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Volume 19, Issue 1
Displaying 1-7 of 7 articles from this issue
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I DIFFERENCE OF PRESSOR EFFECT PRODUCED BY REPEATED ADMINISTRATION OF EPHEDRINE, METHAMPHETAMINE AND PHENIPRAZINE IN DOGSKOICHIRO TAKASAKI, HIROSHI KITAGAWA, SHYOZO ISHIBASHI1972 Volume 19 Issue 1 Pages 1-10
Published: January 20, 1972
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe difference in the appearance of tachyphylaxis in morphine and pentobarbital-anesthetized atropinized dog with repeated administration of three ephedrine-like drugs was studied by assessing the change of blood pressure reaction. 1) Tendency to induce tachyphylaxis was most intense in methamphetamine, followed by ephedrine. The tendency to cause tachyphylaxis of pheniprazine, which is an intense monoamine oxidase inhibitor, was milder than in other drugs. 2) Ephedrine-like drugs causes crossed tachyphylaxis with each other. Especially, when repeated administration of one of ephedrine-like drugs resulted in considerable attenuation of the degree of pressor effect or a fall of pressure (reversal effect), immediate administration of other drugs caused only a fall of blood pressure in many circumstances. 3) After administration of ephedrine-like drugs, the pressor effect due to catecholamines was potentiated. After tachyphylaxis especially the reversal effect with ephedrine-like drugs, the pressor effect to catecholamines may be somewhat attenuated but a sufficient rise was still noted. These results would indicate that the tendency to cause tachyphylaxis is related to the dosage of these drugs and their binding abllty to norepinephrine storage site in tissue.View full abstractDownload PDF (1176K) -
II RECOVERY OF TYRAMINE TACHYPHYLAXIS AND CROSSED TACHYPHYLAXIS BETWEEN TYRAMINE AND OTHER INDI-RECTLY ACTING SYMPATHOMIMETIC AMINES IN DOGSKOICHIRO TAKASAKI, MASANOBU URABE, RYUICHI YAMAMOTO1972 Volume 19 Issue 1 Pages 11-22
Published: January 20, 1972
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe changes of blood pressure response produced by repeated administration of tyramine was investigated in morphine and pentobarbital anesthetized and atropinized dogs. Tyramine causes gradual attenuation of the pressor effect with repeated administration of doses of 0.5 to 1 mg/kg. A definite tachyphylaxis was obtained only with repeated administration of a large dose of tyramine in total doses averaging about 60 mg/kg. The tendency to cause tachyphylaxis of tyramine was more mild than that of ephedrine-like drugs (ephedrine, methamphetamine and pheniprazine). When the pressor effect was somewhat attenuated through repeated administration of tyramine, the pressor effect action of ephedrine-like drugs was slightly reduced. After the definite tachyphylaxis produced by tyramine, administration of ephedrine-like drugs caused a very small or no pressor effect. Sometimes only a slight fall of blood pressure was observed. On the other hand, after tachyphylaxis due to ephedrine-like drugs, the pressor effect in response to tyramine was suppressed considerably. The attenuated pressor effect after repeated dose of tyramine was restored to some extent towards the control pressor effect after about 1 / 2 to 1 hr intervals injections or norepinephrine infusion following the last administration of tyramine. However, if some dose of ephedrine-like drugs was administered during repeated administration of tyramine, the attenuated pressor effect of tyramine was not restored after the above-mentioned intervals. But it was restored slightly to some height after norepinephrine infusion. After tyramine tachyphylaxis the pressor effect to norepinephrine was observed in a normal and sufficiently intense rise. From these observations, it is most likely that the mechanism for producing tyramine tachyphylaxis is different from that of ephedrine-like drugs and primarily correlates with the entrance and accumulation of sufficient dose of tyramine into “labile store”. This replaces norepinephrine in the store, althrough tyramine may not readily bind as easily as ephedrine-like drugs.View full abstractDownload PDF (1416K) -
SHIGERU YAMAMOTO, HIDEFUMI KABUTA, YOH NAKAGAWA1972 Volume 19 Issue 1 Pages 23-31
Published: January 20, 1972
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSTwo mutants were isolated from YH strain. One (L) produces the large plaques on GMK cells in contrast with the small plaque formation by parent virus (S). The other (G) produces larger plaques than L mutant with the formation of multinucleated giant cells. The mutants breed true in the proliferation in RK or GMK cells, but the parent S virus breeds true only when it was passaged in RK cells and not in GMK cells. They are different in growth in GMK cells, and the failure of maintenance of the properties of S virus in GMK cells is due to the greater yield of L mutant in this cells. Although no antigenic difference is detected among them, Gmutant is significantly more labile to heat than the others.View full abstractDownload PDF (2085K) -
YOSHISATO HAGIHARA, MITSUKO SASAKI1972 Volume 19 Issue 1 Pages 33-37
Published: January 20, 1972
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSFactors affecting pathogenicity of Serratia for mice were studied. Results obtained are summerized as follows. 1. The virulence of Serratia was not affected by passage through mice for ten times, but increased by inoculation of the organisms with gastric mucin. 2. The pathogenicity of Serratia for mice previously treated with antiinflamatory drugs betamethasone, ACTH, indomethacin and lysozyme, was the same as that for nontreated mice. 3. Mice previously treated with azathiopurine as immunosuppressive drugs were less resistant against Serratia infection than non-treated one. 4. Mice suffering from experimental diabetes caused by alloxan, were killed by smaller numbers of Serratia than in the case of non-treated mice.View full abstractDownload PDF (585K) -
MINORU AKUSAWA, KENJI MATSUMURA, SHIN-ICHI YAMANOUCHI1972 Volume 19 Issue 1 Pages 39-41
Published: January 20, 1972
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSAnesthetic treatment is important in a veterinary clinic, especially in the cases of operations, diagnoses, or the collection of examination samples. The anesthetics which are used for these purposes must be easy to use or safe for the animals, and reliable in anesthetic effect. Ketalar is an excellent anesthetic for dogs and cats. Its efficacy is especially noticeable as a total anesthesia for cats.View full abstractDownload PDF (240K) -
I. CLINICAL OBSERVATIONIICHIRO FUNATSU, FUMIO YAMASHITA, YUSHI ITO, SHIN TSUGAWA, TAKAKO FUNA ...1972 Volume 19 Issue 1 Pages 43-51
Published: January 20, 1972
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSFour babies born to the poisned mother due to rice oil contaminated with polychlorbiphenyls (Yusho in Japanese) were studied in detail. These babies showed the unusual clinical features which were new clinical entity and might be called as polychlorbiphenyls (PCB) induced fetopathy. The main features were : 1) Intrauterine retardation of the growth (Small-For-Dates Baby in 3 of 4 cases), 2) Dark brown pigmentation on the skin and mucous membrane similar to that in Addison's disease, especially on the skin of the genitalia, axilla, near finger nail, hair follicle and on the mucous membrane of the mouth, palpebra, and limbic conjunctiva, 3) gingival hyperplasia in 3, and the eruption of teeth at birth in 2 cases, 4) Spotted cacification on the parieto-occipital skull in 3 cases and the large or wide frontal and occipital fontanells and saggital suture, 5) edematous face and exophthalmic eye in 3 cases. Possible presence of endocrinologic and enzymatic factor in the pathogenesis of this fetopathy was speculated.View full abstractDownload PDF (4199K) -
II. EXPERIMENTAL STUDIES : POSSIBLE PLACENTAL TRANSFER OF POLYCHLOROBIPHENYLS IN RATSTOSHI KATO, MICHIAKI YAKUSHIJI, HIROFUMI TUDA, AKIO ARIMA, KENICHI TAK ...1972 Volume 19 Issue 1 Pages 53-59
Published: January 20, 1972
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSFour cases of polychlorobiphenyls (PCB) induced fetopathy were described in the previous paper as the part one of this report. The following experimental studies were performed to confirm the possibility of placental transfer of polychlorobiphenyls in pregnant rats, and to elucidate the pathogenesis of the fetopathy. The incidence of maternal death and the abortion increased in proportion to the amount of chlorbiphenyls administered to the mother rat, and histological changes were observed mainly in the liver and in the kidney of the mother. Although, neither external malformation nor abnormal histological findings were noted in the fetus of the rat, 3H-labeled polychlorobiphenyls administered in mother rats were detected in the placenta, amnion and in the whole body of the fetus. The above experimental studies suggest us that the fetopathy obsered in human could be caused by placental transfer of polychlorobiphenyls.View full abstractDownload PDF (6544K)
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