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Volume 44, Issue 3
Displaying 1-12 of 12 articles from this issue
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KIKUO KOUFUJI, JINRYO TAKEDA, ATSUSHI TOYONAGA, SHINO YOSHIHARA, YUICH ...1997 Volume 44 Issue 3 Pages 157-164
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA total of 1, 845 cases of gastric cancer have been resected in our hospital during the past 18 years. Of these, 764 cases (41.5%) were early gastric cancer. The rate of lymph node metastasis was 2% in early mucosal cancer and 19.4% in early submucosal cancer (p<0.001). In the cases of early mucosal cancer, the rate of lymph node metastasis was 0.9% for the elevated type and 2.4% for the depressed type. In the cases of early submucosal cancer, the rate of lymph node metastasis was 25.3% for the elevated type and 17.3% for the depressed type. In the mucosal cancers the rate of lymph node metastasis was high in the 0-IIc and IIc+III macroscopic type, and in the poorly differentiated microscopic type. In the submucosal cancers the rate of lymph node metastasis was 40% in mucinous adenocarcinoma and 33% in papillary adenocarcinoma. There was no lymph node metastasis in any case of early gastric cancer smaller than 1cm surface diameter.View full abstractDownload PDF (2721K) -
Epidermal Cell Cultures from Involved Skin of Patients with Mammary and Extramammary Paget's DiseaseOSAMU MORI, TADASHI KARASHIMA, KEIZO MATSUO, TAKASHI HASHIMOTO1997 Volume 44 Issue 3 Pages 165-169
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIn involved epidermis, Paget cells are completely enclosed by the surrounding keratinocytes, which appear to be intact and unaltered. It is possible that the surrounding keratinocytes inhibit Paget cell proliferation. Accordingly, Paget cells might proliferate differently when cultured as an epidermal cell suspension. In this study, primary monolayer cultures of epithelial cells from involved epidermis of patients with mammary and extramammary Paget's disease were carried out to investigate whether Paget cells proliferate in the same manner as other malignant cells. Skin samples were obtained from one patient with mammary Paget's disease, and from 2 patients with extramammary Paget's disease. The epidermis was separated from the dermis with dispase, and epidermal cell suspensions were obtained with ethylenediamine tetraacetate and trypsin. A commercially available serum-free media, Keratinocyte-SFM, was used. Epithelial monolayers from the involved skin could be maintained for approximately 45 days, while keratinocytes from normal skin were maintained for approximately 35 days. The mechanism for the longer survival of the mixed cell culture of keratinocytes and Paget cells is not known. Permanent cell lines were not developed from these primary cultures. Paget cells could not be distinguished from keratinocytes by phase-contrast microscopy. The proportion of carcinoembryonic antigen (CEA) positive cells in the culture did not increase, but instead decreased. In certain areas of the dish, the CEA positive cells proliferated and accumulated like mushrooms. However, at the periphery of the dish, the Paget cells identified by immunostaining for CEA were dispersed and not clustered. These findings indicate that the influence of keratinocytes on Paget cells also occurs in cultured cells, which may explain why Paget cells survive longer than keratinocytes. In conclusion, the Paget cells in the involved epidermis do not proliferate like other malignant cells.View full abstractDownload PDF (4940K) -
MICHIO SATA, TATSUYA IDE, FUYUHIKO AKIYOSHI, KUNITAKA FUKUIZUMI, SEIJI ...1997 Volume 44 Issue 3 Pages 171-177
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSTo determine the incidence of hepatocellular carcinoma among patients with chronic hepatitis C who received interferon (IFN) therapy, 63 patients with chronic hepatitis C who underwent IFN therapy (IFN α 2a 9 X 106IU daily for 2 weeks and followed 9×106IU three times weekly for 14 weeks) from January to December 1992, were studied. Selection criteria were as follows: within six months before IFN therapy patients were diagnosed with chronic active hepatitis without cirrhosis by hepatic histological examination, and were hepatitis C virus antibody positive. Furthermore, patients had records of follow-up liver function tests (once a month) for more than six months after IFN therapy completion, and of ultrasound scanning (once in three to four months) before and for at least more than six months after the therapy completion. An average period of observation was 2.7 years (0.6 to 3.8 years). Twenty five of 63 patients (39.7%) returned to normal values of serum ALT, whereas 38 of 63 (60.3%) still showed abnormal values at six months after IFN therapy completion. Nine of 63 (14.2%) and 6/63 (9.5%) developed cirrhosis and hepatocellular carcinoma, respectively. All patients who developed cirrhosis and hepatocellular carcinoma were from those (n=38) that showed abnormal ALT values after therapy completion. The five of six patients that progressed to hepatocellular carcinoma were associated with cirrhosis. No patients who returned to normal ALT values developed hepatocellular carcinoma during the period of observation. These results suggest that IFN therapy is effective to prevent the development of hepatocellular carcinoma.View full abstractDownload PDF (786K) -
ISSEI KODAMA, JINRYO TAKEDA, KIKUO KOUFUJI, SHOJIRO YANO, MAT HANZAWA, ...1997 Volume 44 Issue 3 Pages 179-183
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDuring the 27 years between 1966 to 1993, a total of 3, 256 patients with gastric cancer were admitted to our institute. Among these patients, 3 (0.1%) cases of gastric cancer were associated with pregnancy. One cancer stage IVb patient died of peritoneal metastasis without any operation. Another stage Wb patient died of peritoneal metastasis 12 months after palliative gastrectomy. And the other stage IIIb patient is well, and the 8 years old child is also well, after synchronous extended total gastrectomy with cesarean section.View full abstractDownload PDF (526K) -
OSAMU MORI, TADASHI KARASHIMA, KEIZO MATSUO, TAKASHI HASHIMOTO1997 Volume 44 Issue 3 Pages 185-189
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSSagebiel (1969) electronmicroscopically observed that desmosomes are present between adjacent Paget cells, as well as between Paget cells and adjacent keratinizing epidermal cells. Desmosomes contain the proteins desmoglein (Dsg) and desmocollin as their transmembrane components, and Dsg has three isotypes. Among the three isotypes of Dsg, Dsg1 and Dsg3 are autoantigens for pemphigus foliaceus and pemphigus vulgaris (PV), respectively. We examined the expression of Dsgs in Paget cells of mammary and extramammary Paget's disease. Skin samples were obtained from one patient with mammary Paget's disease, and from 2 with extramammary Paget's disease. One part of the samples was cut into small pieces and epidermal sheets were separated with dispase, then treated with a mixture of EDTA and trypsin. The resulting cell suspensions were cultured in low Ca++ medium, then the cells were incubated in high Ca++ medium. Paget cells identified with anti-epithelial membrane antigen (EMA) antibody were positive for serum from a PV patient which was confirmed to react with both Dsg1 and Dsg3. However, the intensity of fluorescence of Paget cells was weaker than that of EMA-negative keratinocytes. In the cryostat sections, Paget cells identified with anti-EMA antibody showed the same staining pattern as cultured cells in high Ca++ medium. The data presented in this study confirm that Paget cells express Dsgs, and are consistent with the electronmicroscopical data by Sagebiel (1969). However, our data do not support the hypothesis that Paget cells are of keratinocyte origin, because sweat ducts or sweat glands could be positive for sera from PV patients. It is necessary to confirm whether or not sweat ducts or sweat glands express Dsgs, because sera from PV patients exhibit high background in the dermis.View full abstractDownload PDF (2293K) -
MASAHIRO SATO1997 Volume 44 Issue 3 Pages 191-199
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIt has been shown that patients with cirrhosis and portal hypertension have hyperdynamic systemic and splanchnic circulation. This study was designed to assess how endoscopic variceal ligation may influence systemic and splanchnic hemodynamics. Sixteen patients with cirrhosis and esophageal varices were studied. Cardiac output and flow volume of the portal vein and the superior mesenteric artery were determined by means of duplex Doppler ultrasonography. Mean arterial pressure was also recorded. These hemodynamic measurements were performed before and after initial (3 days after initial session) and repeated (7 days after last session) variceal ligation. No significant changes in cardiac output and mean arterial pressure were found after either initial or repeated variceal ligation. Thus, systemic vascular resistance was not modified. In splanchnic hemodynamics, portal vein blood flow significantly increased after initial variceal ligation (27%, P<0.01) but it returned to the baseline value after repeated variceal ligation. In contrast, superior mesenteric artery blood flow significantly decreased after initial variceal ligation (17%, P<0.01) and it returned to the baseline value after repeated variceal ligation. Effect of variceal ligation on splanchnic hemodynamics is transient and variceal ligation has very little effect on systemic circulation. Thus, patients with cirrhosis underwent repeated variceal ligation still have abnormal systemic and splanchnic circulation.View full abstractDownload PDF (1182K) -
An Analysis of Schizophrenic Patients in FukuokaMUTSUO HARANO1997 Volume 44 Issue 3 Pages 201-208
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIt has been suggested by Arinami et al. (1994) that there is a positive relationship between schizophrenia and the Cys311 polymorphism of the Dopamine receptor D2 (DRD2) gene. However, some recent reports do not support this relationship. The differing results could be due to two causes, [1] There may be a regional difference in the proportion of schizophrenia due to the Cys311 or [2] the control groups in the recent studies might have included young schizophrenics. Accordingly, an analysis of the age of schizophrenic patients in the Fukuoka region was undertaken. The Cys311 allele frequencies for the control group was 0.040 and for the schizophrenic group was 0.057, which were not statistically different. Although this data did not corroborate the above mentioned positive relationship, it was found that the allele frequency was higher statistically than in any previous report for both the schizophrenic and control groups. These findings indicate that the frequency of the Cys311 is biased geographically and that this must considered when investigating the occurrences of genetic variants and diseases.View full abstractDownload PDF (2292K) -
YOHKO ITO, HIROHUMI JONO, HIDEKI SHOJO1997 Volume 44 Issue 3 Pages 209-215
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe effects of chronic administration of methamphetamine on pancreatic tissues were histopathologically studied in experimental models. Methampheta e (1ml/kg body weight/day) was subcutaneously injected into 14 five-week-old male Wistar Kyoto rats (WKY) for 12 weeks. Age and sex matched 5 WKY rats served as controls. With light microscopy, some scattered edematous lesions and moderate vacuolization were demonstrated in the pancreas of 8 of the methamphetamine treated rats. However, in 4 of the rats, severe regional hemorrhage, partial acinal cell necrosis, destruction of the acinall cells, neutrophile infiltration, interstitial vessel dilatation, interstitial edema and fatty cell invasion were observed after the injections of methamphetamine. In 2 other animals, fibrosis and cirrhosis-like lesions with destruction and degeneration of the acinal cells were observed the small vessels had a slight degeneration of the endothelial cells. In the control animals, no lesions, except for some edematous lesions were found. In all cases, there were no nesidioblastoss-like lesions or necrosis of the Langerhans's islets. In the immunohistochemical study using anti-α1-chymotrypsin antibody, more positive reactive cells were demonstrated among the interstitial and inter acinal cells, both in number and degree, in the methamphetamine treated rats. In addition to the animal model, there were 4 autopsy cases of sudden death in chronic methamphetamine abusers. The autopsies demonstrated a severe acute necrotic hemorrhagic pancreatitis, with only scattered slight hemorrhaging in the brain and lungs. These findings indicate that chronic administration of methamphetamine to rats evoked significant changes in pancreatic tissues including some degeneration of the endothelial cells of the small vessels in this hypoxia-vulnerable organ.View full abstractDownload PDF (4943K) -
TOSHIAKI ASAKURA1997 Volume 44 Issue 3 Pages 217-223
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe aim of this study was to discover the involvement, if any, by bone mineral density (BMD) in the results after osteotomy for osteoarthritis of the hip (OA). The BMD, the Bombelli classification and the postoperative results in 36 joints after Chiari pelvic osteotomy for OA in the advanced and late stage were investigated for any correlations. The Bombelli hypertrophic type showed significantly better improvement than the atrophic type, but there was no correlation between the value of the BMD, and the postoperative result.View full abstractDownload PDF (5555K) -
TETSUKO OKUNO, MASASHI SAGARA, AKIO INOUE, MITSUYOSHI AYABE1997 Volume 44 Issue 3 Pages 225-231
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA 61-year-old woman began to suffer bronchial asthma in 1985. She then developed low back pain and numbness along the lower extremities, eventually leading to bilateral drop foot in 1990. At that time, she was diagnosed as having lumbar disc hernia, and extirpation of the discs at the L3-4 and L4-5 was performed. However, her clinical condition showed little improvement. Six months later, she was emaciated and bedridden with distal dominant muscular atrophy in all four limbs, purpura in the left leg and hypereosinophils. Motor conduction velocity (MCV) was not detected in the peroneal nerves. The toes gradually became cyanotic, and a skin biopsy from the cyanotic region revealed necrosis in the vessels surrounded by infiltration of a large number of neutrocytes and lymphocytes. She was diagnosed as having mononeuritis multiplex due to allergic granulomatous angiitis (AGA), which is characterized by bronchial asthma, hyper-eosinophilia and necrotizing vasculitis. Thirty mg/day prednisolone was then administered. However, the toes and calcaneal areas gradually became necrosed. Finally, amputation of both feet was necessary. We concluded that an early diagnosis of this syndrome is most important, and corticosteroids should be administered early.View full abstractDownload PDF (4865K) -
MAMORU ARIYOSHI, KENSEI NAGATA, KOJI HIRAOKA, KYOSUKE SONODA, REIKO HO ...1997 Volume 44 Issue 3 Pages 233-236
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIt is difficult to assess the healing of the medial malleolar stress fracture. We describe a case of medial malleolar stress fracture which was monitored its healing with repeated magnetic resonance images.View full abstractDownload PDF (2524K) -
HIROSHI HARADA, KOH-ICHI YAMAKI, YOSHIAKI DOI, TETSUSHI HIRATA, TSUYOS ...1997 Volume 44 Issue 3 Pages 237-240
Published: September 16, 1997
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDownload PDF (3713K)
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