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Volume 43, Issue 2
Displaying 1-10 of 10 articles from this issue
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ZHENG-XIONG XI, TAKASHI AKASU1996 Volume 43 Issue 2 Pages 115-122
Published: June 15, 1996
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe presynaptic γ-aminobutyric acidA (GABAA) receptor has long been considered as the site for 'presynaptic inhibition' of synaptic transmission in the central nervous system (CNS). However, recent reports have indicated that the activation of GABAA receptors depolarizes primary afferent neurons and actually facilitates the release of GABA, noradrenaline, adenosine, and luteinizing hormone (LH) in central and peripheral tissues. Isoguvacine, a GABAA receptor agonist, enhances substance P (SP) release in the spinal cord. GABAB receptor agonists, but not GABAA receptor agonists, produce behavioral antinociception in the spinal cord. Baclofen does not directly depolarize the postsynaptic membrane, but presynaptically inhibits the activity of dorsal horn neurons. The excitatory postsynaptic potential (EPSP) evoked by stimulation of dorsal root C-fibers is inhibited by baclofen. Baclofen and GABA inhibit SP release from the primary afferent terminals by activating GABAB receptors. The activation of GABAB receptors inhibits calcium currents in neurons of dorsal root ganglia (DRG). It is likely that the GABAA receptors act as a site for 'presynaptic facilitation' of transmitter release in the CNS.View full abstractDownload PDF (1144K) -
KIKUO KOUFUJI, JINRYO TAKEDA, ISSEI KODAMA, KEISHIRO AOYAGI, JUNJI OHT ...1996 Volume 43 Issue 2 Pages 123-126
Published: June 15, 1996
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSEight rare cases of remnant-stump early gastric cancer (RS-EGC) were investigated, retrospectively. The incidence of RS-EGC was 0.9% (8/845) of all resected early gastric cancers. The macroscopic cancer type was elevated in 75% and mucosal in 88%. All were the differentiated type with no lymph node metastasis. The initial reconstruction involved a Billroth II in 75% of the patients. The RS-EGC was usually found during a periodic endoscopic follow-up. All patients are still alive with no postoperative complications and no cancer recurrence.View full abstractDownload PDF (488K) -
SHIN-ICHIRO TERASAKI1996 Volume 43 Issue 2 Pages 127-136
Published: June 15, 1996
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe presence or absence of latent multiple infections with herpes simplex virus (HSV)-1 was investigated. DNA cleavage patterns resulting from the digestion of viral DNA by restriction enzymes were studied. The DNA cleavage patterns of asymptomatically shed viruses isolated from the saliva of subjects at different times were compared to HSV-1 isolated from patients with HSV-1 infections of the oral cavity. If a patient had HSV-1 isolated from their saliva more than two times, the asymptomatically shed viruses were used in these experiments. This criterion was met by 13 patients. All patients underwent the viral isolation procedure on separate occasions. In addition, 55 viral strains from 10 patients with HSV infections were included in the experiment. The HSV-1 lesions were caused by a reactivation of the same strain of virus. The asymptomatically shed HSV-1 viruses had identical DNA cleavage patterns in only 4 of 13 patients (31%). The viruses isolated on separate occasions from the remaining 9 patients (69%) had different DNA cleavage patterns. Several investigators have reported the existence of latent HSV multiple infections.View full abstractDownload PDF (4582K) -
HIDEAKI TSUDA, AKIHIRO IEMURA, MICHIO SATA, MASAFUMI UCHIDA, KAZUNARI ...1996 Volume 43 Issue 2 Pages 137-147
Published: June 15, 1996
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSAntineoplastons, first described by Burzynski, are naturally occurring peptides and aminoacid derivatives which control neoplastic growth. Antineoplaston A10 (3-phenylacetylamino-2, 6-piperidinedione) is the first chemically identified antineoplaston and when it is administered orally it is hydrolysed in pancreatic juice to phenylacetylglutamine and phenylacetylisoglutamine in the ratio of 4 to 1. These metabolites are water soluble and have antitumor effect, they are further degraded to phenylacetic acid. The mixture of phenylacetylglutamine and phenylacetylisoglutamine in the ratio of 4 to 1 was formulated as Antineoplaston A10 injectable formulation. The mixture of phenylacetylglutamine and phenylacetic acid in the ratio of 1 to 4 was also shown to have antitumor effect in tissue culture study, then formulated as Antineoplaston AS2-1. The reported cytostatic inhibitory effect of A10 on human hepatocellular carcinoma cells and differentiation inducing effect of AS2-1 on various tumor cells suggest potential benefit for the treatment of human hepatocellular carcinoma since this tumor recurs frequently despite initial successful treatment. We report here the effects of Antineoplaston A10 and AS2-1 on cell proliferation, cell morphology, cell cycle, and DNA in human hepatocellular carcinoma cell lines. Both agents inhibited cell proliferation and increased the number of cells in G0 and G1 phases and Antineoplaston AS2-1 induced apoptosis, we also describe our clinical experience of a hepatocellular carcinoma (HCC) patient whose tumor, after incomplete transcatheter arterial embolization (TAE) for a 7 cm*7 cm HCC, has been stable for more than 15 months during which time he has been taking Antineoplaston AS2-1 continuously without any serious adverse effects.View full abstractDownload PDF (6035K) -
HIKARU MARUIWA, TOSHI ABE, KAZUYUKI KOJIMA, HIROSHI NISHIMURA, MASARU ...1996 Volume 43 Issue 2 Pages 149-155
Published: June 15, 1996
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIn 33 histologically verified intracranial meningiomas, the correlation between the pattern of the time-signal intensity curve (TIC) from dynamic MR imaging and the histological subtypes were studied. The patterns of TIC for meningiomas were classified into two types: type A with a steep rise to a peak within a short time; type B with a slow rise to a peak followed by a plateau. Of the 16 meningiomas of the meningothelial type, 14 (87%) were type A on the TIC. On the contrary, all of the fibroblastic meningiomas were type B. The others had an almost equal distribution between the two types. These results indicate that dynamic MRI does not always have a predictive value for the histological subtype of an intracranial meningioma or for the histological architecture of the meningothelial or fibroblastic components.View full abstractDownload PDF (1528K) -
YUTAKA OGATA, YOSHIKAZU HARADA, TERUHIKO FUJII, HIDEAKI YAMANA, HIROMA ...1996 Volume 43 Issue 2 Pages 157-163
Published: June 15, 1996
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe have studied the expression of vascular endothelial growth factor (VEGF) in esophageal cancer using immunohistochemistry. A total of 101 specimens of esophageal cancer tissue were fixed by formalin, embedded in paraffin wax, and examined in 3μm sections by avidin-biotin peroxidase complex method. VEGF was noted in the cytoplasm of normal esophageal glandular cells, monocyte-macrophages, squamous carcinoma cells and of the vascular endothelial cells themselves. VEGF expression by monocyte-macrophages was observed in all cases, in contrast the incidence of VEGF expression in the tumor cells was relatively low at 26.7% of all specimens. However, in the cases where the tumor cells were positive for VEGF, it was discovered that the main source of the VEGF production was the tumor cells themselves. In the cases with proper mucosal invasion the incidence of VEGF expression by the tumor cells was quite low at 7.6%. However, when the tumor invaded the submucosal layer the expression increased to 33.3%. There was also a significant correlation in those with the submucosal invasion between the expression of VEGF in the tumor cells and the density of microvessels at the tumor invasive edge. These results suggest that VEGF may play an important role in tumor progression and in the angiogenesis via auto-crine and para-crine mechanisms in esophageal cancer.View full abstractDownload PDF (3705K) -
Two Case ReportsYOSHIHIKO TAKAHASHI, TOSHI ABE, KAZUYUKI KOJIMA, SATOSHI OCHIAI, JUN M ...1996 Volume 43 Issue 2 Pages 165-170
Published: June 15, 1996
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSTwo patients with Tolosa-Hunt syndrome (THS) who had atypical lesions in the intrasellar and juxtasellar regions are reported. They manifested with painful ophthalmoplegia. Magnetic resonance imaging (MRI) commonly showed an increase in the volume of the cavernous sinus occupied by homogeneously well-enhanced lesions in both cases. These lesions extended to the intrasellar and juxtasellar regions with meningeal enhancement. Follow-up MRI after steroid treatment demonstrated normal-ized or decreased size of the cavernous sinus. These findings suggested nonspecific inflammatory granulomatosis with atypical extension.View full abstractDownload PDF (3807K) -
KEI YAMADA, ZHENG-XIONG XI, TAKASHI AKASU1996 Volume 43 Issue 2 Pages 171-175
Published: June 15, 1996
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (2820K) -
TAKAHIKO SANNOMIYA, KOH-ICHI YAMAKI, YOSHIAKI DOI, KATSUMARO AIDA, HIS ...1996 Volume 43 Issue 2 Pages 177-180
Published: June 15, 1996
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (2882K) -
HIROSHI HARADA, KOH-ICHI YAMAKI, YOSHIAKI DOI, TSUYOSHI SAGA, TAKAHIKO ...1996 Volume 43 Issue 2 Pages 181-184
Published: June 15, 1996
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (3110K)
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