The Kurume Medical Journal
Online ISSN : 1881-2090
Print ISSN : 0023-5679
ISSN-L : 0023-5679
38 巻, 2 号
選択された号の論文の12件中1~12を表示しています
  • SHIGERU YAMAMOTO, HIDEFUMI KABUTA, MASAHISA SHINGU
    1991 年 38 巻 2 号 p. 45-50
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    The DNAs of 14 strains of varicella-zoster virus (VZV) isolated from epidemiologically unrelated individuals were analyzed by restriction endonuclease cleavage and agarose gel electrophoresis. Small but distinct differences in restriction patterns between the isolates were observed when the DNAs were digested with each of four enzymes examined (EcoRI, SalI, PstI, and Hind III). Six out of 14 isolates (43%) were lacking the PstI cleavage site between K and N fragments; one isolate was lacking the Hind III cleavage site between M and N fragments. No changes were observed in restriction patterns in DNA of one of the strains after 33 passages in cultured cells.
  • MASANOBU CHINAMI, EIKO TANIKAWA, HIROSHI HACHISUKA, HACHISUKA SASAI, M ...
    1991 年 38 巻 2 号 p. 51-55
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    To quantitate DNA from photographs, correlations between chromato-scanned (in the fluorescence mode) and virtual areas from white DNA bands on photographs were examined. A linear correlation between the two measurements with coefficients higher than 0.89 was observed. The dynamic range of the fluorescence detection yielded good linearity for a wide range of amounts of DNA (μg-ng) on the photograph.
  • KEIJI OKUBO, TADASHI KARASHIMA, HIROSHI HACHISUKA, YOICHIRO SASAI
    1991 年 38 巻 2 号 p. 57-63
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    High concentrations of interferons can inhibit keratinocyte proliferation and induce the expression of HLA-DR antigen on keratinocytes. In the present study, the effects of low concentrations of recombinant human interferon α, β and γ were examined on DNA synthesis and the expression of HLA-DR and bullous pemphigoid (BP) antigens in normal human keratinocytes. Low concentrations of interferons induced DNA synthesis in normal human keratinocytes when epidermal cell growth factor and low Ca++ were used during the initial stages of culturing. This result indicates that physiological concentrations of interferons can induce keratinocyte activation.
  • Case Report
    EIICHIRO HONDA, TAKASHI HAYASHI, YUKI OSHIMA, SHIN GOTO, TETSUZO OGASA ...
    1991 年 38 巻 2 号 p. 65-71
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    A 65 Year-old man with an episode of absence attacks and mild mental changes was admitted to the clinic. A skull X-ray film demonstrated a mild spotty calcification in the left frontal region. The lesion was recognized as a heterogeneous high density and irregular round egg-sized tumor on computerized tomography and appeared as an avascular mass with cerebral angiography. The patient also had abnormal low-intensity spots that were widely scattered in the supratentorial, parieto-temporal cortex, cerebellum and the pons on MRI (gradient-field echo method). Abdominal echography demonstrated a single tumor shadow in the liver. Only the frontal lesion removed and histological examination confirmed the diagnosis of a cavrnous angioma. The scattered low density lesions observed with the MRI (both T1 and T2 weighted) were also indicative of a cavernous angioma. These lesions were probably caused by hemosiderin at different phases of chemical breakdown. The cases of multiple cavernous angiomas reported by McCormick and Rubinstein had a similar appearance with a spot-shaped hemorrhage or angioma. Many other reports of multiple lesions will probably appear in the future with the use of MR, since a small cavernous angioma can be easily visualized by gradient-field echo method.
  • Case Report
    EIICHIRO HONDA, TAKASHI HAYASHI, YUKI OSHIMA, TETSUZO OGASAWARA, HIDET ...
    1991 年 38 巻 2 号 p. 73-79
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    A radical operation in an elderly man with a giant aneurysm of the vertebral artery was successfully performed. The aneurysm in the posterior fossa caused symtoms such as a disturbance of the lower cranial nerves, as well as pyramidal and cerebellar signs. An aneurysmectomy was performed for decompression of the brain stem and cranial nerves. An extended lateral suboccipital approach was chosen which made it possible to remove the rim of the foramen magnum and reach the condylar fossa. This approach also made access to the vertebro-basilar junction possible for trapping. After resection of the aneurysm and thrombectomy (endaneurysmal microendarterectomy), the aneurysmal neck as well as its clipping was closed, and consequently its parent artery. The procedure is described in this report.
  • JINRYO TAKEDA, KEN HASHIMOTO, KIKUO KOUFUJI, TAKAHO TANAKA, ISSEI KODA ...
    1991 年 38 巻 2 号 p. 81-85
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    From 1979 to 1988, a total of 1083 patients with gastric cancer underwent resection at Kurume University Hospital. Among these cancers, 183 (16.8%) were located in the upper third of the stomach. Of these, 56 (5.2%) were adenocarcinomas in the esophagogastric (E-G) junction. Cancer in this area was designated as cardia cancer when the focus of the cancer was macroscopically located within 2cm of the E-G junction line and the tumor was less than 8cm in diameter. The incidence of early gastric cancer in the cardia was only 13%, while the incidence for stage III advanced cancer was high at 46%, and the positive lymph node metastasis rate was 59% Thirty-nine (70%) were cured by resection with a 5 year-survival rate of 64%, while for non-curative resection, this was only 10%. Twenty-two cases of either advanced cardia or advanced CE cancer underwent combined resection of the diaphragm. The rate of invisible metastasis to the diaphragm was 20% in our experimental study. The two year-survival rate for a combined resection of the diaphragm was 64%, while the rate for those who did not undergo a required combined resection was 42%.
  • MASATOSHI ISHIBASHI, NOBUSHIGE HONDA, FUMITAKA YOSHIOKA, TOSHIAKI YOSH ...
    1991 年 38 巻 2 号 p. 87-92
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    To evaluate the primary site, pulmonary hilar, and mediastinal lesions in patients with lung cancer, thallium-201 using single-photon emission computed tomography (SPECT) was used as a tumor agent. The study population consisted of 7 patients (5 men and 2 women), aged 57 to 82 years (mean 68). T1-201 tomography imaged positive at the primary site in all patients with lung cancer. The images demonstrated the tumor and/or mediastinal lymph nodes that were greater than 2.0 cm. In particular, each tomograms facilitated the identification of the T1-201 increased uptake in proportion to primary site. The short waiting period after injection with T1-201 clearly offers a major advantage over alternative tumor imaging agents, such as Ga-67 or radiolabeled monoclonal antibodies. Futhermore, T1-201 SPECT may be useful to detect the tumor and/or mediastinal lymph nodes in patients with lung cancer.
  • Theory, Technical Considerations and Clinical Application
    MASATOSHI ISHIBASHI, FUMITAKA YOSHIOKA, NORIYOSHI UMEZAKI, SEIICHIRO M ...
    1991 年 38 巻 2 号 p. 93-107
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    The recent expansion of interventional cardiovascular techniques has stimulated the development of non-invasive cardiac studies, to evaluate the outcome of the interventional therapy. Radionuclide ventriculographic technique provides to quantify global left ventricular systolic/diastolic performance, and evaluate the regional left ventricular wall motion during rest or exercise. This concept was extended from the “bedside” to the ambulatory environment with the description of a battery powered device, the radionuclide ventricular function monitor. To assess the performance of cardiac function using radionuclide ventriculography to that using the ambulatory ventricular function monitor, the systolic and diastolic function were measured at rest in a series of healthy volunteers (n=10) and in patients with cardiovascular disease (n=23). Seventeen patients had coronary artery disease (CAD) with prior myocardial infarction, three patients had coronary artery disease, and three patients had dilated cardiomyopathy. The 23 patients manifested a wide variation in LV systolic function. The relationship between the multiple gated acquisition (MUGA) -ejection fraction and the ambulatory ventricular function monitor-ejection fraction correlated well (r=0.90). As a complement to the radionuclide perfusion studies, cardiac blood pool imaging and radionuclide ventricular function monitoring allow for through non-invasive description of cardiac physiology an function in patients with various cardiac disorders.
  • Case Report
    MASAFUMI YOSHIDA, KATSUYASU OHTSURU, SHINKEN KURAMOTO
    1991 年 38 巻 2 号 p. 109-112
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    The case of a 20-year-old male with a mechanical disruption of a shunt valve in which proximal metal portion of the Holter valve was dislocated out of silicone casing is reported. In the three cases previously reported by Zander and Campiche (1980), mechanical traction force exerted on the two metallic extremities of the Holter valve incrusted on the growing skull was incriminated as the causative mechanism. In the present case, growth-related mechanical traction force was exerted on the extended portion of the shunt system. This suggests that the shunt valve of this type can be a locus minoris to long-standing mild mechanical traction force exerted on the extended portion of the shunt system.
  • KENJI YASUMOTO, JINRYO TAKEDA, KEN HASHIMOTO, KIKUO KOUFUJI, TAKAHO TA ...
    1991 年 38 巻 2 号 p. 113-116
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    Twenty-four cases of resected remnant cancers following partial gastrectomy were retrospectively investigated for benign gastroduodenal disease. The time interval between the initial gastrectomy and the remnant gastrectomy was more than 10 years in 19 (79%) patients and less than 10 years in 5 (21%) patients. There were 2 cases with remnant cancer at stage I, 1 at stage II, 3 at stage III and 13 at stage IV for the all cases with a time interval of more than 10 years. Early-type remnant gastric cancer has a fre-quency of only 5%. The proportion of positive lymph node metastases was high, in 84%.
  • JINRYO TAKEDA, KEN HASHIMOTO, TAKAHO TANAKA, KIKUO KOUFUJI, HIDEAKI YA ...
    1991 年 38 巻 2 号 p. 117-122
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    Thirty-two cases of gastric cancer associated with hepatic cirrhosis were reviewed, retrospectively. These patients represented 1.3% of 2590 patients with gastric cancer who were treated over the 23 year period from 1966 to 1988. The male to female ratio was 9.7:1 for gastric cancer patients with hepatic cirrhosis (mean age, 63.2 years) and 2:1 for all patients with gastric cancer (mean age, 61.2 years). Among the 32 patients, one was inoperable, and 31 patients underwent surgical exploration. The gastric cancers were resected in 28 patients (90.3%), while the cancers in 3 patients (9.7%) were non-resectable. Twenty-two patients underwent curative resections with a five-year survival rate of 51%. Postoperative complications occurred in 6 patients (20%), but no anastmotic leakage occurred. There were no operative mortalities. On the basis of the present study, different surgical procedures are indicated depending on the preoperative hepatic conditions for patients with gastric cancer accompanied by hepatic cirrhosis.
  • HIRONARU FUKUSHIMA, MAYUMI FUKUSHIMA, MATSUJI MIZOKAMI, TOSHIHIKO TANA ...
    1991 年 38 巻 2 号 p. 123-127
    発行日: 1991/09/01
    公開日: 2009/08/11
    ジャーナル フリー
    This paper presents a case of a 73-year-old woman with a Borrmann type 4 gastric cancer with diffuse protruded lesions at the angles of the mouth, oral cavity and esophageal mucosa, which was categorized as a malignant acanthosis nigricans.
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