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Volume 27, Issue 1
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KATSUTOSHI OTA1980 Volume 27 Issue 1 Pages 1-24
Published: 1980
Released on J-STAGE: September 04, 2009
JOURNAL FREE ACCESSThis experiment was designed to clarify the effect of low protein diet on cardiac hypertrophy using spontaneously hypertensive rat (SHR) as an experimental model.
Sixteen SHRs were divided into two groups randomly and fed with 23% protein containing diet and 5 % protein containing diet respectively for 120 days.
No definite difference of systolic blood pressure was recorded between two groups during the whole experimental period. The wet left ventricular weight of SHRs fed with low protein diet was significantly lighter than that of SHRs fed with normal protein diet. However, the average values of the left ventricular to body weight ratio were not statistically different between both groups because of poor attainment of body weight in the group fed with low protein diet. Cardiac cell diameter of the SHRs fed with low protein diet was significantly smaller than that of SHRs fed with normal protein diet. Electron microscopically, the cardiac cells of the group fed with normal protein diet showed hypertrophic findings, while more pronounced degenerative findings in the group fed with low protein diet.
It is considered that during the process of cardiac hypertrophy the lack of sufficient amount of dietary protein could disturb the process of cardiac hypertrophy, leading to rather earlier myocardial degenerative changes and consequently to the development of cardiac dysfunction.View full abstractDownload PDF (40946K) -
SPECIAL OBSERVATION ON CT FINDINGS AND INTRACRANIAL PRESSUREEIICHIRO HONDA, TAKASHI HAYASHI, TAKAO SHOJIMA, SHIGETAKA ANEGAWA, AKI ...1980 Volume 27 Issue 1 Pages 25-36
Published: 1980
Released on J-STAGE: September 04, 2009
JOURNAL FREE ACCESSThe existence of subdural effusion is harmful for the brain and it should be strictly warned to let it alone so as not to make the prognosis worse. With an aim to obtaining indexes to decide whether surgical treatment should be positively performed, or the clinical course should be carefully observed without giving surgical treatment, the authors have devised a method in which the record of ICP while patients are sleeping and changes through time of the morphology in the skull by CT scan can be quantitatively obtained.View full abstractDownload PDF (11134K) -
MASAFUMI YOSHIDA, SHINKEN KURAMOTO1980 Volume 27 Issue 1 Pages 37-41
Published: 1980
Released on J-STAGE: September 04, 2009
JOURNAL FREE ACCESSEnteric coated levodopa was administered to 6 parkinsonians who developed early and late complications of levodopa therapy in our clinic. Some of these complications were well controlled by enteric coated levodopa, which seemed to prove that at least part of the problems of levodopa treatment are of peripheral origin. Role of enteric coated levodopa in medical management of parkinsonism is discussed.View full abstractDownload PDF (872K) -
M. MITSUO YOKOYAMA, MASAYUKI NISHIKI, YOSHIKI MATSUI, RAY CRISPEN, MYL ...1980 Volume 27 Issue 1 Pages 43-49
Published: 1980
Released on J-STAGE: September 04, 2009
JOURNAL FREE ACCESSEnglish and Andersen's discontinuous Ficoll-Hypaque density gradient solution was used for the isolation of neutrophils and lymphocytes.
Neutrophil phenotypic typing was carried out for normal individuals and patients with chronic myelocytic leukemia. The null type of neutrophil genetic marker was predominantly found while neutrophils of normal individuals showed an unique distribution of the types.View full abstractDownload PDF (924K) -
M. MITSUO YOKOYAMA, MADAN L. GUPTA, DHARMATURI VIDYASAGAR, MEHRUNNISSA ...1980 Volume 27 Issue 1 Pages 51-56
Published: 1980
Released on J-STAGE: September 04, 2009
JOURNAL FREE ACCESSThe influence of hydrocortisone to lymphocyte response against PHA stimulation was studied in neonatal rabbits. Prenatally, six pregnant rabbits were given hydrocortisone and seven control pregnant rabbits were given physiological saline at the 28th, 29th and 30th day of gestation. After delivery, lymphocytes of the neonates were tested within 48 hours.
The stimulation index after the lymphocytes were cultered with PHA of 1 : 100 was 11. 15 ± 2. 14 in saline-treated control, versus 2.43 ± 1.0 in the steroid-treated group (p<0.005). Similar difference in S. I. was also found with PHA 1 : 1000, 9.56 ± 2.84 in saline versus 1. 54 ± 0. 13 in the steroid group (p<0.02).
Postnatally, neonates were divided into two groups, one was given hydrocortisone, the other saline on the 1st, 2nd and 3rd day of age. The neonates were sacrificed at 72-120 hours of age and the blood collected for lymphocyte studies.
The stimulation index in the treatment neonates with PHA was significantly depressed in the steroid-treated group when the results were compared with the control group. Steroid when administered prenatally or postnatally, suppresses lymphocyte function in the neonatal rabbits.View full abstractDownload PDF (962K) -
TAKASHI YOKOYAMA, HIROHISA KATO, EISEI ICHINOSE1980 Volume 27 Issue 1 Pages 57-61
Published: 1980
Released on J-STAGE: September 04, 2009
JOURNAL FREE ACCESSThe comparative effectiveness of small-dose (30 mg/kg) aspirin and highdose (150 mg/kg) in Kawasaki disease was evaluated in clinical symptoms and platelet aggregation. Twenty-three patients with Kawasaki disease were entered in the randomized study and devided into three groups. The durations of fever were 14.8± 3.5 days in the control group, 11.3 ± 2.1 d. in the small-dose group and 8.7 ± 2.3 d. in the high-dose group. The high-dose group showed a significantly shorter duration of fever (P<.01).
The platelet aggregation induced by ADP in the second week of illness were 82.4 ± 11.6 % in the control group, 66.8 ± 9.6 % in the small-dose group and 88.0 ± 10.7 % in the high-dose group (69.0 ± 5.0 % in healthy children). The control group and high-dose group showed significantly increased aggregation as compared with healthy children. The platelet aggregation in small-dose group was significantly lower than that in the control group (P<.01). SGOT and SGPT elevated in half of the patients treated with high dose of aspirin. In Kawasaki disease, 30 mg/kg/day of aspirin is recommended to prevent arterial thrombi.View full abstractDownload PDF (739K)
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