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Volume 39, Issue 3
Displaying 1-13 of 13 articles from this issue
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TAKAHIRO INOKUCHI, TOSHIHIRO HIDAKA, YASUTAKA NODA, JUICHI NISHI, MASA ...1992 Volume 39 Issue 3 Pages 133-140
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSEpidermal homogenates of hairless mice contained a large amount of lipid material showing a single peak on reverse phase (RP)-high pressure liquid chromatography (HPLC) with a maximum absorbance of 234 nm, which was different in retention time from arachidonate metabolites such as 12-HETE, 15-HETE and 5-HETE. The production of this material was dependent on exogenous linoleate concentration, protein concentration and buffer pH. This material was identified to be a mixture of 13-HODE and 9-NODE on the basis of UV absorbance spectra, retention times on RP-HPLC, straight phase (SP)-HPLC, gas chromatography-mass spectrometry (GC/MS) and mass spectra obtained. As assessed by SP-HPLC after saponification, these two HODEs were found to exist primarily in esterified forms in the skin. Neither substance was produced following heat denaturation of the homogenate. These results indicate that 13-and 9-HODEs are produced from linoleate enzymatically at physiologically relevant levels in the epidermis of hairless mice. Thus, it is possible that these two materials may play some important role in pathophysiology of the skin.View full abstractDownload PDF (3714K) -
JINRYO TAKEDA, KEN HASHIMOTO, KIKUO KOUFUJI, ISSEI KODAMA, KEISHIRO AO ...1992 Volume 39 Issue 3 Pages 141-145
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSFrom 1976 to 1989, a total of 1303 patients with gastric cancers underwent gastrectomies in the First Department of Surgery, Kurume University Hospital. Of these, 358 (27.5%) were total gastrectomies, 84 (6.4%) were proximal gastrectomies and 825 (63.1%) were distal gastrectomies. The 5-year survival rate was 44.8% after the total gastrectomies, 38.9% after the proximal and 72.4% after the distal gastrectomies. The 5-year survival rate was 86.2% with the absolute curative resection, 36.3% with the relative curative resection, 29.3% with the relative non-curative resection and 9.4% with the absolute non-curative resection. Macroscopically, the 5-year survival rate was 95.1% for type 0 (early cancers), 61.3% for Borrmann type 1, 58.8% for Borrmann type 2, 37.5% for Borrmann type 3 and 16.5% for Borrmann type 4. According to the pathological cancer stage, the 5-year survival rate was 94.8% for stage I, 79.3% for stage II, 49.2% for stage III and only 11.3% for stage IV.View full abstractDownload PDF (516K) -
HYOUN CHULL KIM, TADAMITSU KAMEYAMA1992 Volume 39 Issue 3 Pages 147-151
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSBulging of the mandibular angle is considered to be unattractive in the Orient since it gives the face a quadrangular and muscular appearance. In spite of its muscular origin, surgery should be aimed toward bony reduction or osteoplasty and supplemental myotomy. An intraoral approach was utilized with an oscillating saw to resect a predetermined segment of bone (mandibular angloplasty). In 2 patients with a prominent bilateral mandibular angle, only the bony angle was resected. The improvement of facial esthetics was subtle, and the acceptance and satisfaction of the patients were very good. A review of the literature is included with comments on the diagnosis and treatment of benign masseteric hypertrophy.View full abstractDownload PDF (3569K) -
AKIRA ISHIBASHI, TOSHI ABE, KAZUYUKI KOJIMA, HIROSHI NISHIMURA, KIMINO ...1992 Volume 39 Issue 3 Pages 153-158
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSMultiple small lesions of low intensity on T2-weighted images identified by MR imaging were observed in four patients. There were no definite associations between the patients' clinical symptoms and the lesions. MR imaging showed multiple, small areas with slightly high and/or low-intensities on T1-weighted images, and low intensities on T2-weighted images. In two patients these low intensity areas were increased in size with field echo images. These MR studies indicate that multiple ruptures and/or hemorrhagic infarctions of microaneurysms may occur in the brain without any clinical manifestations.View full abstractDownload PDF (3152K) -
GUANG-HAN ZHANG, HIROMASA FUJITA, HIDEAKI YAMANA, TERUO KAKEGAWA1992 Volume 39 Issue 3 Pages 159-165
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSNinety-five patients with thoracic esophageal cancer who had undergone radical esophagectomies through right thoracotomies from 1986 to 1989 were statistically analyzed semi-quantitatively to identify the risk factors predicting “operative (within 45 days of operation) or hospital death.” Age, pulmonary function (%VC or %FEV1.0), cardiac function (EKG or Master test), renal function (Ccr), hepatic function (R15' ICG), diabetes mellitus (75 OGTT), extent of tumor invasion to the adventitia, and the type of operative procedure were each scored according to severity; 0 (no risk), 1, 2, or 3 (high risk). Patients with no severe postoperative complications had an accumulated score of less than 8 and comprised Group I, while those suffering an “operative death” had a total score of 8 or more, and comprised Group II. Group III included those suffering a “hospital death.” There was a significant difference between Group I and Group II (p<0.005), but not between Group I and Group III. “Operative deaths” could be preoperatively predicted from the risk factors. However, “hospital deaths” could not be predicted, since they resulted mainly from recurrences of the cancer. In cases with scores of 8 or more the operative procedure should be changed to a simpler one for an improved prognosis.View full abstractDownload PDF (3444K) -
HIROMASA FUJITA, TERUO KAKEGAWA, HIDEAKI YAMANA, ICHIRO SHIMA, HIROSHI ...1992 Volume 39 Issue 3 Pages 167-174
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe efficacy of an extended radical lymph node dissection for carcinoma in the thoracic esophagus is controversial. Results of a multivariate analysis using clinical data from 127 cases collected from 1982 to 1988 are reported. Twenty-seven of these patients underwent an extended radical (cervico-thoraco-abdominal: 3 fields) lymph node dissection which was recently developed in Japan, while others underwent a standard (thoracoabdominal: 2 fields) lymph node dissection. They all had a locally-curative resection of the tumor through a right thoracotomy. In this study, 13 factors commonly affecting prognosis were examined: sex, age, cancer location, tumor length, radiographic type, depth of invasion, lymph node metastasis, tumor differentiation, postoperative radiotherapy, chemotherapy, operative risk, postoperative complications, and 3-field or 2-field dissection. Based on the survival-rate curves using Kaplan-Meier's statistics, the 3-field dissection was superior to the 2-field dissection. Moreover, when other prognostic factors were adjusted using Cox's proportional hazards general linear model, the same result was obtained from survival-rate curves. From this analysis, it can be concluded that a 3-field dissection is a better approach for management of carcinoma in the thoracic esophagus.View full abstractDownload PDF (2877K) -
A Comparative and Multivariate Analysis of PrognosisHIROMASA FUJITA, TERUO KAKEGAWA, HIDEYUKI KAWAHARA, HIDEAKI YAMANA, IC ...1992 Volume 39 Issue 3 Pages 175-181
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSControversy remains over the comparative efficacy and subsequent prognosis for preoperative radiation for carcinoma of the esophagus involving the trachea, bronchus, and/or aorta. Results of a multi-variate analysis are reported using clinical data from 57 cases from 1981 to 1987. Based on both the survival-rate curves using the Kaplan-Meier method and the adjusted survival-rate curves using Cox's proportional hazards linear model, there was no significant difference in prognosis between patients who received preoperative radiation and those who did not. This analysis indicates that preoperative radiation at doses of 30Gy produces no clinical advantage and therefore is not the best treatment for carcinoma of the esophagus involving these adjacent organs.View full abstractDownload PDF (1756K) -
A Comparative and Multivariate AnalysisHIROMASA FUJITA, TERUO KAKEGAWA, HIDEYUKI KAWAHARA, HIDEAKI YAMANA, IC ...1992 Volume 39 Issue 3 Pages 183-189
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSControversy remains over the comparative efficacy and subsequent prognosis of resections for carcinomas of the esophagus involving the trachea, bronchus, and/or aorta. Results of a multi-variate analysis are reported using clinical data from 103 cases from 1981 to 1987. Based on the survival-rate curves according to the Kaplan-Meier method, resection was superior to non-resection. However, when other prognostic factors were adjusted using Cox's proportional hazards linear model, there was no significant difference between the resection and non-resection groups. This analysis indicates that esophagectomy is not necessarily the best approach for carcinoma of the esophagus involving these adjacent organs, although it must be remembered that resection provides excellent palliation.View full abstractDownload PDF (1779K) -
Reports of Two Cases and a Review of the Literature in JapanOSAMU MORI, HIROSHI HACHISUKA, YOICHIRO SASAI1992 Volume 39 Issue 3 Pages 191-193
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSTwo cases of sclerotic fibromas of the skin are presented. Clinical and light-microscopic findings are also reviewed from 8 sclerotic fibromas of the skin arising in other Japanese patients. The patients in this series had no manifestations of Cowden's disease.View full abstractDownload PDF (1624K) -
KIYOHISA IMAISHI1992 Volume 39 Issue 3 Pages 195-201
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIntra-abdominal implantation of 7, 12 dimethylbenz [a] anthracene (DMBA)-induced rat ovarian cancer tissue produces intraperitoneal carcinomatosis with a high incidence. The peritoneal carcinoma produces malignant ascites in 62% of the donor rats. The ascites is bloody in appearance and includes an average of 1.2×106 cancer cells/ml. To observe the transplantability of the ascitis, 0.1ml of a condensed acsites with 4×106 cancer cells was injected into the abdominal cavity of 118 infant rats that were 2 to 4 days old. In 103 rats (87%), the ascitic cells were successfully transplanted. Twelve rats were sacrificed each week from the 2nd to the 6th week following the inoculation. The omentum was the first site at which the metastastic tumor appeared following the inoculation. Then the tumor disseminated throughout the intraperitoneal cavity and produced bloody ascites by the 3rd week. Eighty-four rats were observed to determine the survival, and it was 34±10 days. Cytologically the ascites had clusters of tumor cells resembling bunches of grapes. The ultrastructure of the ascitic cells was globular shaped with many microvilli and epithelial attachments. The histology of the developed tumor was that of an adenocarcinoma. Due to morphological similarity with advanced human ovarian cancer and the high reproducibility, this experimental system could be a feasible model for human ovarian cancer, especially the type which produces malignant ascites.View full abstractDownload PDF (4469K) -
RYOHEI TANABE1992 Volume 39 Issue 3 Pages 203-208
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThirty-two blood flow velocity wavef orms of the fetal renal artery, umbilical artery and fetal middle cerebral artery were recorded by a pulsed Doppler ultrasound from 28 to 38 gestational weeks in 32 intrauterine growth-retarded (IUGR) fetuses without structural defects. The nonstress test (NST) was performed on the day of pulsed Doppler ultrasonographic examination to assess fetal well-being. Of the 32 fetuses, the pulsatility index (PI: peak systolic velocity minus end diastolic velocity over mean velocity) values in the fetal renal artery were in the normal range in 26 measurements (81.3%), high in 2 (6.3%) and low in 4 (12.5%). The resistance index (RI: peak systolic velocity minus end diastolic velocity over peak systolic velocity) values in the umbilical artery and fetal middle cerebral artery were determined simultaneously in all the patients examined. Of the 12 fetuses with high RI values in the umbilical artery and low RI values in the fetal middle cerebral artery, the PI values in the fetal renal artery were within the normal range in 11 measurements (91.7%) and high in 1 (8.3%). Of the 9 fetuses with loss of fetal heart rate baseline variability in NST, the PI values in the fetal renal artery were within the normal range in 7 measurements (77.8%), high in 1 (11.1%) and low in 1 (11.1%). These data suggest that fetal renal blood flow may not change under the condition of chronic hypoxic state, although the NST shows fetal distress and the pulsed Doppler ultrasound reveals a brain sparing effect in the fetal middle cerebral artery. It is hypothesized that the fetal renal blood flow is controlled by an autoregulation mechanism for oxygen delivery presumably located in the renal artery.View full abstractDownload PDF (4911K) -
SHINGO SHOJI, HIROSHI HASUO, MASARU ISHIMATSU, TAKASHI AKASU1992 Volume 39 Issue 3 Pages 209-212
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (2989K) -
TAKASHI AKASU, SHINGO SHOJI, MASARU ISHIMATSU1992 Volume 39 Issue 3 Pages 213-217
Published: December 10, 1992
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (2411K)
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