巻号一覧
46 巻 (1999)
- 3-4 号 p. 137-
- 2 号 p. 91-
- 1 号 p. 1-
46 巻, 3-4 号
選択された号の論文の12件中1～12を表示しています
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YUSHIRO YAMASHITA, YOSHIHIKO MURAKAMI, NAOKO WADA, AKIKO TOGO, TOYOJIR ...1999 年 46 巻 3-4 号 p. 137-141
発行日: 1999/12/15
公開日: 2010/02/08
ジャーナル フリーWe investigated the effect of indomethacin (INDO) and hyperventilaton (HV) on cerebral hemodynamics and oxygenation in newborn piglets using near-infrared spectroscopy (NIRS). A total of 10 piglets aged 7-10 days were divided into 2 groups. INDO (Experimental group; 0.2 mg/kg IV) or saline (Control group) was administered after steady state, then each group was hyperventilated (pCO2; 20 mm Hg). Cerebral oxyhemoglobin concentrations (HbO2) significantly decreased immediately after INDO administration compared to controls (p<0.01). This decrease continued for 15 min. During HV, HbO2 remained low compared to the steady state (p<0.05) in the experimental group. Total hemoglobin concentrations (HbT) decreased simultaneously with HbO2. In the control group, no changes in HbO2 or HbT were observed after saline administration, and only a slight decrease in HbO2 was observed during the 5 minutes' HV compared to the steady state. No changes in cytochrome aa3 (Cytaa3) were observed in either group during 100% O2 inhalation. We conclude that INDO decreased HbO2 and HbT by vasoconstriction, but that HV did not further aggravate this tendency. Great care should be taken when using INDO for newborn neonates.抄録全体を表示PDF形式でダウンロード (841K) -
TAKASHI AKASU, MASASHI TSURUSAKI1999 年 46 巻 3-4 号 p. 143-150
発行日: 1999/12/15
公開日: 2009/08/11
ジャーナル フリーThe effects of interleukin-1β (IL-1β) on the membrane potential and synaptic transmission were examined in neurons of mammalian pelvic ganglia. Bath-application of recombinant human IL-1β (6-300 pM) for 10 s-5 min produced a long-lasting hyperpolarization associated with increased input resistance in 11 neurons of rat major pelvic ganglia (MPG). In other 8 neurons, IL-1β (300 pM) produced a biphasic response that consists of an initial depolarization followed by a long-lasting hyperpolarization. IL-1β 163-171 (10-100 pM), a synthetic nonapeptide analog that contains the active domain of human IL-1β, mimicked the effect of IL-1β in MPG neurons. γ-Aminobutyric acid (GABA, 300 μM) produced a depolarization followed by a hyperpolarization that was blocked by picrotoxin (100 μM). Db-cyclic guanosine monophosphate (db-cyclic GMP, 100 μM) also produced an initial depolarization followed by a long-lasting hyperpolarization. These results suggest that the IL-1β-induced biphasic response is mediated by a GABA receptor-cyclic GMP pathway. IL-1β and IL-1β 163-171 caused an initial facilitation followed by a long-lasting depression of the excitatory postsynaptic potential (EPSP) in rabbit VPG. The data suggest that IL-1β presynaptically depressed the EPSP by reducing the release of acetylcholine (ACh) from the pelvic nerve terminals.抄録全体を表示PDF形式でダウンロード (11741K) -
HISAFUMI KINOSHITA, HIROYASU IMAYAMA, TOSHIRO OGATA, JUN NAGASHIMA, SH ...1999 年 46 巻 3-4 号 p. 151-156
発行日: 1999/12/15
公開日: 2009/08/11
ジャーナル フリーIn 32 patients with tumor-forming pancreatitis and 109 patients with pancreatic cancer, the usefulness of percutaneous transhepatic portography (PTP) and selective pancreatic venography (SPV) for differential diagnosis of the two diseases was evaluated. The PTP images were type I in 53.1%, type II in 21.9%, type III in 12.5%, and type IV in 12.5% of the patients with tumor-forming pancreatitis and type I in 20.2%, type II in 23.9%, type III in 37.6%, and type IV in 18.3% of the patients with pancreatic cancer. Advanced images (type III or type IV) were observed in more than half the patients with pancreatic cancer. Mild images classified as type II were observed slightly more frequently in the patients with pancreatic cancer, but the differential diagnosis of the two diseases was difficult in patients showing type II PTP images. SPV findings were primarily hypervascularization (78.1%) and vasodilation (68.8%) in the patients with tumorforming pancreatitis. Although encasement (smooth encasement) was noted in 31.3%, obstruction was found in only 3.1%. In the patients with pancreatic cancer, obstruction was observed in 85.3%, and encasement (irregular encasement) was noted in 78.9%. However, hypervascularization or vasodilatation was infrequent, and the tumor was characteristically imaged as a hypovascular area. PTP and SPV were considered to be useful for the differential diagnosis of tumor-forming pancreatitis and pancreatic cancer.抄録全体を表示PDF形式でダウンロード (5627K) -
JUNKO NAGAJI1999 年 46 巻 3-4 号 p. 157-162
発行日: 1999/12/15
公開日: 2010/02/08
ジャーナル フリーA chemiluminescence procedure has been developed to determine superoxide anion (O2-) generation and myeloperoxidase (MPO) release from human activated neutrophils. By using this procedure, the role of protein kinase C (PKC) and cytosolic calcium ion ([Ca2+]i) for O2- generation and MPO release was examined. Activation of FcγR on neutrophils with IgG-coated zymosan (IgGZ) caused a transient rise of [Ca2+]i, followed by O2- generation and MPO release. A PKC inhibitor suppressed completely the O2- generation and slightly the MPO release. Direct activation of PKC by a specific PKC activator, phorbol myristate acetate (PMA), induced a remarkable O2- generation and a small MPO release, indicating that PKC may regulate entirely O2- synthesis and partially MPO degranulation. Influx of extracellular Ca2+ induced by the calcium ionophore A23187 provoked MPO release only. Complete inhibition of this MPO release with a Ca2+/calmodulin (CaM)-coupling inhibitor and a CaM inhibitor provides evidence that [Ca2+]i may regulate MPO degranulation through direct activation of CaM, but not PKC. The Ca2+/CaM inhibitors significantly prevented IgGZ-induced O2- generation and MPO release, while they did not affect PMA-induced O2- generation and MPO release. These results suggest that in FcγR-stimulated neutrophils, [Ca2+]i activates CaM, which in turn mediates not only activation of PKC-induced O2- synthesis and MPO degranulation, but also MPO degranulation without PKC intermediate .抄録全体を表示PDF形式でダウンロード (5126K) -
An In Vitro Chemosensitivity Test for Colorectal Cancer Using Collagen-gel Droplet Embedded CulturesYASUMI ARAKI, HIROHARU ISOMOTO, ATSUSHI MATSUMOTO, ATSUSHI KAIBARA, MA ...1999 年 46 巻 3-4 号 p. 163-166
発行日: 1999/12/15
公開日: 2009/08/11
ジャーナル フリーThis study evaluated in vitro assay for chemosensitivity test using a collagen-gel droplet embedded culture drug sensitivity test (CD-DST) for colorectal cancer. CD-DST was performed in 24 patients with Dukes B, C colorectal cancer. Primary cultures of tumor cell samples from 87.5% (21124) patients with colorectal cancer were successful. The efficacy rates assessed by CD-DST of five anticancer drugs evaluated were : 60.4% for adriamycin, 58.9% for etoposide, 56.7% for cisplatin, 53.4% for 5-fluorouracil, for 31.1% for mitomycin C, and 9.5% for vindesine. The present study demonstrated the clinical usefulness of CD-DST in evaluating the response to chemotherapy in colorectal cancer.抄録全体を表示PDF形式でダウンロード (2935K) -
KEISHIRO AOYAGI, KUKUO KOHFUJI, SHOJIRO YANO, NAOTAKA MURAKAMI, HARUKO ...1999 年 46 巻 3-4 号 p. 167-170
発行日: 1999/12/15
公開日: 2009/08/11
ジャーナル フリーIt is now accepted that the incidence of esophageal carcinoma is highest in the middle thoracic region. Esophageal carcinoma after gastrectomy, however, has a tendency to develop in the lower region. This study was designed to investigate the role of reflux of gastroduodenal juice in the genesis of carcinoma in the esophagus. We found a possible correlation between the development of esophageal carcinoma and gastrectomy, related to alkaline reflux into the esophagus. To elucidate this correlation, the role of alkaline reflux of duodenal contents in the development of esophageal squamous cell carcinoma was investigated in Wister rats. Gastrectomized rats with regurgitation of duodenal contents into the esophagus were not administered any carcinogen and were sacrificed some at the end of 8 weeks and others at 50 weeks for pathological examination. Hyperplasia was found in rats at 8 weeks, and the esophageal squamous cell carcinoma was found in rats at 50 weeks. The carcinomas were found exclusively in the area of the reflux esophagitis and were accompanied by severe dysplasia. These results suggested that alkaline reflux of duodenal contents was strongly correlated to the development of the esophageal squamous cell carcinoma.抄録全体を表示PDF形式でダウンロード (6509K) -
A Clinicopathological StudyKEISHIRO AOYAGI, KIKUO KOHFUJI, SHOJIRO YANO, NAOTAKA MURAKAMI, HARUKO ...1999 年 46 巻 3-4 号 p. 171-174
発行日: 1999/12/15
公開日: 2009/08/11
ジャーナル フリーWe have reviewed the clinicopathological features of submucosal gastric cancer with lymph node metastasis. The degree of vertical submucosal infiltration was classified into three stages as sm1, sm2 or sm3. The number of cases with lymph node metastasis of sm3 was significantly more than that of sm1 or sm2. We found no correlation between the tumor size and the rate of lymph node metastasis from submucosal invasive cancer. Accordingly, we concluded that the vertical submucosal infiltration was a more important factor for lymph node metastasis than horizontal infiltration. Minimal invasive surgery was recommended for a tumor measuring 1 cm or less in size with vertical submucosal invasion of sm1 or sm2.抄録全体を表示PDF形式でダウンロード (598K) -
A Case ReportNAOFUMI ERIGUCHI, SHIGEAKI AOYAGI, MASAO HARA, KOHTARO HASHINO, MAHIRO ...1999 年 46 巻 3-4 号 p. 175-179
発行日: 1999/12/15
公開日: 2009/08/11
ジャーナル フリーThe patient was a 65-year-old woman with a chief complaint of right upper quadrant pain. Under the diagnosis of gallbladder tumor, preduodenal portal vein and absence of the pancreatic tail, cholecystectomy was performed. Intraoperative findings resulted in a diagnosis of gallbladder tumor, absence of the pancreatic tail, presence of preduodenal portal vein, and malrotation of the intestine. Histological examination of the resected specimens showed a so-called carcinosarcoma. Carcinosarcoma of the gallbladder is a rare tumor of the hepatobiliary region. The present case differs from previously reported cases in its presentation with multiple anomalies including the presence of preduodenal portal vein. Many cases of preduodenal portal vein in an association with duodenal stenosis in children have been reported, but reports of cases of preduodenal portal vein in adult patients are rarely seen in the literature.抄録全体を表示PDF形式でダウンロード (7716K) -
NAOFUMI ERIGUCI, SHIGEAKI AOYAGI, KOJI OKUDA, MASAO HARA, TSUYOSHI TAM ...1999 年 46 巻 3-4 号 p. 181-184
発行日: 1999/12/15
公開日: 2009/08/11
ジャーナル フリーSummary: The association of Turner's syndrome and endometrial carcinoma has been previouslyestablished, but has never been described in conjunction with a desmoid tumor of the colon. A caseis described of a colonic desmoid tumor developing in a 38-year-old female with Turner'ssyndrome. The association has not been previously reported. In this report, we describe a 38-yearoldwoman who has Turner's syndrome with a colonic desmoid and review the literature.抄録全体を表示PDF形式でダウンロード (4009K) -
SHIN NAKAHARA, TAKAFUMI YANO, YUICHI OSHITA, YUMIKO SHIGA, HIDEYUKI KO ...1999 年 46 巻 3-4 号 p. 185-189
発行日: 1999/12/15
公開日: 2009/08/11
ジャーナル フリーA 69-year-old man was admitted for evaluation of an abnormal chest X-ray. A diagnosis of primary bronchial amyloidosis was made on the basis of the chest X-ray, CT scans and bronchial biopsy specimens. The patient was treated with low-dose long-term erythromycin therapy (600 mg/day). After four months of therapy, chest CT scans, bronchoscopic findings and bronchial biopsy specimens revealed significant improvement of inflammatory changes. Low-dose erythromycin therapy may be helpful in terms of its anti-inflammatory effects for patients with bronchial amyloidosis.抄録全体を表示PDF形式でダウンロード (6791K) -
HISAFUMI KINOSHITA, HIROYASU IMAYAMA, MITSUO HASHIMOTO, SATOSHI FURUKA ...1999 年 46 巻 3-4 号 p. 191-194
発行日: 1999/12/15
公開日: 2009/08/11
ジャーナル フリーA 58-year-old male underwent pancreatoduodenectomy based on a diagnosis of middle bile duct cancer. Because abdominal drainage revealed bile leakage 5 days postoperatively, leakage at the site of cholangiojejunostomy was diagnosed, and continuous aspiration was performed. Seventeen days postoperatively, pus was discharged through the abdominal drain. Because bleeding was detected by abdominal drainage, and shock ensued 20 days postoperatively, emergency abdominal angiography was carried out to identify the bleeding site. A false aneurysm in the proper hepatic artery and extravasation from the gastroduodenal artery stump were recognized, and therefore, the proper hepatic artery and common hepatic artery were embolized at a site distal to the false aneurysm using microcoils. Celiac arteriography after transcatheter arterial embolization (TAE) did not show extravasation, and revealed blood flow from the right inferior phrenic artery to the liver. Liver function was normal after TAE, and the patient recovered and was discharged from the hospital 54 days postoperatively. This paper presents a patient in whom intraabdominal bleeding due to leakage at the site of cholangiojejunostomy complicated by infection was successfully treated by hemostasis with TAE.抄録全体を表示PDF形式でダウンロード (7709K) -
NAOFUMI ERIGUCHI, SHIGEAKI AOYAGI, KOJI OKUDA, HIROYASU IMAYAMA, TSUYO ...1999 年 46 巻 3-4 号 p. 195-198
発行日: 1999/12/15
公開日: 2009/08/11
ジャーナル フリーWe report a relatively rare case of lymphoepithelial cyst of the pancreas. The patient, a 43-year-old man with no subjective symptoms, was found to have a pancreatic tumor during a physical examination. Based on the ultrasonographic and abdominal computed tomographic findings, a pancreatic cystic tumor was diagnosed. Endoscopic retrograde pancreatography showed a normal duct system. Enucleation was easily performed. Macroscopically, the cyst resembled an atheroma. Histopathologic examination disclosed lymphoepithelial cyst of the pancreas.抄録全体を表示PDF形式でダウンロード (4173K)
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