巻号一覧
43 巻 (1996)
- 4 号 p. 249-
- 3 号 p. 185-
- 2 号 p. 115-
- 1 号 p. 1-
43 巻, 4 号
選択された号の論文の10件中1～10を表示しています
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YOSHIHIRO SATO, YOSHIAKI HONDA, MASANOBU INOUE, YOSHITAKA OHTA, SONOE ...1996 年 43 巻 4 号 p. 249-257
発行日: 1996/12/14
公開日: 2009/08/11
ジャーナル フリーSternothyroid muscle biopsy specimens, obtained during tracheostomies from 15 patients with acute stroke and respiratory failure, were examined immunohistochemically to immunoreactivity to myoglobin (Mb). A marked decrease or lack of Mb immunoreactivity in association with hyaline degeneration was observed in 0.8 to 44.4% of the muscle fibers on both the paretic and non-paretic sides of all patients. The percentages of negative staining for Mb were less than 3.1% in 5 patients with acute respiratory failure due to causes other than stroke. The pattern and incidence of attenuated Mb immunoreactivity in the muscle fibers was found to be distinctively different in the two patients groups. In one group of 5 patients, a large number of muscle fibers (24.8±15.6%) had no Mb staining and were clearly bordered and grouped. In another 10-patient group, only a limited number of muscle fibers (3.3±2.5%) had no staining for Mb and these fibers were scattered. Four patients in the former group had catastrophic outcomes, while all the patients in the latter group survived. Ischemia, produced by an increase in catecholamines, and the consequent vasocon-striction, rather than hypoxemia seemed to be the cause of the negative immunoreactivity for Mb in the group pattern. In contrast, hypoxemia may have caused the scattered pattern of negative Mb immunoreactivity. It was concluded that negative immunostaining for Mb in muscle fibers represents a common and characteristic complication in acute stroke patients.抄録全体を表示PDF形式でダウンロード (3316K) -
Evaluation of 85 CasesFUSEO MATSUMURA, YOHKO ITO1996 年 43 巻 4 号 p. 259-266
発行日: 1996/12/14
公開日: 2009/08/11
ジャーナル フリーEighty-five cases of infantile asphyxia were examined in relation to the degree of conjunctivae petechial hemorrhages and histo-logical and immunohistochemical findings of the lungs and the pancreas. In very young cases, even in the strangulation cases, conjunctivae petechial hemorrhages were unremarkable and sometimes absent. The lungs showed remarkable to moderate congestion, while the pancreas showed only slight to moderate edema and cell infiltrations. Many pancreata of cases of accidental and homicidal asphyxia had hyperplasia and nesidioblastosis of islet cells. In adult asphyxia cases, remarkable congestion has been the main finding in the lungs and the pancreas. This study shows many similarities between the findings in homicidal suffocation and in genuinely accidental suffocation, both in inspection and on histological examination. So, we here, stressed on the necessity of legal necropsy for various infantile asphyxia cases, in the speculation of the, cause of death, in order to not only study infantile sudden death cause but also not to mis-diagnose genuine accidental asphyxia cases or homicidal cases using suffocation for Sudden Infant Death Syndrome (SIDS).抄録全体を表示PDF形式でダウンロード (3860K) -
Clinicopathological StudiesJINRYO TAKEDA, ATSUSHI TOYONAGA, KIKUO KOUFUJI, ISSEI KODAMA, KEISHIRO ...1996 年 43 巻 4 号 p. 267-272
発行日: 1996/12/14
公開日: 2009/08/11
ジャーナル フリーForty-five cases of remnant-stump (R-S) gastric cancer were investigated retrospectively, comparing those which were initially benign (Group 1: 31 cases) with those which were initially malignant (Group 2: 14 cases). The incidence of R-S gastric cancer over all gastrectomy cases from 1967 to 1994 was 1.4% (45/3, 282). The mean period until development of the R-S gastric cancer following partial gastrectomy was 21.6 years in Group 1 and was 15.8 years in Group 2 (p<0.05). Of those R-S cases that underwent resection, total gastrectomy was selected for 82% in Group 1 and for 85% in Group 2. The incidence of negative lymph nodes was only 25% in Group 1 and 62% in Group 2 (p<0.05). The pathological stage I was 21% in Group 1 and 54% in Group 2 (p<0.05). The 5-year-survival rate was 32% in Group 1 and was 62% in Group 2 (p<0.05). To improve the prognosis for R-S gastric cancer, periodic endoscopic follow-up examinations to find any R-S cancer at the earliest stage is most important, especially in cases of a partial gastrectomy for an initially benign case.抄録全体を表示PDF形式でダウンロード (1082K) -
Comparison of the Unilateral Pulmonary Artery Occlusion Test with Expired Gas Analysis during Exercise TestingYOSHINORI NAGAMATSU, SHINZOU TAKAMORI, RYOUZOU HAYASHIDA, HIDEAKI YAMA ...1996 年 43 巻 4 号 p. 273-277
発行日: 1996/12/14
公開日: 2009/08/11
ジャーナル フリーWe attempted to determine if expired gas analysis during exercise testing has equal value to the unilateral pulmonary artery occlusion test (UPAO). Sixty-four lung cancer patients were evaluated. We performed UPAO and measured mean pulmonary artery pressure (PPA) and cardiac output (C.O.) 15 min later, and calculated total pulmonary vascular resistance (TPVR). Expired gas analysis during exercise testing was performed, and the maximum oxygen consumption per unit body surface area (Vo2max/m2) and the anaerobic threshold (AT/m2) were calculated. The patients were divided into two groups according to the PPA as follows: Group PPA(L) and Group PPA(H), and the TPVR as follows: Group TPVR(L) and Group TPVR(H). Comparative studies of the mean values of Vo2max/m2 and AT/m2 were performed between the two groups. Vo2max/m2 was significantly higher in Group PPA(L) than in Group PPA(H). Vo2max/m2 was significantly higher in Group TPVR(L) than in Group TPVR(H). TPVR and Vo2max/m2 showed no significant correlation, but a weak negative quadratic correlation with the equation y=2276-246.6 logx was found. This result led a minimal acceptable levels for lung resection of Vo2max/m2 of 650 ml/min/m2 corresponding to the TPVR levels of 700 dyne.sec.cm-5/m2.抄録全体を表示PDF形式でダウンロード (603K) -
MAKO KATSUKI1996 年 43 巻 4 号 p. 279-287
発行日: 1996/12/14
公開日: 2009/08/11
ジャーナル フリーThe present study was aimed at elucidating the role of inflammatory cells in the pathogenesis of the chronic inflammatory changes in the bronchioles of patients with diffuse panbronchiolitis (DPB) and at determining the mechanism for the clinical efficacy of erythromycin (EM) therapy for these patients. For this purpose, neutrophil percentages, neutrophil chemotactic activity (NCA), IL-8 and TNF-α in the bronchoalveolar lavage fluid (BALF) were measured in 9 patients with DPB. Significantly higher neutrophil percentages, NCA and IL-8 concentrations were demonstrated in the BALF from DPB patients than from chronic bronchitis (CB) patients or healthy control subjects. The levels of these indicators of chronic inflamination in the BALF from DPB patients were significantly decreased after EM therapy. TNF-α was elevated in the BALF from both DPB- and CB-patients and was not decreased by treatment of the DPB patients with EM. From the above results, it can be concluded that IL-8, not TNF-α, is the major chemoat-tractant for neutrophils and that the inhibition of IL-8 production by EM induces the subsequent depression of neutrophil accumulation in the peripheral airways, and consequently, prevents the peripheral airway tissue damage due to accumulated and activated neutrophils.抄録全体を表示PDF形式でダウンロード (949K) -
Clinicopathological StudiesKIKUO KOUFUJI, JINRYO TAKEDA, ATSUSHI TOYONAGA, ISSEI KODAMA, KEISHIRO ...1996 年 43 巻 4 号 p. 289-294
発行日: 1996/12/14
公開日: 2009/08/11
ジャーナル フリーThe clinical and morphological features of 58 cases of the rare mucinous adenocarcinoma of the stomach (MUC) were investigated and compared to those of other pathological types. The incidence of MUC was only 2.9% of all cases of resected gastric cancer. Among the 58 cases of MUC, the incidence of early cases was only 19% (Group 1), while among other pathological types of cancer, it was 42% (Group 2) (p<0.001). The incidence of early mucosal cancer was 0% in Group 1, and 54% in Group 2 of the resected early gastric cancer. The incidence of lymph node metastasis rate was 81% in Group 1, and was 46% in Group 2 (p<0.001). The presence of peritoneal dissemination was 21% in Group 1, and was 8% in Group 2 (p<0.001). The incidence of liver metastasis pre- and intraoperatively was 0% in Group 1, and was 3.5% in Group 2. The overall 5-year-survival rate was 45% in Group 1, and was 61% in Group 2 (p<0.05). In stage III, the 5-year-survival rate was 30% in Group 1, and was 49% in Group 2 (p<0.05). There was no statistical prognostic difference between the two groups in stage I, II and stage IV. Therefore, to improve the outcome for MUC, more effective radical gastrectomy and aggressive immunochemotherapy should be selected, especially for stage III mucinous adenocarcinoma of the stomach.抄録全体を表示PDF形式でダウンロード (671K) -
SHOJI OHTSUKA1996 年 43 巻 4 号 p. 295-304
発行日: 1996/12/14
公開日: 2009/08/11
ジャーナル フリーTo clarify the role of vasoactive peptides in the physiologic response to pneumonectomy, we investigated the changes of atrial (A-type) natriuretic peptide (ANP), C-type natriuretic peptide (CNP), and endothelin-1 (ET-1) levels in the lung and blood after pneumonectomy and the effects of inhaled nitric oxide (NO; 5 ppm) after pneumonectomy in beagle dogs. The concentrations of these peptides in the lung and blood were measured by radioimmunoassay. The dogs in group A (n=10) were observed without NO inhaling after right pneumonectomy, and the dogs in group B (n=5) were observed with NO inhaling from 120 to 180 min after right pneumonectomy. After the thoracotomy, right lung tissue was resected for the pre-operative histological control. Tissue from the left lung was obtained at 120 min (5 dogs in group A), at 180 min (5 dogs in group A), and after 60 min of NO inhalation (group B) for the post-operative histological material. Peripheral blood was collected from the femoral artery. The pulmonary arterial pressure (PAP) was significantly increased after pneumonectomy, but rapidly decreased to the same level as the pre-operative stage after NO inhalation. Increases of plasma ANP, lung ANP and lung CNP levels occurred after pneumonectomy, while the ET-1 level was unchanged. Inhaled NO rapidly reduced the plasma ANP, lung ANP and lung CNP. These results indicate that both ANP and CNP act to maintain normotensive homeostatic balance in the pulmonary circulation.抄録全体を表示PDF形式でダウンロード (6681K) -
Validity of the Baseline Night as a Control and the Effect of Ethyl Loflazepate (CM6912)HIROO KUWAHARA, MASATOSHI TANAKA, HIROSHI ISOZAKI, YASUSHI MIZUKI, MAS ...1996 年 43 巻 4 号 p. 305-312
発行日: 1996/12/14
公開日: 2009/08/11
ジャーナル フリーThe effects of an anxiolytic drug, ethyl loflazepate (CM6912) on sleep EEGs were investigated by the interval histogram method originally developed. EEGs were classified into each of the δ2-β2 and σ1 wave-form parameters, and the individual frequencies were determined on the third baseline, second drug and the first recovery nights in each sleep stage. In comparison with the second baseline night, the σ1 waves in stage 2 sleep an the δ1 waves in REM sleep were decreased and the α and σ1 waves in stage 3 sleep were increased on the third baseline night. In consideration of the 5% significance level and the remarkable influence of drug administration, described below, no major problems were encountered in the use of the night as a control in this experimental schedule. The main characteristics of administration of CM6912 manifested as decreases in the slow wave, increases in the fast wave, and an increase in the σ1 wave in sleep stages other than stage 1. These tendencies were remarkable on the second drug night and were still evident even on the recovery night. Increases in σ1 wave were related to increases in sleep spindles. The increases in the β2 wave were particularly remarkable in REM sleep.抄録全体を表示PDF形式でダウンロード (912K) -
TOSHIHIRO HIDAKA, YOSHIAKI OMATA, MASATO NOGUCHI1996 年 43 巻 4 号 p. 313-324
発行日: 1996/12/14
公開日: 2009/08/11
ジャーナル フリーHeme oxygenase catalyzes the oxidation of heme to biliverdin and carbon monoxide. The gene encoding the truncated soluble rat heme oxygenase-1 (Metl-Pro267) was cloned. The enzyme protein was expressed in E. coil JM109 and purified to homogeneity. The molecular weight of the recombinant enzyme was 30 kDa as assessed by SDS-polyacrylamide gel electrophoresis. From a 3-L culture, about 90 mg of the purified enzyme was routinely obtained. The dependency of the heme oxygenase reaction catalyzed by the soluble enzyme on the NADPH-cytochrome P-450 reductase concentrations and the effect of catalase on the reaction were examined to compare with the purified membrane-bound form of heme oxygenase-1 (Yoshida and Kikuchi, 1978b). The activity of the soluble enzyme was inhibited at high concentrations of NADPH-cytochrome P-450 reductase and the inhibition was not alleviated by addition of catalase unlike the membrane-bound form. The ferric iron of the heme-heme oxygenase complex was in a typical high spin state at acidic to neutral pH (pH 6.5-7.0), but conversion to low spin state was observed at basic pH (pH 9-10). The heme bound to heme oxygenase was converted to biliverdin at a stoichiometric ratio of unity in the presence of NADPH-cytochrome P-450 reductase system. During the heme degradation of the heme-heme oxygenase complex under atmospheric oxygen, several intermediates, that is, oxygenated heme and verdoheme, were spectrally discriminated.抄録全体を表示PDF形式でダウンロード (4709K) -
MOTOICHI IWAMOTO, HIROKO SASAHARA, SHINJI KAWABATA, MASARU HOSHIKO, KE ...1996 年 43 巻 4 号 p. 325-331
発行日: 1996/12/14
公開日: 2009/08/11
ジャーナル フリーWith the development of diagnostic technology, the surgical methods of cancer therapy have been expanded, and operations have been performed using a procedure corresponding to the stage of cancer to improve the postoperative QOL. A 79-year-old man with cancer of the duodena' papilla and obstructive jaundice, and a 63-year-old woman with cholangiocarcinoma in the lower region complicated by cholangitis caused by Candida underwent resections of the pancreatic head and duodenum, and pancreaticogastrostomies retaining the pylorus. Satisfactory results were obtained in both cases. The merits of the procedure were that there were few complaints, sufficient food could be ingested and the QOL was maintained. The benefits of pancreaticogastrostomy are that the anastomosis procedure is simple, the gastric wall is thicker than the jejunum and blood flow is plentiful. The dorsal gastric wall is located close to the pancreatic cut-end, therefore tension is not created, and the pancreatic enzymes are not activated because the anastomosis site does not contact the intestinal fluid. These characteristics should decrease the rate of anastomosis failure which can be a fatal complication. A safer operation is desirable, particularly for elderly patients or patients who have complications.抄録全体を表示PDF形式でダウンロード (6026K)
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