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Volume 50, Issue 1-2
Displaying 1-14 of 14 articles from this issue
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KEISHIRO AOYAGI, KIKUO KOUFUJI, SHOJIRO YANO, NAOTAKA MURAKAMI, MOTOSH ...2003 Volume 50 Issue 1-2 Pages 1-7
Published: June 13, 2003
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSThe aim of the present study was to examine the significance of the p21 expression in gastric cancer. We examined the expression of p53, p21, TGF β1 and PCNA in 75 cases of gastric cancer using immunohistochemical examinations and the expression of p21 RNA by in situ hybridization (ISH). The combination of p53 and p21 expressions was related to depth of invasion, lymph node metastasis, and stage grouping. The survival curves of the p53 negative-Group and the p21-positive Group were significantly higher than those of the p53-positive and the p21-negative Group, the p53-and-p21-both-positive Group, and the p53-and-p21-both-negative Group (each p<0.01). The average PCNA Labelling Index (LI) of the p53-negative-and-p21-positive Group was significantly lower than that of either the p53-positive-and-p21-negative Group or the p53-and-p21-both-positive Group or the p53-and-p21-both-negative Group (p<0.01, p<0.05, p<0.05, respectively). All of the p53-and-p21-both-positive cases were TGF 61 positive, and the rate of the TGF β1 positive cases in the p53-and-p21-both-positive Group was significantly higher than that of the p53-positive-and-p21-negative Group, and than the rate in the p53-and-p21-both-negative Group (each p<0.01). The survival curves of the cases with expression of p21 RNA were higher than that of cases without p21 RNA (p<0.05). Many of the p53-positive-and-p21-negative cases were advanced cancer with very poor prognosis, but many of the p53-negative-and-p21-positive cases were early cancer with good prognosis. These results suggest that p21 suppressed synthesis of DNA via PCNA, and TGF β1 is a regulation factor for the expression of p21, and that the combination of p53 and p21 expression is concluded to be a useful prognostic marker of gastric carcinoma.View full abstractDownload PDF (5322K) -
EIICHIRO SUGIHARA, TAKESHI KOYANAGI, TAKASHI NIIZEKI, NAOTOSHI HIROTA, ...2003 Volume 50 Issue 1-2 Pages 9-15
Published: June 13, 2003
Released on J-STAGE: February 08, 2010
JOURNAL FREE ACCESSSince a “low-dose and long-term” administration of erythromycin (EM) was reported to be effective in patients with chronic respiratory diseases, including diffuse panbronchiolitis (DPB), the modulation of host defense responses by EM has attracted much attention. Despite considerable controversy, it was recently demonstrated that macrolides reduced neutrophil function. In this study, we investigated the effects of EM, a 14-membered ring macrolide, azithromycin (AZM), a 15-membered ring macrolide, and rokitamycin (RKM), a 16-membered ring macrolide, on neutrophil function in terms of active oxygen generation of neutrophils in the absence and presence of mononuclear cells in vitro. EM and AZM significantly suppressed active oxygen generation by neutrophils in the absence of mononuclear cells at low concentration (0.5 μg/ml. p<0.05). At the next step, to confirm that EM and AZM directly reduced active oxygen generation by neutrophils, we investigated whether mononuclear cells affected this effect of EM and AZM. In the presence of mononuclear cells pretreated with EM or AZM, both antibiotics suppressed active oxygen generation at concentrations ranging from 0.5 to 20 μg/ml. However, the inhibition rates induced by EM and AZM at low concentrations were not so different between the absence and the presence of mononuclear cells. These results indicated that EM and AZM have direct effects on the active oxygen generation by neutrophils and those effects that were not influenced by mononuclear cells. This inhibitory effect may be responsible for the therapeutic efficacy of these 14-membered and 15-membered ring macrolides in patients with DPB.View full abstractDownload PDF (4001K) -
HISAFUMI KINOSHITA, MASAO HARA, KAZUNORI NISHIMURA, TAKAHITO KODAMA, H ...2003 Volume 50 Issue 1-2 Pages 17-19
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe evaluated the resection of the papilla of Vater performed in patients with cancer in the papilla of Vater. The subjects were 6 patients who underwent resection of the papilla of Vater between January 1969 and December 2001. The patients aged 57-87 years consisted of 3 males and 3 females. The maximal diameter of the tumors was 0.5 cm in 1 patient, 1.5 cm in 3 patients, and 2.0 cm in 2 patients. Macroscopically, the tumors were of the protruded type (exposed) in 3 patients, of the mixed type (predominant protruded type) in 2 patients, and of the ulcerative type in 1 patient. The histological depth of the tumors was up to the mucosa in 1 patient, up to the oddi in 1 patient, up to the panc0, du1 in 1 patient, up to the panc1, du2 in 1 patient, and unknown in 2 patients. Histologically, the tumors were papillotubular adenocarcinoma (pap-tub) in 4 patients and tubular adenocarcinoma of the well-differentiated type (tubs) in 2 patients. Resection of the papilla of Vater was chosen because of high risk factors such as advanced age in 2 patients, complicated severe cirrhosis and confinement to bed due to poor systemic conditions after intracerebral hemorrhage in 3 patients, and hepatic metastasis observed during surgery in 1 patient. Residual cancer cells around the excised region were positive in 4 patients and unknown in the remaining 2 patients. Of the 6 patients, 5 died within 2 years after surgery, but 1 is alive without symptoms of recurrence 7 years after surgery. The death causes were the primary disease in 3 of the 5 patients. From the viewpoint of radical treatment, resection of the papilla of Vater cannot be chosen as a reduced surgery for cancer in the papilla of Vater. However, resection of the papilla of Vater can be applied to very elderly patients and patients under poor systemic conditions, for whom pancreatoduodenectomy (PD) is considered excessively invasive due to a small diameter of tumor.View full abstractDownload PDF (433K) -
NAOFUMI ONO, HIROYASU IJUIN, HIDEYA SUGA, YOSHINOBU OKABE, KAZUAKI YAK ...2003 Volume 50 Issue 1-2 Pages 21-25
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSUsefulness of Levovist contrast ultrasonography by the B-Flow method was evaluated in cases of hepatic tumor. Subjects included 14 patients with moderately differentiated hepatocellular carcinoma and 4 patients with hepatic hemangioma. Each patients had a single tumor mass. Images showed strong staining in 11 of the 14 nodes in the hepatocellular carcinomas and all 4 hemangiomas. Staing was seen only in lesions located within 4 cm of the probe. Thus B-Flow ultrasonography using Levovist was proved useful for evaluating vascularity of superficially located.View full abstractDownload PDF (6352K) -
MITSUE TAKEYA, HIROSHI HASUO, TAKASHI AKASU2003 Volume 50 Issue 1-2 Pages 27-34
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSEffects of L-arginine on the heat-induced depression of the neuronal activity in the hippocampal CA1 area were investigated using optical recording techniques. An increase in the temperature of hippocampal neurons from 32°C to 38°C reversibly depressed the fast and slow components of the optical response to stimulation of the Schaffer collaterals that correspond to the presynaptic action potential and excitatory postsynaptic response, respectively. The neuronal activity recovered almost completely after cooling the hippocampal neurons back to 32°C. A temperature increase to 40°C produced irreversible depression of the neuronal activity. Pyruvate, but not lactate, in the artificial cerebrospinal fluid (ACSF) attenuated the depression of the neuronal activity induced by a temperature increase to 38°C. Bath-application of L-arginine (1 mM), a nitric oxide (NO) donor, enhanced the depression of the neuronal activity at 38°C. In the presence of L-arginine, the recovery of neuronal activity, upon return to 32°C, was incomplete. The contribution of NO to the heat-induced impairment of the neuronal activity was discussed.View full abstractDownload PDF (3628K) -
AKIRA ISHIBASHI, YOSHITAKE YOKOKURA2003 Volume 50 Issue 1-2 Pages 35-39
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThis study was designed to investigate the outcomes in patients with massive cerebral infarction, and to determine the risk factors associated with worse outcomes in the patients with massive cerebral infarction. Twenty-seven patients with acute massive cerebral infarction were hospitalized in our institution. These 10 men and 17 women had an average age of 77.8 years (range, 42 to 97 years). Some patients had multiple infarctions. Thirteen patients had infarctions of the middle cerebral artery, 12 patients had internal carotid artery infarctions, 6 patients had anterior cerebral artery infarctions, and 3 patients had vertebro-basilar artery infarctions. The causes of the main cerebral arterial infarctions were cardiac embolism in 22 patients, atherothrombosis in 4 patients, and unknown in one patient. Fifteen (55%) of the 27 patients died from transtentorial herniation caused by massive cerebral infarction or from general complications. Of the 12 patients (45%) who survived, 8 patients were moderately disabled, 1 patient was severely disabled, and 3 patients existed in a vegetative state. Worse outcomes were more frequent in younger patients with internal carotid artery infarctions related to cardiogenic embolism.View full abstractDownload PDF (2994K) -
ICHIRO IMAMURA2003 Volume 50 Issue 1-2 Pages 41-48
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSThe purpose of the present study was to investigate, retrospectively, the clinical significance of treatments for extrahepatic metastasis after surgical treatment of hepatocellular carcinoma (HCC). Forty-seven patients, in whom extrahepatic metastasis developed after hepatic resection or microwave coagulation therapy (MCT) for primary HCC, were enrolled in this study. Metastatic organs were lung (38 cases), bone (10 cases), brain (6 cases), adrenal gland (3 cases), and lymph nodes (9 cases), including duplicated cases. Twenty eight patients were treated with surgical resection, anticancer chemotherapy, radiation and immunotherapy for the extrahepatic metastasis (the treatment group). Nineteen patients were in no treatment except symptomatic therapy (the nontreatment group). The 1- and 3-year survival rates after development of extrahepatic metastasis in the treatment group were 42.3% and 17.8%, respectively. No patients in the non-treatment group survived more than 2 years. There was a significant difference between the treatment and the nontreatment group (p=0.0021) with regard to survival rate. Univariate analysis of the treatment group showed the following factors to be significant for survival: 1) intrahepatic lesion(s) was cleared or well controlled by some type of treatment, 2) the treatment for extrahepatic metastasis was effective, 3) extrahepatic metastasis was recognized in Grade A of Child-Pugh classification. Treatment of extrahepatic metastasis of HCC was of great significance for the prognosis.View full abstractDownload PDF (1050K) -
KEISHIRO AOYAGI, KIKUO KOUFUJI, SHOJIRO YANO, MOTOSHI MIYAGI, ATSUHIKO ...2003 Volume 50 Issue 1-2 Pages 49-51
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe have experienced a case of small early mucosal gastric cancer with lymph node metastasis. The patient was a 75-year-old woman diagnosed as having early gastric cancer type 0 ha on the greater curvature of the antrum. We performed distal gastrectomy, with Billroth I method reconstruction. The tumor lesion was on the greater curvature of the antrum. Metastasis was discovered in the number 4d lymph node, histologically. The tumor was type 0 ha confined to the mucosa, 1.0 cm in diameter and differentiated histological type, and no ulcer scar could be seen in tumor lesion. However, the tumor was massively invading to the mucosal membrane, with positive lymph vessel invasion, and was of mixed histological type. This was a rare case of small early mucosal cancer 1.0 cm in diameter with lymph node metastasis.View full abstractDownload PDF (3603K) -
KEISHIRO AOYAGI, KIKUO KOUFUJI, SHOJIRO YANO, MOTOSHI MIYAGI, ATSUHIKO ...2003 Volume 50 Issue 1-2 Pages 53-56
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe have experienced two cases of early gastric cancer with synchronous liver metastasis. One patient was a 64-year-old man diagnosed as having early gastric cancer type 0 lla at 15×10 mm on the lesser curvature of the cardia. The other patient was a 58-year-old man diagnosed as having early gastric cancer type 0 lla+llc at 24×18 mm on the posterior wall of the antrum. The histological findings showed that proliferation of moderately differentiated tubular adenocarcinoma with hepatoid pattern was massively invading to the deep layer of the submucosa, with positive lymph vessel, vein invasion and lymph node metastasis, in both cases. These results suggested that elevated or mixed macroscopic type, differentiated adenocarcinoma massively invading to the deep layer of submucosa, positive lymph vessel and vein invasion, lymph node metastasis, and hepatoid adenocarcinoma were risk factors for liver metastasis from early gastric cancer.View full abstractDownload PDF (5650K) -
YOSHINOBU OKABE, NAOFUMI ONO, HIDEYA SUGA, HIROYASU IJUIN, TAKAHITO KO ...2003 Volume 50 Issue 1-2 Pages 57-61
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSA 55-year-old man with alcoholic chronic pancreatitis was hospitalized for further treatment of intractable repeated upper abdominal pain. A laboratory data showed normal hepatobiliary enzymes and glucose tolerance test, but abnormal pancreatic enzymes including amylase, lipase, trypsin and elastase I. Pancreatic function diagnostant test was 71%. Abdominal ultrasound examination and computed tomography showed an approximately 4 mm main pancreatic duct stone and multiple small stones in the surrounding parenchyma, and the findings being compatible with chronic pancreatitis. Endoscopic retrograde cholangiopancreatrography revealed that there was a main pancreatic duct stone in the pancreas head, and that the caudal pancreatic duct could not be visualized due to the impacted stone. In addition, intrapancreatic bile duct showed no malignant irregularity, but pancreatitis-induced smooth narrowing. The patient underwent extracorporeal shock wave lithotripsy (ESWL) alone, because endoscopic manipulation for pancreatic stone removal was impossible due to tightly impacted stone with stenosis. Successful ESWL was achieved with the stone disappearance and without any complication.View full abstractDownload PDF (7115K) -
KEISHIRO AOYAGI, KIKUO KOUFUJI, SHOJIRO YANO, MOTOSHI MIYAGI, ATSUHIKO ...2003 Volume 50 Issue 1-2 Pages 63-66
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe have experienced two cases of α-fetoprotein (AFP)-producing early gastric cancer. One patient was a 73-year-old man diagnosed as having an early gastric cancer type 0 l+lla at 40××40 mm on the greater curvature of the lower body of the stomach. The histological findings showed that proliferation of a well-differentiated tubular adenocarcinoma with hepatoid pattern was massively invading to the middle layer of the submucosa, with positive lymph vessel, and lymph node metastasis. The other patient was a 76-year-old man diagnosed as having an early gastric cancer type 0 lla+llc at 25×25 mm on the anterior wall on the greater curvature of the antrum. The histological findings showed that proliferation of a small cell carcinoma was massively invading to the deep layer of the submucosa, with positive lymph vessel, and lymph node metastasis. AFP was immunohistochemically found in the tumor cells of these two cases. Both patients died from liver metastasis. AFP-producing early gastric cancer was concluded to be at high risk of liver metastasis.View full abstractDownload PDF (5501K) -
FUMITAKE ONO, OSAMU MORI, TAKASHI HASHIMOTO2003 Volume 50 Issue 1-2 Pages 67-70
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSWe report on a 31-year-old Japanese female with an epidermoid cyst developed in the right inguinal region. The lesion was excised and drained by a surgeon. Since there was a local recurrence of the lesion within 2 months, the patient visited us, and the lesion was completely excised. Only the cells in the lowermost layer of the cyst wall showed dysplasia, which was characterized by irregular, and hyperchromatic nuclei with coarsely clumped nuclear chromatin pattern. However, solar elastosis was not observed, and spongiosis surrounding the atypical cells was present. In addition, melanophages were seen in the upper dermis. In conclusion, atypical keratinocytes in the lowermost portion of the cyst wall were deemed to be secondary to inflammation due to treatment by a surgeon rather than to development of both in situ and invasive squamous cell carcinomas in an epidermoid cyst.View full abstractDownload PDF (2377K) -
RYOHEI KAJI, NOZOMI SASAKI, IKUO TATEISHI, EISUKE NAGATA, YOSHINOBU OK ...2003 Volume 50 Issue 1-2 Pages 71-75
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSPrimary hepatic squamous cell carcinoma is rare. In this case, a malignant lesion was detected in bilateral hepatic lobes by ultrasound sonography and computed tomography. The maximum tumor diameter was approximately 10 cm. Tumor tissue obtained by aspiration liver biopsy was diagnosed as poorly differentiated squamous cell carcinoma. In gallium radioisotope scanning, no focus was detected in any organs other than the liver. As therapy, anti-cancer drugs were administered via hepatic arterial infusion. The patient received 10 mg of cis-diaminedichloroplatinum (CDDP) and 250 mg of 5-fluorouracil (5-FU) for 5 days every week. The therapy was continued for 3 weeks, and the same doses of CDDP and 5-FU were given to the patient once per 2 weeks in the clinic. The intrahepatic tumor lesion began to decrease from the start of treatment, and had almost disappeared 8 months after. Recurrence of the liver tumor occurred at 12 months from the start of treatment. The patient was re-admitted and treated with the same anti-cancer drugs via hepatic arterial injection. However, the drugs showed remarkable effect no longer and she died in month 23. The treatment with chemotherapy via hepatic arterial injection for a patient with squamous cell carcinoma offered a favorable therapeutic effect.View full abstractDownload PDF (6128K) -
SADATAKA INUZUKA, NOBUO TOMIYASU, MASAFUMI KUMAMOTO, TATUNARI EGASHIRA ...2003 Volume 50 Issue 1-2 Pages 77-80
Published: June 13, 2003
Released on J-STAGE: August 11, 2009
JOURNAL FREE ACCESSFibrates are widely used for treatment of hyperlipidemia. It has been reported that gallbladder stones are formed by administration of clofibrate. It is thought that fenofibrate can cause the formation of gallbladder stone as a side effect. We encountered a patient with hyperlipidemia in whom a gallbladder stone was detected by computed tomographic scanning 3 months after the start of administration of fenofibrate during follow-up observation by blood biochemical examination and computed tomographic scanning. This case report will be of great value and importance.View full abstractDownload PDF (2709K)
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