巻号一覧
38 巻 (1991)
- 4 号 p. 221-
- 3 号 p. 129-
- 2 号 p. 45-
- 1 号 p. 1-
38 巻, 4 号
選択された号の論文の17件中1～17を表示しています
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A Transmission and Scanning Electron Microscopic StudyTETSUO INOKUCHI, RYUJI YOKOYAMA, RYUHEI HIGASHI, YOSHIHIKO TAKAHASHI, ...1991 年 38 巻 4 号 p. 221-232
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーThe perineurial cells of the sciatic nerve of mature albino rats were investigated by using light microscope (LM), transmission electron microscope (TEM) and scanning electron microscope (SEM). The perineurium of the sciatic nerve was composed of several lamellae of thin perineurial cells which were held together by the zonula occludens and also by the zonula adherens. The TEM view of the perineurium revealed that the plasmalemma of the perineurial cells presented numerous caveolae similar to those described in the endothelial cells of blood capillaries. By SEM, the perineurial cells were very thin, flattened out with various shapes from rectangular to hexagonal, and arranged closely to each other in the fashion of a stone pavement around the nerve fascicles. It was possible to isolate the perineurium from the nerve and to demonstrate the cellular border of the perineurial cell by silver impregnation method. The SEM observation of the perineurial cells ascertained the figure of the cells which were seen in the silver-impregnated specimen under LM. The present authors have interest in the fact that shapeand arrangement of the perineurial cells of spinal nerves resemble closely those of the myoid cells in the limiting lamina of the seminiferous tubules of the mammalian testes. The meaning and significance of the similarity between these two types of cells was discussed.抄録全体を表示PDF形式でダウンロード (14877K) -
Demonstration of Hepatoma-Associated Alternative Splicing of mRNA PrecursorsKAZUNORI FUKUDA1991 年 38 巻 4 号 p. 233-241
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーThe synthesis and secretion of fibronectin (FN) was observed in 4 human hepatocellular carcinoma (HCC)-derived cell lines using a serum-free conditioned medium. It was also demonstrated that FNs secreted from these cell lines (HCC-FN) were structurally altered compared to plasma FN produced by normal hepatocytes. Using limited proteolysis with cathepsin D followed by immunoblot analysis with a carboxy-terminal specific antibody, the existence of an extra domain (ED) segment in the carboxy-terminal region of HCC-FNs was confirmed. Expression of the additional nucleotide insert (ED sequence), which is reported to be absent in hepatocyte mRNA and is charac-teristic of cellular FN-mRNA, was confirmed in mRNA from all 4 HCC cell lines. It is now evident that HCC cells secrete different variants of FN compared with normal hepatocytes due to alternative splicing of mRNA precursors. This differential RNA processing seems to be one of the phenotypic alterations associated with the oncogenic transformation of hepatocytes.抄録全体を表示PDF形式でダウンロード (7268K) -
ITSUYO HIROHATA, KATSUHIRO FUKUDA, AKIRA SHIBATA, GBNJIRO YAMAGUCHI, T ...1991 年 38 巻 4 号 p. 243-249
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーThe reproducibility of responses on life style measurements observed during a personal interview was assessed by a test-retest method. Fifty-one apparently healthy male subjects were interviewed twice, mostly within a 10 week interval. Responses on past history, smoking and drinking habits yielded relatively high intraclass correlation coefficients between the two interviews, as compared to the responses on dietary habits for the previous 1 to 2 years, which varied depending on the food items.抄録全体を表示PDF形式でダウンロード (745K) -
Effect of Fetal Bovine Serum, Acetyltrypsin and AgarYOSHIHIRO IMAMURA, SHIGERU YAMAMOTO, MASAHISA SHINGU1991 年 38 巻 4 号 p. 251-258
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーDilution of viruses, which were previously treated with 10μg acetyltrypsin/ml, in MEM supplemented with 2.5% fetal bovine serum caused little damage of cell monolayers resulting in the formation of discrete plaques. When agar and acetyltrypsin were added to the overlay medium at the concentrations of 0.8% and 5μg/ml, respectively, clear plaques were induced. Linear relationships were obtained between virus concentration and the number of plaques, thus the precedure described in this report might be used for reliable plaque assay of rotaviruses. Moreover, these conditions for plaque formation were successful for estimating isolated viruses, as well as standard strains.抄録全体を表示PDF形式でダウンロード (8683K) -
Hydrogen-1 Two-Dimensional Nuclear Overhauser Spectroscopy StudiesMASANOBU CHINAMI, MASAHISA SHINGU1991 年 38 巻 4 号 p. 259-263
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーTwo-dimensional nuclear magnetic resonance (2d-NMR) dipolar correlation spectroscopy (NOESY) for the calcium binding protein, staphylococcal nuclease, was used to study the conformations in solution as a function of pH. A series of 2d-NOESY spectra of the nuclease H124L-Ca_??_-thymidine 3'5'-bisphosphate ternary complex demonstrated significant pH dependent changes: NOE cross peaks between 46HisδH and an aliphatic proton at 2.66 ppm appeared at pH 10.2, but not at pH 5.5. Some other NOE cross peaks between aromatic and aliphatic protons displayed chemical shift changes in ω2 or both dimensions (ω1, ω2). These results indicated that a local rearrangement accompanies the ionization of the functional groups and has a role in enzyme function.抄録全体を表示PDF形式でダウンロード (2337K) -
TAKASHI NISHIDA, KIMIO USHIJIMA, TAKAAKI ODA, TORU SUGIYAMA, YOSHIMASA ...1991 年 38 巻 4 号 p. 265-269
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーA case of minimal deviation adenocarcinoma (MDA : adenoma malignum) of the uterine cervix associated with ovarian mucinous carcinoma is documented. Diagnosis was possible only retrospectively after surgery by histological examinations including immunohistochemistry. Three courses of chemotherapy, consisting of cisplatin, doxorubicin and ifosfamide, could eradicate the residual diseases of ovarian cancer from the peritoneal cavity, but was insufficiently effective against lymph node metastases of the cervical MDA. Subsequently, the disease flared-up retroperitoneal ly during the sixth course of treatment course, suggesting chemoresistance developed, and further chemotherapy using different regimens were not effective. Therapeutic intractability of MDA as well as the diagnostic difficulty was again emphasized.抄録全体を表示PDF形式でダウンロード (5335K) -
KIKUO KOUFUJI, JINRYO YAKEDA, KEN HASHIMOTO, TAKAHO TANAKA, TERUO KAKE ...1991 年 38 巻 4 号 p. 271-274
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーDuring the 14 years from 1976 to 1989, 1442 gastric cancers were resected in the Department of Surgery at Kurume University. 546 (37.9%) were primary early gastric cancers. One (0.2%) of these was associated with a synchronous liver metastasis. In the advanced gastric cancers, the rate of synchronous liver metastasis was 12.8%. However, synchronous liver metastasis with an early gastric cancer is quite rate. Only 19 cases have been reported in the Japanese literature. A case involving an early cancer, 10 mm in diameter, that was associated with liver metastasis is reported.抄録全体を表示PDF形式でダウンロード (2980K) -
YOSHIAKI HONDA, YOSHIKAZU ZINNOUCHI, ICHIROU MUARI, HIROSHI SHOJI, KOT ...1991 年 38 巻 4 号 p. 275-279
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーA 23 year-old man was admitted because of weakness and atrophy in both tights. He was 184 cm in height with arachnodactyly and had a mild dilatation of the ascending aorta which was detected by cardiac echogram and chest CT scan. A laboratory examination revealed normal serum values for mucopolysaccarides and amino acids, and 46XY chromosomes. These findings indicate a Marfan's syndrome phenotype. A neurological finding showed a proximal dominant muscle atrophy and increased deep tendon reflexes. The EMG revealed a polyphasic action potential, and a subsequent muscle biopsy demonstrated a small group atrophy and atrophy of Type II fibers. Neuroradiological studies of brain and spinal cord indicated no substantial abnormalities. Only 4 cases of Marfanoid habit accompanied by primary nervous system disturbances have been reported and these had variable complications or severe neurological deficits. The present case, which involved mild neurogenic muscle atrophy and brisk deep tendon reflexes without complications except myopia, was unique.抄録全体を表示PDF形式でダウンロード (3300K) -
Analysis of Prognostic FactorsKEI MATSUOKA, SHOGO UEDA, YUJI OHYABU, SHINSHI NODA1991 年 38 巻 4 号 p. 281-286
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーA recognition of prognostic factors in the treatment of patients with bladder cancer is important. Using a variety of clinical and histological parameters, we have performed monovariable and multivariable analyses on the survival rates of patients. Eighty three patients with bladder cancer who underwent total cystectomy were studied. Eleven factors were evaluated, i. e. age, sex, tumor form, number and size of the tumors, histological stage and grade, intramural infiltration pattern, presence of intramural lymphatic and venous invasion, and the use of adjuvant chemotherapy. Monovariable analysis of survival curves indicated that histological stage and grade, intramural lymphatic invasion, venous invasion, and infiltration pattern are important as prognostic factors. Multivariable analysis, which is more relevant than monovariable analysis, showed that histological stage, followed by age, histological grade, intramural lymphatic invasion and infiltration pattern, in order of decreasing value, were most important as prognostic factors.抄録全体を表示PDF形式でダウンロード (632K) -
TAKAHO TANAKA, JINRYO YAKEDA, KIKUO KOUFUJI, KEN HASHIMOTO, TERUO KAKE ...1991 年 38 巻 4 号 p. 287-290
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーDuring the 12 years from 1977 to 1988, a total of 425 cases of early gastric cancer (EGC) were treated by resection. Of these, 53 (13%) had lymph node metastases, occurring in 6 cases of mucosal cancer (m-cancer) and 47 cases of submucosal cancer (sm-cancer). Among the patients with positive lymph node metastases, 46 (87%) had metastases in the Group 1 perigastric regional nodes, and 8 (2%) had metastases in Group 2 lymph node. These date support the general view that lymph node metastasis occurs in only 2-5% of m-cancers and 15-20% of sm-cancers, and then mainly in Group 1 lymph nodes. A rare case of early cancer with Group 3 juxta regional lymph node metastasis (n3+) is described in this report with special attention to the surgical management and postoperative chemotherapy.抄録全体を表示PDF形式でダウンロード (2550K) -
Present Status and ProblemsAMJAD HUSSAIN, MUSHTAQ AHMAD KHAN, SHAMIM AHMAD QAZI, GUL NAYER RAHMAN1991 年 38 巻 4 号 p. 291-294
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーPediatric neurologic disease is still progressive health problem in developing countries, Disorders of mental and motor development (34.8% of total 5234 neurological patients in 1988-89), seizure disorders (25.8%) and infections of the nervous system (18.9%) are the most common neurological problems in the Islamabad Children's Hospital (ICH), Pakistan. These figures differ from those in children's Hospitals in developed countries such as Japan. ICH needs to establish a good neurology department with better physiother-apy and rehabilitation centre, a workshop and a facilitated physiological laboratory. The global situation can be controlled by improving the basic life and fundamental factors to improve the hygiene and general health status of mothers and their children. The provision of rural rehabilitation services is also needed. Also international technical cooperation and support would be helpful.抄録全体を表示PDF形式でダウンロード (509K) -
KEIJI OKUBO, HIROSHI HACHISUKA, TADASHI KARASHIMA, YOICHIRO SASAI1991 年 38 巻 4 号 p. 295-306
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーThe functional properties of the KOLT-2 antigen, which was placed among the CD28 group in the 3rd International Workshop on Human Leukocyte Differentiation Antigens, are described. The method of production and a detailed characterization of the monoclonal antibody KOLT-2 including stain affinities and influence of T cell activation are presented. While KOLT-2 antigen was selectively expressed on human thymocytes, adult T-cell leuke-mia-lymphoma cells and activated T cells, the antigen was also spontaneously expressed by resting T cells after 24 hrs culture. Expression was transient, since it disappeared after 96 hrs. DNA synthesis and expression of Tac antigen on activated T cells was enhanced by stimulation with the KOLT-2. These observations suggest that the KOLT-2 antigen may have an important role in the early stages of T cell activation.抄録全体を表示PDF形式でダウンロード (2741K) -
TADASHI NISHIKAWA, AKIRA TSUDA, MASATOSHI TANAKA, MARIKO NISHIKAWA, IT ...1991 年 38 巻 4 号 p. 307-310
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーA mentally retarded patient who developed polydipsia and hyponatremia following the long-term use of neuroleptics is described. Before the investigation, he was treated with a combination of five drugs : diazepam, propericiazine, carbamazepine, lithium carbonate and trihexyphenidyl. The treatment was switched to diazepam alone; to propericiazine, trihexyphenidyl and diazepam; to carbamazepine and diazepam; and finally to lithium carbonate with diazepam. Under the five drug treatment protocols, his weight gains during the day were monitored, every day as an index of the water he drank in the day time. The combination of the five drugs caused the greatest weight differences per day and the other drug regimens, except diazepam alone, seemed to increase the weight differences to some extent. These findings indicate that a drug combination such as the neuroleptics, lithium and carbamazepine used for emotional stabilization must be carefully monitored to avoid the induction of compulsive drinking.抄録全体を表示PDF形式でダウンロード (386K) -
Improved ManagementJINRYO TAKEDA, KEN HASHIMOTO, KIKUO KOUFUJI, TAKAHO TANAKA, ISSEI KODA ...1991 年 38 巻 4 号 p. 311-315
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーFrom 1978 to 1989, a total of 1272 patients with gastric cancer were admitted to Kurume University Hospital. Of these, 1184 (93%) underwent gastric resections. Of the resected cancers, 140 cases were gastric cancers invading the esophagus, as confirmed by postoperative pathological studies. For all 168 gastric cancers invading the esophagus, the resectability rate was 83% (140/168). These cancers were subdivided chronologically, with those during 1978-1983 included in Group 1 and those during 1984-1989 in Group 2. Group 2 patients were treated with a higher proportion of aggressive extended radical operations, such as combined resections of the diaphragm and lymph node dissections as far as the paraaortic lymph nodes (N4). The resectability rate was 76% in Group 1 and 93% in Group 2, due to the more aggressive operations. A lower esophagectomy with a total gastrectomy, mainly from a left thoracoabdominal approach, was performed for 71% of the patients in Group 1, and for 90% in Group 2. Lymph node metastasis was related to the extent of esophageal invasion and inversely related to the 5 year-survival rate. In all cases of esophgeal invasion of less than 1 cm, there were no mediastinal lymph node metastases, and the 5 year-survival rate was 76%. On the other hand, when esophageal invasion was more than 4cm, 50% had mediastinal lymph node metastases and the 5 year-survival rate was zero. The tumor size was also related to lymph node metastasis. When the maximal tumor length was less than 5cm, a negative lymph node metastasis was found in 78% of cases, and the 5 year-survival rate was 76%. On the other hand, when the tumor length was more than 10 cm, only 6% had a negative lymph node metastasis and the 5 year-survival rate was only 15%. The 5 year-survival rate with curative resection was 45% for Group 1, and 71% for Group 2. For those at stage III, 12% of Group 1 could be curatively resected with an extended radical operation, 46% of Group 2 (p<0.05) were cured due to the more aggressive operations in this group. The more aggressive extended radical operation is useful for improving the cure rate without increasing operativemortality.抄録全体を表示PDF形式でダウンロード (616K) -
Evaluation by Intracoronary Infusion of Isosorbide Dinitrate in Long-Term Follow-UpTETSU SUGIMURA1991 年 38 巻 4 号 p. 317-325
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーThe coronary artery lesions in Kawasaki disease (KD) are thought to be a possible risk factor for atherosclerosis in the long term from the pathological point of view. Here we report results of a comparative control study to investigate the distensibility of the coronary artery in KD. A total of 146 patients were divided into 5 groups as follows. (I) Normal group (N) ; consisting of 44 patients with a known history of KD but with no coronary artery lesion. Among this group of patients those who each showed a regression in their coronary artery aneurysms were divided into 2 subgroups according to the time since onset of KD. (II) A group in the early stage after regression (ER) ; consisting of 18 patients with a known history of KD followed for 1.8±0.6 years. (III) A group in the later stage after regression (LR) ; consisting of 22 patients with a known history of KD followed for 9.4±2.8 years. (IV) an abnormal group (A); consisting of 21 patients followed for 7.9±4.0 years with a persistent aneurysm and/or stenosis in a coronary artery at the time of this study. And (V) a control group (C); consisting of 41 patients with a congenital heart disease such as a small ventricular septal defect or mild pulmonary stenosis or patent ductus arteriosus and no history of KD. In each case, the coronaryy artery diameter was measured by angiography before and after intracoronary infusion of isosorbide dinitrate (ISDN). Then, the percent change in the coronary artery diameter was calculated as follows;«(After ISDN-Before ISDN)/Before ISDN×100». The percent changes were 16.168±12.494% (N), 11.622±6.975% (ER), 9.891±9.190% (LR), 6.338±7.723% (A), and 14.561±11.652% (C), respectively. In the A group, there was significantly poorer distensibility compared with C, N, or ER group. And the LR group also demonstrated significantly poorer distensibility compared with the N group (P<0.05). Results of this study suggest that the coronary artery in KD may become stiff not only in the persistent abnormal lesion but also possibly in the regressed aneurysm over the long term. Such stiffness may then constitute a risk factor for atherosclerosis.抄録全体を表示PDF形式でダウンロード (4645K) -
YASUKI MAENO1991 年 38 巻 4 号 p. 327-336
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーFetal echocardiographic examination was performed on 945 pregnant women (normal pregnancy: 291, high risk pregnancy: 654) since 1980. Of these, 39 fetuses (4.1%) were diagnosed as having cardiac arrhythmia. Fifteen fetuses had bradycardia, 7 tachycardia and 17 had an ectopic beat. These had been followed from 1 day to 8 years (mean 1 year and 6 months) soon after birth. Of the 15 cases with bradycardia (complete AV block; 8, 2:1 AV block; 3 and sinus bradycardia; 4), four resulted in an intrauterine fetal death, one was terminated and 5 died soon after birth. The remaining 5 cases are alive and 3 of these 5 have received an implanted pacemaker. Of these 15 cases with bradycardia 7 were associated with congenital heart disease, 6 of which died. Seven cases had tachycardia (supraventricular tachycardia : 3 and atrial flutter with 2:1 AV block: 3). Transplacental antiarrhythmic drug (digoxin and/or verapamil) administration was instituted in 5 cases and a conversion of the arrhythmia was achieved in 4 . Paroxysmal tachycardia still remained after delivery in the other 3 cases. Two cases with supraventricular tachycardia (one of them with WPW syndrome type B) were resolved. One case has had persistent chaotic atrial rhythm for 7 years after birth. Of the 17 with an ectopic beat, 11 cases were diagnosed to have a supraventricular ectopic beat and 6 cases with a ventricular ectopic beat. A remaining arrhythmia was observed in 10 cases after delivery but all of these were resolved within 3 months after birth. Fetal tachycardia had relatively favorable prognosis because usually the intrauterine treatment was effective. However, fetal bradycardia had poor prognosis and further investigations to establish more effective treatments are essential.抄録全体を表示PDF形式でダウンロード (5178K) -
HIDEKI YANO, HIDEHO HIGASHI, SYOGORO NISHI1991 年 38 巻 4 号 p. 337-339
発行日: 1992/02/01
公開日: 2010/02/08
ジャーナル フリーPDF形式でダウンロード (301K)
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