20
    公開日: 2009/08/11
    ジャーナル フリー
    When a study was made on the change of B2 quantity in organs by the joint administering of Adenosine and B2-tetrabutyrate, increase of B2 quantity was observed in liver, kidney and heart in drug administered group than in control group. Fractional quantitative analysis by paper chromatography was carried out, by which the FAD fraction in liver, kidney and heart was registered as increasing, and it is considered that total B2 quantity increased in each organ has increased as the result. Considerable increase is also registered in group administered with B2-tetrabutyrate alone as compared with control group, but the group jointly administered with Adenosine showed tendency of growing FAD at higher ratio. It was considered that the fact is substantiated that Adenosine is fully participating as the necessary material in the process of B2-tetrabutyrate becoming FR in the body, and still further to become FAD. As regards the inhibiting effect by B2-tetrabutyrate against test rabbit of high lipid blood, there are tests, et., by Kishikawa et al, but also in the case of author et al, considerable inhibiting effect was observed in cholesterol and triglyceride etc., as compared with control group. Besides, the result was obtained that this effect gets stronger by the joint use of Adenosine. Still more detailed experiment will be necessary in order to ascertain that this is the activity of Adenosine itself, indirect activity of Adenosine becoming nucleotide, or in the relationship with FAD. This time, inhibiting effect against rabbit of high lipid blood by single administering of Adenosine was studied, and remarkable inhibiting effect was observed by Adenosine in cholesterol value, triglyceride and phospholipide etc. As stated already, when it is considered that Lentinacin having Adenine skeleton possesses de-cholesterol activity, it is considered that these series of compounds may have de-cholesterol activity. On the basis of general classification, as mechanism of serum cholesterol lowering, which are (1) hindrance to absorption from digestive canal, (2) hindrance to biosynthesis, (3) promotion of metabolic evacuation, (4) change of bodily distribution, the case of Adenosine is supposed due to promotion activity of metabolic evacuation as in the case of Lentinacin, but as it is only in a stage of presumption, further study is desired to be made. On the basis of above animal tests, the therapy of joint use of Adenosine and Adenosine as well as B2-tetrabutyrate for abnormal metabolism of lipid should be attempted hereafter.
  • SHIGERU YAMAMOTO, HIDEFUMI KABUTA, YOH NAKAGAWA
    1971 年 18 巻 1 号 p. 39-50
    発行日: 1971/03/20
    公開日: 2009/08/11
    ジャーナル フリー
    The commercial protamine sulfate could be separated into two fractions by Sephadex G-50 column which inhibited plaque formation by herpes simplex virus when cell monolayers were treated with them before adding the virus. One of them (Fr. I) contains high molecular weight proteins and the other (Fr. II) contains only protamine molecules. The former is more effective than the latter. The inhibitory effect disappears after incubation of the fractions with a large amount of cells. Both fractions do not directly reduce virus infectivity. Furthermore, they do not inhibit virus replication after virus adsorption. The virus particles remaining unadsorbed to cells pretreated with the fractions could be detected only when virus diluted in Earle's saline containing skim milk and lactalbumin hydrolysate was used for inoculation. These findings gave a clear evidence that protamine (Fr. II) and also high molecular weight proteins in Fr. I adsorb to cell surface or receptor and in consequence inhibit virus attachment to the cell surface resulting in the reduction of plaque formation.
  • KOYO OKABE, MINORU AKUSAWA
    1971 年 18 巻 1 号 p. 51-55
    発行日: 1971/03/20
    公開日: 2009/08/11
    ジャーナル フリー
    The antigenic substance contained in urine of rabbits infected with S. japonicum was easily fractionated by the gel-filtration method using the Sephadex G-50 column. The fractionated substance showed distinct immunological reaction (double diffusion technique by Ouchterlony's and Oakley and Fulthorpe's methods) against the anti-S. japonicum rabbit serum, and was recognized to be the antigenic substance which originated from the adult worms. This is comparatively stable against heating and will partly pass through a cellophane membrane during dialysis. The active fraction obtained with Sephadex G-50 is still positive in Anthron's reaction and active after it was heated, dialyzed, and deproteinized. These results as well as UV absorption may show that this fraction has no close relationships to protein.
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