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Volume 36, Issue 2
Displaying 1-6 of 6 articles from this issue
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TAKAYUKI TOKIMASA, TAKASHI AKASU1989 Volume 36 Issue 2 Pages 49-57
Published: September 01, 1989
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSCultured bullfrog dorsal root ganglion cells were voltage-clamped in the whole-cell configuration. The classical delayed rectifier potassium current (IK) was separated from other ionic currents. Tetraethylammonium (1-50 mM) depressed the amplitude of IK in a concentration-dependent manner, a complete block occurring with 30 mM. With the concentration of potassium ions in the superfusate at 20 mM, the reversal potential of IK amounted to about -30 mV. IK was activated between -30 and +70 mV. The half activation of IK occurred at +15 mV. The amplitude of IK was increased e-fold with 13.6 mV depolarization. The time constant of Ik de-activation was shortened with membrane hyperpolarization (τ≅4 ms at -100 mV). Finally, reciprocal time constant (τ-1) of the de-activating IK was increased e-fold with≅13 mV hyperpolarization. It appears that the properties of IK in amphibian afferent neurons are comparable to those which have been observed with respect to the IK of the squid giant axons (Hodgkin and Huxley, 1952).View full abstractDownload PDF (5343K) -
YASUHISA AKAGI, ATSUO JIMI, YASUHIRO OHMORI, MASAMICHI KOJIRO, JIRO WA ...1989 Volume 36 Issue 2 Pages 59-65
Published: September 01, 1989
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA 70-year-old woman was treated with a simple mastectomy followed by a course of 5000 rad to the breast and chemotherapy with 5-fluorouracil for breast cancer. About 15 months later, the patient died of widespread metastases. An autopsy revealed no recurrent cancer in the breast. The metastases were seen in bones (sternum, ribs and spine), pleura, spleen, uterus, ovaries, small intestine, adrenal glands, and lymph nodes (hilar, periaortic and mesenteric). Histologically, the resected tumor was a solid-tubular carcinoma with an infiltrative growth pattern. At autopsy, the tumor cells in the metastatic foci contained an abundance of lipids in the cytoplasm, while the tumor cells in the primary tumor contained small amounts of lipids.View full abstractDownload PDF (8029K) -
MASAFUMI YOSHIDA, SHINJI NOGUCHI, SHINKEN KURAMOTO1989 Volume 36 Issue 2 Pages 67-74
Published: September 01, 1989
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSL-threo-3, 4-dihydroxyphenylserine (L-DOPS) was administered to six parkinisonian patients for the treatment of gait related akinesia which was refractile to L-DOPA treatment. One responded with marked improvement and one with only mild improvement. Although number of patients who respond markedly to this noradrenaline precursor, L-DOPS, is limited, L-DOPS was felt to be the most effective treatment modality for L-DOPA ref ractile gait related akinesia and L-DOPA related orthostatic hypotension.View full abstractDownload PDF (1134K) -
JINRYO TAKEDA, KEN HASHIMOTO, KIKUO KOUFUJI, TAKAHO TANAKA, TOURU UMEZ ...1989 Volume 36 Issue 2 Pages 75-79
Published: September 01, 1989
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSFrom 1975 to 1984, 894 patients with gastric cancer were operated on in the Department of Surgery at Kurume University School of Medicine. Of these, 86 (10%) had upper gastric cancer invading the esophagus. The 86 resected tumors were divided into two groups according to the surgical approach, thoraco-abdominal or abdominal. Twenty-three (27%) were resected through the abdominal approach and 63 (73%) were resected by the thoracoabdominal approach. The overall positive mediastinal lymphnode metastasis rates for the 55 patients who underwent mediastinal lymphnode dissection by the thoraco-abdominal approach were 22% for differentiated type and 37% for undifferentiated type. The positive mediastinal lymphnode metastasis and the correlation to the extent of esophageal cancer invasion were observed at a minimal 7 mm distance from the esophago-gastric (E-G) junction for the undifferentiated type, and 2.2 cm for the differentiated type. Sixteen patients with cancer invading the esophagus were radically resected by the abdominal approach with an overall survival rate of 39%, while 48 were resected by the thoraco-abdominal approach with a 5 year survival rate of 40%. The 86 resected tumors were further subdivided into two groups according to the year of surgery. From 1975 to 1979, the abdominal approach was employed in 36% and the thoraco-abdominal approach in 64% of the surgeries, with an overall curative resection rate of 47%. However, from 1980 to 1984, the abdominal approach was employed in only 17% and the thoraco-abdominal approach in 83% of the surgeries and the curative resection rate increased to 59%. The 5 year survival rate in stage II and III was 39% for the thoraco-abdominal approach, and 32% for the abdominal approach. The thoraco-abdominal approach was adopted in those patients with more extensive esophageal involvement or with large tumors. The conclusion of this report is a recommendation of extended distal esophagectomy with total gastrectomy by the thoraco-abdominal approach as the best treatment for upper gastric cancer invading the esophagus.View full abstractDownload PDF (575K) -
JINRYO TAKEDA, KEN HASHIMOTO, YOSHIAKI TSUJI, TAKAHO TANAKA, KENJI YAS ...1989 Volume 36 Issue 2 Pages 81-85
Published: September 01, 1989
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThree patients with hepatic cirrhosis who had undergone gastric operations following endoscopic sclerotherapy were retrospectively reviewed. One patient had undergone total gastrectomy for gastric cancer and two had Hassab and Tanner operations for gastric and esophageal varices. All patients were recovering with no complications related to the operations and were free of disease for 2 years, postoperatively. When esophageal varices are found in combination with an upper gastric cancer that requires total gastrectomy, endoscopic sclerotherapy for esophageal varices is contraindicated because severe esophageal injuries may be induced by the sclerosing agent. The Hassab and Tanner method is useful for esophageal and gastric varices after sclerotherapy. A repeat endoscopic sclerotherapy should be performed after this operation.View full abstractDownload PDF (2282K) -
SHINYA SUMIDA, AKIRA NAGATA, KAZUTOYO KANEKO, MIKIO KUBOSHIRO, NAOTO K ...1989 Volume 36 Issue 2 Pages 87-89
Published: September 01, 1989
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe describe a case report of an interstitial pneumonia in which pulmonary involvement of the both lower lobes mimicked idiopathic interstitial pneumonia (IIP) or bronchiolitis obliterans organizing pneumonia (BOOP). Its appearance antedated clinically apparent rheumatoid arthritis by one month and a half.View full abstractDownload PDF (2995K)
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