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Volume 50 (2003)
- Issue 3-4 Pages 81-
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Volume 50, Issue 3-4
Displaying 1-16 of 16 articles from this issue
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MASAYA KAWANO, HIRONOBU ANAN, MASATSUGU SHIMIZU2003 Volume 50 Issue 3-4 Pages 81-85
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSTo clarify the indications and usefulness of Percutanous endoscopic gastrostomy (PEG) in patients with Silicosis and some co-morbidities, we analyzed eight cases of silicosis, who suffered from dysphagia and had received a PEG for tube feeding during the period from 1998 to 2002. The characteristics, and clinical course, of each case were statistically analyzed before and during PEG usage. All cases were bed-ridden males, with a mean age of 80 years. The profusion rate (PR) grade of silicosis was for five cases in category 2, and for three cases in category 4. Most of the co-morbidities were dementia (five cases), and chronic heart failure (four cases). There were no significant improvements in the measured nutrition criteria (albumin, lymphocytes) nor in respiratory function (arterial O2) between before and during PEG usage. Tube feeding through the PEG was not performed in three cases because of repeated aspiration pneumonia. The mean duration of PEG usage was 9 months, ranging from 5 to 20 months. Five cases died of the co-morbidities. Furthermore, there was significant deterioration in the bacteriological data (p=0.001), suggesting a worsening of the swallowing disturbances during PEG usage, or the emergence of more resistant organisms as a result of empirical antibiotic therapy. The present results suggest that the indications of PEG in cases of severe chronic obstructive pulmonary disease (COPD) such as silicosis, associated with other morbidities, and with dysphagia, are somewhat limited. The patient's general condition should be an important factor in deciding whether or not this technique should be used.View full abstractDownload PDF (713K) -
SATSUKI KOBAYASHI2003 Volume 50 Issue 3-4 Pages 87-90
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe previously developed a method of detecting drug-resistant mutation of hepatitis B virus (tyrosine (Y)-methionine (M)-aspartic acid (D)-aspartic acid (D) (YMDD) mutation) caused by the antiviral agent lamivudine. Using this method, we also reported that YMDD mutation is present in asymptomatic carriers that had not been administered antiviral agents. Thus, we investigated the clinical characteristics of 18 asymptomatic carriers of hepatitis B virus by various biochemical and virological examinations, and compared the results between five subjects with YMDD mutation and 13 subjects without mutation. Although there was no significant difference in the results of various examinations between the two groups, the quantity of virus was generally small, and S-antigen disappeared in 2 patients in whom YMDD mutation was detected. These results suggest that there is no particular cause for the appearance of mutant viruses, but that they occur spontaneously as they gain fitness and, with a subsequent decrease in the absolute quantity of viruses, become relatively easy to detect.View full abstractDownload PDF (589K) -
MICHIYO MATSUO2003 Volume 50 Issue 3-4 Pages 91-98
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe present study was performed to investigate the relationship between diabetes mellitus (DM) and primary hepatocellular carcinoma (HCC). Incident HCC cases were recruited in Kyushu, Japan. Ethnicity-, age-, gender-, residence-matched hospital controls and community controls were collected. Information on viral hepatitis B (HB5Ag) or viral hepatitis C infection, history of blood transfusion, past histories including DM, amount of drinking or smoking, and genotypes of alcohol metabolizing enzymes was collected. Associations between these items and HCC were analyzed multivariately by conditional logistic regression analysis. Two hundred and twenty two (177 males and 45 females) case-control sets were completed between July 1995 and June 2000. Since hospital controls turned out to be a biased one or those sampled from a DM-prone population, a multivariate analysis was performed for the HOC-community controls sets, and it yielded significantly elevated odds ratio (OR)s due to past histories of DM (2.522; 95% Confidence Interval (Cl)=1.267-5.020), blood transfusion (1.747; 1.136-2.689), and unit increment of alcohol consumption (1.358; 1.096-1.684) for males. The same analyses of the HOC-community controls sets for females, revealed an elevated but not statistically significant OR due to past histories of DM (4.195; 0.808-21.805). A multivariate analysis revealed that DM might be a risk factor for HOC.View full abstractDownload PDF (1139K) -
KUMIKO HAMAMOTO, TAKASHI SHIMIZU, YUTAKA KIDA, KOICHI KUWANO2003 Volume 50 Issue 3-4 Pages 99-107
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSCationic peptides are known to play critical roles in innate immunity. The peptides exert not only antimicrobial activity but also suppress the activity of lipopolysaccharide (LPS) and lipoteichoic acid (LTA) by binding to them. We have previously reported that L-peptide, a small linear cationic peptide derived from human granulysin displays broad-spectrum antimicrobial activity. In this study, the in vitro interactions of L-peptide with LPS and LTA were examined. LPS and LTA were found to inhibit the antimicrobial activity of the L-peptide in a dose-dependent manner, and they were shown to bind with the L-peptide. On the other hand, L-peptide failed to inhibit LPS- or LTA-induced cytokine production by macrophages or to block the binding of LPS to the cell surface. Thus, there seems to be a hierarchy that places LPS and LTA above L-peptide in the interactions of L-peptide with LPS and LTA.View full abstractDownload PDF (4003K) -
AKIRA SHIBATA, ITSURO OGIMOTO, YOUICHI KUROZAWA, TAKAYUKI NOSE, TAKESU ...2003 Volume 50 Issue 3-4 Pages 109-119
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe relationship between the past history of selected diseases and the risk of dying from hepatocellular carcinoma (HCC) was analyzed using 110, 792 cohort members (46, 465 males and 64, 327 females) recruited between 1988 and 1990 by the JACC Study (the Japan Collaborative Cohort Study for Evaluation of Cancer Risk). Significantly elevated hazard ratios (HRs) were observed in both genders for the past history of kidney diseases, liver diseases, gallstones or cholecystitis, diabetes mellitus, and blood transfusion. Further, when analyzed by age group (those 40-59 years of age were “younger” and those 60-79 years of age were “older”), although the significant associations were generally maintained, the magnitude of the HRs for liver diseases and diabetes mellitus seemed to be considerably different between the younger and older age groups for male cohort members. When the analyses were limited to cohort members without the past history of liver diseases, the past histories which had significantly elevated HRs were hypertension (HR=3.14, 95% confidence interval (Cl):1.25-7.89), diabetes mellitus (HR=4.17, 95% Cl: 1.22-14.25), and blood transfusion (HR=7.69, 95% Cl: 3.09-19.15) in the younger male age group and gallstone or cholecystitis (HR=2.58, 95% Cl: 1.11-5.98) in the older male age group. On the other hand, for females, the significantly elevated HRs were gastric or duodenal ulcer (HR=4.33, 95% Cl: 1.09-17.25) in the younger age group and diabetes mellitus (HR=6.16, 95% Cl: 2.25-16.90) and blood transfusion (HR=3.86, 95% Cl: 1.58-9.41) in the older age group. However, since the evidence from our univariate analyses might not be decisive, multivariate Cox proportional hazards models controlling for potential confounders and effect modifiers will be required to obtain more valid or unbiased hazard ratios.View full abstractDownload PDF (1527K) -
RITSU SAKATA2003 Volume 50 Issue 3-4 Pages 121-130
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA case-control study of idiopathic osteonecrosis of femoral head (ION) was carried out toinvestigate the association between workload intensity, smoking, drinking, ADH2 and ALDH2 genotypeand other factors and development of ION by comparing 43 cases (34 males and 9 females) without history of systemic corticosteroid use with 86 matched controls (68 males and 18 females). Univariate analysis by conditional logistic regression for males showed statistically significant odds ratios (OR) for heavier workload (OR=4.661), cumulative alcohol consumption (OR trend per drink-years=1.015), ALDH21/1 (OR=3.310), consumption of green tea less than 3 or 4 times/week (OR=2.705), body weight over 60 kg at examination (OR=0.413), or body mass index of over 25 at examination (OR=0.208). Multivariate analysis based on a hierarchically well-formulated model strategy for males revealed that heavier workload (OR=5.785, 95% confidence interval (Cl): 1.211, 27.635) and cumulative alcohol consumption (OR=1.016, 95% Cl: 1.005, 1.026) remained as the significantly associated risk factors for ION after adjusting the remaining confounders. The reason for the insignificant multivariate OR of ALDH21/1 may be due to the strong confounding of alcohol consumption on the association between ALDH2 genotype and ION. For females, the small sample size made it impossible to produce any meaningful univariate analysis.View full abstractDownload PDF (1458K) -
YOSHIAKI TANAKA, HIROYOSHI MIZOTE, TAKAHIRO ASAKAWA, HIDEFUMI KOBAYASH ...2003 Volume 50 Issue 3-4 Pages 131-137
Published: December 16, 2003
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSThe aims of this study were to determine the normal values of plasma diamine oxidase (pDAO) activity in children and to examine the influence of several factors (nutritional management, dietary fiber, and chemotherapy) on pDAO activity. The activity of pDAO was measured in 138 healthy children with minor surgical conditions such as inguinal hernia or undescended testis . In order to define normal values patients were subdivided into 5 groups according to age. Next, changes in pDAO activity under different nutritional conditions were studied in 14 patients with adhesive ileus. The influence of chemotherapeutic drugs on pDAO activity was also studied in 19 neuroblastoma patients. I. The normal values of pDAO activity at year<1, 1≤years<3, 3≤years<6, 6≤years<12, 12≤years were 6.65±1.75, 7.70±2.29, 6.53±1.68, 5.85±1.87, 5.06±1.84 units/I, respectively. II. The pDAO activities in patients with ileus were 4.73+1.02 (total parenteral nutrition), 6.84±1.18 (enteral nutrition), 7.62±0.67 (soluble dietary fiber added enteral nutrition) and 8.82.±1.26 units/I (oral feeding). The difference in pDAO activity at enteral or oral feeding vs . total parenteral nutrition was significant (p<.0001). III. The pDAO activity decreased significantly and remained low during the first 4 days after cyclophosphamide administration in neuroblastoma patients. The preadministration of dietary fiber inhibited the influence of cyclophosphamide. Plasma DAO activity was greatly influenced by nutritional management and administration of dietary fiber and/or cyclophosphamide. Plasma DAO activity may bea sensitive marker of intestinal function in children.View full abstractDownload PDF (1081K) -
SHIGEKI HIKIDA, YOSHIAKI TANAKA, TOMOMITSU TSURU, KENJIRO AKIYOSHI, KI ...2003 Volume 50 Issue 3-4 Pages 139-142
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSDespite the numerous approaches described for the management of neonates with “long gap” esophageal atresia, controversy still exists as to the preferred method. Delayed primary anastomosis is probably the most frequently adopted practice but often the native esophagus is abandoned. We report a case of a 2.98 kg newborn with pure esophageal atresia . Although the elongation of the distal esophageal pouch by mechanical bougienage was initiated at 1 year and 8 months, a successful tension-free anastomosis with minimum dissection of the lower esophagus was performed at 2 years and 7 months. Her postoperative quality of life has been quite excellent. This report emphasizes that a tension-free anastomosis without operating on the lower esophagus and stomach is essential for the treatment of long-gap esophageal atresia.View full abstractDownload PDF (4432K) -
KOICHI TAMURA, SHINZO TAKAMORI, AKIHIRO HAYASHI, KEISUKE MIWA, MARI FU ...2003 Volume 50 Issue 3-4 Pages 143-146
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe present a case of a 78-year-old man with a synchronous double cancer of the lung and Vater's papilla. A pancreaticoduodenectomy was performed for Vater's papilla cancer and a partial lung resection for lung cancer. The pathological diagnosis of the tumors was a well differentiated tubular adenocarcinoma and well differentiated bronchioloalveolar carcinoma, respectively. Although most cases of synchronous double cancers involve lung and gastric cancers, a combination of lung and Vater's papilla is extremely rare. This patient is still alive with no recurrence for 5 years after the last operation.View full abstractDownload PDF (5524K) -
HISASHI NAKAMURA, SHINZO TAKAMORI, KEISUKE MIWA, MART FUKUNAGA, KANETA ...2003 Volume 50 Issue 3-4 Pages 147-150
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA giant bulla of the lung is suggested as a risk factor for lung cancer. Here we report a case with lung cancer in a giant bulla, which showed rapid progression. A 57-year-old man, who had a history of heavy smoking, was admitted to our hospital due to hemoptysis. A chest X-ray revealed a giant bulla with a ground glass shadow and a high fluid level in the right upper lung. Sputum cytology was negative for malignant cells. A chest X-ray a month later showed increases of the size of the radio-opaque shadow and of the air-fluid retention, suggesting pulmonary hemorrhage from the giant bulla. Limited resection or lobectomy was indicated, but pneumonectomy was performed due to the severe air-leak. Macroscopically, a multiple nodular tumor arose from the bulla wall, which might be related to blood flow and necrotic tissue. The postoperative pathological diagnosis was papillary adenocarcinoma. Unfortunately, the patient developed a recurrence of carcinoma in the pleuroperitoneal cavity and died at 2.5 months after the operation. Based on this report and review of other cases in the literature, we should keep in mind the rapid progression of lung cancer in association with an emphysematous bulla.View full abstractDownload PDF (5930K) -
MASANORI NOGUCHI, JYUNRO YAHARA, TERUO MOTOMORI, SHINSHI NODA2003 Volume 50 Issue 3-4 Pages 151-153
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSAlthough open simple prostatectomy remains the reference standard for the treatment of excessively large or giant prostatic hyperplasia, advances in technology and techniques have facilitated safe transurethral management of select cases . We report a case undergoing removal over 200 g of prostatic adenoma by three transurethral electrovaporization (TVP) sessions and discuss its feasibility in clinical use.View full abstractDownload PDF (3204K) -
ASUKA SUZUKI, RYUKICHI KUMASHIRO, MIKI SHIRACHI, MINA KUROKI, HIROSHI ...2003 Volume 50 Issue 3-4 Pages 155-159
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe treated a patient simultaneously infected with hepatitis E virus and Leptospira interrogans, both acquired in China. Severe hyperbilirubinemia required nearly 200 days to resolve, transaminase elevation showed a fluctuating course, and liver biopsy specimens showed fibrosis unusual for hepatitis E. Leptospirosis appeared to have altered the course of hepatitis E virus infection in this patient, even though infection with Leptospira was cleared with antibiotics by 50 days after the onset of the hepatitis symptoms.View full abstractDownload PDF (4925K) -
TAKASHI KINOSHITA, RUMI GOHARA, TAKEHARU KOGA, YOSHIKO SUEYASU, HIROSH ...2003 Volume 50 Issue 3-4 Pages 161-163
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSPulmonary arteriovenous malformation (PAVM) is an anomaly condition characterized by abnormal vascular communications between arteries and veins in the lungs. Hereby we describe a 60-year-old female with PAVM. Although the patient was asymptomatic, an abnormal round opacity was found on a chest X-ray film. Computed tomography (CT) of the lung disclosed nodules connected with enlarged vessels. Because PAVM was suspected, the patient was further evaluated by spiral CT coupled with three dimensional reconstruction of the images (3D-CT). As a result, PAVM was clearly visualized and invasive procedures such as angiography was not performed. The present case illustrates that 3D-CT is a diagnostic procedure of choice when PAVM is suspected.View full abstractDownload PDF (3017K) -
YUMI TAKEMOTO, NAOYO NISHIDA, SAKIKO KOJIRO, ATSUROU JIMI, MASAMICHI K ...2003 Volume 50 Issue 3-4 Pages 165-167
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSIn 1991, a carcinoid tumor of the duodenum with metastasis in the regional lymph nodes was resected in a 39-year-old-man. A metastasis in the mediastinum was found and was resected in 1996. In 1999, a metastasis in the left lung was discovered and was excised. In 2001, he noticed right-sided diplopia, and a computed tomography (CT) scan disclosed a tumor of 2 cm diameter in the right orbit with infiltration to the frontal sinus. The tumor was resected, and was diagnosed metastatic carcinoid tumor. An orbital metastasis of carcinoid tumor is rare, and only about 30 cases have been reported in the English literature. The rarity metastasis of carcinoid tumors in the orbit prompted us to report this case.View full abstractDownload PDF (5158K) -
A Report of 2 Resected CasesSAKI KOJIRO, YOSHIHITO TOMIOKA, YUMI TAKEMOTO, NAOYO NISHIDA, TOSHIHAR ...2003 Volume 50 Issue 3-4 Pages 169-172
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSLeiomyoma of the ovary is relatively rare and its origin is still controversial. Here, we report 2 cases of ovarian leiomyoma. Case 1, a 59-year-old woman who complained of abdominal distention. Ultrasonography and computed tomography revealed a large solid mass in the lower abdomen. The mass was diagnosed as uterine myoma preoperatively, but it turned out to be a left ovarian tumor at laparotomy. The tumor was about an adult-head size, grayish, elastic hard, and solid. In case 2, a fist-sized mass was accidentally detected in the right ovary of a 84-year-old woman during laparotomy for rectal cancer. Histologically both tumors were composed of solid proliferation of short spindle-shaped cells, that formed interlacing fascicles and showed varying degrees of hyalinization. Both tumors were diagnosed as leiomyoma. Although this tumor is rather infrequent, it is necessary to consider leiomyoma for differential diagnosis, when a solid tumor is detected in the ovary.View full abstractDownload PDF (6214K) -
NAOYO NISHIDA, AKIKO NONOSHITA, SAKIKO KOJIRO, YUMI TAKEMOTO, MASAMICH ...2003 Volume 50 Issue 3-4 Pages 173-175
Published: December 16, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSUterine intravenous leiomyomatosis a rather rare pathologic condition, and a total of 139 cases have appeared in the English literature. Although two proposals for the histologic origin, uterine lyomyoma itself and/or vascular smooth muscle, have been widely accepted, the precise histogenesis still remains unclear. The additional 140th case of intravenous leiomyomatosis is described, and a third postulation for the histogenesis is proposed.View full abstractDownload PDF (3659K)
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