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Volume 44, Issue 1
Displaying 1-9 of 9 articles from this issue
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JINJUN WANG, FUJIO HIGUCHI1997 Volume 44 Issue 1 Pages 1-6
Published: April 01, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe have applied the Dall-Miles cable grip system for fixation in 15 cases of a transtrochanteric valgus osteotomy for osteoarthritis. After three phases of modification, we could achieve stable fixation for the three fragments of the greater trochanter, proximal and distal femur using only one set of this system and could prevent migration and over-traction of the abductor muscles by this way.View full abstractDownload PDF (4781K) -
Evaluation by Intracoronary Injection of AcetylcholineRUMI YAMAKAWA1997 Volume 44 Issue 1 Pages 7-14
Published: April 01, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe vascular function of the coronary arteries in children after Kawasaki disease (KD) as yet remains uncertain. Here we report our findings of the vascular response of the coronary arteries after intracoronary injection of acetylcholine in patients after KD. A total of 29 patients, 19 after KD and 10 as control, were examined using coronary angiography (CAG). These were divided into 4 groups according to the type of the coronary artery lesions: Group 1 consisted of those with regressed aneurysms and involved 29 sites. These aneurysms had developed in the acute stage and had subsequently regressed and demonstrated normal findings in follow-up CAG. Group 2 consisted of those with persistent aneurysms involved 30 sites. Group 3 involved 52 angiographically normal sites in patients after KD. And Group 4 consisted of control patients and involved 70 sites. These patients had congenital heart disease with normal coronary arteries. During CAG we infused 15 μg acetylcholine chloride into the right or left coronary artery. The luminal diameters were measured using a cine-videodensitometric analyser to study the distensibility of the coronary artery wall. The change in the diameter was an increase of 13.71%±15.09% (mean±SD) in the normal KD Group 3, and 12.21%±13.83% in the control Group 4, demonstrating marked vasodilatation. In contrast, the change in the regressed aneurysms Group 1, and in the persistent aneurysms Group 2, was -2.65%±16.65%, and -0 .08%±6.51%, respectively, demonstrating no change or mild vasoconstriction. The change in Group 1, and in Group 2, was less than in normal Group 3 or control Group 4. The normal Group 3 showed no significant difference from control Group 4. These findings suggested that the coronary artery with regressed aneurysms, or with persistent aneurysms after KD has impaired vascular function and is therefore at risk for developing to atherosclerosis in the long-term.View full abstractDownload PDF (4524K) -
KIMIO USHIJIMA, TAKASHI NISHIDA, NAOFUMI OHKURA, TORU SUGIYAMA, KAN KO ...1997 Volume 44 Issue 1 Pages 15-21
Published: April 01, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSTo clarify the optimal timing of second look operation (SLO) for advanced ovarian cancer, we retrospectively reviewed the records of 53 patients with FIGO stage 2, 3 and 4 epithelial ovarian cancer. SLOs were performed more than 12 months after primary surgery in 35 patients (late SLOs), and immediately after first-line chemotherapy in 18 patients (early SLOs). We examined data on SLO findings and patients' clinical courses. SLO findings were positive 5 (27.7%) of 18 in the early SLO group and in 11 (31.4%) of 35 in late SLO group. Positive findings were detected by washing cytology in 3 (60%) of the 5 in the early SLO group compared with 2 (18.2%) of the 11 in the late SLO group. Patients with microscopic disease had better prognosis than patients with macro lesions. False-negative SLO findings were 30.8% in the early SLO group and 12.5% in the late SLO group . All patients who recurred after negative SLOs had grade 2 and 3 tumors. The benefits of SLO were limited to accurate evaluation of first-line chemotherapy and early detection of persistent disease. In these implications, early performance of SLO is recommended.View full abstractDownload PDF (3252K) -
TOMOYUKI MAEDA1997 Volume 44 Issue 1 Pages 23-32
Published: April 01, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESST cell sublines and clones were established from the parental HLA-A2601-restricted Cytotoxic T lymphocyte line (KE-4 CTL, HLAA2601/2402, -B5101/40012, -Cw0102/0302) to investigate their capability to recognize tumor antigens on HLA-class I alleles other than HLA-A2601. Thirty-nine of 52 (75%) sublines or 30 of 83 (36%) clones produced interferon (IFN)-. A by recognition of the autologous KE-4 tumor cells. Among these 39 CTL sublines, 22, 22, and 2 sublines produced IFN-γ by recognition of HLA-A2402+, -B5101+, and Cw0102+ allogenic tumor cells, respectively. Four, 8, and 4 of these 30 CTL clones also produced IFN-γ by recognition of HLA-A2402, -B5101+, and Cw0102+ allogenic tumor cells, respectively . The other 13 sublines or 53 clones failed to produce IFN-γ by recognition of the autologous tumor cells, respectively. These results suggest the presence of CTL recognizing shared tumor antigens on autologous tumor cells expressed by plural HLA-class I alleles in a patient with esophageal SCC.View full abstractDownload PDF (5655K) -
TAKASHI AKASU, KBI YAMADA1997 Volume 44 Issue 1 Pages 33-41
Published: April 01, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSReceptors responsible for the tachykinin-induced depression of γ-aminobutyric acid-A (GABAA) receptors in neurons of bullfrog dorsal root ganglia (DRG) were investigated by using whole-cell voltage-clamp techniques. Substance P (10 nM-1 μM) depressed the inward current produced by GABA (GABA current) in a concentration-dependent manner . Substance P did not change the reversal potential of the GABA current. Neurokinin A also depressed the GABA current with potency similar to those of substance P. [D-Arg1, D-Trp7, 9 Leu11]substance P (spantide, 1 μM) shifted the concentration-inhibition curve of substance P to the right. Spantide (1 μM) increased the IC50 from 56 nM to 210 nM. Lineweaver-Burk plot, a reciprocal plot of the concentration-inhibition curve, showed that spantide did not change the maximum response (Vmax) to substance P but increased the apparent dissociation constant (Kd). CP99994 (1 μM), an neurokinin-1 (NK1) receptor antagonist, inhibited the substance P-induced depression of the GABA current. These results suggest that the tachykinin-induced depression of the GABAA receptor sensitivity is mediated by NK1 receptors in neurons of bullfrog DRG.View full abstractDownload PDF (3011K) -
TERUKAZU KURAMOTO1997 Volume 44 Issue 1 Pages 43-51
Published: April 01, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe expression of MAGE tumor rejection antigens in brain tumors is unclear. We investigated the expression of MAGE-1 and-4 proteins in brain tumors with antibodies to recombinant MAGE-1 and -4 proteins. MAGE-1 or -4 protein was detected in a majority (12 of 14) or some (5 of 14) of gliomas, respectively, by the immunoblot analysis. In contrast, MAGE-1 or -4 protein was rarely detected in the non-glioma tumors (3 of 14 or 1 of 14, respectively). Cellular MAGE-1 protein was detected in the cytoplasma of the glioblastoma cells with immunohistochemical staining. The expression of the MAGE-4 protein was confirmed by enzyme-linked immunosorbent assay. The results suggest that the MAGE-1 protein is an appropriate target molecule for specific immunotherapy of glioma.View full abstractDownload PDF (5933K) -
TERUKO HINO, MICHIO SATA, NOBUYUKI ARIMA, RYUICHI NOUNO, RYUKICHI KUMA ...1997 Volume 44 Issue 1 Pages 53-60
Published: April 01, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe report the case of a 50-year-old female with malignant lymphoma presenting hemophagocytic syndrome and liver failure. She developed high fever, marked jaundice, and progressive liver failure, followed by evidence of disseminated intravascuiar coagulation (DIC). The course was complicated by severe hepatitis and the patient died six days after admission. Pathological diagnosis on autopsy specimens of the lung hilar lymph nodes was non-Hodgkin's T cell lymphoma, of the diffuse small cell type. Histopathologic examination of the liver demonstrated diffuse liver cell destruction with prominent T lymphocyte infiltration in the portal and periportal area. In addition to marked lymphoma cell infiltration, hemophagocytosis by prominent infiltrative macrophages was observed in various organs, such as the liver and bone marrow, indicating the hemophagocytic syndrome. The emophagocytic syndrome characterized in the present case may have been responsible for the extremely rapid and fulminant course.View full abstractDownload PDF (6096K) -
A Case ReportSHIN-ICHIRO TERASAKI, TADAMITSU KAMEYAMA, SHIGERU YAMAMOTO1997 Volume 44 Issue 1 Pages 61-66
Published: April 01, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA patient with herpes zoster infection affecting the second and third branches of the trigeminal nerve is reported. This case demonstrates the occurrence of a simultaneous VZV and HSV infection. Isolation of these viruses from exudates of the blisters was required to prove coexistence of the two viruses within the same blister. Relevant literature is discussed.View full abstractDownload PDF (6037K) -
AKIO KATAOKA, TAKASHI NISHIDA, HIDETO OKINA, YOSHITO TOMIOKA, NOBUYUMI ...1997 Volume 44 Issue 1 Pages 67-69
Published: April 01, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (2308K)
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