The Kurume Medical Journal
Online ISSN : 1881-2090
Print ISSN : 0023-5679
ISSN-L : 0023-5679
Volume 33, Issue 4
Displaying 1-6 of 6 articles from this issue
  • YUKIO KAWAI, HIROMU KAWASAKI, RYUICHI YAMAMOTO, MASANOBU URABE, KOICHI ...
    1986 Volume 33 Issue 4 Pages 155-161
    Published: March 31, 1987
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    In the electrically driven ventricular muscle (twitch response) of the bullfrog, N-ethylmaleimide (NEM, 10-5 to 10-3M) caused a dose-dependent positive inotropic action (PIA). The NEM-induced PIA was reduced by pretreatment with verapamil (10-5M) and MnCl2 (10-3M) and was blocked by pre-treatment with 1-cysteine (2×10-3M). Ouabain (OU) produced a moderate PIA followed by a negative inotropic action (NIA) concomitant with a marked elevation of the resting tension. The OU-induced PIA at high concentrations (10-5 and 10-4M) was significantly reduced only by verapamil. The PIA induced by either NEM or OU was hardly affected by propranolol. OU produced a greater inhibition of Na+-K+ ATPase activity of cell membranes isolated from the ventricular muscle than that of NEM without affecting Mg2+ dependent ATPase activity. Both NEM and isoprenaline but not OU restored the twitch response which disappeared in the potassium (20 mM K+)-depolarized muscle. The twitch response restored by NEM was abolished by the calcium antagonists, MnCl2 and verapamil and 1-cysteine but not by propranolol. The twitch response restored by isoprenaline was blocked by the calcium antagonists and propranolol but not by 1-cysteine. These results suggest that the NEM-induced PIA may result from the increased calcium influx into the muscle. The results also suggest that the mechanism of the NEM-induced PIA is discrete from that of the OU-induced PIA.
    Download PDF (746K)
  • SHINICHIRO HARAJIRI, HIDEKI KOJIMA, KATSUYOSHI ARIKAWA, CHISHIN MIURA, ...
    1986 Volume 33 Issue 4 Pages 163-165
    Published: March 31, 1987
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    The case of a 25-year-old male with methamphetamine dependence indicating the presence of synergism between methamphetamine and alcohol was reported. The three clinical features observed in the present case were: First, ingesting large quantities of alcohol after an intravenous injection of the psychostimulant induced psychomotor excitement, indicating that alcohol itself could potentiate the psychosis-inducing action of the psychostimulant. Second, repetition of the alcohol intake without the drug injection reactivated a psychotic state, suggesting that there is a cross-reverse tolerance phenomenon to alcohol. Third, drug injection alone, twice aggavated the psychiatric symptoms, indicating the presence of reverse tolerance to the psychostimulant.
    Download PDF (373K)
  • HARUO AKAGAWA, KENICHI KOSUGA, MICHIHIRO KOGA, SHIGEAKI AOYAGI, HIROSH ...
    1986 Volume 33 Issue 4 Pages 167-172
    Published: March 31, 1987
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    Coronary aneurysms associated with Kawasaki disease, a mucocutaneous lymph node syndrome, are annoying complications of this disorder because obstructive coronary involvement, subsequent to the coronary aneurysm, can lead to myocardial infarction and sudden death. There have been increasing numbers of successful reports of surgical treatment for Kawasaki disease. A case of Kawasaki disease treated with successful coronary revascularization with a saphenous vein graft is described in an eight year old boy. Surgical management for this disease is discussed.
    Download PDF (6670K)
  • Cytopathogenic Protein (CPP) Isolated from P. acnes Culture Filtrates and Measurement of the Antibody against CPP
    SHOBUN TOMITA
    1986 Volume 33 Issue 4 Pages 173-180
    Published: March 31, 1987
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    A culture filtrate of Propionibacterium acnes isolated from patients with Kawasaki disease was studied. After inoculation of the culture filtrate of these strains into human embryo liver cells, a cytopathogenic effect and vacuolation were recognized in the cells. From analysis of the culture filtrate, a specific cytopathogenic protein was found only in the culture filtrates from Kawasaki disease patients. This protein was approximately pI 7.0 and had a molecular weight of approximately 100, 000 daltons. The amount of IgG antibody (from sera of Kawasaki disease patients) against this substance (CPP) was measured using the Enzyme-Linked Immunosorbent Assay (ELISA). There were 124 serum samples available from 95 patients with 2-8 days duration of illness, 100 samples from 67 patients with 14-33 days of illness, 61 samples from 42 patients with 11-22 months of illness and 148 samples of age-matched controls. There was a significant elevation in the ELISA values in the patients' groups, particulally in the acute or subacute stages of the illness, as compared with controls.
    Download PDF (4813K)
  • Report of 2 Cases
    SHIGETAKA ANEGAWA, MINORU SHIGEMORI, NOBUTO KOJO, SHINKEN KURAMOTO
    1986 Volume 33 Issue 4 Pages 181-186
    Published: March 31, 1987
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    Two cases of tension pneumocephalus produced by iatrogenic causes are described. Dural tears were produced by a pin of a Mayfield head-holder in one case and by pansinectomy in the other case. In addition, both cases had procedures which induce low cerebrospinal fluid (CSF), such as a ventriculo-peritoneal shunt or lumbar punctures. For production of tension pneumocephalus in these cases, CSF diversionary procedures may play an important role in the accumulation of air in the intracranial space.
    Download PDF (4722K)
  • TAKASHI HAYASHI, TAKAYUKI TOKUNAGA, MASAHIRO MATSUO
    1986 Volume 33 Issue 4 Pages 187-191
    Published: March 31, 1987
    Released on J-STAGE: February 08, 2010
    JOURNAL FREE ACCESS
    We have recently experienced a rare case, idiopathic dural arteriovenous malformation in the anterior cranial fossa, which was operated on and cured completely. The malformation was fed through the anterior ethmoid artery and drained to the cortical vein. Surgery was proceeded with the right frontal craniotomy in extra-and intradural approach. At first, anterior ethmoidal artery was cut at the cribriform plate extradurally. After dura was incised, both the nidus and drainer were coagulated intradurally. The nidus was located at inner surface of the dura. The arachnoid hemorrhage was thought to be caused by rupture of this drainer. He had a quite uneventful postoperative course and was discharged two months after the onset of this episode. Neurological examination after discharge revealed no impairment was found such as his smelling and visual acuity. It was confirmed that the arteriovenous malformation was completely disappeared from a bilateral carotid arteriography taken after the operation.
    Download PDF (4458K)
feedback
Top