All issues
Volume 41, Issue 2
Displaying 1-7 of 7 articles from this issue
- |<
- <
- 1
- >
- >|
-
KYOGO ITOH, YASUIKI UMEZU, TATSUO MORITA, HIDEYUKI SAYA, DAI SEITO, LA ...1994 Volume 41 Issue 2 Pages 53-63
Published: August 01, 1994
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe immunogenicity of human cancer cells transfected with Interleukin 2 (IL-2) gene, a potent vaccine candidate, has not yet been fully investigated. Human renal cell carcinoma (RCC) cells transduced with human IL-2 gene (RCC-IL-2) were investigated in vitro for the capability to induce lymphokine-activated killer (LAK) or cytotoxic T lymphocyte (CTL) activity in peripheral blood mononuclear cells (PBMC) or tumor-infiltrating lymphocyte (TIL). The RCC-IL-2 cells stimulated PBMC to demonstrate LAK activity, and also stimulated autologous TILs to proliferate and exhibit cytotoxicity relatively restricted to autologous tumor cells. In contrast, both parental RCC and RCC transduced with neomycin gene alone failed to induce these activities. These results indicate that RCC-IL-2 cells are more potent than the other RCC cells with regard to inducing cytotoxic lymphocytes against autologous tumor cells.View full abstractDownload PDF (2610K) -
MASASHI TSURUSAKI, TAKASHI AKASU, SHINGO SHOJI1994 Volume 41 Issue 2 Pages 65-72
Published: August 01, 1994
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe role of glucose in neuronal transmission was examined in the rat dorsolateral septal nucleus (DLSN) by using 'slice-patch' techniques. Removal of glucose from the oxygenated Krebs solution produced an outward current associated with an increased K+ conductance. The glucosedepletion depressed the excitatory postsynaptic current (EPSC), the inhibitory postsynaptic current (IPSC) and the late hyperpolarizing current (LHC) produced by stimulation of the fimbria/fornix pathway. It is hypothesized that glucose regulates neurotransmission in the rat DLSN by modulating the release of transmitters from presynaptic nerve terminals.View full abstractDownload PDF (4636K) -
YUJI HIROMATSU, MASAYUKI SATO, MART KOGA, TOSHITAKA KUROKI, KYOHEI NON ...1994 Volume 41 Issue 2 Pages 73-79
Published: August 01, 1994
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe effect of FK506, an immunosuppressive agent, on phytohemagglutinin (PHA) or interferon γ(IFNγ)-induced intercellular adhesion molecule-1 (ICAM-1) expression on cultured human thyroid cells from patients with Graves' disease was investigated. Primary cultured thyroid cells were incubated for three days with IFNγ (10 to 800 U/ml) or PHA (1 to 50μg/ml) in the presence of FK506. The surface expression of ICAM-1 was measured by flow cytometry. In some experiments, polyclonal anti-IFNγ antibody was added to the culture to determine whether ICAM-1 expression was blocked. FK506 inhibited the PHA-induced ICAM-1 expression in thyroid cells, but not the induction by IFNγ. PHA-induced ICAM-1 expression was not inhibited by the polyclonal anti-IFNγ antibody. FK506 did not affect the proliferation of thyroid cells. This data indicates that the inhibitory effect of FK506 on ICAM-1 expression in primary cultured thyroid cells may be due to actions on infiltrating lymphocytes in the thyroid gland. Further studies are necessary to elucidate whether the inhibition of ICAM-1 by FK506 results in the suppression of autoimmune reactions in the thyroid gland.View full abstractDownload PDF (847K) -
AKIRA ISHIBASHI, YOSHITAKE YOKOKURA, JUN MIYAGI1994 Volume 41 Issue 2 Pages 81-85
Published: August 01, 1994
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSNineteen patients with traumatic subdural hygroma (TSH) who were admitted between 1988 and 1992, were reviewed. Diagnosis of TSH was made by serial computerized tomography (CT) after initial head injury, and patients were followed for up to 19 months after head injury. The patients ranged in age from 53 to 91 years (mean 75.6 yrs). Fifteen patients were treated conservatively, and 4 patients underwent surgery. Patients had disturbance of consciousness (transient in 5 cases, persisting in 3 cases), headache (10 cases), vomiting (6 cases), and vertigo (2 cases). TSH began to develop within 24 hs in 10 patients after initial head injury, and in 13 (68%) of 19 patients, TSH was demonstrated within 72 hs after the initial head injury. Chronic subdural hematoma (CSH) developed in 5 (26%) of 19 patients and 2 patients underwent surgery. In 15 patients, who were treated conservatively, TSH disappeared in 10 patients, and decreased in 4 patients, but remained unchanged in 1 patient. Clinically, 11 patients improved. Three patients remained unchanged. One patient, who had cerebral contusion, died of pneumonia. In 4 patients, who underwent surgery, including 2 patients with CSH, TSH disappeared in all patients. Two patients improved, and 1 patient was unchanged. Another patient, who had cerebral contusion and normal pressure hydrocephalus, died. In general, clinical outcome was satisfactory, except for the patients who had accompanying parenchymai lesions before or after head injury. Surgical treatment was limited to the patients who had rapidly enlarging TSH and neurological deterioration.View full abstractDownload PDF (598K) -
Clinicopathological Features of a Cerebellar Neuroblastoma in Comparison with a Metastatic Cerebral NeuroblastomaYASUO SUGITA, JUN MIYAGI, TAKASHI YAMAMOTO, KAZUYA MORIMOTO, MINORU SH ...1994 Volume 41 Issue 2 Pages 87-95
Published: August 01, 1994
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSTwo patients with neuroblastoma of the central nervous system are described. The first, a 10-month-old male infant with symptoms of vomiting and weakness of the right upper extremity, was found on magnetic resonance imaging (MRI) to have enhanced mass lesion in the left hemisphere, vermis of the cerebellum and part of brain stem. The second, a 3-year-old boy who had swelling of the right side of the head, was found on computed tomography (CT) to have enhanced mass lesion of the frontal hemisphere and frontal bone. Histological examination of the surgical specimen of both cases demonstrated neuronal differentiation. The clinicopathological features of cerebellar neuroblastoma in comparison with metastatic neuroblastoma of the frontal lobe were discussed.View full abstractDownload PDF (6869K) -
JUNICHI TAKAGI1994 Volume 41 Issue 2 Pages 97-107
Published: August 01, 1994
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIn view of the characteristics of children's play or exercise activity, we designed a new method of exercise testing for children, called the “Complex Exercise Test” (CET), which includes three kinds of exercise test : (1) a graded exercise test on the treadmill, (2) a simple bending and stretching test to evaluate momentary exercise tolerance and (3) a swimming test with the ECG in the water. The CET was applied to a total of 25 cases which included 10 cases of postoperative tetralogy of Fallot and 15 cases with ventricular premature contraction (VPC). A two-way exercise test, which included the treadmill test and the simple bending and stretching test, was also applied to 36 postoperative cases (21 cyanotic and 15 noncyanotic), 20 VPC cases and 16 control children without any organic cardiac disorders, for a total of 72 cases. The treadmill test was useful to evaluate the maximal exercise tolerance. The simple bending and stretching test, on the other hand, seemed useful for observation of VPC changes by exercise (including postoperative VPC), since the heart rate immediately after bending and stretching exceeded that observed at the time VPC disappeared during the treadmill test, thus proving VPC disappearance by this testing. With ECG during diving, it is possible to detect VPC associated with possible risks which could not be identified by the above two methods of testing. Since each one of the three different types of exercise tests has different characteristics, it seems desirable to control children's exercise after performing the CET.View full abstractDownload PDF (3601K) -
KAZUHIRO FUNATSU, HARUMI NISHIHARA, EMI TABUCHI, YOSHIMI NOZAKI, KOICH ...1994 Volume 41 Issue 2 Pages 109-116
Published: August 01, 1994
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA 69-year-old female was admitted to our hospital for further examination of an intrahepatic mass which had been found while undergoing a complete physical examination. The mass measured 4 cm in size and was located in the medial segment (S4) of the liver. On computed tomography (CT), S4 was observed to be 'atrophied' and was well enhanced segmentally. A celiac angiogram showed segmental staining, and a transarterial portogram demonstrated portal stoppage of S4 from the left branch. However, no segmental intensity difference was seen on magnetic resonance imaging (MRI). An aspiration biopsy showed adenocarcinoma and thus an operation was performed under a tentative diagnosis of intrahepatic cholangiocarcinoma. The postoperative diagnosis of the tumor was combined hepatocellular and cholangiocellular carcinoma. However, no histological abnormality was seen in S4, contrary to the expectation of Zahn's infarct. In this study, we discuss the mechanism and imaging findings of Zahn's infarct, the possible reasons as to why no pathological change was seen in S4, as well as stress the rarity of reports on Zahn's infarct in cases of portal thrombus due to hepatocellular carcinoma.View full abstractDownload PDF (7594K)
- |<
- <
- 1
- >
- >|