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Volume 29, Issue 4
Displaying 1-6 of 6 articles from this issue
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A. DEAN JABS, KYOICHI OKUBO, KEIJI OKUBO, M. MITSUO YOKOYAMA1982 Volume 29 Issue 4 Pages 163-172
Published: May 15, 1983
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSAntibody-dependent cell-mediated cytotoxicity (ADCC) mediated by human peripheral blood mononuclear cells (85 % lymphocytes and 15 % monocytes) or lymphocyte-enriched (98 % lymphocytes) effector cells against human red blood cell (HRBC) targets of various Rh genotypes, with or without papain treatment, was tested in an 18-hour 51Cr release assay. The HRBC were sensitized with Rh0GAM, an anti-Rh0 (D) IgG fraction. Mononuclear cell effectors were found to lyse papain treated Rh0 (D) homozygous cells to a greater degree than Rh0 (D) heterozygotes. The genotypes of the HRBC targets, in order of the amount of lysis from highest to lowest was R1R1, R2R2 or R1R2, R2 r, R1r, R0r, rr. When the target cells were not papain treated and mononuclear cell effectors were used, the amount of lysis was low and the % specific lysis for Rh0 (D) homozygote and heterozygote HRBC was equivalent. Lymphocyteenriched effector cells did not lyse the homozygous target cells to a greater degree than the heterozygotes, although the amount of lysis for both types of HRBC was greater than that noted using mononuclear cells as effectors.View full abstractDownload PDF (3712K) -
MASATOSHI TANAKA, RYOICHI NAKAGAWA, YASUKO KOHNO, YOSHISHIGE IDA, YOSH ...1982 Volume 29 Issue 4 Pages 173-178
Published: May 15, 1983
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSEffects of adrenalectomy on increases in noradrenaline (NA) turnover induced by a one-hour immobilization stress were examined by measuring the levels of NA and its major metabolite, 3-methoxy-4-hydroxyphenyl-ethyleneglycol sulfate (MHPG-SO4) in specific brain regions of the rat. Bilateral adrenalectomy alone does not affect basal levels of NA and MHPG-SO4 in the brain regions examined with the exception of an increase in MHPG-SO4 levels in the hypothalamus and a decrease in NA levels in the cerebral cortex. In sham-operated rats, immobilization stress caused significant increases in MHPG-SO4 levels in five brain regions that were examined, i, e., the hypothalamus, amygdala, hippocampus, cerebral cortex and pons plus medulla oblongata, and significant decreases in NA levels in the hypothalamus and amygdala. These changes in NA and MHPG-SO4 levels induced by stress were not affected by bilateral adrenalectomy. These results suggest that corticosterone is not a causative factor in enhancing brain NA turnover during immobilization stress.View full abstractDownload PDF (2642K) -
RYUICHI HASHIMOTO, MASAHIRO NAKAMURA1982 Volume 29 Issue 4 Pages 179-182
Published: May 15, 1983
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSToxicity of polyethylene glycol (PEG), one of the common fusogens to Mycoplasma pulmonis M 53 and Acholeplasma laidlawii A was reported. For this, PEG with molecular weights of 200, 600, 1000, 2000, 4000 and 6000 were mixed with suspensions of mycoplasmas and the survival of the mycoplasmas determined. The results obtained showed that the higher the molecular weight, the greater was the toxicity. The results presented here strongly suggest that the molecular weight of the PEG should be considered when an experiment on cell fusion in mycoplasmas is carried out.View full abstractDownload PDF (2550K) -
YHUKOU OHTA, TAKASHI AKASU, KYOZO KOKETSU1982 Volume 29 Issue 4 Pages 183-187
Published: May 15, 1983
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSDownload PDF (3029K) -
MIKIE KOJIMA, TAKASHI AKASU, KYOZO KOKETSU1982 Volume 29 Issue 4 Pages 189-192
Published: May 15, 1983
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSDownload PDF (1740K) -
HIROSHI UCHIYAMA, HIDEHO HIGASHI, SYOGORO NISHI1982 Volume 29 Issue 4 Pages 193-196
Published: May 15, 1983
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSDownload PDF (871K)
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