巻号一覧
25 巻 (1978)
- 4 号 p. 241-
- 3 号 p. 157-
- 2 号 p. 65-
- 1 号 p. 1-
25 巻, 4 号
選択された号の論文の16件中1～16を表示しています
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JUN NAKAMURA1978 年 25 巻 4 号 p. 241-253
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーIn an attempt to elucidate the mechanism of neuroleptic action, effects of chlorpromazine, haloperidol and pimozide on the dopaminergic and cholinergic systems in bullfrog and rabbit sympathetic ganglia were investigated with extracellular and intracellular techniques. In bullfrog ganglia, chlorpromazine (10-5 M) and haloperidol (10-5 M) caused a reversible depression of P and LN waves but no changes in LLN wave. Pimozide (10-5 M) was without effect on P wave and other slow postsynaptic potentials. The resting properties of amphibian ganglion cells were affected by none of these drugs, while action potentials were depressed slightly in a small number of cells by chlorpromazine (10-5 M) and haloperidol (10-5 M). The latter two drugs reversibly inhibited both the fast (nicotinic) and slow (muscarinic) depolarization of the cell membrane induced by iontophoretic application of acetylcholine. It was surmised, therefore, that the depression of P wave in the presence of chlorpromazine or haloperidol was mainly due to an impairment of the muscarinic transmission from preganglionic fibers to SIF cells (chromaffin-like interneurons). In contrast to the amphibian preparation, P and LN waves of rabbit ganglia were unaffected by the neuroleptics (10-5 M). Moreover, the dopamine-induced postsynaptic hyperpolarization as well as the dopamine-elicited presynaptic inhibition were well maintained in the medium containing chlorpromazine, haloperidol or pimozide (10-5 M). These results demonstrate that the pre- and postsynaptic dopamine receptors with an inhibitory capacity are insensitive to the blocking action of neuroleptics. This leaves a possibility that dopamine receptors with a facilitatory function might be a candidate for the site of neuroleptic action.抄録全体を表示PDF形式でダウンロード (7743K) -
TAKESUKE MUTEKI, HIDEAKI TSUDA, TOSHIAKI TAKAGI, KUNIO YAMADA, HIROSHI ...1978 年 25 巻 4 号 p. 255-260
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーThe study was aimed at elucidating the effect of plasma expander on the functional behavior of right atria as booster pump, reservior and conduit, under sympathetic denervation due to high spinal anesthesia. Utilizing anesthetized and open-chest dogs, the changes of right atrial diameter (microsonometer), and pressure (Millar's micromanometer) and enlarged P and “a” waves (direct coupling EKG and sample hold circuit) were obtained. In hypotension due to high spinal anesthesia, the effect of plasma expander on right atrial systolic shortening (R. A. S. S.), shortening rate (R. A. S. R.), atrial filling time ratio during ventricular contraction phase (T. R. A. F.), the max. dp/dt of “a” wave and effective compliance of the total vascular beds (EC) were investigated.Following results were obtained : R. A. S. R., max. dp/dt (a), T. R. A. F. and E. C. were all decreased by high spinal anesthesia and these changes were all restored by administration of plasma expander.抄録全体を表示PDF形式でダウンロード (5136K) -
SHIGEYUKI TAKAGI, HIROYUKI AIBA, CHIKASHI ISHII, KENJI NAKAYAMA, TAKAS ...1978 年 25 巻 4 号 p. 261-264
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーThe authors encountered a case of lipoma of the corpus callosum in an infant which is a very rare disease. The present case was a 3-year-old girl admitted to our neurosurgical clinic on September 14, 1977, because of facial anomalies. She was suffering from a saddle nose and occular hypertelorism. No neurological abnormalities were noted in neurological examinations, and her mental and motor developments were kept within normal range during admission. The plain skull films showed an egg-sized radiolucent area which was surrounded by the curvilinear calcification in the midline of the frontal. Angiograms revealed strange bilateral dysplastic pericallosal arteries that were irregularly dilated. CT scan showed an extremely low density area which was enclosed by the characteristic high density area of the calcified lipomal capsule.Its neuroradiological manifestations are discussed.抄録全体を表示PDF形式でダウンロード (4384K) -
YOICHIRO SASAI, KAZUHIKO NAMBA, KOJI KAWAMURA1978 年 25 巻 4 号 p. 265-271
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーThe cell cycle duration of epidermal cells in keratotic dermatoses was investigated with the combination of cytofluorometric and mathematical methods. In normal epidermis, the relative time spent in each phase was 85.6% (G1), 9.7% (S) and 4.7% (G2+M). The relative time in ichthyosis vulgaris epidermis was similar to that in normal epidermis. In the cases of psoriasis, neurodermatitis and non-bullous congenital ichthyosiform erythroderma, the percentage of S phase was larger than that in normal epidermis.抄録全体を表示PDF形式でダウンロード (1099K) -
HIROSHI KAWASAKI, YOSHIHIRO AKAGI, KATSURO NISHI, TAKAMI KAKUDA, EIJI ...1978 年 25 巻 4 号 p. 273-281
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーBloods from normal volunteers and patients of various diseases were examined using the electron spin resonance technique at -196°C in a liquid nitrogen. Three major signals were detected ; g=4.2 for Fe (III) in transferrin, g=2.05 for Cu (II) in ceruloplasmin and g=2.00 for free radical.Electron spin resonance spectroscopy was found to be a good tool for monitoring the variation of blood metal elements and free radical in various disorders and for analysing the metabolic disturbance of oxidation-reduction system in the body.In vitamin C-deficient guinea pigs, Fe (III) and free radical signals were lower than those of the normal while Cu (II) signal was much higher. Such an abnormal pattern was demonstrated from the bloods of patients suffered from influenza. A possible value of vitamin C on these patients was discussed.抄録全体を表示PDF形式でダウンロード (4117K) -
NOBUMITSU OKITA, KENICHI KODAMA, YOICHI ITO, JIRO NAKAYAMA, KENICHI NA ...1978 年 25 巻 4 号 p. 283-289
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーThe relationship between humoral autoantibodies and endocrinological and histological findings of thyroid gland were studied in 45 subjects with Hashimoto's thyroiditis. The positive reaction of autoantibodies were these, thyroglobulin antibody 53.1 % ; anti-microsome antibody 85 .5 % antinuclear factor 40 % parietal cell antibody 28.9 % ; smooth muscle antibody 10.5 % and anti-insulin antibody 2.5 %. The negative reaction were these, anti-thyroxine antibody, abnormal binding of thyroxine to gammaglobulin and anti-DNA antibody. The correlation between these autoantibodies and endocrinological and histological findings of thyroid gland were not significant, while the parietal cell antibody was thought to be correlated with hypothyroid state of Hashimoto's thyroiditis.抄録全体を表示PDF形式でダウンロード (2190K) -
MITSUWO HARA1978 年 25 巻 4 号 p. 291-294
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリー1) Mercy-killing has been a subject creating a serious problem in the field of medical jurisprudence and criminal law in Japan. One case of it which happened seventeen years ago in Japan is briefly introduced along with the Japanese judicial precedent given thereto which defined six conditions to justify the concept of such killing. Since the legal decision was officially made by the court of justice, it has become a n accepted authority which should not be ignored whenever the problem of Mercykilling is debated in Japan.2) Informations gathered by the questionnaire method (some questions propounded in regard to the problem of Euthanasia and answers thereto which are reflecting frank views of a total of 176 physicians) are introduced for your reference.抄録全体を表示PDF形式でダウンロード (431K) -
HIROYOSHI MIZOTE, SHIGEHIRO TERASAKI, TADAHIKO RYU, KOUICHI UEDA, YOSH ...1978 年 25 巻 4 号 p. 295-300
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーWe examined 13 cases of lactose intolerance developing after gastrectomy. The major symtom in these 13 cases was diarrhea developing after ingestion of cow's milk. In all cases stool pH was acid and stool clinitest was positive. These symptoms were improved with administration of 0.5 gm. lactose (Galantase) per 180 ml. of cow's milk of 5 to 10 minuts after milk intake.抄録全体を表示PDF形式でダウンロード (1895K) -
HIROSHI MASUDA, SHIGEKI SHICHIJO, MUTSUYA TAKEUCHI1978 年 25 巻 4 号 p. 301-308
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーA study has been made for the purpose of methodological aspect on Tamm-Horsfall glycoprotein, glycosaminoglycans and glycopeptide contents in such urinary fractions as the one the filtered and the other the supernatant following centrifugation. The contents were measured both biochemically and immunologically. The filtration procedure greatly reduced the Tamm-Horsfall glycoprotein content, while the centrifugation had little effect on its content. Furthermore, either filtration procedure or centrifugation had no effect on the any of uronic acid, hexose or sialic acid content of the glycosaminoglycan-glycopeptide preparations.抄録全体を表示PDF形式でダウンロード (5680K) -
SHIGEKI SHICHIJO, HIROSHI MASUDA, TAKA-AKI KURAKAZU, MUTSUYA TAKEUCHI, ...1978 年 25 巻 4 号 p. 309-316
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーFive glycosaminoglycans were isolated from tryptic digest of bovine fourth gastric mucosa, and were assayed by determining the carbohydrate content of materials. Separation of these five polymers was achieved by preparative zone electrophoresis in a Pevikon C-870 block and by Dowex 1 × 2 column chromatography. They were identified as hyaluronic acid, heparan sulfate, chondroitin-4-sulfate, dermatan sulfate and chondroitin-6-sulfate, respectively.抄録全体を表示PDF形式でダウンロード (3375K) -
HIROSHI MASUDA, SHIGEKI SHICHIJO, TOSHITSUGU YAMAMOTO, MUTSUYA TAKEUCH ...1978 年 25 巻 4 号 p. 317-321
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーThe glycosaminoglycan was studied in the heart of normal human subject. The heart was separated into six different parts including the right ventricle, right atrium, tricuspidal valve, left ventricle, left atrium and mitral valve. The glycosaminoglycan preparation was made by digesting the different parts of the heart with proteolytic enzymes followed by removal of enzymes and undigested protein, and final freeze-drying of the supernatant and the content of uronic acid was determined. Both values per gram of wet and dry tissues were highest in the mitral valve and were lowest in the left ventricle. Cellulose acetate strip-electrophoresis of materials from both the tricuspidal and mitral valves in veronal buffer revealed the presence of two alcian blue positive fractions which corresponded in mobility to hyaluronic acid and chondroitin sulfates, respectively. In each preparation from other four parts of the heart, another component was found in the region between these two fractions which stained with alcian blue and corresponded in mobility to heparan sulfate.抄録全体を表示PDF形式でダウンロード (2313K) -
YOON-YUNG KIM1978 年 25 巻 4 号 p. 323-331
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーThe possibility of a direct endotoxin effect on the kidney was studied in dogs. Endotoxin, at a sub-lethal dose (0.05 mg/kg) caused only a slight reduction in systolic blood pressure but a significant reduction in urinary excretion rate of sodium (UNa·V), effective renal plasma flow (RPF), and glomerular filtration rate (GFR). Neither tubular rejection fraction of sodium (TRFNa) nor filtration fraction of sodium (F. F.) were changed.The endotoxin effects of a reduction in UNa·V, RPF, and GFR were blocked by pretreating the animals with phenoxybenzamine (10 mg/dog, intravenously) or propranolol (0.25 mg/kg, intravenously). A direct, left renal arterial infusion of endotoxin (0.02 mg/kg/min) did not alter renal function of either the left or the right kidney. A left renal arterial infusion of phenoxybenzamine or propranolol, did not modify the renal effects of endotoxin, injected into femoral vein in dogs.These findings suggest that a sub-lethal dose of endotoxin may cause stimulation of extra-renal adrenergic receptors of the vasculature which in turn causes reduction in RPF as well as GFR, and ultimately a retention of sodium and other fluids in the body as a defensive mechanism against endotoxic shock.抄録全体を表示PDF形式でダウンロード (2387K) -
HIROSHI MASUDA, SHIGEKI SHICHIJO, MUTSUYA TAKEUCHI, HIDERO NAKAZONO, M ...1978 年 25 巻 4 号 p. 333-338
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーThe glycosaminoglycan was studied in the interventricular septum, interatrial septum, aortic valve, pulmonary valve, aorta and pulmonary artery which were excised from the human material. The glycosaminoglycan preparation was made by digesting the different parts of the heart, aorta and pulmonary artery with proteolytic enzymes followed by removal of enzymes and undigested protein, and finally freeze-drying of the supernatant. The content of uronic acid was determined on this preparation. Both values per gram of wet and dry tissues were highest in the aortic valve and were lowest in the interventricular septum. Cellulose acetate strip-electrophoresis of materials from both the aortic and pulmonary valves in veronal buffer revealed the presence of two alcian blue positive fractions which corresponded in mobility to hyaluronic acid and chondroitin sulfates, respectively. In each preparation from other two parts of the heart, aorta and pulmonary artery, another component was also found in the region between these two fractions which stained with alcian blue and corresponded in mobility to heparan sulfate.抄録全体を表示PDF形式でダウンロード (2751K) -
HIROSHI MASUDA, SHIGEKI SHICHIJO, MUTSUYA TAKEUCHI1978 年 25 巻 4 号 p. 339-345
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーTamm-Horsfall glycoprotein was assayed in the urines of 5 chronic glomerulonephritis, 5 nephrotic syndrome and 5 chronic renal insufficiency. Urine samples were divided into three groups ; the original urine, the filtered fraction and the supernatant fraction after centrifugation, and then the Tamm-Horsfall glycoprotein content was measured both biochemically and immunologically. The filtration procedure greatly reduced the Tamm-Horsfall glycoprotein content, while the centrifugation had little effect on its content in each of all renal diseases. And furthermore, the Tamm-Horsf all glycoprotein content was significantly higher in the urines of both nephrotic syndrome and chronic renal insufficiency than in the urine of chronic glomerulonephritis.抄録全体を表示PDF形式でダウンロード (4705K) -
HIDEKI KOJIMA, MASAMI YOSHIDA, KAZUMI SUETAKE, SHIGEMI ANRAKU1978 年 25 巻 4 号 p. 347-348
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーPDF形式でダウンロード (1605K) -
MASAHIRO NAKAMURA1978 年 25 巻 4 号 p. 349-351
発行日: 1979/02/15
公開日: 2010/02/08
ジャーナル フリーEnigmatic growth pattern of Myobacterium leprae which had never seen before was observed when the bacilli from a nude mouse were inoculated into ND-15 medium containing malate, tyrosine, and ascorbic acid, and incubated at 30°C for three months. However, many factors to be studied remain, because this feature was quite non-reproducible.抄録全体を表示PDF形式でダウンロード (1830K)
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