The Kurume Medical Journal
Online ISSN : 1881-2090
Print ISSN : 0023-5679
ISSN-L : 0023-5679
23 巻, 4 号
選択された号の論文の7件中1~7を表示しています
  • TAKASHI AKASU, KYOZO KOKETSU
    1976 年 23 巻 4 号 p. 183-188
    発行日: 1976/12/25
    公開日: 2009/08/11
    ジャーナル フリー
    The nature of P-potential of bullfrog sympathetic ganglia of which nicotinic transmissions were completely blocked by d-TC (1.4 mM) was analysed by the sucrose-gap method. The P-potential reversed its polarity during conditioning hyperpolarizations at a potential level which appeared to be the K+ -equilibrium potential, and only a small fraction of the Ppotential was depressed by ouabain (2×10-3 mM). These natures of the Ppotential were different from those of the P-potential of nicotinized ganglia which were analysed in our previous experiments. The ionic mechanism underlying the P-potential was discussed on the basis of the present results together with our previous results obtained from nicotinized ganglia, and it was suggested that the P-potential (slow IPSP) was composed with, at least, two different components, viz. an activation of the electrogenic Na+ pump and increase of K+ conductance of the subsynaptic membrane.
  • YASUTO FURUKAWA
    1976 年 23 巻 4 号 p. 189-197
    発行日: 1976/12/25
    公開日: 2009/08/11
    ジャーナル フリー
    I discussed radioactive Mercury Chloride about the distribution in various tissue including tumor tissue, the uptake rate and the adhesion rate into human serum albumin. Although radioactive Mercury Chloride had the fault being distributed more in kidney and liver, the positive rate in lung neoplasm was relatively high. The uptake rate in tumor tissue was as same as in the other tumor affinity substances. In the expression of sc inti-image, the digital map display was more clear than the original image. I thought that radioactive Mercury Chloride was a useful nuclide in the diagnosis of lung neoplasm.
  • KOSEI KUHARA
    1976 年 23 巻 4 号 p. 199-208
    発行日: 1976/12/25
    公開日: 2009/08/11
    ジャーナル フリー
    Serum gastrin, gastric acid secretion, parietal cell mass and cyclic-AMP level of gastric mucosa were measured in a total of 50 patients with gastric carcinoma and 12 controls. The serum gastrin level of the patients appeared to be normal. The maximal gastric acid output was significantly lower in the patients than in the controls. The output was found to be independent of the stage of progression, size, site of growth or histological type of gastric carcinoma. The parietal cell mass was estimated to be 4.5×106/cm2 in the early stage of carcinoma and 4.0×106/cm2 in the advanced stage. There was no significant difference between them, but each value was markedly lower as compared with that of the control group (6.4×106/cm2). In 8 of 33 cases, the maximal acid output did not relate to the parietal cell mass. Such cases showed a markedly lower cyclic-AMP level in the gastric mucosa of acid bearing area. This study supports the hypothesis that achlorhydria may predispose the development of carcinoma, and suggests that the resistance of parietal cells to gastrin is very important in the pathogenesis of achlorhydria as well as parietal cell diminution.
  • II. RECOMBINATION BETWEEN VIRUSES WITH NON-FUSING AND FUSING ABILITY
    SHIGERU YAMAMOTO, HIDEFUMI KABUTA
    1976 年 23 巻 4 号 p. 209-217
    発行日: 1976/12/25
    公開日: 2009/08/11
    ジャーナル フリー
    Mixed infection with non-fusing (S) and fusing (G) viruses produced the recombinant (L) which was non-fusing but formed the plaque intermediate in size between parents. Genetic analysis in combination with IDU-resistance (Ir) demonstrated that the progeny designated as LIs (IDU-sensitive), LIr and GIr were produced at the ratio of 2 : 2 : 1 by genetic recombination between SIr and GIs, leading the hypothesis that cell fusion resulting in polykaryocytosis can be expressed by two cistrons each of which determines L character when functioning separately, and recombination units between these L cistrons could be calculated to be 13.0. Further cross experiments using the L-type recombinants suggested that additional cistron (s) would participate in the process involved in cell fusion or that the intracistronic crossovers are possible.
  • HISAHARU YOSHIOKA, TAKASHI SUGITA, MOTOAKI RYU
    1976 年 23 巻 4 号 p. 219-230
    発行日: 1976/12/25
    公開日: 2009/08/11
    ジャーナル フリー
    A 52-year-old woman presented all ocular and systemic findings of the spontaneously occurred uveal effusion described by Schepens and Brockhurst associated with microphthalmos and high degrees of hyperopia was reported. Fluorescenn angiography revealed the presence of profound leakages from the choroid into subretinal spaces at the posterior and equatorial region, and the presence of focal leakages in some central retinal veins of the right eye. Left eye showed numerous fluorescent dots due to pigment epithelial defects of the posterior pole and of the equatorial region. It was thus suggested that uveal effusion described by Schepens and Brockhurst may be the same disease as bullous retinal detachment (Gass, 1973), peculiar type of secondary retinal detachment (Tsukahara, 1973), characteristic chorioretinal lesion with peripheral retinal detachment (Mimura et al., 1973), or effusive central serous choroidoretinopathy (Yoshioka, 1973) in Japan.
  • SEIICHI IN
    1976 年 23 巻 4 号 p. 231-254
    発行日: 1976/12/25
    公開日: 2009/08/11
    ジャーナル フリー
    The blood vessels of human brain tumors were studied in comparison with normal architecture under electron microscope. 1) In benign glial tumors, their blood vessels were apperently similar to those of normal tissue. 2) In malignant glial tumors, immature vessels were observed as might be expected in young, immature cells. The nucleus-cytoplasm ratio was high, and cytoplasm was filled with an abundance of organelles, especially free ribosomes and mitochondria. These findings suggest a high metabolic activity of endothelium. Opened intercellular junction, increased pinocytotic and coated vesicles were recognized in the endothelial cells, and proliferated endothelial cells had irregular luminal surface and elongated processes. These facts suggest an increased capacity to trasfer materials between the luman and the parenchyma. 3) In non-glial tumors, a fenestrated endothelium was commonly observed. The perivascular basement membrane was often reduplicated and was composed of several layers. 4) Adhesive devices between adjacent endothelial cells presented commonly macula adherens and desmosome-like pattern. 5) Tubular bodies were observed in the vascular endothelial cytoplasm of glioblastoma multiforme, pinealoma, craniopharyngioma, astrocytoma, teratoma with choriocarcinoma and pituitary adenoma. These tubular bodies showed various spectra from immature type to mature, might reflect a marked vascular reaction in angiogenesis with brain tumor formation. 6) Furthermore, in the case of pinealoma, its vascular basement membrane filled with collagen fibers and some dense materials merged continuously into the intercellular space of tumor tissue as seen in meningioma. These facts suggest that the origin of the pinealoma might be the mesodermal tissue.
  • CHOKUDO SUJAKU, TADAMITSU KAMEYAMA, HIDEJIRO INOUE, YOUICHI MATSUSE, F ...
    1976 年 23 巻 4 号 p. 255-267
    発行日: 1976/12/25
    公開日: 2009/08/11
    ジャーナル フリー
    This time, case analysis was made of 911 cases who were admitted to the ward of the Department of Dentistry and Oral Surgery, Kurume University Hospital, Kurume, Japan, during the period from August 1, 1961, until July 31, 1973. In addition, the results of the present analyses were compared with the frequencies classed by diagnosis of inpatients during the one year following an increase in number of beds assigned to our department. 1. There were 22173 new patients who came to the Outpatient Clinic at our department during the above-mentioned period, and 911 of them, accounting for 4.2% of the new patiens, were hospitalized. 2. On sex difference, males was more frequent, the male-female ratio being 1.5: 1. On age difference, there were 418 infant and children aged less than 10 years, accounting for 46% of the 911, and the higher the age, the less was the number of hospitalized patients. 3. With regard to the classification of diseases by diagnosis, 429 cases of malformation were most frequent, amounting to 47.1 % of the whole, followed by 175 cases of trauma, (19.2%); by tumor, (11.4%); by inflammation, (8.9%), and by cyst, (8%). 4. The patients were hospitalized for a minimum of two days, for a maximum of 285 days, and for 38 days on the average, and the average periods of hospitalization of main disease were as follows : malformation for 40 days, trauma for 51 days, malignant tumor for 74 days, and benign tumor for 36 days. 5. The regional distribution pattern of the inpatients was such that 261 of them, accounting for the greatest part, i. e., 28.6% of the whole, were from the area within 10 kilometers, and all the cases from the areas within 20 kilometers, accounted for more than one half of all the whole.
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